About 1,735 results

ALLMedicine™ Adrenocortical Carcinoma Center

Research & Reviews  654 results

Spironolactone is associated with reduced mitotane levels in adrenocortical carcinoma p...
Endocrine-related Cancer; Haberbosch L, Maurer L et. al.

Jan 12th, 2022 - Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a poor prognosis. Mitotane, a derivative of the pesticide DDT, has been used successfully as first line chemotherapy since the 1960s, if maintained within a narrow therapeutic wind...

ASO Visual Abstract: Adrenocortical Carcinoma-The Value of Lymphadenectomy.
Annals of Surgical Oncology; Tseng J, DiPeri T et. al.

Jan 8th, 2022 - ASO Visual Abstract: Adrenocortical Carcinoma-The Value of Lymphadenectomy.|2022|Tseng J,DiPeri T,Chen Y,Shouhed D,Ben-Shlomo A,|

A revised mechanism of action of hyperaldosteronism-linked mutations in cytosolic domai...
The Journal of Physiology; Shalomov B, Handklo-Jamal R et. al.

Dec 28th, 2021 - G protein-gated, inwardly rectifying potassium channels (GIRK) mediate inhibitory transmission in brain and heart, and are present in the adrenal cortex. GIRK4 (KCNJ5) subunits are abundant in the heart and adrenal cortex. Multiple mutations of KC...

Identification of prognostic metabolic genes in adrenocortical carcinoma and establishm...
Medicine Chen Q, Ren Z et. al.

Dec 18th, 2021 - Adrenocortical carcinoma is an invasive malignancy with poor prognosis, high recurrence rate and limited therapeutic options. Therefore, it is necessary to establish an effective method to diagnose and evaluate the prognosis of patients, so as to ...

see more →

Guidelines  1 results

Case detection, diagnosis, and treatment of patients with primary aldosteronism: an end...
The Journal of Clinical Endocrinology and Metabolism; Funder JW, Carey RM et. al.

Jun 17th, 2008 - Our objective was to develop clinical practice guidelines for the diagnosis and treatment of patients with primary aldosteronism. The Task Force comprised a chair, selected by the Clinical Guidelines Subcommittee (CGS) of The Endocrine Society, si...

see more →

Clinicaltrials.gov  16 results

Evaluation of Side Effects of Mitotane

Jul 13th, 2021 - Mitotane is standard therapy in the treatment of adrenocortical carcinoma. However, many side effects are not well documented. Therefore, we are aiming at collecting data about side effects in patients treated with mitotane

Preclinical Study Towards an Immunotherapy in Adrenocortical Carcinoma

Jun 7th, 2021 - Adrenocortical carcinoma (ACC) is a rare and heterogeneous malignancy with poor prognosis. Surgical resection of the tumor is the treatment of choice. However, even after complete resection more than 80 % of patients will experience recurrence of ...

German Adrenocortical Carcinoma Registry

Jun 4th, 2021 - Basic objective of the German Adrenocortical Carcinoma Registry is to improve the care of patients with adrenocortical cancer. The registration of as many patients as possible helps to collect data for the prognosis and prospects of success regard...

Single Agent Pembrolizumab in Subjects With Advanced Adrenocortical Carcinoma

Apr 6th, 2021 - Pembrolizumab is a type of immunotherapy, and the purpose of this study is to find out what effects, good and/or bad, pembrolizumab has on you, and your cancer.

Surgery and Heated Intraperitoneal Chemotherapy for Adrenocortical Carcinoma

Jan 28th, 2021 - Adrenocortical carcinoma (ACC) is a rare tumor with an overall 5-year mortality rate of 75 - 90% and an average survival from the time of diagnosis of 14.5 months. The treatment of choice for a localized primary or recurrent tumor is surgical rese...

see more →

News  23 results

Exceptional Responder Provides Treatment Clues in Bladder Cancer

Oct 6th, 2021 - Nikhil Wagle, MD An exceptional responder with advanced urothelial carcinoma experienced a complete radiologic response lasting 13.8 months following treatment with the combination of everolimus (Afinitor) and pazopanib (Votrient), according to r...

Neuroendocrine Tumors Clinical Practice Guidelines (NCCN, 2021)

Sep 30th, 2021 - Updated clinical guidelines on the diagnosis and management of neuroendocrine and adrenal tumors were released in 2021 by the National Comprehensive Cancer Network (NCCN). The new version of the guidelines, published in the Journal of the National...

Genetic Data Points to Potential New Therapeutic Target for Adrenocortical Carcinoma

Dec 20th, 2020 - According to study results presented at the 21st Annual Congress of the American Association of Clinical Endocrinologists, overexpression of pituitary tumor transforming gene 1 (PTTG1) is associated with low survival rates in patients with adrenoc...

Urine Screen as Part of Triple Test Improves ID of Adrenal Cancer

Jul 29th, 2020 - A strategy that includes a urine steroid test along with imaging characteristics and tumor size criteria can significantly improve the challenging diagnosis of adrenocortical cancer, helping to avoid unnecessary, and often unsuccessful, further im...

Adrenocortical Carcinoma Clinical Practice Guidelines (2018)

Nov 5th, 2018 - Clinical practice guidelines for the management of adrenocortical carcinoma in adults were released in October 2018 by the European Society of Endocrinology.[1] Diagnosis Perform a detailed hormonal workup of all patients with suspected adrenocort...

see more →