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ALLMedicine™ Xeroderma Pigmentosum Center

Research & Reviews  394 results

Cancer Risk in Carriers of the Gene for Xeroderma Pigmentosum
https://clinicaltrials.gov/ct2/show/NCT00046189

May 20th, 2022 - Xeroderma Pigmentosum (XP) is a rare, recessive disorder with a more than 1000-fold increase in the frequency of all major skin cancers in association with defective DNA repair. The risk of skin and other cancers among normal appearing XP heterozy...

Examination of Clinical and Laboratory Abnormalities in Patients With Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or Trichothiodystrophy
https://clinicaltrials.gov/ct2/show/NCT00001813

May 20th, 2022 - Three rare genetic diseases, xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD) have defective DNA excision repair although only XP has increased cancer susceptibility. We plan to perform careful clinical examination...

Advanced basal cell carcinoma: What dermatologists need to know about diagnosis.
https://doi.org/10.1016/j.jaad.2022.03.023
Journal of the American Academy of Dermatology; Krakowski AC, Hafeez F et. al.

May 17th, 2022 - Basal cell carcinoma (BCC) is the most common human cancer, with approximately 3.6 million cases diagnosed each year. About 2000 deaths annually in the United States are attributed to basal and squamous cell skin cancers. There is a direct link be...

XPA Enhances Temozolomide Resistance of Glioblastoma Cells by Promoting Nucleotide Exci...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096195
Cell Transplantation; Dai W, Wu A et. al.

May 11th, 2022 - Glioblastoma is the most frequent, as well as aggressive kind of high-grade malignant glioma. Chemoresistance is posing a significant clinical barrier to the efficacy of temozolomide-based glioblastoma treatment. By suppressing xeroderma pigmentos...

Management of coexisting bilateral ocular surface disease in xeroderma pigmentosum - se...
https://doi.org/10.1177/11206721221100903
European Journal of Ophthalmology; Rajagopal R, Srinivasan B et. al.

May 11th, 2022 - To report a rare presentation of bilateral, coexisting ocular surface disease in a case of Xeroderma pigmentosum and its successful management. Case report. A 21-year-old male with Xeroderma pigmentosum presented with bilateral ocular surface squa...

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Drugs  1 results see all →

Clinicaltrials.gov  6 results

Cancer Risk in Carriers of the Gene for Xeroderma Pigmentosum
https://clinicaltrials.gov/ct2/show/NCT00046189

May 20th, 2022 - Xeroderma Pigmentosum (XP) is a rare, recessive disorder with a more than 1000-fold increase in the frequency of all major skin cancers in association with defective DNA repair. The risk of skin and other cancers among normal appearing XP heterozy...

Examination of Clinical and Laboratory Abnormalities in Patients With Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or Trichothiodystrophy
https://clinicaltrials.gov/ct2/show/NCT00001813

May 20th, 2022 - Three rare genetic diseases, xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD) have defective DNA excision repair although only XP has increased cancer susceptibility. We plan to perform careful clinical examination...

XPAND Trial: Enhancing XP Photoprotection Activities - New Directions
https://clinicaltrials.gov/ct2/show/NCT03445052

Jul 22nd, 2020 - Xeroderma Pigmentosum (XP) is a rare autosomal recessive inherited condition caused by defective Nucleotide Excision Repair. Patients may develop skin cancers from childhood onwards, ocular damage, and neurological deterioration. The clinical mana...

Isotretinoin in Preventing Skin Cancer
https://clinicaltrials.gov/ct2/show/NCT00025012

Jun 19th, 2013 - OBJECTIVES: I. Determine the lowest effective dose of oral isotretinoin for long-term therapy that is capable of reducing the rate of formation of new skin cancers in patients with xeroderma pigmentosum or nevoid basal cell carcinoma syndrome. II....

DNA Repair Genes and Outcomes in Patients With Stage III NSCLC
https://clinicaltrials.gov/ct2/show/NCT00797238

Jul 15th, 2010 - Patients with clinical stage IIIA N2 non-small cell lung cancer (NSCLC) have a 5-year survival rate of 10% to 15%, much worse than those of earlier stages of disease. The use of pre-operative (neo-adjuvant) chemotherapy has been shown to be benefi...

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News  9 results

Fast Five Quiz: Malignant Melanoma
https://reference.medscape.com/viewarticle/936083_2

Aug 21st, 2020 - Primary risk factors and clinical warning signs for melanoma include: Changing mole (most important clinical warning sign) Presence of xeroderma pigmentosum or familial atypical mole melanoma syndrome Clinical atypical/dysplastic nevi in familial ...

NHS England Boss Knighted in New Year Honours
https://www.medscape.com/viewarticle/923186

Dec 28th, 2019 - Simon Stevens, head of NHS England becomes a Sir, leading this year's healthcare field in the 2020 New Year Honours List. The recipients in healthcare are alongside stars of sport, entertainment, public service, politics, charity work, and "the ou...

Expert spotlights telltale clinical signs of xeroderma pigmentosum
https://www.mdedge.com/pediatrics/article/207921/pediatrics/expert-spotlights-telltale-clinical-signs-xeroderma-pigmentosum?channel=39313
Doug Brunk

Sep 10th, 2019 - AUSTIN, TEX. – If a child presents with acute photosensitivity at a young age, onset of freckling before the age of 2 years, and severe sun damage of the lips and eyes, think xeroderma pigmentosum (XP), a rare autosomal recessive disorder.

Atypical Fibroxanthoma Arising Within Erosive Pustular Dermatosis of the Scalp
https://www.mdedge.com/dermatology/article/148349/nonmelanoma-skin-cancer/atypical-fibroxanthoma-arising-within-erosive
Jeffrey D. Cizenski, MD, Ramsay S. Farah, MD

Sep 29th, 2017 - Atypical fibroxanthoma (AFX) is a low-grade dermal malignancy comprised of atypical spindle cells. 1 Classified as a superficial fibrohistiocytic tumor with intermediate malignant potential, AFX has an incidence of approximately 0.

An Alternative Diagnostic Algorithm for Detecting Pediatric Melanomas
https://www.medscape.com/viewarticle/807168

Jul 8th, 2013 - Pediatric Melanoma: Results of a Large Cohort Study and Proposal for Modified ABCD Detection Criteria for Children Cordoro KM, Gupta D, Frieden IJ, McCalmont T, Kashani-Sabet M J Am Acad Dermatol. 2013;68:913-925 Study Summary Pediatric melanomas ...

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Patient Education  1 results see all →