ALLMedicine™ Ependymoma Center

May 20th, 2022 - Recurrent ACVR1 mutations in posterior fossa ependymoma.|2022|Pratt D,Lucas CG,Selvam PP,Abdullaev Z,Ketchum C,|

May 18th, 2022 - Radiation therapy is commonly used to treat a variety of brain tumors in children including ependymoma, craniopharyngioma and low- and high-grade glioma. The ability of the therapy to control brain tumors in children is known to depend on the tumo...

May 15th, 2022 - The aim of the study was to evaluate the feasibility of texture analysis in differentiating between posterior fossa ependymoma type A (PF-EPN-A) and type B (PF-EPN-B) among children. Our retrospective study included 43 patients (37 PF-EPN-A and 6 ...

Apr 13th, 2022 - Ependymomas are rare primary tumors of the brain and spinal cord that arises from the ependymal cell layer. Cranial ependymomas commonly occur in the posterior fossa; however, approximately 30% of all tumors can be found in the supratentorial regi...

Apr 8th, 2022 - Patients with relapsed medulloblastoma, ependymoma and ATRT have a very poor prognosis whether treated with conventional chemotherapy, high-dose chemotherapy with stem cell rescue, irradiation or combinations of these modalities. Antiangiogenetic ...

May 18th, 2022 - Radiation therapy is commonly used to treat a variety of brain tumors in children including ependymoma, craniopharyngioma and low- and high-grade glioma. The ability of the therapy to control brain tumors in children is known to depend on the tumo...

Apr 8th, 2022 - Patients with relapsed medulloblastoma, ependymoma and ATRT have a very poor prognosis whether treated with conventional chemotherapy, high-dose chemotherapy with stem cell rescue, irradiation or combinations of these modalities. Antiangiogenetic ...

Apr 1st, 2022 - Recent lab-based discoveries suggest that IDO (indoleamine 2,3-dioxygenase) and BTK (Bruton's tyrosine Kinase) form a closely linked metabolic checkpoint in tumor-associated antigen-presenting cells. The central clinical hypothesis for the GCC2020...

Mar 25th, 2022 - Disease-specific Cohorts : Cohort 1A, 1B: progressive glioblastoma (relapsed or refractory) Cohort 2A, 2B: progressive medulloblastoma (relapsed or refractory) Cohort 3A, 3B, 3C: progressive ependymoma (relapsed or refractory) Cohort 4C: newly-dia...

Feb 9th, 2022 - To study whether Granulocyte Macrophage Colony Stimulation Factor (GM-CSF) increases macrophage infiltration in children with ependymoma (EPN) who are to have planned surgery as a standard procedure for incomplete resection or recurrent tumor. To ...

Nov 3rd, 2021 - Many cancers with known genetic causes can be treated by targeting tumors and leaving healthy cells unscathed. But that's not the case for a rare type of brain and spinal cord cancer that primarily strikes children and has no obvious genetic cause...

Aug 25th, 2021 - WEE1 is a key regulator of the cell cycle that has been a target of cancer drug discovery efforts for more than a decade. The lead novel candidate, the WEE1 inhibitor adavosertib (AZD1775), has been tested in more than 50 completed or ongoing clin...

Apr 14th, 2021 - The FDA has granted a rare pediatric disease (RPD) designation to the p-STAT3 inhibitor WP1066 for the treatment of patients with ependymoma, a rare type of tumor that can develop in the brain or the spinal cord.1 The FDA’s recognition of the h...

Dec 20th, 2020 - Santhosh Upadhyaya, MD, neuro-oncologist, St. Jude Children’s Research Hospital, discusses radiation therapy for young children under the age of 3 who have ependymoma. He highlighted outcomes of the 10-year-long SJYC07 trial at the 2018 ASCO Annua...

Dec 5th, 2020 - Medulloblastoma, a malignant brain tumor that most commonly affects children, is not one disease but several, said researchers with St. Jude Children’s Hospital in Memphis, Tennessee. Similar discoveries have been made in other cancers, leading to...