×
About 2,753 results

ALLMedicine™ Progressive Supranuclear Palsy Center

Research & Reviews  1,017 results

Locus Coeruleus Integrity from 7 T MRI Relates to Apathy and Cognition in Parkinsonian ...
https://doi.org/10.1002/mds.29072
Movement Disorders : Official Journal of the Movement Dis... Ye R, O'Callaghan C et. al.

May 17th, 2022 - Neurodegeneration in the locus coeruleus (LC) contributes to neuropsychiatric symptoms in both Parkinson's disease (PD) and progressive supranuclear palsy (PSP). Spatial precision of LC imaging is improved with ultrahigh field 7 T magnetic resonan...

Advanced diffusion imaging to track progression in Parkinson's disease, multiple system...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062732
NeuroImage. Clinical; Mitchell T, Wilkes BJ et. al.

May 1st, 2022 - Advanced diffusion imaging which accounts for complex tissue properties, such as crossing fibers and extracellular fluid, may detect longitudinal changes in widespread pathology in atypical Parkinsonian syndromes. We implemented fixel-based analys...

Diagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055455
JAMA Network Open; Illán-Gala I, Nigro S et. al.

Apr 30th, 2022 - The accurate diagnosis of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) is hampered by imperfect clinical-pathological correlations. To assess and compare the diagnostic value of the magnetic resonance parkinsonism index...

The tauopathies: Neuroimaging characteristics and emerging experimental therapies.
https://doi.org/10.1111/jon.13001
Journal of Neuroimaging : Official Journal of the America... Riley KJ, Graner BD et. al.

Apr 27th, 2022 - The tauopathies are a heterogeneous group of neurodegenerative disorders in which the prevailing underlying disease process is intracellular deposition of abnormal misfolded tau protein. Diseases often categorized as tauopathies include progressiv...

A Study to Assess Tolerability, Safety, Pharmacokinetics and Effect of AZP2006 in Patients With PSP
https://clinicaltrials.gov/ct2/show/NCT04008355

Apr 26th, 2022 - A phase 2 study to assess tolerability, safety, pharmacokinetics and effect of AZP2006 at different doses versus placebo on cerebrospinal fluid biomarkers in 36 patients with progressive supranuclear palsy. The patient study duration is 29 weeks i...

see more →

Drugs  2 results see all →

Clinicaltrials.gov  39 results

A Study to Assess Tolerability, Safety, Pharmacokinetics and Effect of AZP2006 in Patients With PSP
https://clinicaltrials.gov/ct2/show/NCT04008355

Apr 26th, 2022 - A phase 2 study to assess tolerability, safety, pharmacokinetics and effect of AZP2006 at different doses versus placebo on cerebrospinal fluid biomarkers in 36 patients with progressive supranuclear palsy. The patient study duration is 29 weeks i...

Human CNS Tau Kinetics in Tauopathies
https://clinicaltrials.gov/ct2/show/NCT03545126

Apr 13th, 2022 - Tauopathies are neurodegenerative diseases with tau pathology. These tauopathies are the most common pathology in neurodegenerative diseases, and they are reaching epidemic proportions. The rates of tau kinetics are central to understanding normal...

Saliva and Extracellular Vesicles for Parkinson's Disease
https://clinicaltrials.gov/ct2/show/NCT05320250

Apr 11th, 2022 - Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms such as bradykinesia, tremor, rigidity and postural instability. An accurate rehabilitation program designed considering the specific characteristics of the p...

Biomarkers in Parkinsonian Syndromes
https://clinicaltrials.gov/ct2/show/NCT02114242

Mar 31st, 2022 - The differential diagnosis between Parkinson's disease, multiple system atrophy and progressive supranuclear palsy can be very difficult in early disease. PD, MSA and PSP are neurodegenerative disorders. PD and MSA belong to the alpha-synucleinopa...

The Study to Evaluate the Safety and Efficacy of Spinal Cord Stimulation on Progressive Supranuclear Palsy
https://clinicaltrials.gov/ct2/show/NCT04367116

Mar 25th, 2022 - The Study to Evaluate the Safety and Efficacy of Spinal Cord Stimulation on Progressive Supranuclear Palsy is an open-label, prospective, single-arm, unicentral and exploratory clinical trial. In the screening stage, patients clinically and radiol...

see more →

News  36 results

Tau Moderated by Menopause; CTE Risk Underestimated; When Is a Single Study Enough?
https://www.medpagetoday.com/neurology/generalneurology/98523

May 3rd, 2022 - Menopause status moderated sex differences in tau burden, with a divergence in tauopathy between the sexes apparent 20 years earlier than previously reported. (Annals of Neurology) Plasma p-tau was a less consistent marker of brain amyloidosis in ...

Blood Biomarkers May Distinguish Dementia Disorders
https://www.medpagetoday.com/neurology/dementia/96915

Jan 28th, 2022 - Blood-based biomarkers may help differentiate people with different dementias and monitor disease changes over time, a longitudinal study showed. Plasma markers showed different profiles in Alzheimer's disease, frontotemporal dementia, Lewy body d...

Alzheimer's Blood Test Predicts Pathology
https://www.medpagetoday.com/neurology/alzheimersdisease/90555

Jan 6th, 2021 - This story was published originally on May 4, 2020. As part of MedPage Today's review of stories in the past year, we're republishing it, along with an update on further developments in blood tests for Alzheimer's disease. An ultrasensitive blood ...

Negative Phase 2 Trial Data Ends Development of PSP Drug
https://www.medscape.com/viewarticle/922592

Dec 13th, 2019 - Topline results from the phase two PASSPORT trial show the experimental drug gosuranemab (BIIB092, Biogen) did not meet its primary or key secondary endpoints in patients with the atypical parkinsonian disorder of progressive supranuclear palsy (P...

The Falls and Frustrations of Progressive Supranuclear Palsy
https://www.medscape.com/viewarticle/921622

Nov 25th, 2019 - I often repeat her presentation to medical students: my only patient ever to fall walking into a clinic visit had progressive supranuclear palsy (PSP). Her impaired postural reflexes were no match for a set of brick steps. Perhaps she didn't notic...

see more →

Patient Education  7 results see all →