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About 240 results

ALLMedicine™ Congenital Insensitivity To Pain Center

Research & Reviews  94 results

Autism spectrum disorder in a boy with congenital insensitivity to pain with anhidrosis...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915475
BMC Pediatrics; Zhang M, Cao X et. al.

Mar 13th, 2022 - In this case report, we described the past history, clinical manifestations, genetic characteristics and cognitive evaluation of a boy with congenital insensitivity to pain with anhidrosis (CIPA) who developed autism spectrum disorder (ASD). The b...

Prdm12 modulates pain-related behavior by remodeling gene expression in mature nocicept...
https://doi.org/10.1097/j.pain.0000000000002536
Pain Latragna A, Sabaté San José A et. al.

Dec 29th, 2021 - Prdm12 is a conserved epigenetic transcriptional regulator that displays restricted expression in nociceptors of the developing peripheral nervous system. In mice, Prdm12 is required for the development of the entire nociceptive lineage. In humans...

Nav1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice.
https://doi.org/10.1093/brain/awab482
Brain : a Journal of Neurology; Middleton SJ, Perini I et. al.

Dec 28th, 2021 - Patients with bi-allelic loss of function mutations in the voltage-gated sodium channel Nav1.7 present with congenital insensitivity to pain (CIP), whilst low threshold mechanosensation is reportedly normal. Using psychophysics (n = 6 CIP particip...

Congenital insensitivity to pain: a novel mutation affecting a U12-type intron causes m...
https://doi.org/10.1097/j.pain.0000000000002535 10.3390/cells8121513 10.1038/s41598-018-30151-z
Pain Marchi M, D'Amato I et. al.

Nov 21st, 2021 - Mutations in the alpha subunit of voltage-gated sodium channel 1.7 (NaV1.7), encoded by SCN9A gene, play an important role in the regulation of nociception and can lead to a wide range of clinical outcomes, ranging from extreme pain syndromes to c...

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Clinicaltrials.gov  1 results

A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and Anhidrosis
https://clinicaltrials.gov/ct2/show/NCT02624310

Sep 12th, 2016 - CIPA patient do have very low or undetectable levels of norepinephrine in plasma and also have significant cognitive and behavioral problems. The aim of this project is to increase NE levels in brain and evaluate if this increase improve cognitive...

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News  1 results

Morning Break: NPs Step It Up; Real-Life Animorphs
https://www.medpagetoday.com/primarycare/generalprimarycare/51747

May 26th, 2015 - In the wake of recent changes giving nurse practitioners in Nebraska full reign to practice, they're finding that they're expected to do it all, writes the New York Times. A 52-year-old woman presented with an odd condition, according to researche...

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