ALLMedicine™ Frontotemporal Dementia Center
Research & Reviews 2,130 results
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Molecular Psychiatry; Wagner M, Lorenz G et. al.
Sep 26th, 2021 - Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous disorder. To which extent genetic aberrations dictate clinical presentation remains elusive. We investigated the spectrum of genetic causes and assessed the genotype-drive...
https://doi.org/10.1001/jamanetworkopen.2021.25584
JAMA Network Open; Ljubenkov PA, Edwards L et. al.
Sep 25th, 2021 - Histone deacetylase inhibitors have been repeatedly shown to elevate progranulin levels in preclinical models. This report describes the first randomized clinical trial of a histone deacetylase inhibitor in frontotemporal dementia (FTD) resulting ...
https://doi.org/10.1212/WNL.0000000000012702
Neurology Spinelli EG, Ghirelli A et. al.
Sep 22nd, 2021 - To assess cortical, subcortical and cerebellar grey matter (GM) atrophy using magnetic resonance imaging (MRI) in patients with disorders of the frontotemporal lobar degeneration (FTLD) spectrum with known genetic mutations. Sixty-six patients car...
https://doi.org/10.3233/JAD-210559
Journal of Alzheimer's Disease : JAD; Sogorb-Esteve A, Colas RA et. al.
Sep 21st, 2021 - The pathophysiology of frontotemporal dementia (FTD) is poorly understood but recent studies implicate neuroinflammation as an important factor. However, little is known so far about the role of the resolution pathway, the response to inflammation...
https://doi.org/10.1093/brain/awab345
Brain : a Journal of Neurology; Legaz A, Abrevaya S et. al.
Sep 17th, 2021 - Social feedback can selectively enhance learning in diverse domains. Relevant neurocognitive mechanisms have been studied mainly in healthy persons, yielding correlational findings. Neurodegenerative lesion models, coupled with multimodal brain me...
News 74 results
https://www.medscape.com/viewarticle/946285
Feb 23rd, 2021 - Increased white matter hyperintensities (WMH) are strongly associated with Alzheimer's disease (AD), but new research reveals they are also a "core feature" of frontotemporal dementia (FTD) in findings that may help physicians make this difficult ...
https://www.medscape.com/viewarticle/943096
Dec 22nd, 2020 - Apathy is an early marker of frontotemporal dementia (FTD) and predicts future cognitive decline, a new study has shown. Results showed that apathy occurs early in the disease course of genetic FTD before cognitive decline, reflecting early brain ...
https://www.medscape.com/viewarticle/941673
Nov 27th, 2020 - NEW YORK (Reuters Health) - Neuroinflammation appears to be a typical feature of the three most common monogenic forms of familial frontotemporal dementia (FTD), according to a new case series from the U.K. Based on this finding, the authors sugge...
https://www.medscape.com/viewarticle/941516
Nov 24th, 2020 - The eyes may offer a window into the brain when it comes to build-up of amyloid, a key hallmark of Alzheimer's disease (AD). Elevated amyloid deposits in the proximal mid-periphery (PMP) of the superotemporal retinal region in patients with mild c...
https://reference.medscape.com/viewarticle/930571
May 21st, 2020 - "Dementia" refers to various symptoms of impaired cognitive functioning and other behavioral abilities. Multiple neuropathologic processes may be responsible, including neurodegenerative diseases and vascular disease. Approximately 47 million peop...
