ALLMedicine™ Adult Brain Tumor Center

Aug 12th, 2022 - Background Diffuse midline gliomas are the most aggressive brain tumors of childhood and young adults, with documented 2 year survival rates of <10%. These tumors are infiltrative midline high-grade gliomas. Treatment failure is due in part to the...

Jul 28th, 2022 - Glioblastoma (GBM) is the most common type of primary adult brain tumor. Glioma stem cell (GSC) residence and Temozolomide (TMZ) resistance in GBM both contribute to poor patient outcome. TRAF4 is a scaffold protein with E3 ubiquitin ligase activi...

Jul 26th, 2022 - Adult brain tumors (glioma) represent a cancer of unmet need where standard-of-care is non-curative; thus, new therapies are urgently needed. It is unclear whether isocitrate dehydrogenases (IDH1/2) when not mutated have any role in gliomagenesis ...

May 24th, 2022 - Harnessing the effector mechanisms of the immune system to combat brain tumors with antigen specificity and memory has been in research and clinical testing for many years. Government grant mechanisms and non-profit organizations have supported ma...

Apr 27th, 2022 - In Reply: Postacute Cognitive Rehabilitation for Adult Brain Tumor Patients.|2022|Weyer-Jamora C,Brie MS,Luks TL,Smith EM,Hervey-Jumper SL,|

Aug 12th, 2022 - Background Diffuse midline gliomas are the most aggressive brain tumors of childhood and young adults, with documented 2 year survival rates of <10%. These tumors are infiltrative midline high-grade gliomas. Treatment failure is due in part to the...

Feb 7th, 2022 - Malignant brain tumors now represent the most frequent cause of cancer death in children. Despite aggressive and highly toxic multi-modality therapy including surgery, craniospinal radiation, and high-dose chemotherapy coupled with peripheral bloo...

Sep 13th, 2017 - Five evaluable patients with newly diagnosed high grade gliomas who will undergo standard concomitant radiation and temozolomide followed by adjuvant temozolomide will be accrued to this open-label, single arm, safety study. Oral fingolimod will b...

Jan 14th, 2016 - A significant proportion of brain tumor patients treated with radiation or chemotherapy who are in disease remission experience cognitive sequelae from their treatment. Cognitive dysfunction can be of sufficient severity to interfere with their ab...

Aug 27th, 2015 - PRIMARY OBJECTIVES: I. To estimate the objective response rate (partial response [PR] or complete response [CR] ≥ 8 weeks) to sunitinib in 2 strata (recurrent/progressive/refractory high-grade glioma vs ependymoma) of recurrent or progressive brai...

Oct 6th, 2021 - Jian Li Campian, MD, PhD Medical Oncologist Assistant Professor of Medicine Siteman Cancer Center Washington University School of Medicine St. Louis, MO The concept that the immune system plays a pivotal role in the prevention and co...

Apr 20th, 2015 - Adult brain tumor survivors taking donepezil, a drug approved for the treatment of Alzheimer’s disease, showed significant improvements in the cognitive functions of memory, motor speed, and dexterity, compared with those taking a placebo. However.

Sep 5th, 2008 - September 5, 2008 — A trio of genomic studies published yesterday in Nature and Science point to specific genes and signaling pathways that characterize 2 human cancers. The results suggest a potential for targeted therapies in glioblastoma multif...