ALLMedicine™ Lynch Syndrome Center
Research & Reviews 1,325 results
https://doi.org/10.1038/s41467-022-29920-2 10.1200/JCO.2008.17.5950 10.1002/(SICI)1097-0215(19990412)81:2<214::AID-IJC8>3.0.CO;2-L 10.1002/ijc.2910640613 10.1001/jama.2011.743 10.1053/j.gastro.2009.07.039 10.1038/s41588-021-00930-y 10.1038/nature11252 10.1126/science.7632227 10.1038/sj.onc.1204449 10.1038/s41586-019-1672-7 10.1016/j.cell.2020.06.036 10.1038/s41586-020-2214-z 10.1038/s41588-019-0525-5 10.1038/nature12477 10.1016/j.cell.2012.04.024 10.1038/s41467-019-12594-8 10.1038/s41586-020-2080-8 10.1371/journal.pone.0056964 10.1126/science.1224820 10.1038/s41586-020-1943-3 10.1038/modpathol.2017.39 10.1002/ijc.31300 10.1371/journal.pone.0121980 10.1016/S1470-2045(12)70109-2 10.1038/s41596-020-00437-6 10.1093/bioinformatics/btp324 10.1002/cpbi.20 10.1186/s12862-018-1131-3 10.1002/0471250953.bi1507s52 10.1093/bioinformatics/btp394 10.1198/016214506000000302 10.1016/j.cell.2017.09.042 10.1158/2159-8290.CD-12-0095 10.1126/scisignal.2004088 10.1186/s13059-016-0924-1 10.1073/pnas.1009843107 10.1002/cpbi.17 10.1002/9780470942390.mo130179 10.1093/bioinformatics/btp352 10.1093/nar/gkq603 10.1038/nature19768
Nature Communications; Lee BCH, Robinson PS et. al.
May 18th, 2022 - Lynch Syndrome (LS) is an autosomal dominant disease conferring a high risk of colorectal cancer due to germline heterozygous mutations in a DNA mismatch repair (MMR) gene. Although cancers in LS patients show elevated somatic mutation burdens, in...
https://doi.org/10.1016/j.hoc.2022.02.005
Hematology/oncology Clinics of North America; Dharwadkar P, Zaki TA et. al.
May 17th, 2022 - Contrary to decreasing incidence rate of colorectal cancer (CRC) in older adults, incidence rates have nearly doubled in younger adults (age <50 years) in the United States since the early 1990s. A similar increase has been observed across the glo...
https://doi.org/10.1097/PAS.0000000000001918
The American Journal of Surgical Pathology; Farchoukh LF, Celebrezze J et. al.
May 14th, 2022 - We evaluated 368 consecutively resected rectal cancers with neoadjuvant therapy for DNA mismatch repair (MMR) protein status, tumor response to neoadjuvant therapy, histopathologic features, and patient survival. Nine (2.4%) rectal cancers were mi...
https://doi.org/10.1038/s41431-022-01098-7 10.1038/sj.onc.1207714 10.1038/gim.2015.30 10.1038/gim.2018.42 10.1038/gim.2015.166 10.1016/j.jmoldx.2019.03.001 10.1016/j.cancergen.2016.06.008 10.1590/S1415-47572012000400009 10.1007/s12282-018-00938-z 10.1038/s10038-020-00849-y 10.1038/s41598-018-27315-2 10.1136/jmg.2004.027243 10.1093/annonc/mdq460 10.1007/s10549-010-0853-8 10.1007/s10549-011-1718-5 10.1007/s10549-014-2971-1 10.1371/journal.pone.0047993 10.1007/s10689-012-9561-3 10.1186/s12885-017-3422-2 10.1245/s10434-018-6621-4 10.1371/journal.pone.0187630 10.1200/JCO.1996.14.5.1730 10.1200/JCO.2013.50.9257 10.1038/sj.bjc.6602175 10.1086/301670 10.1136/jmg.2003.017996 10.1016/j.maturitas.2017.06.002 10.1200/JGO.19.00170 10.1590/1678-4685-gmb-2014-0350
European Journal of Human Genetics : EJHG; de Oliveira JM, Zurro NB et. al.
May 10th, 2022 - Hereditary cancer risk syndromes are caused by germline variants, commonly in tumor suppressor genes. Most studies on hereditary cancer have been conducted in white populations. We report the largest study in Brazilian individuals with multiple et...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058703
BMJ Case Reports; Fulk K, Turner M et. al.
Apr 30th, 2022 - Despite advances in genetic testing for Lynch syndrome, nearly one quarter of mismatch repair-deficient (MMRd) colorectal and endometrial cancers remain unexplained. When added to germline DNA testing, RNA sequencing can increase diagnostic yield,...
Guidelines 21 results
https://doi.org/10.1111/1471-0528.16896
BJOG : an International Journal of Obstetrics and Gynaeco... Manchanda R, Gaba F et. al.
Oct 22nd, 2021 - This paper deals with the use of hormone replacement therapy (HRT) after the removal of fallopian tubes and ovaries to prevent ovarian cancer in premenopausal high risk women. Some women have an alteration in their genetic code, which makes them m...
https://doi.org/10.1002/bjs.11902
The British Journal of Surgery; Seppälä TT, Latchford A et. al.
May 28th, 2021 - Lynch syndrome is the most common genetic predisposition for hereditary cancer but remains underdiagnosed. Large prospective observational studies have recently increased understanding of the effectiveness of colonoscopic surveillance and the hete...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034349
Gut Monahan KJ, Bradshaw N et. al.
Nov 30th, 2019 - Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost 30% of the population in the UK have a family history of CRC. The quantification of an individual's lifetime risk of gastrointestinal cancer may incorporat...
https://doi.org/10.1097/AOG.0000000000003562
Obstetrics and Gynecology;
Nov 26th, 2019 - A hereditary cancer syndrome is a genetic predisposition to certain types of cancer, often with onset at an early age, caused by inherited pathogenic variants in one or more genes. Most hereditary cancer syndromes exhibit autosomal dominant inheri...
https://doi.org/10.1055/a-1031-7657
Endoscopy Bisschops R, East JE et. al.
Nov 12th, 2019 - 1: ESGE suggests that high definition endoscopy, and dye or virtual chromoendoscopy, as well as add-on devices, can be used in average risk patients to increase the endoscopist's adenoma detection rate. However, their routine use must be balanced...
Clinicaltrials.gov 32 results
https://clinicaltrials.gov/ct2/show/NCT05078866
Apr 25th, 2022 - PRIMARY OBJECTIVES: I. To evaluate the safety and tolerability of adenoviral tumor-specific neoantigen priming vaccine GAd-209-FSP (GAd20-209-FSPs) (1 prime) and MVA tumor-specific neoantigen boosting vaccine MVA-209-FSP (MVA-209-FSPs) (1 boost) v...
https://clinicaltrials.gov/ct2/show/NCT05334836
Apr 19th, 2022 - Pancreatic cancer is the fifth leading cause of cancer mortality in Hong Kong and the seventh leading cause of cancer mortality worldwide. In 2020, approximately 496000 new cases of pancreatic cancers were diagnosed globally . Pancreatic cancer is...
https://clinicaltrials.gov/ct2/show/NCT04125914
Apr 14th, 2022 - PRIMARY OBJECTIVES: I. Identify the most effective intervention components for weight loss (primary outcome) and percent energy from fat, vegetable and fruit consumption, physical activity, and theory based behavioral determinants (secondary outco...
https://clinicaltrials.gov/ct2/show/NCT02705846
Mar 31st, 2022 - Over 900,000 new cases of prostate cancer (PCa) are diagnosed worldwide every year. PCa is rarely diagnosed in men younger than 50 years, but its incidence rises rapidly thereafter. Excluding advanced age, the strongest risk factor for the disease...
https://clinicaltrials.gov/ct2/show/NCT04920149
Mar 28th, 2022 - This is a multicenter, multinational, randomized, 2-arm, double-blind, phase II clinical study with 2000mg mesalamine (5-ASA) or placebo in LS patients for a 2-year treatment. 260 tumor free carriers of a known genetic mutation in a major MMR gene...
News 203 results
https://www.medscape.com/viewarticle/971333
Apr 1st, 2022 - Guidelines on the management of endometrial cancer were published on March 21, 2022 by the Spanish Society of Medical Oncology (SEOM) and the Spanish Group for Investigation in Ovarian Cancer (GEICO), in Clinical and Translational Oncology.[1] Rou...
https://www.onclive.com/view/using-ici-therapy-in-msi-high-mcrc
Jan 27th, 2022 - Tanios S. Bekaii-Saab, MD: Let’s assume this patient was MSI [microsatellite instability] high—she had an MSI-high tumor—regardless of the other elements. This was sporadic, so a non–Lynch syndrome, MSI-high tumor. What is the treatment paradigm i...
https://www.onclive.com/view/prostate-cancer-consensus-panel-to-script-testing-guidelines-for-inherited-disease
Jan 3rd, 2022 - Veda Giri, MD Although the oncology community has made many advancements in understanding the role of germline mutations in prostate cancer, a pressing need exists for clarity in determining which genes should be included in testing panels and wh...
https://www.onclive.com/view/atomic-looks-at-immunotherapy-in-earlystage-dmmr-colon-cancer
Jan 3rd, 2022 - Frank Sinicrope, MD Investigators are seeking to determine whether immunotherapy that has been effective in metastatic colon cancers with deficient DNA mismatch repair (dMMR) can be applied to earlier-stage disease, specifically, nonmetastatic st...
https://www.onclive.com/view/overview-of-colorectal-cancer
Nov 30th, 2021 - Tanios S. Bekaii-Saab, MD: Hello, and welcome to this OncLive® Insights® program titled My Treatment Approach: Metastatic Colorectal Cancer. My name is Tanios Bekaii-Saab. I’m at the Mayo Clinic. I lead the GI [gastrointestinal] cancer program and...