ALLMedicine™ Antisynthetase Syndrome Center

Jul 10th, 2022 - Idiopathic inflammatory myopathies (IIM) are heterogeneous autoimmune diseases. There are distinct subgroups, including antisynthetase syndrome, dermatomyositis, polymyositis, immune-mediated necrotizing myopathy, and sporadic inclusion body myosi...

Jul 8th, 2022 - BACKGROUND Antisynthetase syndrome (ASS) is a rare systemic autoimmune disease. The clinical features of ASS include interstitial lung disease (ILD), myositis, arthritis, Raynaud's phenomenon, mechanic's hands, and unexplained fever. There is a pa...

Jun 22nd, 2022 - Patients with anti-tRNA autoantibodies are characterized by arthritis, mechanic´s hands, fever, Raynaud´s phenomenon, and interstitial lung disease (ILD), in at least two clinical scenarios: the antisynthetase syndrome (ASSD) and interstitial pneu...

Jun 14th, 2022 - Patients classified as interstitial pneumonia with autoimmune features (IPAF) have interstitial lung disease (ILD) and features of autoimmunity but do not fulfill criteria for connective tissue diseases (CTDs). Our goal was to identify patients cl...

May 6th, 2022 - To evaluate MRI changes to define muscle-lesion specific patterns in patients with antisynthetase syndrome (ASS), and compare them with those in other common idiopathic inflammatory myopathy (IIM) subtypes. Qualitative and semi-quantitative thigh ...

Jun 28th, 2021 - Idiopathic inflammatory myopathies area heterogeneous group of disease involving mainly muscles, which paraneoplastic feature has been well characterized, specifically in some subgroups such as dermatomyositis. In contrast, antisynthetase syndrome...

Jun 14th, 2021 - Antisynthetase syndrome (ASS) is an overlap connective tissue disease characterized by the presence of myositis-specific autoantibodies directed against tRNA-synthetases. Clinical manifestations are myositis, interstitial lung disease (ILD), Rayna...

Feb 9th, 2021 - "During the study period, according to randomization into two groups (n=38 patients, respectively), patients will receive either: - Group 1 & 2 : 3 IV pulses of Methylprednisolone (7.5 mg/kg/day followed by tapering doses of oral Prednisone, start...

Feb 16th, 2022 - Rheumatologists looking for clues to whether their patients with certain inflammatory myopathies will improve on immunosuppressive drugs may find them in a new study appearing in Arthritis Care & Research. Presence of dermatomyositis-specific auto...

Jul 30th, 2019 - To the Editor: Erlotinib is a small-molecule selective tyrosine kinase inhibitor that functions by blocking the intracellular portion of the epidermal growth factor receptor (EGFR)1,2; EGFR normally is expressed in the basal layer of the epidermis.

Feb 20th, 2019 - Overlap Sometimes patients with polymyositis also have other rheumatologic conditions that shouldn’t be overlooked, therefore “overlap is its own category,” she said. “In our experience, the most common overlap is scleroderma,” she noted, adding t.

Feb 20th, 2019 - True polymyositis is rare, so it’s important to carefully consider other likely diagnoses, according to Lisa Christopher-Stine, MD. Dr.

Dec 13th, 2018 - Action Points Anti-TNF1-Ab positive dermatomyositis (DM) is linked to an elevated risk of cancer, especially ovarian cancer. This risk is present approximately 3 years on either side of DM onset. The link between DM and cancer is present for patie...