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About 20,915 results

ALLMedicine™ Amyotrophic Lateral Sclerosis Center

Research & Reviews  7,287 results

Associations of the circulating levels of cytokines with risk of amyotrophic lateral sc...
https://doi.org/10.1186/s12916-023-02736-7
BMC Medicine; Liu B, Lyu L et. al.

Feb 5th, 2023 - Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that is accompanied by muscle weakness and muscle atrophy, typically resulting in death within 3-5 years from the disease occurrence. Though the cause of ALS remains unclear, incr...

lncRNA NEAT1: key player in neurodegenerative diseases.
https://doi.org/10.1016/j.arr.2023.101878
Ageing Research Reviews; Li K, Wang Z

Feb 5th, 2023 - Neurodegenerative diseases are the most common causes of disability worldwide. Given their high prevalence, devastating symptoms, and lack of definitive diagnostic tests, there is an urgent need to identify potential biomarkers and new therapeutic...

Percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis: outcomes of a ded...
https://doi.org/10.1007/s00464-023-09896-w
Surgical Endoscopy; Morrell DJ, Chau MH et. al.

Feb 4th, 2023 - Patients requiring percutaneous endoscopic gastrostomy (PEG) for amyotrophic lateral sclerosis (ALS) related dysphagia represent a clinical challenge. Diminished pulmonary function and aspiration risks can lead to anesthesia-related complications,...

Evaluating the contribution of the gene TARDBP in Italian patients with amyotrophic lat...
https://doi.org/10.1111/ene.15727
European Journal of Neurology; Lattante S, Sabatelli M et. al.

Feb 4th, 2023 - Genetic variants in the gene TARDBP, encoding TDP-43 protein, are associated to amyotrophic lateral sclerosis (ALS) in familial (fALS) and sporadic (sALS) cases. Objectives of this study were to assess the contribution of TARDBP in a large cohort ...

Identification of a novel pathway in sporadic Amyotrophic Lateral Sclerosis mediated by...
https://doi.org/10.1016/j.nbd.2023.106030
Neurobiology of Disease; Rey F, Maghraby E et. al.

Feb 4th, 2023 - Deregulation of transcription in the pathogenesis of sporadic Amyotrophic Lateral Sclerosis (sALS) is taking central stage with RNA-sequencing analyses from sALS patients tissues highlighting numerous deregulated long non-coding RNAs (lncRNAs). Th...

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Guidelines  3 results

Provisional best practices guidelines for the evaluation of bulbar dysfunction in amyot...
https://doi.org/10.1002/mus.26408
Muscle & Nerve; Pattee GL, Plowman EK et. al.

Jan 9th, 2019 - Universally established comprehensive clinical bulbar scales objectively assessing disease progression in amyotrophic lateral sclerosis (ALS) are currently lacking. The goal of this working group project is to design a best practice set of provisi...

ESPEN guideline clinical nutrition in neurology.
https://doi.org/10.1016/j.clnu.2017.09.003
Clinical Nutrition (Edinburgh, Scotland); Burgos R, Bretón I et. al.

Dec 25th, 2017 - Neurological diseases are frequently associated with swallowing disorders and malnutrition. Moreover, patients with neurological diseases are at increased risk of micronutrient deficiency and dehydration. On the other hand, nutritional factors may...

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764728
Neurology Miller RG, Jackson CE et. al.

Oct 14th, 2009 - To systematically review evidence bearing on the management of patients with amyotrophic lateral sclerosis (ALS). The authors analyzed studies from 1998 to 2007 to update the 1999 practice parameter. Topics covered in this section include breaking...

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Drugs  18 results see all →

Clinicaltrials.gov  547 results

Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS)
https://clinicaltrials.gov/ct2/show/NCT05237284

Feb 3rd, 2023 - Part A of the study will last for 24 weeks, and participants will receive BID oral SAR443820 or placebo in a double-blind fashion for 24 weeks. All ongoing participants in Part A will rollover to Part B. Part B begins at the end of Week 24 and con...

Regulatory T Cells for Amyotrophic Lateral Sclerosis
https://clinicaltrials.gov/ct2/show/NCT05695521

Feb 3rd, 2023 - CK0803, neurotrophic allogenic T regulatory Cells (Treg), utilizes Cellenkos' proprietary CRANE technology to generate disease specific products. The primary objective of the upcoming phase 1 study is to establish safety and tolerability of multip...

Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) or Frontotemporal Dementia (FTD)
https://clinicaltrials.gov/ct2/show/NCT04931862

Feb 3rd, 2023 - This is a Phase 1b/2a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, PK, and PD of intrathecal (IT) WVE-004 in adult patients with C9orf72-associated ALS or FTD. To participate in the study, p...

PET Imaging of Neuroinflammation in Neurodegenerative Diseases Via a Novel TSPO Radioligand
https://clinicaltrials.gov/ct2/show/NCT03958630

Feb 3rd, 2023 - Objectives The primary objective is to explore if human subjects with neurodegenerative diseases exhibit different level of neuroinflammation, as measured by brain uptake of a 3rd generation [11C]ER176 TSPO ligand, compared to control subjects. Th...

A 6-Month Extension Study to Assess the Long-Term Safety of Engensis in Amyotrophic Lateral Sclerosis
https://clinicaltrials.gov/ct2/show/NCT05176093

Feb 2nd, 2023 - The purpose of this study is to evaluate the long-term safety of intramuscular (IM) administration of Engensis in Participants with Amyotrophic Lateral Sclerosis (ALS) who were previously randomized, received treatment, and completed the Day 180 V...

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News  483 results

Viruses Tied to Subsequent Dementia, Other Neurodegenerative Diseases
https://www.medpagetoday.com/neurology/generalneurology/102872

Jan 30th, 2023 - At least 22 viral illnesses were linked with an increased risk of subsequent neurodegenerative disease, NIH researchers found. Using data from the U.K. and Finland, Mike Nalls, PhD, of the NIH Center for Alzheimer's and Related Dementias, and co-a...

'Concerning' Gonorrhea Strain; DeSantis Targets Trans Students; Pandemic Is Over?
https://www.medpagetoday.com/infectiousdisease/stds/102714

Jan 20th, 2023 - Note that some links may require subscriptions. The CDC and Massachusetts health officials are investigating "concerning" new cases of drug-resistant gonorrhea. (CBS News) Israel has no data linking Pfizer's updated COVID vaccine with risk for str...

High Drug Costs Exclude Most Neurology Patients From Cutting-Edge Treatment
https://www.medscape.com/viewarticle/984953

Dec 2nd, 2022 - Because of high out-of-pocket costs of new-to-market neurologic drugs that are of similar benefit as older agents, only a small percentage of patients with neurologic disorders have access to these cutting-edge medications, new research shows. "Ou...

Trending Clinical Topic: Vitamin B12
https://www.medscape.com/viewarticle/983670

Nov 11th, 2022 - Each week, we identify one top search term, speculate about what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what's trending and why, share them with us on Twitter or Facebook.  The potentia...

Amyotrophic Lateral Sclerosis (ALS)
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/336726

Learn about this progressive disease attacks the nerve cells that control voluntary movement.

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Patient Education  28 results see all →