About 213 results

ALLMedicine™ Acute Megakaryoblastic Leukemia Center

Research & Reviews  82 results

Outcome and Prognostic Features in Pediatric Acute Megakaryoblastic Leukemia Without Do...
Clinical Lymphoma, Myeloma & Leukemia; Wang Y, Lu A et. al.

Dec 1st, 2020 - Acute megakaryoblastic leukemia (AMKL) is a biologically heterogeneous subtype of acute myeloid leukemia that originates from megakaryocytes. Patients with AMKL with non-Down syndrome (DS) had a poorer prognosis. However, clear prognostic indicato...

SON inhibits megakaryocytic differentiation via repressing RUNX1 and the megakaryocytic...
Cancer Gene Therapy; Vukadin L, Kim JH et. al.

Nov 28th, 2020 - A high incidence of acute megakaryoblastic leukemia (AMKL) in Down syndrome patients implies that chromosome 21 genes have a pivotal role in AMKL development, but the functional contribution of individual genes remains elusive. Here, we report tha...

t(1;22)(p13;q13) Acute Megakaryoblastic Leukemia Complicated by Hepatic Fibrosis: Antif...
Journal of Pediatric Hematology/oncology; Feng J, Leung AWK et. al.

Oct 30th, 2020 - There is no established effective treatment for patients with t(1;22)(p13;q13) acute megakaryoblastic leukemia (AMKL) and hepatic fibrosis. Here we report the outcomes of 2 t(1;22)(p13;q13) AMKL patients with hepatic fibrosis. One patient died fro...

Utility of CD36 as a novel addition to the immunophenotypic signature of RAM-phenotype ...
Cytometry. Part B, Clinical Cytometry; Panda D, Chatterjee G et. al.

Aug 31st, 2020 - In 2016, Children Oncology Group (COG) described a new high-risk subtype of acute myeloid leukemia (AML) with a distinct immunophenotypic-signature, RAM-phenotype (RAM-AML). Data on clinical and laboratory features of RAM-AML are still limited to ...

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Clinicaltrials.gov  2 results

Alisertib in Treating Patients With Myelofibrosis or Relapsed or Refractory Acute Megakaryoblastic Leukemia

Feb 18th, 2018 - PRIMARY OBJECTIVES: I. Determine the safety profile of alisertib in patients with acute megakaryoblastic leukemia (AMKL) and in patients with myelofibrosis (MF). SECONDARY OBJECTIVES: I. Determine preliminary efficacy of alisertib in both populati...

Studying Genes in Samples From Younger Patients With Acute Megakaryoblastic Leukemia

May 17th, 2016 - Study Subtype: Ancillary/Correlative Observational Study Model: Cohort Time Perspective: Retrospective Biospecimen Retention: Samples With DNA Biospecimen Description: Cryopreserved mRNA Study Population Description: Samples from AAML0531 Sampling...

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News  1 results

New recommendations for pediatric AMKL
HT Staff

Jan 24th, 2017 - Micrograph showing AMKL Image courtesy of St. Jude Children’s Research Hospital and Tina Motroni Research has revealed genetic alterations that may prove useful for predicting treatment outcomes in pediatric patients with acute megakaryoblastic le.

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