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About 868 results

ALLMedicine™ Anaplastic Thyroid Cancer Center

Research & Reviews  308 results

Glycolytic inhibition with 3-bromopyruvate suppresses tumor growth and improves surviva...
https://doi.org/10.1016/j.surg.2021.05.055
Surgery Zhao B, Aggarwal A et. al.

Aug 3rd, 2021 - Anaplastic thyroid cancer is a rare but devastating malignancy. Anaplastic thyroid cancer cells exhibit the Warburg effect by preferentially undergoing glycolysis even in aerobic conditions, leading to high glucose use. Here we assess if targeted ...

Inhibition of IRAK1/4 enhances the antitumor effect of lenvatinib in anaplastic thyroid...
https://doi.org/10.1111/cas.15095
Cancer Science; Kawamura Y, Saijo K et. al.

Jul 31st, 2021 - Anaplastic thyroid cancer (ATC) is an extremely aggressive tumor associated with poor prognosis due to a lack of efficient therapies. In Japan, lenvatinib is the only drug approved for patients with ATC; however, its efficacy is limited. Therefore...

Dihydrotanshinone exerts antitumor effects and improves the effects of cisplatin in ana...
https://doi.org/10.3892/or.2021.8155
Oncology Reports; Allegri L, Domenis R et. al.

Jul 29th, 2021 - Anaplastic thyroid cancer (ATC) is the most aggressive type of thyroid cancer and is responsible for 20‑50% of thyroid cancer‑associated deaths. The absence of response to conventional treatments makes the search for novel therapeutics a clinical ...

Management of Anaplastic and Recurrent Differentiated Thyroid Cancer: Indications for S...
https://doi.org/10.1016/j.nic.2021.04.005
Neuroimaging Clinics of North America; Cabanillas ME, Ahmed S et. al.

Jul 11th, 2021 - Differentiated and anaplastic thyroid cancer are tumors derived from follicular thyroid cancers and are clinically and genetically distinct. Treatment of these tumors has evolved over the past decade, with 6 drugs/drug combinations that are US Foo...

Pyrexia in patients treated with dabrafenib plus trametinib across clinical trials in B...
https://doi.org/10.1016/j.ejca.2021.05.005
European Journal of Cancer (Oxford, England : 1990); Schadendorf D, Robert C et. al.

Jul 6th, 2021 - Dabrafenib plus trametinib has demonstrated clinical benefit across multiple BRAF-mutant tumours, leading to approval for resected stage III and metastatic melanoma, non-small-cell lung cancer (NSCLC) and anaplastic thyroid cancer. Pyrexia is a co...

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Guidelines  1 results

Anaplastic Thyroid Carcinoma, Version 2.2015.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986600
Journal of the National Comprehensive Cancer Network : JN... Haddad RI, Lydiatt WM et. al.

Sep 12th, 2015 - This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Thyroid Carcinoma focuses on anaplastic carcinoma because substantial changes were made to the systemic therapy recommendations for the 2015 update. Dosage...

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Clinicaltrials.gov  13 results

Intensity-Modulated Radiation Therapy and Paclitaxel With or Without Pazopanib Hydrochloride in Treating Patients With Anaplastic Thyroid Cancer
https://clinicaltrials.gov/ct2/show/NCT01236547

Apr 17th, 2020 - PRIMARY OBJECTIVES: I. To evaluate the safety of IMRT, paclitaxel, and pazopanib (pazopanib hydrochloride) suspension. (Run-in component) II. To evaluate and compare overall survival at 1 year from study registration. (Phase II component) SECONDAR...

Pembrolizumab, Chemotherapy, and Radiation Therapy With or Without Surgery in Treating Patients With Anaplastic Thyroid Cancer
https://clinicaltrials.gov/ct2/show/NCT03211117

Mar 25th, 2020 - PRIMARY OBJECTIVES: I. To assess the efficacy of pembrolizumab in improving overall survival at 6 months (OS-6) in combination with multimodal therapy involving standard chemo-radiotherapy in anaplastic thyroid cancer (ATC) in comparison to a hist...

A Phase 2 Trial of Lenvatinib for the Treatment of Anaplastic Thyroid Cancer (ATC)
https://clinicaltrials.gov/ct2/show/NCT02657369

Oct 29th, 2018 - The primary purpose of the study is to evaluate objective response rate ([ORR]: complete response [CR] and partial response [PR]) by investigator review in participants with anaplastic thyroid cancer (ATC) treated with lenvatinib.

Anaplastic Thyroid Cancer and Follicular Thyroid Cancer-derived Exosomal Analysis Via Treatment of Lovastatin and Vildagliptin and Pilot Prognostic Study Via Urine Exosomal Biological Markers in Th...
https://clinicaltrials.gov/ct2/show/NCT02862470

Oct 16th, 2018 - Although papillary and follicular thyroid cancers are low-grade endocrine malignancy, they were fatal if the cancer cells were poorly-differentiated or anaplastic change. Prior researches indicated that one-third well-differentiated thyroid cancer...

Avastin and Doxorubicin Postoperatively for Patients With Anaplastic Thyroid Cancer
https://clinicaltrials.gov/ct2/show/NCT00804830

Aug 28th, 2018 - Patients with Anaplastic Thyroid Cancer have a poor prognosis. We will treat the patients initially with our standard radiochemotherapy, which consists of doxorubicin 20mg fixed dose/week and hyperfractionated radiotherapy 1,6 Gy twice daily up to...

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News  24 results

Targeted Treatment Tied to Longer Survival in Patients With Anaplastic Thyroid Cancer
https://www.medscape.com/viewarticle/936044

Aug 21st, 2020 - NEW YORK (Reuters Health) - With the introduction of targeted treatments for anaplastic thyroid carcinoma, patients have seen significant improvements in survival, according to a new report. "Over the last 5 years, a greater understanding of the m...

Targeted Treatment Tied to Longer Survival in Patients With Anaplastic Thyroid Cancer
https://www.staging.medscape.com/viewarticle/936044

Aug 21st, 2020 - NEW YORK (Reuters Health) - With the introduction of targeted treatments for anaplastic thyroid carcinoma, patients have seen significant improvements in survival, according to a new report. "Over the last 5 years, a greater understanding of the m...

My Strangest Case: The Man With a Heavy Tongue
https://reference.medscape.com/viewarticle/934944_3

Aug 4th, 2020 - Discussion Four aspects make this case unusual. First, the length of time between the diagnosis and relapse, 40 years, was remarkable. Ordinarily, the prognosis for the patient's original tumor type, follicular thyroid cancer, is excellent; howeve...

Endocrinologists Navigate Deferments, Telehealth Amid COVID-19
https://www.medscape.com/viewarticle/930116

May 7th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's  Coronavirus Resource Center. James V. Hennessey, MD, has been working from home, like so many others, since the lockdowns went into effect. The director of clinical endocrino...

Multimodal therapies almost double survival in anaplastic thyroid cancer
https://www.mdedge.com/endocrinology/article/212736/pituitary-thyroid-adrenal-disorders/multimodal-therapies-almost-double?channel=53
Kari Oakes

Nov 20th, 2019 - CHICAGO – Overall survival for patients with anaplastic thyroid cancer was boosted when their care facilitated a rapid work-up, comprehensive treatment planning, and integrated implementation of multimodal therapies. Median survival for participan.

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Patient Education  1 results see all →