About 217,424 results
Significance and impact of dietary factors on systemic lupus erythematosus pathogenesis
Experimental and Therapeutic Medicine;

Nov 15th, 2018 - Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown etiology, although its mechanisms involve genetic, epigenetic and environmental risk factors. Considering that SLE pathogenesis is yet to be explored, recent studies aimed to investigate the impact of diet, in terms of triggering or altering the course of the disease. To study the impact of diet on SLE pathogenesis, we condu...

Osteoporosis - StatPearls
Porter, J. et. al.

Nov 14th, 2018 - Osteoporosis is defined as low bone mineral density caused by altered bone microstructure ultimately predisposing patients to low-impact, fragility fractures. Osteoporotic fractures lead to a significant decrease in quality of life, with an increased morbidity, mortality, and disability.[1] Over 50% of postmenopausal Caucasian women will have an osteoporotic-related fracture. Only 33% of senior...

Tick-Borne Disease Working Group: 2018 Report to Congress

Nov 13th, 2018 - Tick-Borne Diseases have rapidly become a serious and growing threat to public health in the United States. Despite many scientific unknowns, experts agree that the incidence and distribution of tick-borne diseases are increasing. Over the past 25 years, reports of Lyme disease have increased steadily with estimated annual cases approximating 300,000 (Hinckley et al., 2014; Nelson et al., 2...

ACR Appropriateness Criteria®: Chronic Chest Pain-Noncardiac Etiology Unlikely: Low to Intermediate Probability of Coronary Artery Disease

Oct 31st, 2018 - Chronic chest pain (CCP) with low to intermediate probability of coronary artery disease (CAD) can arise from cardiac and noncardiac etiologies. While there are multiple potential noncardiac causes of CCP, such as costochondritis, arthritic or degenerative diseases, prior trauma, primary or metastatic tumors, pleural disease, or gastrointestinal causes, the scope of this document is focused ...

Dietary Recommendations for Adults With Psoriasis or Psoriatic Arthritis From the Medical Board of the National Psoriasis Foundation
JAMA Dermatology;

Oct 1st, 2018 - Question What dietary interventions help adult patients with psoriasis and/or psoriatic arthritis reduce their disease severity? Findings In this systematic review of 55 studies and 4534 patients with psoriasis, we identify the strongest evidence for dietary weight reduction with a hypocaloric diet in overweight and obese patients with psoriasis. The utility of gluten-free diet and supplem...

National Psoriasis Foundation | Psoriasis and Diet

Sep 13th, 2018 - The question of what to eat permeates our daily lives. It rings especially true when you’re living with a chronic disease like psoriasis. When April Armstrong, M.D., MPH, sees patients, many ask what factors they can control when it comes to managing their disease – particularly their diet.

Psoriatic arthritis – new perspectives
Archives of Medical Science; Krakowski, P.

Aug 22nd, 2018 - Psoriatic arthritis (PsA) is a seronegative arthropathy with many clinical manifestations, and it may affect nearly a half of patients with psoriasis. PsA should be diagnosed as early as possible to slow down joint damage and progression of disability. To improve the diagnosis of PsA, physicians should look for peripheral inflammatory pain, axial inflammatory pain, dactylitis, and buttock and s...

Distinguishing rheumatoid arthritis from psoriatic arthritis
RMD Open; Merola, J. et. al.

Aug 12th, 2018 - Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) have key differences in clinical presentation, radiographic findings, comorbidities and pathogenesis to distinguish between these common forms of chronic inflammatory arthritis. Joint involvement is typically, but not always, asymmetric in PsA, while it is predominantly symmetric in RA. Bone erosions, without new bone growth, and cervical ...

Arthritis-Related Statistics | Data and Statistics | Arthritis | CDC

Jul 16th, 2018 - Basic statistics about arthritis, such as prevalence, disabilities and limitations, quality of life, and costs.

Depression as a risk factor for the development of rheumatoid arthritis: a population-based cohort study
RMD Open; Vallerand, I. et. al.

Jul 10th, 2018 - Objectives Major depressive disorder (MDD) is associated with increased levels of systemic proinflammatory cytokines, including tumour necrosis factor alpha. As these cytokines are pathogenic in autoimmune diseases such as rheumatoid arthritis (RA), our aim was to explore on a population-level whether MDD increases the risk of developing RA. Methods A retrospective cohort study was conducted...

Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update
Donahue, K. et. al.

Jun 30th, 2018 - This systematic review updates a 2012 report that evaluated the benefits and harms of drug therapies for adults with rheumatoid arthritis (RA).1 This updated review, however, has a targeted scope focusing solely on patients with early RA. Early RA has no formal consensus definition. Based on guidance from a recent task force of experts,2 we define early RA as no more than 1 year of diagno...

NIH Fact Sheets - Rheumatoid Arthritis

Jun 29th, 2018 - Rheumatoid arthritis is an inflammatory disease affecting about 1.3 million adults, and causes pain, swelling, stiffness, and loss of function in the joints. Several features make it different from other kinds of arthritis – such as generally occurring in a symmetrical pattern. This means that if one knee or hand is involved, the other one also is. The disease often affects the wrist joints and...

NIH Fact Sheets - Lupus

Jun 28th, 2018 - Lupus statistics (systemic lupus erythematosus) is a serious and potentially fatal disease that mainly affects young women. The cause of the disease is not known, but it is believed to be an autoimmune disease (an illness that occurs when the body mistakenly detects its own tissue as foreign and attacks itself).The disease often starts between the ages of 15 and 44. The manifestations of lupus ...

Rheumatoid Arthritis - Lab Tests Online

Jun 6th, 2018 - Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes stiffness, pain, loss of mobility, inflammation, and erosion (deterioration) in the joints. It usually affects multiple joints symmetrically, the hand and wrists most commonly, but also elbows, neck, shoulders, hips, knees, and feet.

Upadacitinib Meets All Primary and Ranked Secondary Endpoints Including Superiority Versus Adalimumab in Phase 3 Study in Rheumatoid Arthritis

Apr 8th, 2018 - AbbVie (NYSE: ABBV), a research-based global biopharmaceutical company, today announced positive top-line results from the Phase 3 SELECT-COMPARE clinical trial showing that after 12 weeks, upadacitinib (15 mg, once-daily) met the primary endpoints of ACR20a and clinical remissionb versus placebo.1 All ranked secondary endpoints were also achieved versus either placebo or adalimumab (40 mg eve...

Secukinumab Versus Adalimumab for Psoriatic Arthritis: Comparative Effectiveness up to 48 Weeks Using a Matching-Adjusted Indirect Comparison
Rheumatology and Therapy; Nash, P. et. al.

Mar 30th, 2018 - Introduction Secukinumab and adalimumab are approved for adults with active psoriatic arthritis (PsA). In the absence of direct randomized controlled trial (RCT) data, matching-adjusted indirect comparison can estimate the comparative effectiveness in anti-tumor necrosis factor (TNF)-naïve populations. Methods Individual patient data from the FUTURE 2 RCT (secukinumab vs. placebo; N = 299)...

Arthritis By The Numbers

Mar 1st, 2018 - Arthritis is very common but not well understood. Actually, “arthritis” is not a single disease; it is an informal way of referring to joint pain or joint disease. There are more than 100 different types of arthritis (see Appendix) and related conditions. People of all ages, genders and races have arthritis, the leading cause of disability in the United States. We don’t know the true number...

New Treatment Guidelines for Sjögren's Syndrome

Feb 13th, 2018 - Among all the chronic autoimmune rheumatic disorders, Sjo¨ gren’s disease (SD) is among the most difficult to evaluate and manage. Clinicians are frequently challenged to differentiate symptoms related to disease activity from those that result from preexisting damage. Additionally, the presence of multiple SD-related comorbidities, including anxiety, depression and fibromyalgia,1,2 may infl...

Systemic lupus erythematosus images | DermNet NZ

Dec 30th, 2017 - Systemic lupus erythematosus images. SLE. Authoritative facts about the skin from DermNet New Zealand Trust.

Targeting IL-17 in psoriatic arthritis
European Journal of Rheumatology; Wang, E. et. al.

Nov 9th, 2017 - Psoriatic arthritis (PsA) is a chronic and progressive inflammatory arthritis intimately associated with psoriasis, and can be an impairing disease that leads to reduced quality of life and significant morbidity. Treatment often requires TNF antagonists, yet many patients with PsA are not responsive to the standard anti-TNF therapies. The interleukin-17 (IL-17)/IL-17 receptor (IL-17R) family ha...