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New Treatment Guidelines for Sjögren's Syndrome
https://www.sjogrens.org/files/research/RheumatologyCPG.pdf

Feb 13th, 2018 - Among all the chronic autoimmune rheumatic disorders, Sjo¨ gren’s disease (SD) is among the most difficult to evaluate and manage. Clinicians are frequently challenged to differentiate symptoms related to disease activity from those that result from preexisting damage. Additionally, the presence of multiple SD-related comorbidities, including anxiety, depression and fibromyalgia,1,2 may infl...

Severe intestinal dysbiosis is prevalent in primary Sjögren's syndrome and is associate...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655865
Arthritis Research & Therapy; Mandl T, Marsal J et. al.

Oct 26th, 2017 - Altered microbial composition of the intestine, commonly referred to as dysbiosis, has been associated with several autoimmune diseases including primary Sjögren's syndrome (pSS). The aims of the current study were to study the intestinal microbial balance in pSS and to identify clinical features associated with dysbiosis. Forty-two consecutive pSS patients and 35 age-matched and sex-matched co...

Risk of Ischemic Heart Disease in Patients With Sjögren's Syndrome.
https://doi.org/10.1016/j.amjms.2017.05.001
The American Journal of the Medical Sciences; Luni FK, Malik SA et. al.

Oct 28th, 2017 - Ischemic heart disease (IHD) has emerged as a major cause of morbidity and mortality in patients with autoimmune conditions such as systemic lupus erythematosus and rheumatoid arthritis, but the risk of IHD in Sjögren's syndrome (SjS) is unknown. To fill this knowledge gap, we estimated the prevalence and risk of IHD with SjS compared to controls from the general population using the Healthcare...

Deregulation of microRNA expression in purified T and B lymphocytes from patients with ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754740
Annals of the Rheumatic Diseases; Wang-Renault SF, Boudaoud S et. al.

Sep 16th, 2017 - MicroRNAs (miRNAs) play an important role in the pathogenesis of autoimmune diseases such as primary Sjögren's syndrome (pSS). This study is the first to investigate miRNA expression patterns in purified T and B lymphocytes from patients with pSS using a high-throughput quantitative PCR (qPCR) approach. Two independent cohorts of both patients with pSS and controls, one for discovery and one fo...

Fibromyalgia prevalence and associated factors in primary Sjögren's syndrome patients i...
https://www.ncbi.nlm.nih.gov/pubmed/28240585
Clinical and Experimental Rheumatology; Torrente-Segarra V, Corominas H et. al.

Feb 27th, 2017 - To assess fibromyalgia (FM) prevalence in a large cohort of primary Sjögren's syndrome patients (pSS) from a National Database. Data included in the national retrospective register of pSS patients of the Spanish Society of Rheumatology (SJOGRENSER) were analysed. 437 pSS patients were included and a 14.6% of FM prevalence was found. FM-pSS patients significantly showed more constitutional, fati...

Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren'...
https://doi.org/10.1136/annrheumdis-2016-209952
Annals of the Rheumatic Diseases; Brito-Zerón P, Acar-Denizli N et. al.

Dec 2nd, 2016 - To analyse the influence of geolocation and ethnicity on the clinical presentation of primary Sjögren's syndrome (SjS) at diagnosis. The Big Data Sjögren Project Consortium is an international, multicentre registry designed in 2014. By January 2016, 20 centres from five continents were participating. Multivariable logistic regression analyses were performed. We included 7748 women (93%) and 562...

New Treatment Guidelines for Sjögren's Disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812283
Rheumatic Diseases Clinics of North America; Vivino FB, Carsons SE et. al.

Jul 19th, 2016 - Sjögren's disease is associated with a high burden of illness, diminished quality of life, and increased health care costs. The Sjögren's Syndrome Foundation developed the first US clinical practice guidelines for management of the oral, ocular, and rheumatologic or systemic manifestations. Guideline recommendations were reviewed by a consensus expert panel using a modified Delphi process. This...

Treatment Guidelines for Rheumatologic Manifestations of Sjögren's Syndrome: Use of Bio...
https://doi.org/10.1002/acr.22968
Arthritis Care & Research; Carsons SE, Vivino FB et. al.

Jul 8th, 2016 - The Sjögren's Syndrome Foundation clinical practice guidelines (CPGs) are designed to improve quality and consistency of care in Sjögren's syndrome by offering recommendations for management. Management questions for the systemic manifestations of Sjögren's syndrome were posed by the CPG committee with input from patients and rheumatologists. Clinical questions were assigned to a topic review g...

Epigenetic Signatures of Salivary Gland Inflammation in Sjögren's Syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132022
Arthritis & Rheumatology (Hoboken, N.J.); Cole MB, Quach H et. al.

Jun 22nd, 2016 - Sjögren's syndrome (SS) is a complex multisystem autoimmune disease that results in progressive destruction of the exocrine glands. The purpose of this study was to characterize epigenetic changes in affected gland tissue and describe the relationship of these changes to known inflammatory processes. A genome-wide DNA methylation study was performed on human labial salivary gland (LSG) biopsy s...

A validated method of labial minor salivary gland biopsy for the diagnosis of Sjögren's...
https://doi.org/10.1002/lary.25974
The Laryngoscope; Kim J, Sun D et. al.

Apr 23rd, 2016 - To validate a technique and outcomes of labial minor salivary gland biopsy (LSGB) used for the diagnosis of Sjögren's syndrome (SS). Prospective cohort study. Clinical data were prospectively obtained pre- and postbiopsy using patient-reported questionnaires. LSGB was performed using described methods. Specimens were analyzed by a pathologist with expertise in SS and assessed using established ...

Sjögren's syndrome complicated with Fanconi syndrome and Hashimoto's thyroiditis: Case ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536691
The Journal of International Medical Research; Shi M, Chen L

Mar 11th, 2016 - We report a unique case of Sjögren's syndrome complicated with Fanconi syndrome and Hashimoto's thyroiditis in a 53-year-old Chinese woman, initially found to have proteinuria, fatigue and multiple old costal fractures. Distal tubular dysfunction is the most common renal damage in Sjögren's syndrome, while Fanconi syndrome (which is caused by proximal tubular dysfunction) and Hypothyroidism are...

What is the evidence for Sjögren's syndrome being triggered by viral infection? Subplot...
https://doi.org/10.1097/BOR.0000000000000287
Current Opinion in Rheumatology; Nakamura H, Kawakami A

Mar 10th, 2016 - To clarify the involvement of viral infections in the pathogenesis of Sjögren's syndrome and to discuss whether viruses can be a trigger for the development of Sjögren's syndrome. Although some viruses are candidate triggers of Sjögren's syndrome, we focus on human T lymphotropic virus type I (HTLV-I). Clinicoepidemiological studies show a relationship between HTLV-I and Sjögren's syndrome with...

Heat shock proteins and chronic fatigue in primary Sjögren's syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804286
Innate Immunity; Bårdsen K, Nilsen MM et. al.

Feb 27th, 2016 - Fatigue occurs frequently in patients with cancer, neurological diseases and chronic inflammatory diseases, but the biological mechanisms that lead to and regulate fatigue are largely unknown. When the innate immune system is activated, heat shock proteins (HSPs) are produced to protect cells. Some extracellular HSPs appear to recognize cellular targets in the brain, and we hypothesize that fat...

Association of Anticentromere Antibodies With More Severe Exocrine Glandular Dysfunctio...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429972
Arthritis Care & Research; Baer AN, Medrano L et. al.

Feb 12th, 2016 - Anticentromere antibodies (ACAs) define a subset of primary Sjögren's syndrome (SS) with a unique phenotype, including features of limited cutaneous systemic sclerosis and a lower frequency of anti-SSA/SSB antibodies. We sought to determine whether ACAs are associated with more severe exocrine glandular dysfunction in a large cohort of primary SS subjects. We performed a cross-sectional analysi...

Defective DNA methylation in salivary gland epithelial acini from patients with Sjögren...
https://doi.org/10.1016/j.jaut.2015.12.002
Journal of Autoimmunity; Konsta OD, Le Dantec C et. al.

Jan 4th, 2016 - The pathogenesis of primary Sjögren's syndrome (pSS) is complex, in part due to DNA methylation abnormalities. This study was undertaken to evaluate the importance of global DNA methylation ((5m)C) as determined in minor salivary glands (MSG) from well characterized pSS patients. Twenty-two pSS patients and ten controls were selected, and MSG were stained with anti-(5m)C, anti-(5m)C/anti-cytoke...

Rheumatoid Factor and Disease Activity Are Independent Predictors of Lymphoma in Primar...
https://doi.org/10.1002/art.39518
Arthritis & Rheumatology (Hoboken, N.J.); Nocturne G, Virone A et. al.

Nov 25th, 2015 - To define parameters predictive of lymphoma development in patients with primary Sjögren's syndrome (SS). A multicenter case-control survey was performed to identify predictors of lymphoma. Cases were patients who developed lymphoma after diagnosis of primary SS and were mainly recruited through the Club Rhumatismes et Inflammation network. For each case, 2 controls (matched for disease duratio...

Rate, risk factors and causes of mortality in patients with Sjögren's syndrome: a syste...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009445
Rheumatology (Oxford, England); Singh AG, Singh S et. al.

Sep 28th, 2015 - There is conflicting evidence regarding prognosis in patients with primary SS (pSS). The aim of this study was to estimate the rate, risk factors and causes of mortality in patients with pSS through a systematic review and meta-analysis. Through a systematic review of multiple databases through October 2014, we identified cohort studies reporting relative risk (compared with standardized popula...

Dental Implants in Patients with Sjögren's Syndrome.
https://doi.org/10.1111/cid.12376
Clinical Implant Dentistry and Related Research; Korfage A, Raghoebar GM et. al.

Sep 24th, 2015 - Limited evidence is available for applying dental implants in Sjögren's syndrome (SS) patients. This study aims to retrospectively assess clinical outcome of implant therapy in a cohort of well-classified patients with SS. All SS patients attending the University Medical Center Groningen for follow-up (n = 406) were asked whether they had implants. In SS patients with implants peri-implant heal...

Silicone implants and lymphoma: The role of inflammation.
https://doi.org/10.1016/j.jaut.2015.08.009
Journal of Autoimmunity; Bizjak M, Selmi C et. al.

Sep 3rd, 2015 - The risk of hematological malignancies is mainly determined by genetic background, age, sex, race and ethnicity, geographic location, exposure to certain chemicals and radiation; along with the more recently proposed immune factors such as chronic inflammation, immunodeficiencies, autoimmunity, and infections. Paradigmatic examples include the development of lymphoma in Sjögren's syndrome and H...

Prevalence and clinical impact of fibromyalgia in patients with primary Sjögren's syndr...
https://www.ncbi.nlm.nih.gov/pubmed/26315451
Clinical and Experimental Rheumatology; Choi BY, Oh HJ et. al.

Aug 31st, 2015 - Clinical features of primary Sjögren's syndrome (pSS) overlap with those of fibromyalgia (FM). This cross-sectional study was conducted to investigate the prevalence of FM in pSS patients and to compare the clinical features of pSS patients with FM to those without FM. One hundred pSS patients were consecutively assessed to identify the presence of FM according to the American College of Rheuma...