ALLMedicine™ Allan-Herndon-Dudley Syndrome Center
Research & Reviews 50 results
https://clinicaltrials.gov/ct2/show/NCT04143295
Feb 14th, 2023 - MCT8 deficiency (that is also known as Allan-Herndon-Dudley syndrome) is a rare X-linked inherited disorder of brain development that causes severe intellectual disability and problems with movement. This condition, which occurs almost exclusively...
https://doi.org/10.1007/s43032-022-01162-z
Reproductive Sciences (Thousand Oaks, Calif.); Thomas J, Sairoz et. al.
Jan 4th, 2023 - The review aims to summarize the available research focusing on the importance of monocarboxylate transporter (MCT8) in thyroid hormone trafficking across the placenta and fetal development. A systematic search was carried out in PubMed; studies a...
https://clinicaltrials.gov/ct2/show/NCT02396459
Oct 31st, 2022 - This therapeutic trial will be conducted in patients with MCT8 deficiency (also called Allan-Herndon-Dudley Syndrome (AHDS)), which is due to mutations in monocarboxylate transporter (MCT)8. MCT8 is a thyroid hormone transporter which is crucial f...
https://doi.org/10.1016/j.nbd.2022.105896
Neurobiology of Disease; Valcárcel-Hernández V, Guillén-Yunta M et. al.
Oct 16th, 2022 - Inactivating mutations in the specific thyroid hormone transporter monocarboxylate transporter 8 (MCT8) lead to an X-linked rare disease named MCT8 deficiency or Allan-Herndon-Dudley Syndrome. Patients exhibit a plethora of severe endocrine and ne...
https://doi.org/10.1530/JOE-22-0189
The Journal of Endocrinology; Bernal J, Morte B et. al.
Oct 12th, 2022 - Brain development is critically dependent on the timely supply of thyroid hormones. The thyroid hormone transporters are central to the action of thyroid hormones in the brain, facilitating their passage through the blood-brain barrier. Mutations ...
Clinicaltrials.gov 3 results
https://clinicaltrials.gov/ct2/show/NCT04143295
Feb 14th, 2023 - MCT8 deficiency (that is also known as Allan-Herndon-Dudley syndrome) is a rare X-linked inherited disorder of brain development that causes severe intellectual disability and problems with movement. This condition, which occurs almost exclusively...
https://clinicaltrials.gov/ct2/show/NCT02396459
Oct 31st, 2022 - This therapeutic trial will be conducted in patients with MCT8 deficiency (also called Allan-Herndon-Dudley Syndrome (AHDS)), which is due to mutations in monocarboxylate transporter (MCT)8. MCT8 is a thyroid hormone transporter which is crucial f...
https://clinicaltrials.gov/ct2/show/NCT05019417
Aug 24th, 2021 - Introduction and rationale Thyroid hormone (TH) is crucial for the development and metabolic state of virtually all tissues. TH signaling is regulated at the tissue level by intracellular conversion of the prohormone thyroxine (T4) to receptor-act...
