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About 245,749 results
Use of Direct Oral Anticoagulants in Morbidly Obese Patients.
https://doi.org/10.1002/phar.2353
Pharmacotherapy Kido K, Lee JC et. al.

Dec 13th, 2019 - In 2016, the International Society on Thrombosis and Haemostasis (ISTH) published guidelines advising caution when using direct oral anticoagulants (DOACs) in patients with morbid obesity due to limited clinical efficacy and safety data supporting their use in this patient population. In this review, we analyzed published articles in the MEDLINE database (from inception through May 29, 2019), a...

Epipericardial fat necrosis as cause of chest pain in patient after heart transplantation.
https://doi.org/10.1111/ajt.15744
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons; Cafezeiro CRF, Lopes MP et. al.

Dec 13th, 2019 - Epipericardial fat necrosis is an uncommon clinical condition of unknown etiology. It typically presents as acute pleuritic chest pain and should be differentiated from acute pulmonary embolism and acute coronary syndrome. This condition is diagnosed by characteristic chest computed tomography (CT) findings of an ovoid mediastinal fatty lesion with intrinsic and surrounding soft-tissue strandin...

Quantitative analysis of ablation technique predicts arrhythmia recurrence following at...
https://doi.org/10.1016/j.ahj.2019.11.011
American Heart Journal; Jankelson L, Dai M et. al.

Dec 13th, 2019 - Optimal ablation technique, including catheter-tissue contact during atrial fibrillation (AF) radiofrequency (RF) ablation, is associated with improved procedural outcomes. We used a custom developed software to analyze high-frequency catheter position data to study the interaction between catheter excursion during lesion placement, lesion-set sequentiality, and arrhythmia recurrence. A total o...

Restitution metrics in Brugada syndrome: a systematic review and meta-analysis.
https://doi.org/10.1007/s10840-019-00675-z
Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing; Tse G, Lee S et. al.

Dec 13th, 2019 - Brugada syndrome (BrS) is an ion channelopathy that predisposes affected subjects to ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death. Restitution analysis has been examined in BrS patients but not all studies have reported significant differences between BrS patients and controls. Therefore, we conducted a systematic review and meta-analysis to investigate the different re...

EXCEL Leaders Answer Back After BBC Exposé
https://www.medscape.com/viewarticle/922642

Dec 12th, 2019 - Allegations that the EXCEL investigators concealed key data and downplayed a longer-term mortality increase for patients treated with percutaneous coronary intervention (PCI) vs surgery were met with a fierce 11-page rebuttal signed by 11 members of the trial's leadership. BBC Newsnight alleged earlier this week that the rate of myocardial infarction (MI) was 80% higher if left-main coronary le...

Pivotal Study of Endovenous Stent Placement for Symptomatic Iliofemoral Venous Obstruct...
https://doi.org/10.1161/CIRCINTERVENTIONS.119.008268
Circulation. Cardiovascular Interventions; Razavi MK, Black S et. al.

Dec 12th, 2019 - Chronic venous insufficiency is characterized by inadequate venous return from the lower extremities, which may arise from intravenous obstruction after deep vein thrombosis or from extrinsic venous compression. The purpose of this study was to determine the safety and effectiveness of a dedicated endovenous stent for symptomatic iliofemoral venous obstruction. The VIRTUS trial (VIRTUS Safety a...

Utility of 30-Day Continuous Ambulatory Monitoring to Identify Patients With Delayed Oc...
https://doi.org/10.1161/CIRCINTERVENTIONS.118.007635
Circulation. Cardiovascular Interventions; Tian Y, Padmanabhan D et. al.

Dec 12th, 2019 - Mechanical injury in the conduction system requiring permanent pacemaker (PPM) associated with transcatheter aortic valve replacement (TAVR) procedure is a common complication. The objective of this study was to use ambulatory monitor BodyGuardian to assess late occurrence of atrioventricular block (AVB) after TAVR. This prospective study evaluated 365 patients who underwent TAVR at Mayo Clinic...

Fenestrated endografting is the preferred option for juxta-renal aortic aneurysm recons...
https://doi.org/10.23736/S0021-9509.19.11185-8
The Journal of Cardiovascular Surgery; Gargiulo M, Gallitto E et. al.

Dec 12th, 2019 - The aim of this study was to report early/mid-term-up outcomes of fenestrated endografting(FEVAR) for juxta-renal aneurysms(j-AAAs). Between 2008 and 2019, all consecutive j-AAAs treated by FEVAR were prospectively collected and retrospectively analyzed. Early endpoints were technical success, renal function worsening and 30-day mortality. Follow-up endpoints were survival, freedom from re-inte...

High-Cervical Carotid Endarterectomy - Outcome Analysis.
https://doi.org/10.1016/j.wneu.2019.12.002
World Neurosurgery; Kondo T, Ota N et. al.

Dec 12th, 2019 - Carotid endarterectomy (CEA) for high cervical internal carotid artery stenosis is considered to be technically demanding because of the difficulty to dissect the distal end. We report the surgical technique and outcome analysis of CEA for high-cervical lesion. We retrospectively analyzed the records of 98 patients treated by CEA from December 2013 to June 2018. The plaque positions rostral to ...

Outcomes and Anticoagulation Use After Catheter Ablation for Atrial Fibrillation.
https://doi.org/10.1161/CIRCEP.119.007612
Circulation. Arrhythmia and Electrophysiology; Freeman JV, Shrader P et. al.

Dec 12th, 2019 - Studies evaluating the effects of atrial fibrillation (AF) catheter ablation versus antiarrhythmic therapy on outcomes have shown mixed results. In addition, guidelines recommend continuing oral anticoagulation (OAC) after ablation for those at risk of stroke, but real-world data are lacking. We evaluated outcomes including death, myocardial infarction, stroke or systemic embolism, intracranial...

A PIK3CA mutation in an acquired capillary malformation.
https://doi.org/10.1111/pde.14068
Pediatric Dermatology; Rosenthal J, Sibbald C et. al.

Dec 12th, 2019 - Acquired capillary malformations are rare vascular anomalies composed of dilated capillaries in the skin. We present a pediatric case of an acquired capillary malformation as a novel presentation of the PIK3CA-related overgrowth syndromes. Using next-generation sequencing, we identified a PIK3CA p.Val344Met mutation within the acquired capillary malformation with possible prognostic and therape...

Repeated mechanical thrombectomy for acute ischemic stroke in a dialysis patient: A cas...
https://doi.org/10.1111/hdi.12811
Hemodialysis International. International Symposium on Home Hemodialysis; Ding YL, Niu JL et. al.

Dec 12th, 2019 - Mechanical thrombectomy (MT) can significantly improve the prognosis of patients with large vessel occlusion (LVO) stroke. It is still unclear whether repeated MT in a short period of time is safe and effective in patients with renal failure and atrial fibrillation (AF). We present the case of an LVO patient with AF and uremia who was successfully treated with MT for M1 segment occlusion of the...

Increased frequency of FBN1 frameshift and nonsense mutations in Marfan syndrome patien...
https://doi.org/10.1002/mgg3.1041
Molecular Genetics & Genomic Medicine; Xu S, Li L et. al.

Dec 12th, 2019 - Marfan syndrome (MFS) is an inherited connective tissue disease that mainly involves Fibrillin-1 (FBN1) mutations and aortic manifestations. In this study, we investigated the correlations between the FBN1 genotype-phenotype and aortic events (aortic dissection and aortic aneurysm) in patients with Marfan syndrome. Genotype and phenotype information was evaluated in 180 patients with MFS. DNA s...

Mitral valve prolapse, a familial condition worth screening for?
https://doi.org/10.1177/2047487319893368
European Journal of Preventive Cardiology; Regieli JJ, J Cramer M et. al.

Dec 12th, 2019 - Mitral valve prolapse, a familial condition worth screening for?|2019|Regieli JJ,J Cramer M,Baas AF,Sieswerda GT,Nathoe HM,|

Longitudinal changes in ganglion cell-inner plexiform layer of fellow eyes in unilatera...
https://doi.org/10.1016/j.ajo.2019.12.003
American Journal of Ophthalmology; Lee MW, Kim JM et. al.

Dec 12th, 2019 - To determine longitudinal changes in the ganglion cell-inner plexiform layer (GC-IPL) thickness of the fellow eyes of patients with neovascular age-related macular degeneration (AMD). A prospective cohort study. Patients with unilateral neovascular AMD, unilateral polypoidal choroidal vasculopathy (PCV), and controls were included. After the initial visit, GC-IPL thickness was measured twice mo...

Predictors of Left Ventricular Dysfunction after Surgery for Degenerative Mitral Regurg...
https://doi.org/10.1016/j.athoracsur.2019.10.044
The Annals of Thoracic Surgery; Kislitsina ON, Thomas JD et. al.

Dec 12th, 2019 - This study was performed to determine if strain can supplement the ability of left ventricular ejection fraction (LVEF) to predict post-op ventricular dysfunction in patients undergoing mitral valve (MV) surgery for degenerative mitral regurgitation (DMR). From 2004 to 2017, 520 patients with an LVEF > 60% underwent MV surgery (98% repair) for DMR. All patients had preoperative (pre-op), pre-di...

Association of Abnormal P-Wave Indices With Dementia and Cognitive Decline Over 25 Year...
https://doi.org/10.1161/JAHA.119.014553
Journal of the American Heart Association; Gutierrez A, Norby FL et. al.

Dec 12th, 2019 - Background Abnormal P-wave indices (PWIs)-reflecting underlying left atrial abnormality-are associated with increased risk of stroke independent of atrial fibrillation. We assessed whether abnormal PWIs are associated with incident dementia and greater cognitive decline, independent of atrial fibrillation and ischemic stroke. Methods and Results We included 13 714 participants (mean age, 57±6 y...

Feasibility and Efficacy of His Bundle Pacing or Left Bundle Pacing Combined With Atrio...
https://doi.org/10.1161/JAHA.119.014253
Journal of the American Heart Association; Wang S, Wu S et. al.

Dec 12th, 2019 - Background Persistent atrial fibrillation may lead to a higher probability of inappropriate shocks in heart failure patients with an implantable cardioverter-defibrillator (ICD). The aim of this study was to evaluate the impact of His-Purkinje conduction system pacing combined with atrioventricular node ablation in improving heart function and preventing inappropriate shock therapy in these pat...

The cardiac sympathetic co-transmitter neuropeptide Y is pro-arrhythmic following ST-el...
https://doi.org/10.1093/eurheartj/ehz852
European Heart Journal; Kalla M, Hao G et. al.

Dec 12th, 2019 - ST-elevation myocardial infarction is associated with high levels of cardiac sympathetic drive and release of the co-transmitter neuropeptide Y (NPY). We hypothesized that despite beta-blockade, NPY promotes arrhythmogenesis via ventricular myocyte receptors. In 78 patients treated with primary percutaneous coronary intervention, sustained ventricular tachycardia (VT) or fibrillation (VF) occur...

Admission glucagon-like peptide-1 levels in acute myocardial infarction: is this a new ...
https://doi.org/10.1093/eurheartj/ehz868
European Heart Journal; Roever L, Tse G et. al.

Dec 12th, 2019 - Admission glucagon-like peptide-1 levels in acute myocardial infarction: is this a new biomarker of cardiovascular risk?|2019|Roever L,Tse G,Versaci F,Biondi-Zoccai G,|