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About 250 results

ALLMedicine™ Hereditary Pancreatitis Center

Research & Reviews  85 results

Pancreas Registry and High Risk Registry
https://clinicaltrials.gov/ct2/show/NCT02775461

May 20th, 2022 - The overall purpose of this research project is to establish a registry of patients with pancreatic diseases. Patients included in the registry may include those with: pancreatic cancer, precancerous lesions of the pancreas such as intraductal pap...

Inherited pancreatic exocrine insufficiency and pancreatitis: When children transition ...
https://doi.org/10.1016/j.bpg.2021.101782
Best Practice & Research. Clinical Gastroenterology; Scheers I

Mar 26th, 2022 - Hereditary pancreatitis (HP) encompasses two distinct disease groups: the first manifests as congenital exocrine pancreatic insufficiency (EPI), and the second includes hereditary forms of pancreatitis. EPI represents the ultimate expression of gl...

Wild-Type Human PRSS2 and PRSS1R122H Cooperatively Initiate Spontaneous Hereditary Panc...
https://doi.org/10.1053/j.gastro.2022.03.009
Gastroenterology Wang J, Wan J et. al.

Mar 16th, 2022 - Wild-Type Human PRSS2 and PRSS1R122H Cooperatively Initiate Spontaneous Hereditary Pancreatitis in Transgenic Mice.|2022|Wang J,Wan J,Wang L,Pandol SJ,Bi Y,|

Chronic Pancreatitis Is a Risk Factor for Pancreatic Cancer, and Incidence Increases Wi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963838
Clinical and Translational Gastroenterology; Gandhi S, de la Fuente J et. al.

Feb 11th, 2022 - Observational studies have suggested an increased risk of pancreatic ductal adenocarcinoma (PDAC) in patients with acute and chronic pancreatitis. We conducted a systematic review and meta-analysis to evaluate the magnitude of this association and...

Chronic progression of cerulein-induced acute pancreatitis in trypsinogen mutant mice.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941852
Pancreatology : Official Journal of the International Ass... Jancsó Z, Sahin-Tóth M

Jan 23rd, 2022 - T7K24R mice carry mutation p.K24R in mouse cationic trypsinogen (isoform T7), which is analogous to the human hereditary pancreatitis-associated mutation p.K23R. The mutation renders trypsinogen more prone to autoactivation. We recently reported t...

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Clinicaltrials.gov  3 results

Pancreas Registry and High Risk Registry
https://clinicaltrials.gov/ct2/show/NCT02775461

May 20th, 2022 - The overall purpose of this research project is to establish a registry of patients with pancreatic diseases. Patients included in the registry may include those with: pancreatic cancer, precancerous lesions of the pancreas such as intraductal pap...

Registry of Subjects at Risk of Pancreatic Cancer
https://clinicaltrials.gov/ct2/show/NCT04095195

Sep 19th, 2019 - Pancreatic cancer is a devastating disease with a dismal prognosis. One of the ways to improve survival might be early detection. Within years, many predisposing diseases or genetic conditions have been identified, thus screening/surveillance have...

Role of Antioxidants Supplementation in Chronic Pancreatitis
https://clinicaltrials.gov/ct2/show/NCT00319358

Jan 29th, 2009 - INTRODUCTION Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas accompanied by abdominal pain and in late stages, by exocrine and endocrine insufficiency. The etiology of CP include alcohol abuse, hereditary, ductal ob...

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News  12 results

High incidence of EPI but not diabetes in childhood-onset hereditary pancreatitis
https://www.mdedge.com/gihepnews/article/240858/exocrine-pancreatic-insufficiency/high-incidence-epi-not-diabetes-childhood

Jun 1st, 2021 - Key clinical point: Over half of the patients with childhood-onset hereditary pancreatitis developed exocrine pancreatic insufficiency (EPI). EPI development preceded loss of endocrine function in this rare patient population.

JAK Inhibitors Used as Anti-inflammatory Therapeutics for Pancreatic Cancer
https://www.onclive.com/view/jak-inhibitors-used-as-anti-inflammatory-therapeutics-for-pancreatic-cancer

Dec 5th, 2020 - Abstract Pancreatic cancer will be second only to lung cancer as the most common cause of death from cancer in US by 2030. Most patients are diagnosed with unresectable disease. In this setting, novel combinations of cytotoxics such as FOLFIR...

Prevention Program Targets Pancreatic Cancer Before It Gains a Foothold
https://www.onclive.com/view/prevention-program-targets-pancreatic-cancer-before-it-gains-a-foothold

Dec 5th, 2020 - Rebecca M. Minter, MD Alvin Baldwin Jr Chair in Surgery Professor, Surgery UT Southwestern Medical Center Dallas, Texas Nisa Kubiliun, MD Director, Endoscopic Services Assistant Professor, Department of Internal Medicine UT Southw...

AGA clinical practice update: Pancreatic cancer screening
https://www.mdedge.com/internalmedicine/article/223652/gastroenterology/aga-clinical-practice-update-pancreatic-cancer
Richard Mark Kirkner

Jun 10th, 2020 - Individuals at high risk for pancreatic cancer should at least be considered for screening for the disease, states a new clinical practice update from the American Gastroenterological Association that further defines what constitutes high risk for.

May 2019 - Question 2
https://www.mdedge.com/gihepnews/article/199938/mixed-topics/may-2019-question-2?channel=27442

Apr 30th, 2019 - Q2. Correct Answer: B Rationale: The PRSS1 mutation has been shown to be the causative genetic factor in hereditary pancreatitis.

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