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About 2,170 results

ALLMedicine™ Lennox-gastaut Syndrome Center

Research & Reviews  315 results

International League Against Epilepsy classification and definition of epilepsy syndrom...
https://doi.org/10.1111/epi.17241
Epilepsia Specchio N, Wirrell EC et. al.

May 4th, 2022 - The 2017 International League Against Epilepsy classification has defined a three-tier system with epilepsy syndrome identification at the third level. Although a syndrome cannot be determined in all children with epilepsy, identification of a spe...

Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lenno...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062770
JAMA Neurology; Knupp KG, Scheffer IE et. al.

May 3rd, 2022 - New treatment options are needed for patients with Lennox-Gastaut syndrome (LGS), a profoundly impairing, treatment-resistant, developmental and epileptic encephalopathy. To evaluate the efficacy and safety of fenfluramine in patients with LGS. Th...

Short-term and long-term efficacy and safety of antiseizure medications in Lennox Gasta...
https://doi.org/10.1016/j.seizure.2022.04.004
Seizure Devi N, Madaan P et. al.

Apr 30th, 2022 - To assess the short-term and long-term comparative efficacy and safety of ASMs for Lennox-Gastaut syndrome (LGS). Following a systematic literature search, randomized controlled trial (RCT) and open-label extension (OLE) studies on LGS comparing A...

Age at onset in patients with Lennox-Gastaut syndrome: Correlations with clinical manif...
https://doi.org/10.1016/j.jocn.2022.04.020
Journal of Clinical Neuroscience : Official Journal of Th... Asadi-Pooya AA, Farazdaghi M

Apr 26th, 2022 - The aim of the current study was to investigate the age at onset in patients with Lennox-Gastaut Syndrome (LGS). We also investigated the clinical and EEG characteristics of these patients in different age groups. This was a retrospective study. A...

The Optimal Target and Connectivity for Deep Brain Stimulation in Lennox-Gastaut Syndrome.
https://doi.org/10.1002/ana.26368
Annals of Neurology; Warren AEL, Dalic LJ et. al.

Apr 17th, 2022 - Deep brain stimulation (DBS) can reduce seizures in Lennox-Gastaut syndrome (LGS). However, little is known about the optimal target and whether efficacy depends on connectivity of the stimulation site. Using outcome data from the ESTEL trial, we ...

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Drugs  434 results see all →

Clinicaltrials.gov  17 results

A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut Syndrome
https://clinicaltrials.gov/ct2/show/NCT05163314

Apr 12th, 2022 - The drug being tested in this study is called soticlestat (TAK-935). Soticlestat administered long-term in pediatric and adult participants who participated in either of the antecedent Phase 3 clinical studies, TAK-935-3001 [NCT04940624] (particip...

Study of Perampanel as Adjunctive Treatment for Inadequately Controlled Seizures Associated With Lennox-Gastaut Syndrome
https://clinicaltrials.gov/ct2/show/NCT02834793

Mar 9th, 2022 - This is a multicenter, double-blind, randomized, placebo-controlled, parallel-group study of perampanel as adjunctive therapy in participants with inadequately controlled seizures associated with LGS. The study will consist of 3 phases: Prerandomi...

Multicentre Real-life Follow-up Study of Rare Epileptic Syndromes in Children and Adolescents
https://clinicaltrials.gov/ct2/show/NCT05126914

Nov 19th, 2021 - Rare epilepsies as a whole account for 20-30% of epilepsies, but knowledge about prognostic factors is currently limited. This means that it is difficult to provide adequate information to families at diagnosis and during follow-up. Prognostic fac...

A Study to Investigate the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution in Children and Adults With Epileptic Encephalopathy Including Dravet Syndrome and Lennox-Gastaut Syn...
https://clinicaltrials.gov/ct2/show/NCT03936777

Jun 18th, 2021 - This is an international, multicenter, open-label, long-term safety study of ZX008 in patients with epileptic encephalopathy, including Dravet syndrome or Lennox-Gastaut syndrome. Subjects eligible for participation are those with Dravet syndrome ...

Research on Cognitive Effect of Cannabidiol on Dravet Syndrome and Lennox-Gastaut SyndromeGastaut Syndrome
https://clinicaltrials.gov/ct2/show/NCT04611438

Nov 2nd, 2020 - Selection criteria of the patients are as below: Age: 2 years old to 18 years old Investigation center: Severance hospital, Yonsei University College of Medicine, Seoul, Korea A) Diagnosed as Dravet syndrome by clinical manifestations and/or genet...

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News  102 results

Phase 3 Data on Fenfluramine for Lennox-Gastaut Published
https://www.medscape.com/viewarticle/973485

May 5th, 2022 - A daily dose of fenfluramine (Fintepla, UCB), when added to an existing anti-epileptic treatment regimen, significantly reduced the frequency of drop seizures associated with Lennox-Gastaut syndrome (LGS) in the phase 3 study that led to US approv...

Tau Moderated by Menopause; CTE Risk Underestimated; When Is a Single Study Enough?
https://www.medpagetoday.com/neurology/generalneurology/98523

May 3rd, 2022 - Menopause status moderated sex differences in tau burden, with a divergence in tauopathy between the sexes apparent 20 years earlier than previously reported. (Annals of Neurology) Plasma p-tau was a less consistent marker of brain amyloidosis in ...

Dementia-Physical Activity Link; Nausea Drugs and Stroke; Epilepsy and COVID
https://www.medpagetoday.com/neurology/generalneurology/97929

Mar 29th, 2022 - Higher levels of moderate-to-vigorous physical activity were tied to a lower risk for disabling dementia in Japanese men. (JAMA Network Open) At current expected prices, neither aducanumab (Aduhelm) nor donanemab, an investigational anti-amyloid d...

FDA Okays New Med for Lennox-Gastaut Syndrome
https://www.medscape.com/viewarticle/971158

Mar 29th, 2022 - The US Food and Drug Administration (FDA) has approved fenfluramine (Fintepla) oral solution, a Schedule IV controlled substance, for the treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in children aged 2 years and older, the c...

CBD Gel a Promising Adjunct for Kids With Severe Epilepsy
https://www.medscape.com/viewarticle/958889

Sep 16th, 2021 - Topical cannabidiol (CBD) gel, added to antiseizure medication, may help reduce seizures and improve quality of life in children with developmental and epileptic encephalopathies, according to the results of a nonrandomized controlled trial. Devel...

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