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About 32,632 results

ALLMedicine™ Amyotrophic Lateral Sclerosis Center

Research & Reviews  15,853 results

Effects of an optimised approach to home-based respiratory care in individuals with amy...
https://doi.org/10.1136/bmjopen-2020-042780
BMJ Open; Pondofe K, Fregonezi GAF et. al.

Apr 10th, 2021 - This study aims to investigate the effects of an optimal home-based respiratory care protocol in individuals with amyotrophic lateral sclerosis (ALS). This is a randomised, blinded controlled trial involving patients diagnosed with ALS, both sexes...

People with amyotrophic lateral sclerosis and their caregivers: what matters most?
https://doi.org/10.1136/bmjspcare-2020-002741
BMJ Supportive & Palliative Care; Brunori P, Celani MG et. al.

Apr 9th, 2021 - The aim of this study is to collect the perspectives and values of people affected by amyotrophic lateral sclerosis (ALS) and their carers to offer clinicians, researchers and policymakers aspects which are precious in prioritising future research...

Connecting TDP-43 Pathology with Neuropathy.
https://doi.org/10.1016/j.tins.2021.02.008
Trends in Neurosciences; Klim JR, Pintacuda G et. al.

Apr 9th, 2021 - Transactive response DNA-binding protein 43 kDa (TDP-43), a multifunctional nucleic acid-binding protein, is a primary component of insoluble aggregates associated with several devastating nervous system disorders; mutations in TARDBP, its encodin...

Targeting Gys1 with AAV-SaCas9 Decreases Pathogenic Polyglucosan Bodies and Neuroinflam...
https://doi.org/10.1007/s13311-021-01040-7 10.2174/1566524024605761 10.1016/j.tplants.2013.08.004 10.1002/ana.410440604 10.1016/j.gene.2012.12.065 10.1074/jbc.M807428200 10.1073/pnas.0503285102 10.1038/s41582-018-0057-0 10.1038/2470 10.1038/ng1238 10.1371/journal.pgen.1002037 10.1002/acn3.51211 10.1007/s12035-019-01842-z 10.1017/erm.2020.5 10.1007/s12035-016-9884-4 10.1016/j.nbd.2020.105173 10.1007/s12035-020-02170-3 10.1111/jnc.15176 10.1074/jbc.RA120.015773 10.1093/hmg/11.11.1251 10.1002/ana.22156 10.1093/hmg/ddv385 10.1002/ana.24104 10.1093/hmg/ddu024 10.1007/s11481-019-09849-y 10.1016/j.lfs.2020.118165 10.1038/nbt.2647 10.1038/nature14299 10.1089/hum.2016.013 10.1038/mtm.2016.2 10.1038/nmeth.2089 10.1038/s41592-019-0582-9 10.1074/jbc.RA120.015061 10.1124/jpet.106.115550 10.3389/fncel.2015.00431 10.15252/emmm.201707608 10.1016/j.devcel.2015.01.035 10.1007/s11011-020-00630-2 10.1016/j.brainres.2011.03.014 10.1016/j.ymthe.2020.09.033 10.1186/s13059-015-0817-8 10.1038/sj.gt.3301514 10.1038/sj.gt.3302134 10.1016/j.omtm.2018.02.005 10.1016/S0378-1119(02)00878-8 10.1016/j.febslet.2009.10.036 10.1007/s12035-021-02285-1
Neurotherapeutics : the Journal of the American Society F... Gumusgoz E, Guisso DR et. al.

Apr 8th, 2021 - Many adult and most childhood neurological diseases have a genetic basis. CRISPR/Cas9 biotechnology holds great promise in neurological therapy, pending the clearance of major delivery, efficiency, and specificity hurdles. We applied CRISPR/Cas9 g...

Activation of cGAS/STING pathway upon TDP-43-mediated mitochondrial injury may be invol...
https://doi.org/10.1111/liv.14895
Liver International : Official Journal of the Internation... Yong H, Wang S et. al.

Apr 8th, 2021 - Recently, we read with great interest the article published in Cell by Yu et al, which reported that TAR DNA-binding protein 43 (TDP-43) overexpression stimulated the released of mitochondrial DNA (mtDNA) into the cytoplasm through mitochondrial p...

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Guidelines  9 results

Aquestive Therapeutics Receives FDA Approval for Exservan (riluzole) Oral Film
http://aquestive.com/aquestive-therapeutics-receives-fda-approval-for-exservan-riluzole-oral-film/

Nov 24th, 2019 - Aquestive Therapeutics, Inc. (NASDAQ: AQST), a specialty pharmaceutical company focused on developing and commercializing differentiated products to solve therapeutic problems, today announced that Exservan™ (riluzole) Oral Film received early-act...

Provisional best practices guidelines for the evaluation of bulbar dysfunction in amyot...
https://doi.org/10.1002/mus.26408
Muscle & Nerve; Pattee GL, Plowman EK et. al.

Jan 8th, 2019 - Universally established comprehensive clinical bulbar scales objectively assessing disease progression in amyotrophic lateral sclerosis (ALS) are currently lacking. The goal of this working group project is to design a best practice set of provisi...

MDA U.S. Neuromuscular Disease Registry
https://www.mda.org/services/neuromuscular-disease-registry
Muscular Dystrophy Association (USA)

Dec 31st, 2015 - In 2013, MDA launched the U. S.

EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS)--rev...
https://doi.org/10.1111/j.1468-1331.2011.03501.x
European Journal of Neurology; , Andersen PM et. al.

Sep 14th, 2011 - The evidence base for the diagnosis and management of amyotrophic lateral sclerosis (ALS) is weak. To provide evidence-based or expert recommendations for the diagnosis and management of ALS based on a literature search and the consensus of an exp...

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764728
Neurology Miller RG, Jackson CE et. al.

Oct 13th, 2009 - To systematically review evidence bearing on the management of patients with amyotrophic lateral sclerosis (ALS). The authors analyzed studies from 1998 to 2007 to update the 1999 practice parameter. Topics covered in this section include breaking...

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Drugs  31 results see all →

Clinicaltrials.gov  16,263 results

Effects of an optimised approach to home-based respiratory care in individuals with amy...
https://doi.org/10.1136/bmjopen-2020-042780
BMJ Open; Pondofe K, Fregonezi GAF et. al.

Apr 10th, 2021 - This study aims to investigate the effects of an optimal home-based respiratory care protocol in individuals with amyotrophic lateral sclerosis (ALS). This is a randomised, blinded controlled trial involving patients diagnosed with ALS, both sexes...

People with amyotrophic lateral sclerosis and their caregivers: what matters most?
https://doi.org/10.1136/bmjspcare-2020-002741
BMJ Supportive & Palliative Care; Brunori P, Celani MG et. al.

Apr 9th, 2021 - The aim of this study is to collect the perspectives and values of people affected by amyotrophic lateral sclerosis (ALS) and their carers to offer clinicians, researchers and policymakers aspects which are precious in prioritising future research...

Connecting TDP-43 Pathology with Neuropathy.
https://doi.org/10.1016/j.tins.2021.02.008
Trends in Neurosciences; Klim JR, Pintacuda G et. al.

Apr 9th, 2021 - Transactive response DNA-binding protein 43 kDa (TDP-43), a multifunctional nucleic acid-binding protein, is a primary component of insoluble aggregates associated with several devastating nervous system disorders; mutations in TARDBP, its encodin...

Targeting Gys1 with AAV-SaCas9 Decreases Pathogenic Polyglucosan Bodies and Neuroinflam...
https://doi.org/10.1007/s13311-021-01040-7 10.2174/1566524024605761 10.1016/j.tplants.2013.08.004 10.1002/ana.410440604 10.1016/j.gene.2012.12.065 10.1074/jbc.M807428200 10.1073/pnas.0503285102 10.1038/s41582-018-0057-0 10.1038/2470 10.1038/ng1238 10.1371/journal.pgen.1002037 10.1002/acn3.51211 10.1007/s12035-019-01842-z 10.1017/erm.2020.5 10.1007/s12035-016-9884-4 10.1016/j.nbd.2020.105173 10.1007/s12035-020-02170-3 10.1111/jnc.15176 10.1074/jbc.RA120.015773 10.1093/hmg/11.11.1251 10.1002/ana.22156 10.1093/hmg/ddv385 10.1002/ana.24104 10.1093/hmg/ddu024 10.1007/s11481-019-09849-y 10.1016/j.lfs.2020.118165 10.1038/nbt.2647 10.1038/nature14299 10.1089/hum.2016.013 10.1038/mtm.2016.2 10.1038/nmeth.2089 10.1038/s41592-019-0582-9 10.1074/jbc.RA120.015061 10.1124/jpet.106.115550 10.3389/fncel.2015.00431 10.15252/emmm.201707608 10.1016/j.devcel.2015.01.035 10.1007/s11011-020-00630-2 10.1016/j.brainres.2011.03.014 10.1016/j.ymthe.2020.09.033 10.1186/s13059-015-0817-8 10.1038/sj.gt.3301514 10.1038/sj.gt.3302134 10.1016/j.omtm.2018.02.005 10.1016/S0378-1119(02)00878-8 10.1016/j.febslet.2009.10.036 10.1007/s12035-021-02285-1
Neurotherapeutics : the Journal of the American Society F... Gumusgoz E, Guisso DR et. al.

Apr 8th, 2021 - Many adult and most childhood neurological diseases have a genetic basis. CRISPR/Cas9 biotechnology holds great promise in neurological therapy, pending the clearance of major delivery, efficiency, and specificity hurdles. We applied CRISPR/Cas9 g...

Activation of cGAS/STING pathway upon TDP-43-mediated mitochondrial injury may be invol...
https://doi.org/10.1111/liv.14895
Liver International : Official Journal of the Internation... Yong H, Wang S et. al.

Apr 8th, 2021 - Recently, we read with great interest the article published in Cell by Yu et al, which reported that TAR DNA-binding protein 43 (TDP-43) overexpression stimulated the released of mitochondrial DNA (mtDNA) into the cytoplasm through mitochondrial p...

see more →

News  457 results

Theatrics, Hypnosis, and the Roots of Modern Neurology
https://www.medscape.com/viewarticle/947504

Mar 14th, 2021 - "Symptoms, then, are in reality nothing but a cry from suffering organs" – Jean-Martin Charcot Nearly 130 years after his death, Jean-Martin Charcot's name still resonates with modern neurologists. The famed 19th century French physician made myri...

New Compound Promising for ALS, Other Upper Motor Neuron Diseases
https://www.medscape.com/viewarticle/947056

Mar 10th, 2021 - NEW YORK (Reuters Health) - A new compound, NU-9, improved diseased upper motor neurons (UMN) in mice and shows promise for treating amyotrophic lateral sclerosis (ALS) in humans, though more work is needed before a clinical trial can be started, ...

After a Decade of Lobbying, ALS Patients Gain Faster Access to Disability Payments
https://www.medscape.com/viewarticle/944474

Jan 20th, 2021 - Anita Baron first noticed something was wrong in August 2018, when she began to drool. Her dentist chalked it up to a problem with her jaw. Then her speech became slurred. She managed to keep her company, which offers financing to small businesses...

VA Study Finds More ALS Hospitalizations With Edaravone
https://www.staging.medscape.com/viewarticle/938926

Oct 14th, 2020 - NEW YORK (Reuters Health) - Amyotrophic lateral sclerosis (ALS) patients prescribed edaravone are hospitalized more frequently, a new surveillance study in U.S. military veterans shows. Patients on edaravone had significantly higher rates of all-c...

VA Study Finds More ALS Hospitalizations With Edaravone
https://www.medscape.com/viewarticle/938926

Oct 14th, 2020 - NEW YORK (Reuters Health) - Amyotrophic lateral sclerosis (ALS) patients prescribed edaravone are hospitalized more frequently, a new surveillance study in U.S. military veterans shows. Patients on edaravone had significantly higher rates of all-c...

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Patient Education  19 results see all →