About 753 results

ALLMedicine™ Morphea Center

Research & Reviews  254 results

Linear morphea following Blaschko's line with epidermal downmodulation of friend leukem...
International Journal of Dermatology; Hashimoto T, Shinada Y et. al.

May 12th, 2022 - Linear morphea following Blaschko's line with epidermal downmodulation of friend leukemia integration 1 transcription factor.|2022|Hashimoto T,Shinada Y,Okuzawa M,Satoh T,|

Reactive granulomatous dermatitis associated with ovarian cancer and a review of its ro...
Dermatology Online Journal; Sherban A, Cha J et. al.

May 3rd, 2022 - Reactive granulomatous dermatitis (RGD) is a rare dermatosis with a variety of cutaneous manifestations unified by a dermal granulomatous infiltrate on histology. Rheumatoid arthritis and autoimmune disease are classic associations, but an increas...

Immunologic underpinnings and treatment of morphea.
Expert Review of Clinical Immunology; LaChance AH, Goldman N et. al.

Apr 12th, 2022 - Morphea is a chronic autoimmune fibrosing condition of the skin and underlying tissue with the potential for significant disease-associated morbidity. While the exact etiology of morphea is not fully elucidated, many studies have explored the immu...

Linear Scleroderma Causing Arrest of Root Development in a Pediatric Patient.
Journal of Dentistry for Children (Chicago, Ill.); Chua JMC, Fei Yeo J et. al.

Mar 27th, 2022 - Localized scleroderma (LoS) or morphea is a rare group of inflammatory disorders resulting in excessive collagen deposition and subsequent sclerosis of the skin and subdermal tissues. Linear scleroderma (LiS) or linear morphea is the most common s...

The Immunogenetics of Morphea and Lichen Sclerosus.
Advances in Experimental Medicine and Biology; Khan Mohammad Beigi P

Mar 15th, 2022 - Morphea and lichen sclerosis et atrophicus (LSA) are two distinct immune-mediated diseases with a dominant presentation of dermal fibrosis and sclerosis. The two diseases have many similar clinical and histological features and tend to co-occur. B...

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Clinicaltrials.gov  6 results

Clinical Trial to Evaluate Efficacy and Safety of Dupilumab in Localized Scleroderma

Oct 18th, 2021 - Localized scleroderma (LS) comprises a heterogenous group of sclerotic skin disorders. The incidence of LS is reported to be approximately 27 cases/ 1x106 and is hence approximately 2-3-fold higher compared to systemic scleroderma. Although in mos...

Patient Reported Outcomes With UVA-1 Therapy for Treatment of Sclerosing Skin Diseases

Jul 30th, 2021 - Ultraviolet (UV) therapy has been used in dermatology for decades. UVA-1 phototherapy uses the longest wavelengths in the UV spectrum from 340-400 nm. It can penetrate the skin deeper than other types of phototherapy and target different cell type...

Adult-onset Generalized Morphea

Feb 13th, 2020 - This study aimed to describe the demographical and clinical characteristics of a retrospective cohort of adult-onset GM and to investigate whether these findings differ between patients with an isomorphic and a symmetric pattern of lesion distribu...

Treatment Study Comparing UVA-1 Phototherapy Versus Placebo Treatment for Morphea

Sep 25th, 2019 - This is a randomized, blinded, and controlled trial to assess the efficacy and safety of UVA1 phototherapy in the treatment of active morphea in adults and children. Forty patients will be randomized to receive either medium dose (70 J/cm2) photot...

Imiquimod 5% Cream in Plaque-type Morphea: A Pilot, Prospective Open-label Study

Apr 23rd, 2015 - Localized scleroderma or morphea is a fibrotic disease, imiquimod induces cytokines which inhibit fibrotic activity . We propose that topical imiquimod 5% cream is efficacious and safe in treating plaque-type morphea. Twenty adults will be enrolle...

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News  38 results

White macules on knee
MDedge Family Medicine;

May 13th, 2021 - The ivory white appearance and slight atrophy of the lesions raised the possibility of extragenital lichen sclerosus (LS). A 4-mm punch biopsy confirmed the diagnosis.

Fast Five Quiz: Presentation and Diagnosis of Systemic Sclerosis

Feb 4th, 2021 - Systemic sclerosis (SSc) is a rare, heterogenous autoimmune disease characterized by sclerodermatous skin changes, vasculopathy, and involvement of the lungs and other organs. The cause of SSc is largely unknown, but both genetic and environmental...

Morphea Often Follows Relapsing-Remitting Course

Apr 10th, 2020 - NEW YORK (Reuters Health) - Morphea, or localized scleroderma, often follows a relapsing-remitting course over several years, but existing treatment plans appear to improve disease activity and stabilize disease damage, researchers report. Morphea...

Skin changes on abdomen
MDedge Family Medicine;

Oct 24th, 2019 - The FP suspected that the child had morphea because the skin was somewhat firm and thickened, and there was hypo- and hyperpigmentation. Morphea is a localized type of scleroderma and may be seen in children.

Telangiectasias with tight skin
MDedge Family Medicine;

Oct 17th, 2019 - The FP suspected that the patient had CREST (calcinosis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias) syndrome also known as limited cutaneous systemic sclerosis (LcSSc). He examined her arms and found that she had.

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Patient Education  3 results see all →