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About 3,978 results

ALLMedicine™ Lynch Syndrome Center

Research & Reviews  1,325 results

Mutational landscape of normal epithelial cells in Lynch Syndrome patients.
https://doi.org/10.1038/s41467-022-29920-2 10.1200/JCO.2008.17.5950 10.1002/(SICI)1097-0215(19990412)81:2<214::AID-IJC8>3.0.CO;2-L 10.1002/ijc.2910640613 10.1001/jama.2011.743 10.1053/j.gastro.2009.07.039 10.1038/s41588-021-00930-y 10.1038/nature11252 10.1126/science.7632227 10.1038/sj.onc.1204449 10.1038/s41586-019-1672-7 10.1016/j.cell.2020.06.036 10.1038/s41586-020-2214-z 10.1038/s41588-019-0525-5 10.1038/nature12477 10.1016/j.cell.2012.04.024 10.1038/s41467-019-12594-8 10.1038/s41586-020-2080-8 10.1371/journal.pone.0056964 10.1126/science.1224820 10.1038/s41586-020-1943-3 10.1038/modpathol.2017.39 10.1002/ijc.31300 10.1371/journal.pone.0121980 10.1016/S1470-2045(12)70109-2 10.1038/s41596-020-00437-6 10.1093/bioinformatics/btp324 10.1002/cpbi.20 10.1186/s12862-018-1131-3 10.1002/0471250953.bi1507s52 10.1093/bioinformatics/btp394 10.1198/016214506000000302 10.1016/j.cell.2017.09.042 10.1158/2159-8290.CD-12-0095 10.1126/scisignal.2004088 10.1186/s13059-016-0924-1 10.1073/pnas.1009843107 10.1002/cpbi.17 10.1002/9780470942390.mo130179 10.1093/bioinformatics/btp352 10.1093/nar/gkq603 10.1038/nature19768
Nature Communications; Lee BCH, Robinson PS et. al.

May 18th, 2022 - Lynch Syndrome (LS) is an autosomal dominant disease conferring a high risk of colorectal cancer due to germline heterozygous mutations in a DNA mismatch repair (MMR) gene. Although cancers in LS patients show elevated somatic mutation burdens, in...

Colorectal Cancer in Younger Adults.
https://doi.org/10.1016/j.hoc.2022.02.005
Hematology/oncology Clinics of North America; Dharwadkar P, Zaki TA et. al.

May 17th, 2022 - Contrary to decreasing incidence rate of colorectal cancer (CRC) in older adults, incidence rates have nearly doubled in younger adults (age <50 years) in the United States since the early 1990s. A similar increase has been observed across the glo...

DNA Mismatch Repair-deficient Rectal Cancer Is Frequently Associated With Lynch Syndrom...
https://doi.org/10.1097/PAS.0000000000001918
The American Journal of Surgical Pathology; Farchoukh LF, Celebrezze J et. al.

May 14th, 2022 - We evaluated 368 consecutively resected rectal cancers with neoadjuvant therapy for DNA mismatch repair (MMR) protein status, tumor response to neoadjuvant therapy, histopathologic features, and patient survival. Nine (2.4%) rectal cancers were mi...

RNA sequencing uncovers clinically actionable germline intronic MSH2 variants in previo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058703
BMJ Case Reports; Fulk K, Turner M et. al.

Apr 30th, 2022 - Despite advances in genetic testing for Lynch syndrome, nearly one quarter of mismatch repair-deficient (MMRd) colorectal and endometrial cancers remain unexplained. When added to germline DNA testing, RNA sequencing can increase diagnostic yield,...

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Guidelines  21 results

Risk-Reducing Salpingo-Oophorectomy and the Use of Hormone Replacement Therapy Below th...
https://doi.org/10.1111/1471-0528.16896
BJOG : an International Journal of Obstetrics and Gynaeco... Manchanda R, Gaba F et. al.

Oct 22nd, 2021 - This paper deals with the use of hormone replacement therapy (HRT) after the removal of fallopian tubes and ovaries to prevent ovarian cancer in premenopausal high risk women. Some women have an alteration in their genetic code, which makes them m...

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition...
https://doi.org/10.1002/bjs.11902
The British Journal of Surgery; Seppälä TT, Latchford A et. al.

May 28th, 2021 - Lynch syndrome is the most common genetic predisposition for hereditary cancer but remains underdiagnosed. Large prospective observational studies have recently increased understanding of the effectiveness of colonoscopic surveillance and the hete...

Guidelines for the management of hereditary colorectal cancer from the British Society ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034349
Gut Monahan KJ, Bradshaw N et. al.

Nov 30th, 2019 - Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost 30% of the population in the UK have a family history of CRC. The quantification of an individual's lifetime risk of gastrointestinal cancer may incorporat...

Hereditary Cancer Syndromes and Risk Assessment: ACOG COMMITTEE OPINION, Number 793.
https://doi.org/10.1097/AOG.0000000000003562
Obstetrics and Gynecology;

Nov 26th, 2019 - A hereditary cancer syndrome is a genetic predisposition to certain types of cancer, often with onset at an early age, caused by inherited pathogenic variants in one or more genes. Most hereditary cancer syndromes exhibit autosomal dominant inheri...

Advanced imaging for detection and differentiation of colorectal neoplasia: European So...
https://doi.org/10.1055/a-1031-7657
Endoscopy Bisschops R, East JE et. al.

Nov 12th, 2019 - 1:  ESGE suggests that high definition endoscopy, and dye or virtual chromoendoscopy, as well as add-on devices, can be used in average risk patients to increase the endoscopist's adenoma detection rate. However, their routine use must be balanced...

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Clinicaltrials.gov  32 results

Cancer Preventive Vaccine Nous-209 for Lynch Syndrome Patients
https://clinicaltrials.gov/ct2/show/NCT05078866

Apr 25th, 2022 - PRIMARY OBJECTIVES: I. To evaluate the safety and tolerability of adenoviral tumor-specific neoantigen priming vaccine GAd-209-FSP (GAd20-209-FSPs) (1 prime) and MVA tumor-specific neoantigen boosting vaccine MVA-209-FSP (MVA-209-FSPs) (1 boost) v...

Determination of Pancreatic Steatosis Prevalence and Correlation With High-risk Cyst Features
https://clinicaltrials.gov/ct2/show/NCT05334836

Apr 19th, 2022 - Pancreatic cancer is the fifth leading cause of cancer mortality in Hong Kong and the seventh leading cause of cancer mortality worldwide. In 2020, approximately 496000 new cases of pancreatic cancers were diagnosed globally . Pancreatic cancer is...

Weight Management and Health Behavior Intervention in Lowering Cancer Risk for BRCA Positive and Lynch Syndrome Families
https://clinicaltrials.gov/ct2/show/NCT04125914

Apr 14th, 2022 - PRIMARY OBJECTIVES: I. Identify the most effective intervention components for weight loss (primary outcome) and percent energy from fat, vegetable and fruit consumption, physical activity, and theory based behavioral determinants (secondary outco...

Analysing Outcomes After Prostate Cancer Diagnosis and Treatment in Carriers of Rare Germline Mutations
https://clinicaltrials.gov/ct2/show/NCT02705846

Mar 31st, 2022 - Over 900,000 new cases of prostate cancer (PCa) are diagnosed worldwide every year. PCa is rarely diagnosed in men younger than 50 years, but its incidence rises rapidly thereafter. Excluding advanced age, the strongest risk factor for the disease...

Mesalamine for Colorectal Cancer Prevention Program in Lynch Syndrome
https://clinicaltrials.gov/ct2/show/NCT04920149

Mar 28th, 2022 - This is a multicenter, multinational, randomized, 2-arm, double-blind, phase II clinical study with 2000mg mesalamine (5-ASA) or placebo in LS patients for a 2-year treatment. 260 tumor free carriers of a known genetic mutation in a major MMR gene...

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News  203 results

Endometrial Cancer Clinical Practice Guidelines (SEOM/GEICO, 2022)
https://www.medscape.com/viewarticle/971333

Apr 1st, 2022 - Guidelines on the management of endometrial cancer were published on March 21, 2022 by the Spanish Society of Medical Oncology (SEOM) and the Spanish Group for Investigation in Ovarian Cancer (GEICO), in Clinical and Translational Oncology.[1] Rou...

Using ICI Therapy in MSI-High mCRC
https://www.onclive.com/view/using-ici-therapy-in-msi-high-mcrc

Jan 27th, 2022 - Tanios S. Bekaii-Saab, MD: Let’s assume this patient was MSI [microsatellite instability] high—she had an MSI-high tumor—regardless of the other elements. This was sporadic, so a non–Lynch syndrome, MSI-high tumor. What is the treatment paradigm i...

Prostate Cancer Consensus Panel to Script Testing Guidelines for Inherited Disease
https://www.onclive.com/view/prostate-cancer-consensus-panel-to-script-testing-guidelines-for-inherited-disease

Jan 3rd, 2022 - Veda Giri, MD Although the oncology community has made many advancements in understanding the role of germline mutations in prostate cancer, a pressing need exists for clarity in determining which genes should be included in testing panels and wh...

ATOMIC Looks at Immunotherapy in Early-Stage dMMR Colon Cancer
https://www.onclive.com/view/atomic-looks-at-immunotherapy-in-earlystage-dmmr-colon-cancer

Jan 3rd, 2022 - Frank Sinicrope, MD Investigators are seeking to determine whether immunotherapy that has been effective in metastatic colon cancers with deficient DNA mismatch repair (dMMR) can be applied to earlier-stage disease, specifically, nonmetastatic st...

Overview of Colorectal Cancer
https://www.onclive.com/view/overview-of-colorectal-cancer

Nov 30th, 2021 - Tanios S. Bekaii-Saab, MD: Hello, and welcome to this OncLive® Insights® program titled My Treatment Approach: Metastatic Colorectal Cancer. My name is Tanios Bekaii-Saab. I’m at the Mayo Clinic. I lead the GI [gastrointestinal] cancer program and...

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Patient Education  10 results see all →