ALLMedicine™ Spinocerebellar Ataxia Type 6 Center

Jun 17th, 2022 - Fear and anxiety have proven to be essential during the evolutionary process. However, the mechanisms involved in recognizing and categorizing threat probability (i.e. low to high) to elicit the appropriate defensive behavior has yet to be determi...

May 25th, 2022 - To elucidate clinically useful imaging characteristics of multiple system atrophy with predominant cerebellar ataxia (MSA-C) at the initial stage showing pure cerebellar ataxia but unfilling consensus criteria (MSA-pc), clinical and neuroradiologi...

May 27th, 2021 - Peripheral neuropathy has been reported commonly in several spinocerebellar ataxia (SCA) types. To date, there is a lack of robust evidence for neuropathy or neuronopathy in SCA type 6 (SCA6). Here, we aim to evaluate the presence of neuropathy or...

Dec 4th, 2020 - The Bacillus sp. SAM1606 alpha-glucosidase with a broad substrate specificity is the only known alpha-glucosidase that can hydrolyze alpha,alpha'-trehalose efficiently. The enzyme exhibits a very high sequence similarity to the oligo-1,6-glucosida...

Apr 28th, 2020 - To investigate the genetic and environmental factors responsible for phenotype variability in a family carrying a novel CACNA1A missense mutation. Mutations in the CACNA1A gene were identified as responsible for at least three autosomal dominant d...

Apr 28th, 2015 - Specifically, we would expect to see Parkinsonism and other non-ataxia symptoms are more commonly present in SCA6 patients than we used to think. Parkinsonism is associated with the loss of DAT in striatum. Parkinsonism and other non-ataxia sympto...