ALLMedicine™ Autoimmune Lymphoproliferative Syndrome Center
Research & Reviews 115 results
Expert Review of Clinical Immunology; Lambert MP
Sep 11th, 2021 - Autoimmune lymphoproliferative syndrome (ALPS) is a rare disorder of immune dysregulation characterized by derangements in first apoptosis signal-mediated apoptosis and elevations in CD3+TCRαβ+CD4-CD8- 'double negative' T cells. As our understandi...
Haematologica Brar N, Spinner MA et. al.
Sep 4th, 2021 - Not available.
Clinical Immunology (Orlando, Fla.); Matas Pérez E, Valdivieso Shephard JL et. al.
Jul 31st, 2021 - Autoimmune lymphoproliferative syndrome is a primary immunodeficiency caused by variants in FAS-mediated apoptosis related genes and is characterized by lymphadenopathy, splenomegaly and autoimmunity. A total of six different variants in CASP10 ha...
International Journal of Immunopathology and Pharmacology; Gu H, Chen Z et. al.
Jul 1st, 2021 - Autoimmune lymphoproliferative syndrome (ALPS) usually presents in childhood with fever, nonmalignant splenomegaly, and lymphadenopathy along with cytopenia, which is caused by mutations in the FAS apoptotic pathway. The TCRαβ + CD4/CD8 double-neg...
The Journal of Clinical Endocrinology and Metabolism; Andrews A, Maharaj A et. al.
Jun 18th, 2021 - Growth hormone insensitivity (GHI) in children is characterized by short stature, functional IGF-I deficiency and normal or elevated serum GH concentrations. The clinical and genetic etiology of GHI is expanding. We undertook genetic characterizat...
Guidelines 1 results
Blood Oliveira JB, Bleesing JJ et. al.
Jun 12th, 2010 - Lymphadenopathy in children for which no infectious or malignant cause can be ascertained constitutes a challenging diagnostic dilemma. Autoimmune lymphoproliferative syndrome (ALPS) is a human genetic disorder of lymphocyte apoptosis resulting in...
News 1 results
Oct 27th, 2015 - Red and white blood cells New research suggests the immunosuppressant sirolimus may be a promising treatment option for patients with refractory autoimmune cytopenias. The drug proved particularly effective in children with autoimmune lymphoprolif.