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ALLMedicine™ Huntington Disease Center

Research & Reviews  732 results

FAN1 nuclease helps to delay Huntington disease.
https://doi.org/10.1038/s41582-022-00670-5 10.1038/s41593-022-01033-5
Nature Reviews. Neurology; Wood H

May 10th, 2022 - FAN1 nuclease helps to delay Huntington disease.|2022|Wood H,|

Nuclear pore complexes - a doorway to neural injury in neurodegeneration.
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Nature Reviews. Neurology; Coyne AN, Rothstein JD

Apr 30th, 2022 - The genetic underpinnings and end-stage pathological hallmarks of neurodegenerative diseases are increasingly well defined, but the cellular pathophysiology of disease initiation and propagation remains poorly understood, especially in sporadic fo...

Clinical Correlates of Depression and Suicidality in Huntington Disease: An Analysis of...
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Cognitive and Behavioral Neurology : Official Journal of ... Rocha NP, Tuazon MR et. al.

Apr 30th, 2022 - Depression and suicidality are commonly experienced by Huntington disease (HD) gene carriers. Research on these behavioral symptoms is imperative, not only to increase our understanding of the symptoms and how they relate to HD, but also to contri...

Hunting out the autophagic problem in Huntington disease.
Autophagy Pircs K, Barker RA et. al.

Apr 26th, 2022 - Huntington disease is an inherited, progressive, incurable neurodegenerative disorder that primarily affects cells in the brain. Although the genetic basis for this condition has been known for nearly 30 years, how this causes disease is still unr...

Altered cortical processing of sensory input in Huntington disease mouse models.
Neurobiology of Disease; Sepers MD, Mackay JP et. al.

Apr 24th, 2022 - Huntington disease (HD), a hereditary neurodegenerative disorder, manifests as progressively impaired movement and cognition. Although early abnormalities of neuronal activity in striatum are well established in HD models, there are fewer in vivo ...

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Guidelines  1 results

American College of Medical Genetics and Genomics Standards and Guidelines for Clinical...
Genetics in Medicine : Official Journal of the American C... Bean L, Bayrak-Toydemir P

Oct 31st, 2014 - Huntington disease is an autosomal-dominant neurodegenerative disease of mid-life onset caused by expansion of a polymorphic trinucleotide (CAG) repeat. Variable penetrance for alleles carrying 36-39 repeats has been noted, but the disease appears...

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Drugs  2 results see all →

Clinicaltrials.gov  14 results

Within Subject Crossover Study of Cognitive Effects of Neflamapimod in Early-Stage Huntington Disease

Apr 6th, 2022 - The study was designed as within-subject crossover study. However, due to the Covid19 lockdowns and restrictions on clinical research, and only one subject entered the second crossover period. As a result, the baseline and outcomes are reported by...

Safety and Efficacy of AMT-130 in European Adults With Early Manifest Huntington Disease

Feb 18th, 2022 - The aim of the European study is to build upon the safety demonstrated in the first human dose (FHD) randomized, double blind, sham-controlled sequential dose escalation study (CT-AMT-130-01; clinicaltrials.gov NCT04120493) being conducted in the ...

Impact of Deutetrabenazine on Functional Speech and Gait Dynamics in Huntington Disease

Dec 28th, 2021 - This is a two-year, prospective, single-arm study examining the effects of deutetrabenazine on functional speech and gait impairment. Participants will undergo comprehensive evaluations of speech production, fine motor skills, gait, and balance bo...

Efficacy, Safety, and Tolerability of Valbenazine for the Treatment of Chorea Associated With Huntington Disease

Dec 15th, 2021 - This is a Phase 3, randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, and tolerability of valbenazine to treat chorea in subjects with Huntington disease.

Behavioural Problems in Huntington Disease : Analysis and Enhancement of Caregiver and Patient Experience

Oct 22nd, 2020 - The study hypothesis is that caregivers experience allows them to develop a lot of knowledge and know-how about behavioural problems in Huntington Disease and its consequences. The purpose of this study is to collect, describe and analyse caregive...

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News  37 results

Synthetic Triglyceride Shows Potential in Huntington Disease

Sep 23rd, 2021 - The synthetic medium-chain triglyceride triheptanoin has shown potential to restore brain energy and decrease caudate atrophy in Huntington disease, and improved motor function for up to a year, according to data presented at the International Con...

Discovery of Schizophrenia Gene Could Advance Research, Therapies

Mar 26th, 2021 - Todd Lencz, PhD A new genetic mutation in schizophrenia that blocks neuron communication in the brain may lead to novel treatment strategies and improve understanding of the mechanics of this disease. The discovery of this new gene, PCDHA3, could ...

Posttraumatic Stress Disorder-Associated Cognitive Deficits on the Repeatable Battery for the Assessment of Neuropsychological Status in a Veteran Population
Nathan Hantke, PhD, ABPP-CN*, Maheen M. Adamson, PhD* et. al.

Jan 7th, 2021 - Posttraumatic stress disorder (PTSD) affects about 10 to 25% of veterans in the US and is associated with reductions in quality of life and poor occupational functioning. 1,2 PTSD is often associated with multiple cognitive deficits that play a rol.

Certifying Medical Cannabis: What APRNs Need to Know

Jan 5th, 2021 - A patient asks an advanced practice registered nurse (APRN) to approve them for "medical marijuana." What are the clinician's responsibilities? The first hurdle is legal. In 18 states, an APRN has the legal authority to certify a patient to use ma...

A 12-Year-Old Boy With Repetitive Motions: Osmosis USMLE Study Question

Sep 18th, 2020 - The patient is American soccer star Tim Howard, who has Tourette syndrome (TS). He was diagnosed with TS in the sixth grade and used sports to focus. Coprolalia is the involuntary swearing or utterance of obscene words or socially inappropriate an...

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Patient Education  1 results see all →