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ALLMedicine™ Autoimmune Lymphoproliferative Syndrome Center

Research & Reviews  329 results

Underlying CTLA4 Deficiency in a Patient With Juvenile Idiopathic Arthritis and Autoimm...
https://doi.org/10.1097/MPH.0000000000002120
Journal of Pediatric Hematology/oncology; Mazzoni M, Dell'Orso G et. al.

Feb 24th, 2021 - Functional variants of the cytotoxic T-lymphocyte antigen-4 (CTLA4) could contribute to the pathogenesis of disorders characterized by abnormal T-cell responses. We report a case of a 13-year-old girl who first presented with polyarticular juvenil...

A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is contro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658692
The Journal of Experimental Medicine; Maccari ME, Fuchs S et. al.

Nov 10th, 2020 - The identification and characterization of rare immune cell populations in humans can be facilitated by their growth advantage in the context of specific genetic diseases. Here, we use autoimmune lymphoproliferative syndrome to identify a populati...

Persistent Interferon Production by Double Negative T Cells and Collapsing Focal Segmen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785627
Nephron Lohani S, Sadasivam M et. al.

Oct 15th, 2020 - Collapsing glomerulopathy has multiple associations, including viral infections, medications like bisphosphonates and interferon, autoimmune diseases, and genetic predisposition. We report a case of collapsing focal segmental glomerulosclerosis as...

Protein Kinase C-Delta Defect in Autoimmune Lymphoproliferative Syndrome-Like Disease: ...
https://doi.org/10.1080/08820139.2020.1829638
Immunological Investigations; Sharifinejad N, Azizi G et. al.

Oct 13th, 2020 - Protein kinase C is a family of serine/threonine kinases that play a key role in the adaptive immune cell signaling, as well as regulation of growth, apoptosis, and differentiation of a variety of cell types. Patients homozygous for a null mutatio...

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Guidelines  1 results

Revised diagnostic criteria and classification for the autoimmune lymphoproliferative s...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953894
Blood Oliveira JB, Bleesing JJ et. al.

Jun 11th, 2010 - Lymphadenopathy in children for which no infectious or malignant cause can be ascertained constitutes a challenging diagnostic dilemma. Autoimmune lymphoproliferative syndrome (ALPS) is a human genetic disorder of lymphocyte apoptosis resulting in...

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Clinicaltrials.gov  329 results

Underlying CTLA4 Deficiency in a Patient With Juvenile Idiopathic Arthritis and Autoimm...
https://doi.org/10.1097/MPH.0000000000002120
Journal of Pediatric Hematology/oncology; Mazzoni M, Dell'Orso G et. al.

Feb 24th, 2021 - Functional variants of the cytotoxic T-lymphocyte antigen-4 (CTLA4) could contribute to the pathogenesis of disorders characterized by abnormal T-cell responses. We report a case of a 13-year-old girl who first presented with polyarticular juvenil...

A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is contro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658692
The Journal of Experimental Medicine; Maccari ME, Fuchs S et. al.

Nov 10th, 2020 - The identification and characterization of rare immune cell populations in humans can be facilitated by their growth advantage in the context of specific genetic diseases. Here, we use autoimmune lymphoproliferative syndrome to identify a populati...

Persistent Interferon Production by Double Negative T Cells and Collapsing Focal Segmen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785627
Nephron Lohani S, Sadasivam M et. al.

Oct 15th, 2020 - Collapsing glomerulopathy has multiple associations, including viral infections, medications like bisphosphonates and interferon, autoimmune diseases, and genetic predisposition. We report a case of collapsing focal segmental glomerulosclerosis as...

Protein Kinase C-Delta Defect in Autoimmune Lymphoproliferative Syndrome-Like Disease: ...
https://doi.org/10.1080/08820139.2020.1829638
Immunological Investigations; Sharifinejad N, Azizi G et. al.

Oct 13th, 2020 - Protein kinase C is a family of serine/threonine kinases that play a key role in the adaptive immune cell signaling, as well as regulation of growth, apoptosis, and differentiation of a variety of cell types. Patients homozygous for a null mutatio...

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News  1 results

Immunosuppressant can treat autoimmune cytopenias
https://www.mdedge.com/hematology-oncology/article/187516/anemia/immunosuppressant-can-treat-autoimmune-cytopenias
HT Staff

Oct 27th, 2015 - Red and white blood cells New research suggests the immunosuppressant sirolimus may be a promising treatment option for patients with refractory autoimmune cytopenias. The drug proved particularly effective in children with autoimmune lymphoprolif.

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