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About 5,515 results

ALLMedicine™ Frontotemporal Dementia Center

Research & Reviews  2,130 results

Clinico-genetic findings in 509 frontotemporal dementia patients.
https://doi.org/10.1038/s41380-021-01271-2 10.1111/jnc.13588 10.1093/brain/awr179 10.1136/jmedgenet-2016-104271 10.1093/brain/awr195 10.1007/s00401-009-0612-2 10.1111/nan.12526 10.1212/01.wnl.0000325058.10218.fc 10.1136/jnnp-2017-317492 10.1212/WNL.0000000000005261 10.1212/WNL.0b013e31821103e6 10.1093/brain/awn234 10.1080/21678421.2016.1241279 10.1212/WNL.0000000000003688 10.1136/jmedgenet-2014-102360 10.1038/s41467-019-12620-9 10.1038/gim.2015.30 10.1038/gim.2017.102 10.1038/nn.4000 10.1038/nrneurol.2012.263 10.1001/jama.1997.03550160069041 10.1038/s41586-020-2308-7 10.1212/WNL.0000000000003154 10.1002/acn3.325 10.1038/ng.803 10.1038/ng.3246 10.1016/S1474-4422(15)00133-7 10.1083/jcb.201302044 10.1016/j.neuron.2017.07.025 10.1080/21678421.2017.1413118 10.1016/j.neurobiolaging.2018.05.005 10.1016/j.ajhg.2020.03.010 10.1212/WNL.58.11.1615 10.1212/WNL.0000000000004494 10.1016/S1474-4422(19)30394-1 10.1007/s00401-015-1436-x 10.1186/s40035-018-0136-6 10.1093/brain/awx254 10.1093/hmg/dds558 10.1016/j.neurobiolaging.2016.06.018 10.1016/j.dadm.2018.12.001 10.1002/ana.24198 10.3233/JAD-181038 10.1016/j.neurobiolaging.2005.03.008 10.1016/j.ajhg.2020.07.011 10.1056/NEJMoa1408617 10.1001/jamacardio.2018.3965 10.15252/emmm.201809711 10.1016/j.jns.2005.05.015 10.1016/j.neurobiolaging.2017.10.016 10.1136/jnnp-2020-323541 10.1016/S1474-4422(19)30354-0
Molecular Psychiatry; Wagner M, Lorenz G et. al.

Sep 26th, 2021 - Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous disorder. To which extent genetic aberrations dictate clinical presentation remains elusive. We investigated the spectrum of genetic causes and assessed the genotype-drive...

Effect of the Histone Deacetylase Inhibitor FRM-0334 on Progranulin Levels in Patients ...
https://doi.org/10.1001/jamanetworkopen.2021.25584
JAMA Network Open; Ljubenkov PA, Edwards L et. al.

Sep 25th, 2021 - Histone deacetylase inhibitors have been repeatedly shown to elevate progranulin levels in preclinical models. This report describes the first randomized clinical trial of a histone deacetylase inhibitor in frontotemporal dementia (FTD) resulting ...

Structural MRI Signatures in Genetic Presentations of the Frontotemporal Dementia-Motor...
https://doi.org/10.1212/WNL.0000000000012702
Neurology Spinelli EG, Ghirelli A et. al.

Sep 22nd, 2021 - To assess cortical, subcortical and cerebellar grey matter (GM) atrophy using magnetic resonance imaging (MRI) in patients with disorders of the frontotemporal lobar degeneration (FTLD) spectrum with known genetic mutations. Sixty-six patients car...

Differential Lipid Mediator Involvement in the Different Forms of Genetic Frontotempora...
https://doi.org/10.3233/JAD-210559
Journal of Alzheimer's Disease : JAD; Sogorb-Esteve A, Colas RA et. al.

Sep 21st, 2021 - The pathophysiology of frontotemporal dementia (FTD) is poorly understood but recent studies implicate neuroinflammation as an important factor. However, little is known so far about the role of the resolution pathway, the response to inflammation...

Multimodal mechanisms of human socially reinforced learning across neurodegenerative di...
https://doi.org/10.1093/brain/awab345
Brain : a Journal of Neurology; Legaz A, Abrevaya S et. al.

Sep 17th, 2021 - Social feedback can selectively enhance learning in diverse domains. Relevant neurocognitive mechanisms have been studied mainly in healthy persons, yielding correlational findings. Neurodegenerative lesion models, coupled with multimodal brain me...

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News  74 results

'Core Feature' of Frontotemporal Dementia May Aid Diagnosis
https://www.medscape.com/viewarticle/946285

Feb 23rd, 2021 - Increased white matter hyperintensities (WMH) are strongly associated with Alzheimer's disease (AD), but new research reveals they are also a "core feature" of frontotemporal dementia (FTD) in findings that may help physicians make this difficult ...

Apathy an Early Marker of Frontotemporal Dementia
https://www.medscape.com/viewarticle/943096

Dec 22nd, 2020 - Apathy is an early marker of frontotemporal dementia (FTD) and predicts future cognitive decline, a new study has shown. Results showed that apathy occurs early in the disease course of genetic FTD before cognitive decline, reflecting early brain ...

Neuroinflammation Common in Familial Frontotemporal Dementia
https://www.medscape.com/viewarticle/941673

Nov 27th, 2020 - NEW YORK (Reuters Health) - Neuroinflammation appears to be a typical feature of the three most common monogenic forms of familial frontotemporal dementia (FTD), according to a new case series from the U.K. Based on this finding, the authors sugge...

Amyloid in the Retina Correlates With Alzheimer's Brain Changes
https://www.medscape.com/viewarticle/941516

Nov 24th, 2020 - The eyes may offer a window into the brain when it comes to build-up of amyloid, a key hallmark of Alzheimer's disease (AD). Elevated amyloid deposits in the proximal mid-periphery (PMP) of the superotemporal retinal region in patients with mild c...

Fast Five Quiz: Dementia Key Aspects
https://reference.medscape.com/viewarticle/930571

May 21st, 2020 - "Dementia" refers to various symptoms of impaired cognitive functioning and other behavioral abilities. Multiple neuropathologic processes may be responsible, including neurodegenerative diseases and vascular disease. Approximately 47 million peop...

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Patient Education  2 results see all →