ALLMedicine™ Alexander Disease Center

Apr 17th, 2021 - Adult-onset Alexander disease mimicking multiple system atrophy predominant cerebellar ataxia.|2021|Watanabe Y,Tsukahara Y,Fujita H,Sakuramoto H,Shiina T,|

Mar 9th, 2021 - Alexander disease (AxD) is a rare neurodegenerative disorder that is caused by dominant mutations in the gene encoding glial fibrillary acidic protein (GFAP), an intermediate filament that is primarily expressed by astrocytes. In AxD, mutant GFAP ...

Jan 4th, 2021 - In infantile Alexander disease (iAxD), one of the serious symptoms is intractable epilepsy, and some reports have suggested that neuroinflammation may be involved in the pathophysiology of the disease. Drug-resistant seizures adversely affect not ...

Nov 11th, 2020 - Alexander disease, a progressive disorder of cerebral white matter caused by a heterozygous GFAP pathogenic variant, comprises a continuous clinical spectrum most recognizable in infants and children and a range of nonspecific neurologic manifesta...

Nov 8th, 2020 - A case of adult onset of Alexander disease with nocturnal painless burns, autonomic dysfunction, and peripheral nerve impairment.|2020|Sun Y,Wang Z,Li F,Wei L,Sun W,|

Apr 17th, 2021 - Adult-onset Alexander disease mimicking multiple system atrophy predominant cerebellar ataxia.|2021|Watanabe Y,Tsukahara Y,Fujita H,Sakuramoto H,Shiina T,|

Mar 9th, 2021 - Alexander disease (AxD) is a rare neurodegenerative disorder that is caused by dominant mutations in the gene encoding glial fibrillary acidic protein (GFAP), an intermediate filament that is primarily expressed by astrocytes. In AxD, mutant GFAP ...

Jan 4th, 2021 - In infantile Alexander disease (iAxD), one of the serious symptoms is intractable epilepsy, and some reports have suggested that neuroinflammation may be involved in the pathophysiology of the disease. Drug-resistant seizures adversely affect not ...

Nov 11th, 2020 - Alexander disease, a progressive disorder of cerebral white matter caused by a heterozygous GFAP pathogenic variant, comprises a continuous clinical spectrum most recognizable in infants and children and a range of nonspecific neurologic manifesta...

Nov 8th, 2020 - A case of adult onset of Alexander disease with nocturnal painless burns, autonomic dysfunction, and peripheral nerve impairment.|2020|Sun Y,Wang Z,Li F,Wei L,Sun W,|