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About 430 results

ALLMedicine™ Alexander Disease Center

Research & Reviews  215 results

Adult-onset Alexander disease mimicking multiple system atrophy predominant cerebellar ...
https://doi.org/10.1016/j.jocn.2021.03.001
Journal of Clinical Neuroscience : Official Journal of Th... Watanabe Y, Tsukahara Y et. al.

Apr 17th, 2021 - Adult-onset Alexander disease mimicking multiple system atrophy predominant cerebellar ataxia.|2021|Watanabe Y,Tsukahara Y,Fujita H,Sakuramoto H,Shiina T,|

Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941726
Journal of Neuroinflammation; Boyd MM, Litscher SJ et. al.

Mar 9th, 2021 - Alexander disease (AxD) is a rare neurodegenerative disorder that is caused by dominant mutations in the gene encoding glial fibrillary acidic protein (GFAP), an intermediate filament that is primarily expressed by astrocytes. In AxD, mutant GFAP ...

Ketogenic Diet Therapy for Intractable Epilepsy in Infantile Alexander Disease: A Small...
https://doi.org/10.1016/j.eplepsyres.2020.106519
Epilepsy Research; Hamada S, Kato T et. al.

Jan 4th, 2021 - In infantile Alexander disease (iAxD), one of the serious symptoms is intractable epilepsy, and some reports have suggested that neuroinflammation may be involved in the pathophysiology of the disease. Drug-resistant seizures adversely affect not ...

Alexander Disease - GeneReviews® - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/n/gene/alexander/

Nov 11th, 2020 - Alexander disease, a progressive disorder of cerebral white matter caused by a heterozygous GFAP pathogenic variant, comprises a continuous clinical spectrum most recognizable in infants and children and a range of nonspecific neurologic manifesta...

A case of adult onset of Alexander disease with nocturnal painless burns, autonomic dys...
https://doi.org/10.1016/j.clineuro.2020.106350
Clinical Neurology and Neurosurgery; Sun Y, Wang Z et. al.

Nov 8th, 2020 - A case of adult onset of Alexander disease with nocturnal painless burns, autonomic dysfunction, and peripheral nerve impairment.|2020|Sun Y,Wang Z,Li F,Wei L,Sun W,|

see more →

Clinicaltrials.gov  215 results

Adult-onset Alexander disease mimicking multiple system atrophy predominant cerebellar ...
https://doi.org/10.1016/j.jocn.2021.03.001
Journal of Clinical Neuroscience : Official Journal of Th... Watanabe Y, Tsukahara Y et. al.

Apr 17th, 2021 - Adult-onset Alexander disease mimicking multiple system atrophy predominant cerebellar ataxia.|2021|Watanabe Y,Tsukahara Y,Fujita H,Sakuramoto H,Shiina T,|

Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941726
Journal of Neuroinflammation; Boyd MM, Litscher SJ et. al.

Mar 9th, 2021 - Alexander disease (AxD) is a rare neurodegenerative disorder that is caused by dominant mutations in the gene encoding glial fibrillary acidic protein (GFAP), an intermediate filament that is primarily expressed by astrocytes. In AxD, mutant GFAP ...

Ketogenic Diet Therapy for Intractable Epilepsy in Infantile Alexander Disease: A Small...
https://doi.org/10.1016/j.eplepsyres.2020.106519
Epilepsy Research; Hamada S, Kato T et. al.

Jan 4th, 2021 - In infantile Alexander disease (iAxD), one of the serious symptoms is intractable epilepsy, and some reports have suggested that neuroinflammation may be involved in the pathophysiology of the disease. Drug-resistant seizures adversely affect not ...

Alexander Disease - GeneReviews® - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/n/gene/alexander/

Nov 11th, 2020 - Alexander disease, a progressive disorder of cerebral white matter caused by a heterozygous GFAP pathogenic variant, comprises a continuous clinical spectrum most recognizable in infants and children and a range of nonspecific neurologic manifesta...

A case of adult onset of Alexander disease with nocturnal painless burns, autonomic dys...
https://doi.org/10.1016/j.clineuro.2020.106350
Clinical Neurology and Neurosurgery; Sun Y, Wang Z et. al.

Nov 8th, 2020 - A case of adult onset of Alexander disease with nocturnal painless burns, autonomic dysfunction, and peripheral nerve impairment.|2020|Sun Y,Wang Z,Li F,Wei L,Sun W,|

see more →