Aug 31st, 2019 - Oxygen supplementation has been a cornerstone in the initial treatment of individuals with acute coronary syndrome. While consensus for oxygen supplementation exists for patients with hypoxia, oxygen supplementation has also been routinely used in those presenting with acute myocardial infarction (MI) with normal oxygen saturations based on the rationale that oxygen therapy could improve oxygen...
Kim, K. et. al.
Mar 1st, 2019 - Nitroglycerin is a vasodilatory drug that is used primarily to provide relief from anginal chest pain. Nitroglycerin has been FDA approved since 2000 and was first sold by Pfizer under the brand name Nitrostat. It is currently FDA approved for the acute relief of an attack or acute prophylaxis of angina pectoris secondary to coronary artery disease. Off-label, non-FDA approved uses include trea...
Lancet (London, England); Tegn N, Abdelnoor M et. al.
Jan 22nd, 2016 - Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina pectoris are frequent causes of hospital admission in the elderly. However, clinical trials targeting this population are scarce, and these patients are less likely to receive treatment according to guidelines. We aimed to investigate whether this population would benefit from an early invasive strategy versus a conservative st...
Journal of the American College of Cardiology;
Dec 11th, 2006 - The importance of resting heart rate (HR) as a prognostic factor and potential therapeutic target is not yet generally accepted. Recent large epidemiologic studies have confirmed earlier studies that showed resting HR to be an independent predictor of cardiovascular and all-cause mortality in men and women with and without diagnosed cardiovascular disease. Clinical trial data suggest that HR re...
CORGARD (nadolol) is available for oral administration as 20 mg, 40 mg, and 80 mg tablets.
KAPSPARGO Sprinkle is a beta1-selective adrenoceptor blocking agent indicated for the treatment of: Hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.
Official HCP website for Ranexa® (ranolazine). Learn about dosing, safety and side effects, benefits, and risks.
When discontinuing chronically administered TOPROL-XL, particularly in patients with ischemic heart disease, the dosage should be gradually reduced over a ...
Lancet (London, England); Mäkikallio T, Holm NR et. al.
Nov 4th, 2016 - Coronary artery bypass grafting (CABG) is the standard treatment for revascularisation in patients with left main coronary artery disease, but use of percutaneous coronary intervention (PCI) for this indication is increasing. We aimed to compare PCI and CABG for treatment of left main coronary artery disease. In this prospective, randomised, open-label, non-inferiority trial, patients with left...
Journal of the American Geriatrics Society; Rothschild DP, Novak E et. al.
Jun 13th, 2016 - To examine the effect of statins on long-term mortality in older adults hospitalized with coronary artery disease (CAD). Retrospective analysis. University teaching hospital. Individuals aged 80 and older (mean aged 85.2, 56% female) hospitalized from January 2006 to December 2010 with acute myocardial infarction (AMI), unstable angina pectoris, or chronic CAD and discharged alive (N = 1,262). ...
Journal of the American Geriatrics Society; Baldasseroni S, Pratesi A et. al.
Aug 17th, 2016 - To assess the effect of cardiac rehabilitation (CR) and identify predictors of changes in functional capacity with CR in a consecutive series of older adults with a recent cardiac event. Observational. In-hospital CR unit. Individuals aged 75 and older referred to an outpatient CR Unit after an acute coronary event (unstable angina pectoris, acute myocardial infarction) or cardiac surgery (coro...
Clinical Journal of the American Society of Nephrology : CJASN; Araki S, Haneda M et. al.
Nov 13th, 2015 - We investigated the association of urinary potassium and sodium excretion with the incidence of renal failure and cardiovascular disease in patients with type 2 diabetes. A total of 623 Japanese type 2 diabetic patients with eGFR≥60 ml/min per 1.73 m(2) were enrolled in this observational follow-up study between 1996 and 2003 and followed-up until 2013. At baseline, a 24-hour urine sample was c...
Kapspargo Sprinkle™ extended-release capsules are for the treatment of hypertension, angina pectoris, and heart failure. Learn more here.
Proceedings of the National Academy of Sciences of the United States of America; Gravel A, Dubuc I et. al.
Jun 16th, 2015 - Inherited chromosomally integrated human herpesvirus-6 (iciHHV-6) results in the germ-line transmission of the HHV-6 genome. Every somatic cell of iciHHV-6+ individuals contains the HHV-6 genome integrated in the telomere of chromosomes. Whether having iciHHV-6 predisposes humans to diseases remains undefined. DNA from 19,597 participants between 40 and 69 years of age were analyzed by quantita...
Heart (British Cardiac Society); Kessous R, Shoham-Vardi I et. al.
Jan 7th, 2015 - To investigate whether severe and recurrent pre-eclampsia increase the risk for long-term maternal atherosclerotic disease. A population-based study compared the incidence of long-term atherosclerotic morbidity in a cohort of women who delivered in the years 1988-2012. The exposure variable was pre-eclampsia. Mean follow-up duration was 11.2 years. Kaplan-Meier survival curves were used to esti...
JACC. Cardiovascular Interventions; Radico F, Cicchitti V et. al.
Apr 21st, 2014 - Angina and myocardial ischemia without obstructive coronary artery disease are common clinical findings, often neglected for the assumption of a good prognosis. Most often, such patients are neither further investigated nor offered specific treatment beyond reassurance. However, the absence of significant coronary stenoses on angiography does not necessarily imply a "healthy" coronary tree. In ...
Circulation Moran AE, Forouzanfar MH et. al.
Feb 27th, 2014 - Ischemic heart disease (IHD) burden consists of years of life lost from IHD deaths and years of disability lived with 3 nonfatal IHD sequelae: nonfatal acute myocardial infarction, angina pectoris, and ischemic heart failure. Our aim was to estimate the global and regional burden of IHD in 1990 and 2010. Global and regional estimates of acute myocardial infarction incidence and angina and heart...
European Heart Journal; Münzel T, Meinertz T et. al.
Sep 27th, 2013 - The organic nitrate pentaerithrityl tetranitrate (PETN) has been shown to have ancillary properties that prevent the development of tolerance and endothelial dysfunction. This randomized, double-blind, placebo-controlled, multicentre study ('CLEOPATRA' study) was designed to investigate the anti-ischaemic efficacy of PETN 80 mg b.i.d. (morning and mid-day) over placebo in patients with chronic ...
The American Journal of Cardiology; Villano A, Di Franco A et. al.
Apr 5th, 2013 - Patients with microvascular angina (MVA) often have persistence of symptoms despite full classical anti-ischemic therapy. In this study, we assessed the effect of ivabradine and ranolazine in MVA patients. We randomized 46 patients with stable MVA (effort angina, positive exercise stress test [EST], normal coronary angiography, coronary flow reserve <2.5), who had symptoms inadequately controll...
The American Journal of Cardiology; Tamura A, Naono S et. al.
Mar 18th, 2013 - Previous investigations have demonstrated the presence of gender differences in the symptoms of angina pectoris and acute coronary syndrome. However, most of these investigations have had certain limitations, including being retrospective, an interview-related bias, a various duration of myocardial ischemia, and a lack of multivariate analysis, all of which would have affected the results. Acco...