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About 75 results

ALLMedicine™ Acquired Generalized Lipodystrophy Center

Research & Reviews  24 results

Lipodystrophy for the Diabetologist-What to Look For.
https://doi.org/10.1007/s11892-022-01485-w
Current Diabetes Reports; Patni N, Garg A

Jul 14th, 2022 - Genetic or acquired lipodystrophies are characterized by selective loss of body fat along with predisposition towards metabolic complications of insulin resistance, such as diabetes mellitus, hypertriglyceridemia, hepatic steatosis, polycystic ova...

Characterization and Clinical Association of Autoantibodies Against Perilipin 1 in Pati...
https://doi.org/10.2337/db21-1086
Diabetes Corvillo F, Abel BS et. al.

Jul 1st, 2022 - Acquired generalized lipodystrophy (AGL) is a rare condition characterized by massive loss of adipose tissue through the body, causing severe metabolic complications. Autoimmune destruction of adipocytes is strongly suspected based on the frequent...

Dermatologic Manifestations of Generalized Lipodystrophy Treatment & Management
https://emedicine.medscape.com/article/1113171-treatment

Jun 17th, 2022 - Medical Care Successful treatment of acanthosis nigricans (AN) in association with generalized lipodystrophy was accomplished in 1 patient with etretinate beginning at 75 mg/d. [21] Therapy for AN was undertaken in this patient for cosmetic reason...

Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy.
https://doi.org/10.2337/db21-1172
Diabetes Mandel-Brehm C, Vazquez SE et. al.

Jun 17th, 2022 - Acquired lipodystrophy is often characterized as an idiopathic subtype of lipodystrophy. Despite suspicion of an immune-mediated pathology, biomarkers such as autoantibodies are generally lacking. Here, we used an unbiased proteome-wide screening ...

Immunogenicity of Metreleptin in Patients With Generalized Lipodystrophy
https://clinicaltrials.gov/ct2/show/NCT04026178

Jul 9th, 2020 - MYALEPT™ (metreleptin) has been approved as an adjunct to diet as replacement therapy to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy (MYALEPT Prescribing Information). This study i...

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Drugs  1 results see all →

Clinicaltrials.gov  1 results

Immunogenicity of Metreleptin in Patients With Generalized Lipodystrophy
https://clinicaltrials.gov/ct2/show/NCT04026178

Jul 9th, 2020 - MYALEPT™ (metreleptin) has been approved as an adjunct to diet as replacement therapy to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy (MYALEPT Prescribing Information). This study i...

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News  4 results

Table of Surrogate Endpoints That Were the Basis of Drug Approval or Licensure
http://www.fda.gov/drugs/development-resources/table-surrogate-endpoints-were-basis-drug-approval-or-licensure

What is the purpose of the Surrogate Endpoint Table? FDA’s surrogate endpoint table provides valuable information for drug developers on endpoints that may be considered and discussed with FDA for individual development programs. This table also f...

FDA OKs Myalept for Leptin Deficiency
https://www.medpagetoday.com/endocrinology/generalendocrinology/44477

Feb 25th, 2014 - The FDA has approved metreleptin (Myalept) for congenital or acquired generalized lipodystrophy, the agency announced. The leptin analog injection will be used alongside diet to relieve the symptoms of this condition, in which patients are born wi...

Myalept (Metreleptin) Approved for Generalized Lipodystrophy
https://www.staging.medscape.com/viewarticle/821056

Feb 25th, 2014 - The US Food and Drug Administration (FDA) has approved Amylin Pharmaceuticals' Myalept (metreleptin for injection) as replacement therapy to treat the complications of leptin deficiency, in addition to diet, in patients with congenital generalized...

Myalept (Metreleptin) Approved for Generalized Lipodystrophy
https://www.medscape.com/viewarticle/821056

Feb 25th, 2014 - The US Food and Drug Administration (FDA) has approved Amylin Pharmaceuticals' Myalept (metreleptin for injection) as replacement therapy to treat the complications of leptin deficiency, in addition to diet, in patients with congenital generalized...

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