About 765 results

ALLMedicine™ Palmoplantar Keratoderma Center

Research & Reviews  274 results

Paraneoplastic Pityriasis Rubra Pilaris Preceding Leukemia.
Advances in Skin & Wound Care; Vance P, Wyles S et. al.

Jun 16th, 2022 - Pityriasis rubra pilaris (PRP) is a rare, chronic papulosquamous disorder that presents with scaling plaques, palmoplantar keratoderma, and keratotic follicular papules. Typically, there are distinctive unaffected areas referred to as "islands of ...

KERATIN 17-related recessive atypical pachyonychia congenita with variable hair and too...
https://doi.org/10.1038/s41431-022-01128-4 10.1093/hmg/ddr379 10.1038/ng0395-273 10.1111/1523-1747.ep12335315 10.1046/j.0022-202x.2001.01565.x 10.1046/j.1523-1747.2001.01335.x 10.1046/j.0022-202x.2001.01701.x 10.1111/j.0022-202X.2004.22408.x 10.1038/jid.2011.20 10.1038/jid.2011.484 10.1111/ijd.14082 10.1111/bjd.18794 10.1111/ced.14030 10.1101/gad.979502
European Journal of Human Genetics : EJHG; Koprulu M, Naeem M et. al.

Jun 9th, 2022 - We present the first pachyonychia congenita (PC) to involve all ectodermal derivatives and the first recessive KRT17-related PC in total seven members of two consanguineous Pakistani families. This atypical PC is characterized by an unusual combin...

Effect of mutations on the hydrophobic interactions of the hierarchical molecular struc...
International Journal of Biological Macromolecules; Huang TL, Chou CC

May 28th, 2022 - Human epithelial keratin is an intermediate filament protein that serves as a backbone to maintain the stability of the cell nucleus and mechanical stability of the whole cells. The present study focused on two point mutations, F231L and S233L, of...

A new de novo heterozygous missense mutation in the desmoplakin gene, causing Naxos and...
Clinical and Experimental Dermatology; Ou S, Cesarato N et. al.

May 17th, 2022 - A new de novo heterozygous mutation in the desmoplakin gene, causing Naxos and Carvajal disease, has been reported in a 13-year-old Caucasian girl, with expanded clinical phenotype. In addition to woolly hair, palmoplantar keratoderma and cardiomy...

Nonsense mutations in KRT1 caused recessive epidermolytic palmoplantar keratoderma with...
Journal of the European Academy of Dermatology and Venere... Mo R, Lin M et. al.

May 2nd, 2022 - Epidermolytic palmoplantar keratoderma (EPPK) is characterized by diffuse hyperkeratosis affecting palms and soles with suprabasal epidermolysis or vacuolar degeneration histopathologically. The disorder is caused by heterozygous mutations in KRT9...

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News  32 results

Atypical Presentation of Pityriasis Rubra Pilaris: Challenges in Diagnosis and Management
Michael Abrouk, MD, Mio Nakamura, MD et. al.

Oct 7th, 2021 - To the Editor: Pityriasis rubra pilaris (PRP) is a rare inflammatory dermatosis of unknown etiology characterized by erythematosquamous salmon-colored plaques with well-demarcated islands of unaffected skin and hyperkeratotic follicles. 1 In the Un.

Micronychia of the Index Finger
Anil Harishchandra Patki, MD, Paras Choudhary, MD

Jul 14th, 2021 - Congenital onychodysplasia of the index finger (COIF), or Iso-Kikuchi syndrome, is a rare disorder characterized by malformation of one or both nails of the index fingers. The various anomalies described are anonychia, micronychia, polyonychia, ma.

Thick Hyperkeratotic Plaques on the Palms and Soles
Nicole L. Bolick, MD, MPH, Lisa E. Trivedi, MD et. al.

Mar 12th, 2021 - The Diagnosis: Keratoderma Climactericum Keratoderma climactericum was first reported in 1934 by Haxthausen1 as nonpruritic circumscribed hyperkeratosis located mainly on the palms and soles. The initial eruption was described as discrete lesions.

Ixekizumab deemed effective for pityriasis rubra pilaris
Bruce Jancin

Jul 24th, 2020 - Ixekizumab appears to be a safe and effective treatment for patients with pityriasis rubra pilaris refractory to other systemic therapies, Teri Greiling, MD, PhD, said at the virtual annual meeting of the American Academy of Dermatology. The inter.

What's your diagnosis?
Alexis Tracy, MD, Lawrence F. Eichenfield, MD

May 14th, 2020 - Pityriasis rubra pilaris (PRP) is the name given to a heterogeneous group of rare inflammatory papulosquamous dermatoses. There are six sub-types that can present with various skin findings, however, the cardinal features across sub-types include.

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