ALLMedicine™ Frontotemporal Dementia Center

May 18th, 2022 - In this review, the authors explored the clinical features of frontotemporal dementia (FTD), focusing on treatment. The clinical features of FTD are unique, with disinhibition, apathy, loss of empathy, and compulsions common. Motor changes occur l...

May 18th, 2022 - Interactors of protein products of known genes for frontotemporal dementia (FTD) are likely to be involved in the molecular pathways towards disease. We therefore applied protein interaction network (PIN) analysis to prioritize candidate genes for...

May 14th, 2022 - Frontotemporal dementia is a neurodegenerative disease characterized by focal degeneration of the frontal and temporal lobes, clinically presenting with disinhibited behavior, personality changes, progressive non-fluent aphasia and/or impaired sem...

May 10th, 2022 - Dementia is a neurodegenerative condition with progressive decline in cognitive faculties and associated with different clinical phenomena. Mirror phenomenon in terms of both mirror agnosia and mirror image agnosia wherein there is difficulty in p...

May 7th, 2022 - Intermediate CAG (polyQ) expansions in the gene ataxin-2 (ATXN2) are now recognized as a risk factor for ALS. The threshold for increased risk is not yet firmly established, with reports ranging from 27 to 31 repeats. We investigated the presence ...

Apr 27th, 2022 - Frontotemporal dementia (FTD) is a genetically and pathologically heterogeneous neurodegenerative disease caused by the loss or damage of nerve cells in the brain's frontal and temporal lobes. This leads to abnormalities in behaviour, personality,...

Apr 13th, 2022 - Tauopathies are neurodegenerative diseases with tau pathology. These tauopathies are the most common pathology in neurodegenerative diseases, and they are reaching epidemic proportions. The rates of tau kinetics are central to understanding normal...

Apr 7th, 2022 - The purpose of this study is to learn more about amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases, including frontotemporal dementia (FTD), primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progr...

Mar 3rd, 2022 - Study PRV-FTD101 is a Phase 1/2, multi-center, open-label ascending dose, first-in-human study that will evaluate the safety and effect of intra-cisternal PR006 administration on progranulin protein (PGRN) levels in patients with frontotemporal de...

Feb 18th, 2022 - This is an interventional, multi-site, randomized, double-blind, placebo-controlled study of tACS in patients with FTD. The main aim of this study is to investigate the safety, tolerability and efficacy of gamma-tACS in patients with behavioral va...

Apr 12th, 2022 - People who start abusing alcohol later in life may have an underlying neurologic condition such as dementia, according to researchers from the Icahn School of Medicine at Mount Sinai and the University of California, San Francisco. What to know: A...

Mar 1st, 2022 - Electroencephalography (EEG) recordings from the dying human brain of an 87-year-old man with seizures and cardiac arrest found coordinated low- and high-frequency activity near death, which researchers speculated may represent a "last recall of l...

Feb 25th, 2022 - A new study from University College London (UCL) and National Institutes of Health (NIH) has revealed why a common genetic variant worsens disease outcomes for people with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The ...

Jan 28th, 2022 - Blood-based biomarkers may help differentiate people with different dementias and monitor disease changes over time, a longitudinal study showed. Plasma markers showed different profiles in Alzheimer's disease, frontotemporal dementia, Lewy body d...

Jan 24th, 2022 - The study covered in this summary was published on medRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaways This study proved very useful in distinguishing cerebrospinal fluid neurofilament (NfL) from phenocopy nonprogressor var...