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About 210 results

ALLMedicine™ Alexander Disease Center

Research & Reviews  81 results

A Study to Evaluate the Safety and Efficacy of ION373 in Patients With Alexander Disease (AxD)
https://clinicaltrials.gov/ct2/show/NCT04849741

Jun 22nd, 2022 - This is a Phase 1-3, multi-center, double-blind, placebo-controlled, multiple-ascending dose (MAD) study in up to 58 patients with AxD. Participants will be randomized in a 2:1 ratio to receive ION373 or matching placebo for a 60-week double-blind...

Novel Glial Fibrillary Acidic Protein Variant in a Probable Adult-Onset Alexander Disease.
https://doi.org/10.1093/jnen/nlac014
Journal of Neuropathology and Experimental Neurology; Mork E, Jamshidi P et. al.

Apr 2nd, 2022 - Novel Glial Fibrillary Acidic Protein Variant in a Probable Adult-Onset Alexander Disease.|2022|Mork E,Jamshidi P,Lee JM,|genetics,genetics,genetics,

Anastasis Drives Senescence and Non-Cell Autonomous Neurodegeneration in the Astrogliop...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944235
The Journal of Neuroscience : the Official Journal of The... Wang L, Bukhari H et. al.

Feb 3rd, 2022 - Anastasis is a recently described process in which cells recover after late-stage apoptosis activation. The functional consequences of anastasis for cells and tissues are not clearly understood. Using Drosophila, rat and human cells and tissues, i...

Isolated Myoclonus of the Vocal Folds in Alexander Disease.
https://doi.org/10.1001/jamaneurol.2021.4707
JAMA Neurology; Fan S, Zhao Y et. al.

Dec 21st, 2021 - Isolated Myoclonus of the Vocal Folds in Alexander Disease.|2021|Fan S,Zhao Y,Guan H,|complications,physiopathology,genetics,etiology,physiopathology,physiopathology,

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Clinicaltrials.gov  2 results

A Study to Evaluate the Safety and Efficacy of ION373 in Patients With Alexander Disease (AxD)
https://clinicaltrials.gov/ct2/show/NCT04849741

Jun 22nd, 2022 - This is a Phase 1-3, multi-center, double-blind, placebo-controlled, multiple-ascending dose (MAD) study in up to 58 patients with AxD. Participants will be randomized in a 2:1 ratio to receive ION373 or matching placebo for a 60-week double-blind...

Evaluation of Outcome Metrics in Alexander Disease
https://clinicaltrials.gov/ct2/show/NCT02714764

Aug 30th, 2021 - Participants will be asked to complete physical examinations including physical therapy, occupational therapy, speech and language therapy, neurocognitive and swallowing assessments. Patients (or caretakers) may be asked to complete questionnaires...

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Patient Education  1 results

Alexander Disease: Leukodystrophy, Neurologica
https://my.clevelandclinic.org/health/diseases/6027-alexander-disease

Apr 26th, 2022 - Overview What is Alexander disease? Alexander disease is an extremely rare nervous system (neurological) disorder. It’s a type of leukodystrophy, conditions that affect white matter in your brain. Alexander disease damages myelin, the fatty white ...

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