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About 1,113 results

ALLMedicine™ Myotonic Dystrophy Type 1 Center

Research & Reviews  423 results

Breathlessness Assessment in Adult Patients With Myotonic Dystrophy Type 1
https://clinicaltrials.gov/ct2/show/NCT04835298

Jun 15th, 2022 - Myotonic dystrophy type 1 (DM1) is one of the most common neuromuscular diseases in adults. As respiratory dysfunction is the most common cause of death in patients with DM1, a respiratory disease progression must be monitored combining symptom sc...

Pharmacological and exercise-induced activation of AMPK as emerging therapies for myoto...
https://doi.org/10.1113/JP282725
The Journal of Physiology; Ravel-Chapuis A, Duchesne E et. al.

Jun 14th, 2022 - Myotonic dystrophy type 1 (DM1) is a multisystemic disorder with variable clinical features. Currently, there is no cure or effective treatment for DM1. The disease is caused by an expansion of CUG repeats in the 3'UTR of DMPK mRNAs. Mutant DMPK m...

Effects of a 12-week Strength Training Program in Women With Myotonic Dystrophy Type 1
https://clinicaltrials.gov/ct2/show/NCT05400629

Jun 1st, 2022 - 20 women with myotonic dystrophy type 1 (DM1) will complete a 12-week lower-limb strength training program. The training program consist of 3 series of 6 to 8 maximal repetitions of 5 different exercises: Leg extension, leg press, hip abduction, s...

A retrospective study of needs and interventions among patients with myotonic dystrophy...
https://doi.org/10.1111/jep.13706
Journal of Evaluation in Clinical Practice; Allergodt K, Handberg C et. al.

May 27th, 2022 - RATIONALE, AIMS AND OBJECTIVES: Myotonic dystrophy type 1 (DM1) is a progressive multisystem disorder that requires a special focus on the delivery of health and rehabilitation. The aim of the study was to identify the needs and interventions in p...

Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neur...
https://doi.org/10.1523/JNEUROSCI.2006-21.2022
The Journal of Neuroscience : the Official Journal of The... Wang LH, Lin CY et. al.

May 24th, 2022 - Increasing loss of structure and function of neurons and decline in cognitive function is commonly seen during the progression of neurologic diseases, although the causes and initial symptoms of individual diseases are distinct. This observation s...

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Guidelines  2 results

2022 HRS expert consensus statement on evaluation and management of arrhythmic risk in ...
https://doi.org/10.1016/j.hrthm.2022.04.022
Heart Rhythm; Groh WJ, Bhakta D et. al.

May 3rd, 2022 - This international multidisciplinary document is intended to guide electrophysiologists, cardiologists, other clinicians, and health care professionals in caring for patients with arrhythmic complications of neuromuscular disorders (NMDs). The doc...

ADDENDUM: Technical standards and guidelines for myotonic dystrophy type 1 testing.
https://doi.org/10.1038/gim.2015.176
Genetics in Medicine : Official Journal of the American C...

Jan 13th, 2016 - ADDENDUM: Technical standards and guidelines for myotonic dystrophy type 1 testing.|2016||diagnosis,genetics,

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Clinicaltrials.gov  14 results

Breathlessness Assessment in Adult Patients With Myotonic Dystrophy Type 1
https://clinicaltrials.gov/ct2/show/NCT04835298

Jun 15th, 2022 - Myotonic dystrophy type 1 (DM1) is one of the most common neuromuscular diseases in adults. As respiratory dysfunction is the most common cause of death in patients with DM1, a respiratory disease progression must be monitored combining symptom sc...

Effects of a 12-week Strength Training Program in Women With Myotonic Dystrophy Type 1
https://clinicaltrials.gov/ct2/show/NCT05400629

Jun 1st, 2022 - 20 women with myotonic dystrophy type 1 (DM1) will complete a 12-week lower-limb strength training program. The training program consist of 3 series of 6 to 8 maximal repetitions of 5 different exercises: Leg extension, leg press, hip abduction, s...

DM-IMT - Controlled, Randomized, Three-arm Intervention Study on the Safety and Efficacy of Regular Respiratory Muscle Training in Patients With Myotonic Dystrophy Type 1
https://clinicaltrials.gov/ct2/show/NCT04052958

May 2nd, 2022 - For some diseases, regular respiratory muscle training could delay the start of ventilation. For DM1, however, there are no clinically high-quality studies. Only a case description from the year 2006 showed a missing improvement of the symptoms af...

Poor Neck Proprioception May Cause Balance Deficits in Myotonic Dystrophy 1
https://clinicaltrials.gov/ct2/show/NCT04712422

Mar 31st, 2022 - Impairment of balance and gait are frequent complaints in patients with myotonic dystrophy type 1 (DM1). In these persons, there is an increased risk for stumbles and falls when compared to normal subjects. An underestimated cause of falls might b...

Myotonic Dystrophy Type 1 Aerobic Exercise Study
https://clinicaltrials.gov/ct2/show/NCT04187482

Mar 14th, 2022 - The present study is a repeated measures design, with sampling of the cohorts on two separate occasions. Upon obtaining informed consent, participants will be assigned into one of two groups: Group 1: DM1 Exercise Group DM1 diagnosed, physically i...

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News  6 results

Vertex Pharmaceuticals expands into Duchenne gene therapy with new deals
https://www.reuters.com/article/us-exonics-therapeutics-m-a-vertex-pharm/vertex-pharmaceuticals-expands-into-duchenne-gene-therapy-with-new-deals-idUSKCN1T72YK

Jun 6th, 2019 - (Reuters) - Vertex Pharmaceuticals Inc said here on Thursday it would acquire privately held Exonics Therapeutics for an upfront payment of $245 million and potential milestone payments of up to $750 million. Exonics Therapeutics develops gene edi...

Blood Test for Alzheimer’s? CTE in Woodpeckers; Comeback for NGF
https://www.medpagetoday.com/neurology/generalneurology/70976

Feb 6th, 2018 - A team of Australian and Japanese scientists announced a novel blood test to detect amyloid-β buildup in the brain. Measurements of the protein and its precursors in blood can predict amyloid-β deposition, paving the way for an efficient screening...

Team care recommended for pregnant women with genetic conditions
https://www.mdedge.com/familymedicine/article/102824/obstetrics/team-care-recommended-pregnant-women-genetic-conditions
MDedge ObGyn; Shannon Aymes

Sep 22nd, 2015 - The American College of Obstetricians and Gynecologists is calling on ob. gyns.

Cardiac Pacing Improves Survival in Myotonic Dystrophy Type 1
https://www.mdedge.com/neurology/article/49086/neurology/cardiac-pacing-improves-survival-myotonic-dystrophy-type-1
Mary Ann Moon

Mar 27th, 2012 - A strategy of implanting permanent cardiac pacing markedly improved survival for patients with myotonic dystrophy type 1 who presented with surface electrocardiogram manifestations of cardiac conduction abnormalities, compared with a noninvasive s.

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