ALLMedicine™ Congenital Insensitivity To Pain Center
Research & Reviews 94 results
https://doi.org/10.1038/s41572-022-00365-7 10.1242/dmm.041608 10.1002/humu.22709 10.1083/jcb.202105011 10.3390/ijms22179472 10.1101/633396 10.1126/science.aaf3928 10.15252/embj.201899259 10.15252/embj.201899847 10.1016/j.neuron.2021.07.006 10.1007/s00415-021-10552-3 10.1111/ene.15310 10.1093/brain/awab482 10.1111/bph.15327 10.1126/scitranslmed.aay9056 10.1038/d41573-41019-00065-41570 10.1126/scisignal.aah4874 10.1001/jamaneurol.2021.2598 10.1172/JCI139076 10.3390/ijms21207631 10.1136/jnnp-2021-327909 10.1126/scitranslmed.aay6848 10.1038/s41436-020-01084-8 10.1097/j.pain.0000000000002535 10.1101/mcs.a002212 10.7554/eLife.71752 10.1101/741660
Nature Reviews. Disease Primers; Lischka A, Lassuthova P et. al.
Jun 18th, 2022 - Genetic pain loss includes congenital insensitivity to pain (CIP), hereditary sensory neuropathies and, if autonomic nerves are involved, hereditary sensory and autonomic neuropathy (HSAN). This heterogeneous group of disorders highlights the esse...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915475
BMC Pediatrics; Zhang M, Cao X et. al.
Mar 13th, 2022 - In this case report, we described the past history, clinical manifestations, genetic characteristics and cognitive evaluation of a boy with congenital insensitivity to pain with anhidrosis (CIPA) who developed autism spectrum disorder (ASD). The b...
https://doi.org/10.1097/j.pain.0000000000002536
Pain Latragna A, Sabaté San José A et. al.
Dec 29th, 2021 - Prdm12 is a conserved epigenetic transcriptional regulator that displays restricted expression in nociceptors of the developing peripheral nervous system. In mice, Prdm12 is required for the development of the entire nociceptive lineage. In humans...
https://doi.org/10.1093/brain/awab482
Brain : a Journal of Neurology; Middleton SJ, Perini I et. al.
Dec 28th, 2021 - Patients with bi-allelic loss of function mutations in the voltage-gated sodium channel Nav1.7 present with congenital insensitivity to pain (CIP), whilst low threshold mechanosensation is reportedly normal. Using psychophysics (n = 6 CIP particip...
https://doi.org/10.1097/j.pain.0000000000002535 10.3390/cells8121513 10.1038/s41598-018-30151-z
Pain Marchi M, D'Amato I et. al.
Nov 21st, 2021 - Mutations in the alpha subunit of voltage-gated sodium channel 1.7 (NaV1.7), encoded by SCN9A gene, play an important role in the regulation of nociception and can lead to a wide range of clinical outcomes, ranging from extreme pain syndromes to c...
Clinicaltrials.gov 1 results
https://clinicaltrials.gov/ct2/show/NCT02624310
Sep 12th, 2016 - CIPA patient do have very low or undetectable levels of norepinephrine in plasma and also have significant cognitive and behavioral problems. The aim of this project is to increase NE levels in brain and evaluate if this increase improve cognitive...
News 1 results
https://www.medpagetoday.com/primarycare/generalprimarycare/51747
May 26th, 2015 - In the wake of recent changes giving nurse practitioners in Nebraska full reign to practice, they're finding that they're expected to do it all, writes the New York Times. A 52-year-old woman presented with an odd condition, according to researche...
