About 249,013 results
Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study.
BMJ (Clinical Research Ed.); Pasternak B, Inghammar M et. al.

Mar 9th, 2018 - To investigate whether oral fluoroquinolone use is associated with an increased risk of aortic aneurysm or dissection. Nationwide historical cohort study using linked register data on patient characteristics, filled prescriptions, and cases of aortic aneurysm or dissection. Sweden, July 2006 to December 2013. 360 088 treatment episodes of fluoroquinolone use (78%ciprofloxacin) and propensity sc...

Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty.
The New England Journal of Medicine; Anderson DR, Dunbar M et. al.

Feb 21st, 2018 - Clinical trials and meta-analyses have suggested that aspirin may be effective for the prevention of venous thromboembolism (proximal deep-vein thrombosis or pulmonary embolism) after total hip or total knee arthroplasty, but comparisons with direct oral anticoagulants are lacking for prophylaxis beyond hospital discharge. We performed a multicenter, double-blind, randomized, controlled trial i...

Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection.
The New England Journal of Medicine; Kwong JC, Schwartz KL et. al.

Jan 24th, 2018 - Acute myocardial infarction can be triggered by acute respiratory infections. Previous studies have suggested an association between influenza and acute myocardial infarction, but those studies used nonspecific measures of influenza infection or study designs that were susceptible to bias. We evaluated the association between laboratory-confirmed influenza infection and acute myocardial infarct...

Anticoagulation-Related Major Bleeding in Patients With Atrial Fibrillation
Circulation Adam J. Nelson et al

Nov 30th, 2019 - Antithrombotic therapy for cardiovascular disease revolves around balancing 2 key outcomes—reducing ischemic events without increasing bleeding. There has been a subtle but progressive shift away from a dominant focus on reducing ischemic events to a more balanced and explicit interest in avoiding bleeding. Bleeding is common and, in part, an expected result of the increased use of anticoagulan...

Association of Testosterone Therapy With Risk of Venous Thromboembolism Among Men With and Without Hypogonadism
JAMA Internal Medicine; Rob F. Walker, et al

Nov 30th, 2019 - Testosterone therapy is increasingly prescribed in patients without a diagnosis of hypogonadism. This therapy may be associated with increased risk of venous thromboembolism (VTE) through several mechanisms, including elevated hematocrit levels, which increase blood viscosity.

Searching for Atrial Fibrillation Poststroke: A White Paper of the AF-SCREEN International Collaboration
Circulation Schnabel RB, et al

Nov 25th, 2019 - Cardiac thromboembolism attributed to atrial fibrillation (AF) is responsible for up to one-third of ischemic strokes. Stroke may be the first manifestation of previously undetected AF. Given the efficacy of oral anticoagulants in preventing AF-related ischemic strokes, strategies of searching for AF after a stroke using ECG monitoring followed by oral anticoagulation (OAC) treatment have been ...

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction
New England Journal of Medicine; Tardif JC et al

Nov 16th, 2019 - Experimental and clinical evidence support the role of inflammation in atherosclerosis and its complications. Colchicine is an orally administered, potent antiinflammatory medication that is indicated for the treatment of gout and pericarditis.

Subclinical and Device-Detected Atrial Fibrillation: Pondering the Knowledge Gap: A Scientific Statement From the American Heart Association
Circulation Peter A. Noseworthy, et al.

Nov 14th, 2019 - The widespread use of cardiac implantable electronic devices and wearable monitors has led to the detection of subclinical atrial fibrillation in a substantial proportion of patients. There is evidence that these asymptomatic arrhythmias are associated with increased risk of stroke. Thus, detection of subclinical atrial fibrillation may offer an opportunity to reduce stroke risk by initiating a...

TCT 2019: Top Interventional Takeaways

Oct 17th, 2019 - TCT 2019 in San Francisco has left us with a few trials that potentially may change our interventional practice. The COMPLETE study is now complete! To refresh your memory, the COMPLETE trial was presented at ESC Congress 2019, one month before TCT, and studied patients presented with STEMI and multivessel disease. At a median of three-years follow-up, complete revascularization was superior to...

Philips introduces new 200mm and 150mm Stellarex 0.035” low-dose drug-coated balloons to broaden treatment options for peripheral artery disease patients

Oct 14th, 2019 - Royal Philips (NYSE: PHG, AEX: PHIA), a global leader in health technology, today introduced two new balloons to its Stellarex 0.035” low-dose drug-coated balloon (DCB) portfolio. The new 200mm and 150mm Stellarex 0.035” low-dose DCBs have received approval from the U.S. Food and Drug Administration (FDA) for the treatment of de novo and restenotic lesions in native superficial femoral or popli...

Predicting the Risk of Postoperative Pulmonary Complications
American Family Physician;

Oct 14th, 2019 - The incidence of pulmonary complications following major surgery is estimated to be 1% to 23%, with the risk varying based on patient factors and the type of surgery.1 Postoperative pulmonary complications include pneumonia, tracheobronchitis, pulmonary edema, pulmonary embolism, atelectasis, pleural effusion, pneumothorax, bronchospasm, aspiration, respiratory failure, and acute respiratory di...

U.S. FDA Approves XARELTO® (rivaroxaban) to Help Prevent Blood Clots in Acutely Ill Medical Patients

Oct 13th, 2019 - he Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) has approved XARELTO® (rivaroxaban) for the prevention of venous thromboembolism (VTE), or blood clots, in hospitalized acutely ill medical patients at risk for thromboembolic complications who are not at high risk of bleeding. With the approval of this new indication, XAREL...

Anticoagulation: Updated Guidelines for Outpatient Management
American Family Physician;

Sep 30th, 2019 - Anticoagulation therapy is recommended for preventing, treating, and reducing the recurrence of venous thromboembolism, and preventing stroke in persons with atrial fibrillation. Direct oral anticoagulants are first-line agents for eligible patients for treating venous thromboembolism and preventing stroke in those with nonvalvular atrial fibrillation. Vitamin K antagonists are recommended for ...

Five-Year Outcomes after PCI or CABG for Left Main Coronary Disease

Sep 27th, 2019 - BACKGROUND Long-term outcomes after percutaneous coronary intervention (PCI) with contemporary drug-eluting stents, as compared with coronary-artery bypass grafting (CABG), in patients with left main coronary artery disease are not clearly established. METHODS We randomly assigned 1905 patients with left main coronary artery disease of low or intermediate anatomical complexity (according t...

Children Exposed to Secondhand Smoke at Higher Risk for Atrial Fibrillation

Sep 22nd, 2019 - Children of parents who smoke had a significantly increased chance of developing atrial fibrillation later in life, according to a study published today in the Journal of the American College of Cardiology. The findings highlight a new association between secondhand smoke exposure and heart rhythm disorder risk.

Menopausal Estrogen-Alone Therapy and Health Outcomes in Women With and Without Bilateral Oophorectomy: A Randomized Trial
Annals of Internal Medicine;

Sep 9th, 2019 - Background: Whether health outcomes of menopausal estrogen therapy differ between women with and without bilateral salpingo-oophorectomy (BSO) is unknown. Objective: To examine estrogen therapy outcomes by BSO status, with additional stratification by 10-year age groups. Design: Subgroup analyses of the randomized Women's Health Initiative Estrogen-Alone Trial. (ClinicalTrials.gov: NCT...

Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes
The New England Journal of Medicine; Schüpke, S. et. al.

Aug 31st, 2019 - BACKGROUND The relative merits of ticagrelor as compared with prasugrel in patients with acute coronary syndromes for whom invasive evaluation is planned are uncertain. METHODS In this multicenter, randomized, open-label trial, we randomly assigned patients who presented with acute coronary syndromes and for whom invasive evaluation was planned to receive either ticagrelor or prasugrel. Th...

Taking the Air Out of Oxygen Supplementation in Individuals With Diabetes and Acute Coronary Syndromes
Diabetes Care;

Aug 31st, 2019 - Oxygen supplementation has been a cornerstone in the initial treatment of individuals with acute coronary syndrome. While consensus for oxygen supplementation exists for patients with hypoxia, oxygen supplementation has also been routinely used in those presenting with acute myocardial infarction (MI) with normal oxygen saturations based on the rationale that oxygen therapy could improve oxygen...

New European Society of Cardiology Guidelines Address Dyslipidemias, SVT, CCS, Acute Pulmonary Embolism and Diabetes

Aug 29th, 2019 - The European Society of Cardiology (ESC) released five separate guidelines covering dyslipidemias, supraventricular tachycardia, chronic coronary syndrome, acute pulmonary embolism, and diabetes as part of ESC Congress 2019 and published in the European Heart Journal.

Perfusion Assessment in Critical Limb Ischemia: Principles for Understanding and the Development of Evidence and Evaluation of Devices

Aug 11th, 2019 - There are >12 million patients with peripheral artery disease in the United States. The most severe form of peripheral artery disease is critical limb ischemia (CLI). The diagnosis and management of CLI is often challenging. Ethnic differences in comorbidities and presentation of CLI exist. Compared with white patients, black and Hispanic patients have higher prevalence rates of diabetes m...

Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer

Aug 4th, 2019 - PURPOSE To provide updated recommendations about prophylaxis and treatment of venous thromboembolism (VTE) in patients with cancer. METHODS PubMed and the Cochrane Library were searched for randomized controlled trials (RCTs) and meta-analyses of RCTs published from August 1, 2014, through December 4, 2018. ASCO convened an Expert Panel to review the evidence and revise previous recommenda...

Risk of Acute Myocardial Infarction and Ischemic Stroke in Patients with Asthma Exacerbation: A Population-Based, Self-Controlled Case Series Study
The Journal of Allergy and Clinical Immunology: In Practice; Raita, Y. et. al.

Jul 15th, 2019 - Background Patients with asthma have a high incidence of acute myocardial infarction and ischemic stroke. Objective To investigate the acute effect of asthma exacerbation on these cardiovascular events. Methods Using population-based inpatient data of 3 geographically diverse US states (Florida, Nebraska, and New York) during the period 2011 to 2014, we conducted a self-controlled case...

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map
Annals of Internal Medicine; Khan, S. et. al.

Jul 8th, 2019 - Background: The role of nutritional supplements and dietary interventions in preventing mortality and cardiovascular disease (CVD) outcomes is unclear. Purpose: To examine evidence about the effects of nutritional supplements and dietary interventions on mortality and cardiovascular outcomes in adults. Data Sources: PubMed, CINAHL, and the Cochrane Library from inception until March 20...

Application of High-Sensitivity Troponin in Suspected Myocardial Infarction
The New England Journal of Medicine; Neumann, J. et. al.

Jun 26th, 2019 - Data regarding high-sensitivity troponin concentrations in patients presenting to the emergency department with symptoms suggestive of myocardial infarction may be useful in determining the probability of myocardial infarction and subsequent 30-day outcomes.

Compass MI

Jun 26th, 2019 - Cardiac troponin is a cornerstone in the diagnostic evaluation of patients with suspected myocardial infarction in the emergency department. Various triage algorithms exist, providing assay-specific troponin cutoff combinations to rule-out or rule-in myocardial infarction. The COMPASS-MI project aimed to extend this concept by estimating low-/high-risk probabilities for diagnosis of myocardial ...

Abdominal Aortic Aneurysm: Screening - Draft Recommendation Statement

Jun 19th, 2019 - The USPSTF recommends one-time screening for abdominal aortic aneurysm (AAA) with ultrasonography in men ages 65 to 75 years who have ever smoked.

A New Index for Pre-Operative Cardiovascular Evaluation
Journal of the American College of Cardiology; Dakik, H. et. al.

Jun 14th, 2019 - Background Currently used indices for pre-operative cardiovascular evaluation are either powerful, but complex, or simple, but with weak discriminatory power. Objectives This study sought to prospectively derive and validate a simple powerful index that can stratify the cardiovascular risk of patients undergoing noncardiac surgery. Methods The derivation cohort consisted of 3,284 prospect...

Depression Following Acute Coronary Syndrome Events: Screening and Treatment Guidelines from the AAFP
American Family Physician;

Jun 14th, 2019 - Purpose: To review the evidence and provide clinical recommendations for the screening and treatment of depression in patients who have had a recent acute coronary syndrome event. Methods: This guideline is based on a systematic review of randomized controlled trials and observational studies from January 1, 2003, to August 15, 2017. It is an update to a previous systematic review published ...

Spinal Stenosis And Neurogenic Claudication - StatPearls
Munakomi, S. et. al.

Jun 3rd, 2019 - Approximately 90% of the population will present with low back pain at some point in their lifetime. Spinal stenosis is a condition that is caused by the narrowing of the central canal, the lateral recess, or neural foramen. This is a condition that can cause significant discomfort, interfere with activities of daily living, and may result in progressive disability.With increasing longevity of...

Expert Consensus Statement on Catheter Ablation of Ventricular Arrhythmias

May 9th, 2019 - The consensus statement, accompanied by a systematic review and meta-analysis published in conjunction with this document, serves as a resource guide and comprehensive review of the field for clinicians around the world who are working to improve the care of patients undergoing ablation for ventricular arrhythmias. It relates to ablation therapy for ventricular arrhythmias, from premature vent...

FDA Approves Praluent® (Alirocumab) To Prevent Heart Attack, Stroke And Unstable Angina Requiring Hospitalization

Apr 25th, 2019 - Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) and Sanofi today announced that the U.S. Food and Drug Administration (FDA) has approved Praluent® (alirocumab) to reduce the risk of heart attack, stroke and unstable angina requiring hospitalization in adults with established cardiovascular (CV) disease.

Duration of dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stent: systematic review and network meta-analysis
BMJ Yin, S. et. al.

Apr 14th, 2019 - Objective To evaluate the efficacy and safety of standard term (12 months) or long term (>12 months) dual antiplatelet therapy (DAPT) versus short term (<6 months) DAPT after percutaneous coronary intervention (PCI) with drug-eluting stent (DES). Design Systematic review and network meta-analysis. Data sources Relevant studies published between June 1983 and April 2018 from Medline, Embas...

Type 2 Myocardial Infarction: JACC Review Topic of the Week

Apr 7th, 2019 - Acute myocardial infarction (MI) can occur from increased myocardial oxygen demand and/or reduced supply in the absence of acute atherothrombotic plaque disruption; a condition called type 2 myocardial infarction (T2MI). As with any MI subtype, there must be clinical evidence of myocardial ischemia to make the diagnosis. This condition is increasingly diagnosed due to the increasing sensitivity...

Varicose Veins (Varicosities) in Adults: Condition, Treatments, and Pictures - Overview

Mar 31st, 2019 - Images of Varicosities Varicose veins (varicosities) are twisted, enlarged veins at the skin surface. The word comes from the Latin word varix, which means "twisted." Varicose veins occur due to poor functioning (malfunction) of valves in the deeper leg veins (venous insufficiency), making blood back up (pool) in the legs, with the resulting pressure causing surface veins to enlarge.

Pregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism
The New England Journal of Medicine; van der Pol, L. et. al.

Mar 20th, 2019 - Pulmonary embolism is one of the leading causes of maternal death in the Western world. Because of the low specificity and sensitivity of the d-dimer test, all pregnant women with suspected pulmonary embolism undergo computed tomographic (CT) pulmonary angiography or ventilation–perfusion scanning, both of which involve radiation exposure to the mother and fetus. Whether a pregnancy-adapted alg...

The Evolving Role of the Cardiac Catheterization Laboratory in the Management of Patients With Out-of-Hospital Cardiac Arrest

Mar 18th, 2019 - Coronary artery disease is prevalent in different causes of out-of-hospital cardiac arrest (OHCA), especially in individuals presenting with shockable rhythms of ventricular fibrillation/pulseless ventricular tachycardia (VF/pVT). The purpose of this report is to review the known prevalence and potential importance of coronary artery disease in patients with OHCA and to describe the emerging pa...

Twenty-Year Trends in Outcomes for Older Adults With Acute Myocardial Infarction in the United States
JAMA Network Open; Krumholz, H. et. al.

Mar 14th, 2019 - Question What are the patterns of hospitalizations, treatments, and outcomes for older patients with acute myocardial infarction (AMI) over a recent 20-year period in the United States? Findings In this cohort study of data from more than 4.3 million Medicare fee-for-service beneficiaries aged 65 years and older discharged with AMI, declines were found in AMI hospitalizations (914 to 566 p...

Reduction Of Type 1 And Type 2 Myocardial Infarctions In Patients Treated With Alirocumab: Insights From The Odyssey Trial
White, H. et. al.

Feb 28th, 2019 - LDL cholesterol (LDL-C) reduction with statins and PCSK9 inhibitors reduces risk of myocardial infarction (MI), but effects on specific types of MI are unknown. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab (ALI) with placebo (PBO) in 18924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C despite intensive statin therapy. ALI reduced the primary composite endpoin...

Effects of Icosapent Ethyl on Total Ischemic Events: From REDUCE-IT
Bhatt, D. et. al.

Feb 28th, 2019 - Background In time-to-first-event analyses, icosapent ethyl significantly reduced the risk of ischemic events, including cardiovascular death, among patients with elevated triglycerides receiving statins. These patients are at risk for not only first but also subsequent ischemic events. Objectives Pre-specified analyses determined the extent to which icosapent ethyl reduced total ischemic ev...

Tinnitus - StatPearls

Feb 27th, 2019 - Tinnitus is defined as a sound a person hears that is generated by the body, rather than by outside source. Most tinnitus is subjective. This means the examiner cannot hear it, and there are no tools to measure or hear that sound. Objective tinnitus can arise from an aneurysm. This can be objectified and heard by the examiner. Other objective tinnitus investigation includes temporomandibular jo...

FDA Approves BIOTRONIK's Ultrathin Orsiro Stent for the Treatment of Coronary Artery Disease

Feb 21st, 2019 - BIOTRONIK today announced FDA approval of the Orsiro drug-eluting stent (DES) system. Orsiro is the first and only ultrathin DES to outperform the clinical standard, Xience. Orsiro received CE marking in 2011 and has been used to treat more than one million patients worldwide to date. Orsiro's unprecedented clinical performance in the BIOFLOW-V pivotal trial demonstrated significantly lower ra...

Apixaban to Prevent Venous Thromboembolism in Patients with Cancer
The New England Journal of Medicine; Carrier, M. et. al.

Feb 20th, 2019 - Patients with active cancer have an increased risk of venous thromboembolism, which results in substantial morbidity, mortality, and health care expenditures. The Khorana score (range, 0 to 6, with higher scores indicating a higher risk of venous thromboembolism) has been validated to identify patients with cancer at elevated risk for this complication and may help select those who could benefi...

Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer
Khorana. A., et al

Feb 20th, 2019 - Ambulatory patients receiving systemic cancer therapy are at varying risk for venous thromboembolism. However, the benefit of thromboprophylaxis in these patients is uncertain. In high-risk ambulatory patients with cancer, treatment with rivaroxaban did not result in a significantly lower incidence of venous thromboembolism or death due to venous thromboembolism in the 180-day trial period. Dur...

Arterial thromboembolic events preceding the diagnosis of cancer in older persons
Blood Havi, B. et. al.

Feb 20th, 2019 - Cancer patients face an increased risk of arterial thromboembolism; however, it is uncertain when this excess risk begins. This study evaluated the risk of arterial thromboembolism before cancer diagnosis. Using the population-based Surveillance Epidemiology and End Results-Medicare linked dataset, we identified 374 331 patients ≥67 years of age with a new primary diagnosis of breast, lung, pro...

Impact of Abnormal Coronary Reactivity on Long-Term Clinical Outcomes in Women
Journal of the American College of Cardiology; AlBadri, A. et. al.

Feb 14th, 2019 - Background Currently as many as one-half of women with suspected myocardial ischemia have no obstructive coronary artery disease (CAD), and abnormal coronary reactivity (CR) is commonly found. Objectives The authors prospectively investigated CR and longer-term adverse cardiovascular outcomes in women with and with no obstructive CAD in the National Heart, Lung, and Blood Institute–sponsored...

Prevalence, symptom burden, and natural history of deep vein thrombosis in people with advanced cancer in specialist palliative care units (HIDDen): a prospective longitudinal observational study
White, C. et. al.

Jan 31st, 2019 - The prevalence of deep venous thrombosis in patients with advanced cancer is unconfirmed and it is unknown whether current international thromboprophylaxis guidance is applicable to this population. We aimed to determine prevalence and predictors of femoral deep vein thrombosis in patients admitted to specialist palliative care units (SPCUs).

2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
Calkins, H.

Jan 27th, 2019 - Since 1980, the American College of Cardiology (ACC) and American Heart Association (AHA) have translated scientific evidence into clinical practice guidelines with recommendations to improve cardiovascular health. These guidelines, which are based on systematic methods to evaluate and classify evidence, provide a foundation for the delivery of quality cardiovascular care. The ACC and AHA spons...

Incidence, Risk Factors, and Outcomes Associated With In-Hospital Acute Myocardial Infarction
Bradley, S. et. al.

Jan 17th, 2019 - Question: What are the incidence, risk factors, and outcomes associated with in-hospital acute myocardial infarction (AMI)? Findings: This cohort study of 1.3 million patients hospitalized in US Veterans Health Administration facilities found an incidence of in-hospital AMI of 4.27 per 1000 admissions, and risk factors associated with in-hospital AMI included history of coronary artery disease,...

Appropriate Use Criteria for Multimodality Imaging in the Assessment of Cardiac Structure and Function in Nonvalvular Heart Disease

Jan 7th, 2019 - This document is the second of 2 companion appropriate use criteria (AUC) documents developed by the American College of Cardiology, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed ...