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ALLMedicine™ Ichthyosis Center

Research & Reviews  632 results

Clinical and Basic Investigations Into Known and Suspected Congenital Disorders of Glycosylation
https://clinicaltrials.gov/ct2/show/NCT02089789

May 20th, 2022 - Congenital disorders of glycosylation (CDGs) are a group of diseases characterized by an abnormal glycosylation of proteins, but that can also result from an abnormal synthesis of glycosaminoglycans, glycophospholipids or glycosylphosphatidylinosi...

Perifolliculitis Capitis Abscedens et Suffodiens
https://emedicine.medscape.com/article/1072603-print

May 16th, 2022 - Practice Essentials Perifolliculitis capitis abscedens et suffodiens (PCAS, or dissecting cellulitis of the scalp) is a therapeutically challenging suppurative scalp disease of unknown etiology. Spitzer first described the disease in 1903, and Hof...

ω-O-Acylceramides but not ω-hydroxy ceramides are required for healthy lamellar phase a...
https://doi.org/10.1016/j.jlr.2022.100226
Journal of Lipid Research; Opálka L, Meyer JM et. al.

May 15th, 2022 - Epidermal omega-O-acylceramides (ω-O-acylCers) are essential components of a competent skin barrier. These unusual sphingolipids with ultralong N-acyl chains contain linoleic acid esterified to the terminal hydroxyl of the N-acyl, the formation of...

Keratosis Pilaris
https://emedicine.medscape.com/article/1070651-print

May 12th, 2022 - Practice Essentials Keratosis pilaris (KP) is a genetic disorder of keratinization of hair follicles of the skin. It is an extremely common benign condition that manifests as small, rough folliculocentric keratotic papules, often described as chic...

Nonsense mutations in KRT1 caused recessive epidermolytic palmoplantar keratoderma with...
https://doi.org/10.1111/jdv.18189
Journal of the European Academy of Dermatology and Venere... Mo R, Lin M et. al.

May 2nd, 2022 - Epidermolytic palmoplantar keratoderma (EPPK) is characterized by diffuse hyperkeratosis affecting palms and soles with suprabasal epidermolysis or vacuolar degeneration histopathologically. The disorder is caused by heterozygous mutations in KRT9...

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Guidelines  1 results

Management of congenital ichthyoses: European guidelines of care, part two.
https://doi.org/10.1111/bjd.16882
The British Journal of Dermatology; Mazereeuw-Hautier J, Hernández-Martín A et. al.

Jun 14th, 2018 - These guidelines for the management of congenital ichthyoses have been developed by a multidisciplinary group of European experts following a systematic review of the current literature, an expert conference held in Toulouse in 2016, and a consens...

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Drugs  44 results see all →

Clinicaltrials.gov  9 results

Clinical and Basic Investigations Into Known and Suspected Congenital Disorders of Glycosylation
https://clinicaltrials.gov/ct2/show/NCT02089789

May 20th, 2022 - Congenital disorders of glycosylation (CDGs) are a group of diseases characterized by an abnormal glycosylation of proteins, but that can also result from an abnormal synthesis of glycosaminoglycans, glycophospholipids or glycosylphosphatidylinosi...

A Safety, Efficacy and Systemic Exposure Study of CD5789 Cream in Adults and Adolescents With Lamellar Ichthyosis
https://clinicaltrials.gov/ct2/show/NCT03738800

Sep 17th, 2021 - This is a 2-cohort, multicenter study in subjects with moderate to severe LI. Adults (Cohort A) and adults and adolescents (Cohort B) will be randomized in a double-blind fashion to 1 of 2 doses of active or vehicle and treated twice weekly for 90...

The Efficacy and Safety of Secukinumab in Patients With Ichthyoses
https://clinicaltrials.gov/ct2/show/NCT03041038

Aug 25th, 2021 - The ichthyoses are a group of lifelong genetic disorders which share characteristics of generalized skin thickening, scaling and underlying cutaneous inflammation. The vast majority are orphan disorders and are associated with extremely poor quali...

A Six Week Topical Cream Study for Subjects With Ichthyosis Vulgaris
https://clinicaltrials.gov/ct2/show/NCT03173547

Aug 10th, 2021 - The objective of this study is to determine and compare the safety and efficacy of topical 146-9251 cream and vehicle cream applied twice daily for 6 weeks in subjects with moderate to severe ichthyosis vulgaris (IV).

A Study of Topical NS2 Cream to Treat Ichthyosis in Sjögren-Larsson Syndrome (SLS)
https://clinicaltrials.gov/ct2/show/NCT02402309

Jul 21st, 2021 - This is a multi-center, randomized, double-blind, vehicle-controlled, parallel-group study designed to evaluate the safety, PK, and exploratory activity of topically-applied NS2 dermatologic cream administered once-daily (QD) to subjects with icht...

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News  32 results

Novel Isotretinoin Ointment For Congenital Ichthyosis Shows Promise
https://www.medscape.com/viewarticle/970990

Mar 27th, 2022 - Patients with recessive X-linked and autosomal recessive lamellar congenital ichthyosis (CI) achieved treatment success with a novel topical isotretinoin ointment known as TMB-001, results from a phase 2b study demonstrated. "Patients with these d...

Despite New Ichthyosis Treatment Recommendations, 'Many Questions Still Exist'
https://www.medscape.com/viewarticle/949188

Apr 13th, 2021 - For as many disorders of cornification and types of ichthyosis that have been shown to benefit from retinoids, a seemingly equal number have no data or show no improvement. According to a consensus statement published in the February issue of Pedi...

Consensus Statement Issued on Retinoids for Ichthyosis, Disorders of Cornification
https://www.medscape.com/viewarticle/945212

Feb 3rd, 2021 - Clinicians using systemic retinoids for treating ichthyosis and other disorders of cornification (DOC) in children and adolescents should aim for the lowest dose possible to balance therapeutic goals with acceptable toxicity levels, advised the au...

Off-Label Prescribing Off Limits, Leaving Some Untreated
https://www.medscape.com/viewarticle/927658

Mar 27th, 2020 - One of the aphorisms in dermatology, according to Lawrence Eichenfield, MD, is that prescription pads have become suggestion pads. Patients face consistent head-on refusals from insurers to fill off-label prescriptions for the many dermatologic co...

BRIEF-Aldeyra Therapeutics Provides Updates On Anticipated Clinical Milestones
https://www.reuters.com/article/brief-aldeyra-therapeutics-provides-upda/brief-aldeyra-therapeutics-provides-updates-on-anticipated-clinical-milestones-idUSASA00HFO

Mar 12th, 2020 - March 12 (Reuters) - Aldeyra Therapeutics Inc: * ALDEYRA THERAPEUTICS REPORTS FULL-YEAR 2019 FINANCIAL RESULTS AND PROVIDES UPDATES ON ANTICIPATED CLINICAL MILESTONES * ALDEYRA THERAPEUTICS - STRATEGIC PRIORITIZATION OF LATE-STAGE OCULAR PIPELINE ...

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