About 10,145 results

ALLMedicine™ Neuroblastoma Center

Research & Reviews  3,906 results

Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nerv...
Proceedings of the National Academy of Sciences of the Un... Gkikas D, Stellas D et. al.

Sep 26th, 2021 - Nervous system malignancies are characterized by rapid progression and poor survival rates. These clinical observations underscore the need for novel therapeutic insights and pharmacological targets. To this end, here, we identify the orphan nucle...

Growth factor signaling predicts therapy resistance mechanisms and defines neuroblastom...
https://doi.org/10.1038/s41388-021-02018-7 10.1136/bmj.j1863 10.1200/JCO.2008.16.6785 10.1186/s12943-017-0686-8 10.1038/ng.2529 10.1016/j.ccr.2012.02.010 10.1093/jnci/djh004 10.3892/ijo.2016.3792 10.18632/oncotarget.22011 10.1093/annonc/mds648 10.1080/2162402X.2018.1468953 10.1016/S1470-2045(13)70095-0 10.1002/ijc.24606 10.1158/1078-0432.CCR-20-4224 10.1016/j.tranon.2017.09.008 10.1038/ng.3438 10.1038/nature10910 10.1158/0008-5472.CAN-05-4618 10.1038/cddis.2013.84 10.1038/nbt.3001 10.1158/2159-8290.CD-16-0861 10.1038/s41467-021-21247-8 10.1055/s-2000-9677 10.1186/1471-2407-9-57 10.1101/cshperspect.a002287 10.18632/oncotarget.19662 10.1007/978-1-0716-0138-9_15 10.1093/jnci/djj330 10.1073/pnas.0506580102 10.1038/nature11003 10.1038/s41598-021-90701-w 10.3389/fonc.2019.01046 10.1016/j.lfs.2015.07.022 10.1016/j.cell.2014.04.039 10.1016/j.critrevonc.2007.03.001 10.1002/cncr.22879 10.1158/0008-5472.CAN-13-0248 10.1182/blood-2001-12-0169 10.3389/fcell.2019.00105 10.1038/ng.3333 10.1038/mt.2008.6 10.1038/leu.2014.130 10.1093/nar/gkaa216 10.1093/bioinformatics/19.2.185 10.1093/nar/gkv468 10.1200/JCO.2006.06.1879 10.1186/s13059-014-0523-y 10.1038/nature09609 10.1371/journal.pone.0021800 10.1101/gr.1239303 10.1093/bioinformatics/btr095
Oncogene Lebedev T, Vagapova E et. al.

Sep 25th, 2021 - Neuroblastoma (NB) has a low frequency of recurrent mutations compared to other cancers, which hinders the development of targeted therapies and novel risk stratification strategies. Multikinase inhibitors have shown potential in treating high-ris...

KMT2A-MAML2 rearrangement emerged and regressed during neuroblastoma therapy without le...
Pediatric Blood & Cancer; Felix CA, Slater DJ et. al.

Sep 23rd, 2021 - Twelvepatients without therapy-related leukemia were studied after completing TOP2 poison chemotherapy in a high-risk neuroblastoma regimen. One patient harbored an inv(11) that was a KMT2A rearrangement. The KMT2A-MAML2 transcript was expressed a...

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Guidelines  1 results

Consensus criteria for sensitive detection of minimal neuroblastoma cells in bone marro...
British Journal of Cancer; Beiske K, Burchill SA et. al.

Apr 30th, 2009 - Disseminating disease is a predictive and prognostic indicator of poor outcome in children with neuroblastoma. Its accurate and sensitive assessment can facilitate optimal treatment decisions. The International Neuroblastoma Risk Group (INRG) Task...

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Drugs  46 results see all →

News  104 results

'Remarkable' Results for Targeted Therapy of Rare CNS Tumors

Jun 16th, 2021 - The results from three small studies of targeted therapy for rare brain tumors were "remarkable," according to Jaishri Blakeley, MD, a neurology professor at Johns Hopkins Medicine, Baltimore, who discussed the studies after they were presented at...

Novel UK Developed Immunotherapy Shows Promise Against Neuroblastoma

Dec 1st, 2020 - A novel chimeric antigen receptor (CAR) T-cell therapy developed by researchers at University College London (UCL) to target cancerous tumours has shown promising early results in children with neuroblastoma. In the UCL study, paediatric patients’...

New Drug Approved for Neuroblastoma Based on MSKCC Research

Nov 26th, 2020 - The US Food and Drug Administration (FDA) has granted accelerated approval for a new drug for certain patients with neuroblastoma based on response rate results in small open-label trials. The drug is naxitamab (Danyelza, Y-mAbs Therapeutics), a h...

Neuroblastoma: Osmosis Study Video

Mar 27th, 2020 - Neuroblastoma is the most common extracranial solid cancer in childhood and the most common cancer in infancy. It is a neuroendocrine tumor, arising from any neural crest element of the sympathetic nervous system. It most frequently originates in ...

Adult survivors of childhood cancer are experiencing fewer major cardiac events
Jeff Craven

Jan 21st, 2020 - Adult survivors of pediatric cancers appear to be experiencing fewer major cardiac events in adulthood partly because of reduced radiotherapy exposure, especially among survivors of Hodgkin lymphoma, recent research published in BMJ has shown. “Co.

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Patient Education  1 results see all →