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Menopausal Estrogen-Alone Therapy and Health Outcomes in Women With and Without Bilateral Oophorectomy: A Randomized Trial
https://annals.org/aim/article-abstract/2749725/menopausal-estrogen-alone-therapy-health-outcomes-women-without-bilateral-oophorectomy
Annals of Internal Medicine;

Sep 9th, 2019 - Background: Whether health outcomes of menopausal estrogen therapy differ between women with and without bilateral salpingo-oophorectomy (BSO) is unknown. Objective: To examine estrogen therapy outcomes by BSO status, with additional stratification by 10-year age groups. Design: Subgroup analyses of the randomized Women's Health Initiative Estrogen-Alone Trial. (ClinicalTrials.gov: NCT...

Osteoporosis - StatPearls
https://www.ncbi.nlm.nih.gov/books/NBK441901/
Porter, J. et. al.

Nov 14th, 2018 - Osteoporosis is defined as low bone mineral density caused by altered bone microstructure ultimately predisposing patients to low-impact, fragility fractures. Osteoporotic fractures lead to a significant decrease in quality of life, with an increased morbidity, mortality, and disability.[1] Over 50% of postmenopausal Caucasian women will have an osteoporotic-related fracture. Only 33% of senior...

Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Reco...
https://doi.org/10.1001/jama.2018.7498
JAMA , Curry SJ et. al.

Jun 27th, 2018 - By 2020, approximately 12.3 million individuals in the United States older than 50 years are expected to have osteoporosis. Osteoporotic fractures, particularly hip fractures, are associated with limitations in ambulation, chronic pain and disability, loss of independence, and decreased quality of life, and 21% to 30% of patients who experience a hip fracture die within 1 year. The prevalence o...

Prevalence of Concussion Among US Adolescents and Correlated Factors.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817894
JAMA Veliz P, McCabe SE et. al.

Oct 3rd, 2017 - Prevalence of Concussion Among US Adolescents and Correlated Factors.|2017|Veliz P,McCabe SE,Eckner JT,Schulenberg JE,|epidemiology,epidemiology,

Association Between Alendronate Use and Hip Fracture Risk in Older Patients Using Oral ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817469
JAMA Axelsson KF, Nilsson AG et. al.

Jul 11th, 2017 - Oral glucocorticoid treatment increases fracture risk, and evidence is lacking regarding the efficacy of alendronate to protect against hip fracture in older patients using glucocorticoids. To investigate whether alendronate treatment in older patients using oral prednisolone is associated with decreased hip fracture risk and adverse effects. Retrospective cohort study using a national database...

Point of Health Care Entry for Youth With Concussion Within a Large Pediatric Care Netw...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025897
JAMA Pediatrics; Arbogast KB, Curry AE et. al.

May 31st, 2016 - Previous epidemiologic research on concussions has primarily been limited to patient populations presenting to sport concussion clinics or to emergency departments (EDs) and to those high school age or older. By examining concussion visits across an entire pediatric health care network, a better estimate of the scope of the problem can be obtained. To comprehensively describe point of entry for...

Clinical Risk Score for Persistent Postconcussion Symptoms Among Children With Acute Co...
https://doi.org/10.1001/jama.2016.1203
JAMA Zemek R, Barrowman N et. al.

Mar 9th, 2016 - Approximately one-third of children experiencing acute concussion experience ongoing somatic, cognitive, and psychological or behavioral symptoms, referred to as persistent postconcussion symptoms (PPCS). However, validated and pragmatic tools enabling clinicians to identify patients at risk for PPCS do not exist. To derive and validate a clinical risk score for PPCS among children presenting t...

Nonbenzodiazepine Sedative Hypnotics and Risk of Fall-Related Injury.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835298
Sleep Tom SE, Wickwire EM et. al.

Mar 4th, 2016 - The objective of this study was to test the hypothesis that use of zolpidem, eszopiclone, and zaleplon would be associated with increased risk of traumatic brain injury (TBI) and hip fracture. We conducted a case-crossover study on a 5% random sample of Medicare beneficiaries age 65 y or older hospitalized with either TBI (n = 15,031) or hip fracture (n = 37,833) during 2007-2009. Use of zolpid...

Factors Associated With Concussion-like Symptom Reporting in High School Athletes.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333772
JAMA Pediatrics; Iverson GL, Silverberg ND et. al.

Oct 12th, 2015 - Every state in the United States has passed legislation for sport-related concussion, making this health issue important for physicians and other health care professionals. Safely returning athletes to sport after concussion relies on accurately determining when their symptoms resolve. To evaluate baseline concussion-like symptom reporting in uninjured adolescent student athletes. In this cross...

Rehabilitation After Immobilization for Ankle Fracture: The EXACT Randomized Clinical T...
https://doi.org/10.1001/jama.2015.12180
JAMA Moseley AM, Beckenkamp PR et. al.

Oct 6th, 2015 - The benefits of rehabilitation after immobilization for ankle fracture are unclear. To determine the effectiveness of a supervised exercise program and advice (rehabilitation) compared with advice alone and to determine if effects are moderated by fracture severity or age and sex. The EXACT trial was a pragmatic, randomized clinical trial conducted from December 2010 to June 2014. Patients with...

Trends in Ambulatory Care for Children with Concussion and Minor Head Injury from Easte...
https://doi.org/10.1016/j.jpeds.2015.05.036
The Journal of Pediatrics; Taylor AM, Nigrovic LE et. al.

Jun 27th, 2015 - To characterize trends in health care utilization and costs for children diagnosed with concussion or minor head injury within a large pediatric primary-care association. We conducted a retrospective cohort analysis from 2007 through 2013 examining all outpatient medical claims related to concussion and minor head injury from 4 commercial insurance companies for children 6-21 years of age who w...

Clinically relevant effectiveness of focused extracorporeal shock wave therapy in the t...
https://doi.org/10.2106/JBJS.M.01331
The Journal of Bone and Joint Surgery. American Volume; Gollwitzer H, Saxena A et. al.

May 7th, 2015 - The effectiveness of extracorporeal shock wave therapy in the treatment of plantar fasciitis is controversial. The objective of the present study was to test whether focused extracorporeal shock wave therapy is effective in relieving chronic heel pain diagnosed as plantar fasciitis. Two hundred and fifty subjects were enrolled in a prospective, multicenter, double-blind, randomized, and placebo...

Vestibular Deficits following Youth Concussion.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485554
The Journal of Pediatrics; Corwin DJ, Wiebe DJ et. al.

Mar 9th, 2015 - To characterize the prevalence and recovery of pediatric patients with concussion who manifest clinical vestibular deficits and to describe the correlation of these deficits with neurocognitive function, based on computerized neurocognitive testing, in a sample of pediatric patients with concussion. This was a retrospective cohort study of patients ages 5-18 years with concussion referred to a ...

Benefits of strict rest after acute concussion: a randomized controlled trial.
https://doi.org/10.1542/peds.2014-0966
Pediatrics Thomas DG, Apps JN et. al.

Jan 6th, 2015 - To determine if recommending strict rest improved concussion recovery and outcome after discharge from the pediatric emergency department (ED). Patients aged 11 to 22 years presenting to a pediatric ED within 24 hours of concussion were recruited. Participants underwent neurocognitive, balance, and symptom assessment in the ED and were randomized to strict rest for 5 days versus usual care (1-2...

The new neurometabolic cascade of concussion.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479139
Neurosurgery Giza CC, Hovda DA

Sep 18th, 2014 - Since the original descriptions of postconcussive pathophysiology, there has been a significant increase in interest and ongoing research to study the biological underpinnings of concussion. The initial ionic flux and glutamate release result in significant energy demands and a period of metabolic crisis for the injured brain. These physiological perturbations can now be linked to clinical char...

Duration and course of post-concussive symptoms.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531270
Pediatrics Eisenberg MA, Meehan WP et. al.

May 13th, 2014 - To examine the incidence, duration, and clinical course of individual post-concussive symptoms in patients presenting to a pediatric emergency department (ED) with a concussion. We conducted secondary analysis of a prospective cohort study of patients 11 to 22 years old presenting to the ED of a children's hospital with an acute concussion. The main outcome measure was duration of symptoms, ass...

Association of Physical Activity and Fracture Risk Among Postmenopausal Women.
https://doi.org/10.1001/jamanetworkopen.2019.14084
JAMA Network Open; LaMonte MJ, Wactawski-Wende J et. al.

Oct 1st, 2019 - Physical activity is inversely associated with hip fracture risk in older women. However, the association of physical activity with fracture at other sites and the role of sedentary behavior remain unclear. To assess the associations of physical activity and sedentary behavior with fracture incidence among postmenopausal women. The Women's Health Initiative prospective cohort study enrolled 77 ...

Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture.
https://doi.org/10.1056/NEJMoa1906190
The New England Journal of Medicine; , Bhandari M et. al.

Sep 26th, 2019 - Globally, hip fractures are among the top 10 causes of disability in adults. For displaced femoral neck fractures, there remains uncertainty regarding the effect of a total hip arthroplasty as compared with hemiarthroplasty. We randomly assigned 1495 patients who were 50 years of age or older and had a displaced femoral neck fracture to undergo either total hip arthroplasty or hemiarthroplasty....

Effect of a Multicomponent Home-Based Physical Therapy Intervention on Ambulation After...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737521
JAMA Magaziner J, Mangione KK et. al.

Sep 10th, 2019 - Disability persists after hip fracture in older persons. Current rehabilitation may not be sufficient to restore ability to walk in the community. To compare a multicomponent home-based physical therapy intervention (training) with an active control on ability to walk in the community. Parallel, 2-group randomized clinical trial conducted at 3 US clinical centers (Arcadia University, University...

Children with Attention-Deficit/Hyperactivity Disorder Perform Differently on Pediatric...
https://doi.org/10.1016/j.jpeds.2019.07.048
The Journal of Pediatrics; Cook NE, Kelshaw PM et. al.

Sep 3rd, 2019 - To compare Child Sport Concussion Assessment Tool Fifth Edition (Child SCAT5) performance between uninjured children with attention-deficit/hyperactivity disorder (ADHD) and precisely matched controls without ADHD. A nested case-control study was conducted within a cohort of middle school athletes (age 11-12 years) who completed preseason testing. Students with ADHD were individually matched to...