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About 220 results

ALLMedicine™ Alexander Disease Center

Research & Reviews  85 results

Pathologic Alexander Disease with Normal GFAP Sequencing: An Autopsy Case Report and Li...
https://doi.org/10.1093/jnen/nlac086
Journal of Neuropathology and Experimental Neurology; Alexander AL, Lim SY et. al.

Sep 23rd, 2022 - Pathologic Alexander Disease with Normal GFAP Sequencing: An Autopsy Case Report and Literature Review.|2022|Alexander AL,Lim SY,Massingham LJ,Phillips O,Chambers MK,|genetics,pathology,genetics,metabolism,pathology,

A Study to Evaluate the Safety and Efficacy of ION373 in Patients With Alexander Disease (AxD)
https://clinicaltrials.gov/ct2/show/NCT04849741

Sep 16th, 2022 - This is a Phase 1-3, multi-center, double-blind, placebo-controlled, multiple-ascending dose (MAD) study in up to 58 patients with AxD. Participants will be randomized in a 2:1 ratio to receive ION373 or matching placebo for a 60-week double-blind...

Identification of a novel de novo pathogenic variant in GFAP in an Iranian family with ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464415
European Journal of Medical Research; Heshmatzad K, Naderi N et. al.

Sep 11th, 2022 - Alexander disease (AxD) is a rare leukodystrophy with an autosomal dominant inheritance mode. Variants in GFAP lead to this disorder and it is classified into three distinguishable subgroups: infantile, juvenile, and adult-onset types. The aim of ...

Evaluation of Outcome Metrics in Alexander Disease
https://clinicaltrials.gov/ct2/show/NCT02714764

Aug 30th, 2022 - Participants will be asked to complete physical examinations including physical therapy, occupational therapy, speech and language therapy, neurocognitive and swallowing assessments. Patients (or caretakers) may be asked to complete questionnaires...

Identification of association fibers using ex vivo diffusion tractography in Alexander ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474676
Journal of Neuroimaging : Official Journal of the America... Shiohama T, Stewart N et. al.

Aug 20th, 2022 - Alexander disease (AxD) is a neurodegenerative disorder caused by heterozygous Glial Fibrillary Acidic Protein mutation. The characteristic structural findings of AxD, such as leukodystrophic features, are well known, while association fibers of A...

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Clinicaltrials.gov  2 results

A Study to Evaluate the Safety and Efficacy of ION373 in Patients With Alexander Disease (AxD)
https://clinicaltrials.gov/ct2/show/NCT04849741

Sep 16th, 2022 - This is a Phase 1-3, multi-center, double-blind, placebo-controlled, multiple-ascending dose (MAD) study in up to 58 patients with AxD. Participants will be randomized in a 2:1 ratio to receive ION373 or matching placebo for a 60-week double-blind...

Evaluation of Outcome Metrics in Alexander Disease
https://clinicaltrials.gov/ct2/show/NCT02714764

Aug 30th, 2022 - Participants will be asked to complete physical examinations including physical therapy, occupational therapy, speech and language therapy, neurocognitive and swallowing assessments. Patients (or caretakers) may be asked to complete questionnaires...

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Patient Education  1 results

Alexander Disease: Leukodystrophy, Neurologica
https://my.clevelandclinic.org/health/diseases/6027-alexander-disease

Apr 26th, 2022 - Overview What is Alexander disease? Alexander disease is an extremely rare nervous system (neurological) disorder. It’s a type of leukodystrophy, conditions that affect white matter in your brain. Alexander disease damages myelin, the fatty white ...

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