About 5,763,985 results
Statins and Multiple Noncardiovascular Outcomes: Umbrella Review of Meta-analyses of Ob... Preview
Annals of Internal Medicine; He Y, Li X et. al.

Oct 11th, 2018 - Many effects of statins on non-cardiovascular disease (non-CVD) outcomes have been reported. To evaluate the quantity, validity, and credibility of evidence regarding associations between statins and non-CVD outcomes and the effects of statins on these outcomes. MEDLINE and EMBASE (English terms only, inception to 28 May 2018). Meta-analyses (published in English) of observational studies and o...

2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guid... Preview
Stroke Powers WJ, Rabinstein AA et. al.

Jan 25th, 2018 - The purpose of these guidelines is to provide an up-to-date comprehensive set of recommendations for clinicians caring for adult patients with acute arterial ischemic stroke in a single document. The intended audiences are prehospital care providers, physicians, allied health professionals, and hospital administrators. These guidelines supersede the 2013 guidelines and subsequent updates. Membe...

Single-Molecule hsTnI and Short-Term Risk in Stable Patients With Chest Pain. Preview
Journal of the American College of Cardiology; Januzzi JL, Suchindran S et. al.

Jan 24th, 2019 - Evaluation of stable symptomatic outpatients with suspected coronary artery disease (CAD) may be challenging because they have a wide range of cardiovascular risk. The role of troponin testing to assist clinical decision making in this setting is unexplored. This study sought to evaluate the prognostic meaning of single-molecule counting high-sensitivity troponin I (hsTnI) (normal range <6 ng/l...

Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma. Preview
The New England Journal of Medicine; Dimopoulos MA, Dytfeld D et. al.

Nov 7th, 2018 - The immunostimulatory monoclonal antibody elotuzumab plus lenalidomide and dexamethasone has been shown to be effective in patients with relapsed or refractory multiple myeloma. The immunomodulatory agent pomalidomide plus dexamethasone has been shown to be effective in patients with multiple myeloma that is refractory to lenalidomide and a proteasome inhibitor. Patients with multiple myeloma t...

Screening for Intimate Partner Violence, Elder Abuse, and Abuse of Vulnerable Adults: U... Preview
JAMA , Curry SJ et. al.

Oct 25th, 2018 - Intimate partner violence (IPV) and abuse of older or vulnerable adults are common in the United States but often remain undetected. In addition to the immediate effects of IPV, such as injury and death, there are other health consequences, many with long-term effects, including development of mental health conditions such as depression, posttraumatic stress disorder, anxiety disorders, substan...

Energy-Dense versus Routine Enteral Nutrition in the Critically Ill. Preview
The New England Journal of Medicine; , Chapman M et. al.

Oct 22nd, 2018 - The effect of delivering nutrition at different calorie levels during critical illness is uncertain, and patients typically receive less than the recommended amount. We conducted a multicenter, double-blind, randomized trial, involving adults undergoing mechanical ventilation in 46 Australian and New Zealand intensive care units (ICUs), to evaluate energy-dense (1.5 kcal per milliliter) as comp...

Influenza and Tdap Vaccination Coverage Among Pregnant Women - United States, April 2018. Preview
MMWR. Morbidity and Mortality Weekly Report; Kahn KE, Black CL et. al.

Sep 27th, 2018 - Vaccinating pregnant women with influenza and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines can reduce the risk for influenza and pertussis for themselves and their infants. The Advisory Committee on Immunization Practices (ACIP) recommends that all women who are or might be pregnant during the influenza season receive influenza vaccine, which can be adminis...

Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis. Preview
The New England Journal of Medicine; Chitnis T, Arnold DL et. al.

Sep 12th, 2018 - Treatment of patients younger than 18 years of age with multiple sclerosis has not been adequately examined in randomized trials. We compared fingolimod with interferon beta-1a in this population. In this phase 3 trial, we randomly assigned patients 10 to 17 years of age with relapsing multiple sclerosis in a 1:1 ratio to receive oral fingolimod at a dose of 0.5 mg per day (0.25 mg per day for ...

Intrauterine Device Expulsion After Postpartum Placement: A Systematic Review and Meta-... Preview
Obstetrics and Gynecology; Jatlaoui TC, Whiteman MK et. al.

Sep 11th, 2018 - To estimate expulsion rates among women with postpartum intrauterine device (IUD) placement by timing of insertion, IUD type, and delivery method. We searched PubMed, Cochrane Library, and ClinicalTrials.gov from 1974 to May 2018. We searched databases for any published studies that examined postpartum placement of a copper IUD or levonorgestrel intrauterine system and reported counts of expuls...

Brexanolone injection in post-partum depression: two multicentre, double-blind, randomi... Preview
Lancet (London, England); Meltzer-Brody S, Colquhoun H et. al.

Sep 4th, 2018 - Post-partum depression is associated with substantial morbidity, and improved pharmacological treatment options are urgently needed. We assessed brexanolone injection (formerly SAGE-547 injection), a positive allosteric modulator of γ-aminobutyric-acid type A (GABAA) receptors, for the treatment of moderate to severe post-partum depression. We did two double-blind, randomised, placebo-controlle...

Oral steroids for resolution of otitis media with effusion in children (OSTRICH): a dou... Preview
Lancet (London, England); Francis NA, Cannings-John R et. al.

Aug 28th, 2018 - Children with persistent hearing loss due to otitis media with effusion are commonly managed by surgical intervention. A safe, cheap, and effective medical treatment would enhance treatment options. Underpowered, poor-quality trials have found short-term benefit from oral steroids. We aimed to investigate whether a short course of oral steroids would achieve acceptable hearing in children with ...

Labor Induction versus Expectant Management in Low-Risk Nulliparous Women. Preview
The New England Journal of Medicine; Grobman WA, Rice MM et. al.

Aug 8th, 2018 - The perinatal and maternal consequences of induction of labor at 39 weeks among low-risk nulliparous women are uncertain. In this multicenter trial, we randomly assigned low-risk nulliparous women who were at 38 weeks 0 days to 38 weeks 6 days of gestation to labor induction at 39 weeks 0 days to 39 weeks 4 days or to expectant management. The primary outcome was a composite of perinatal death ...

Outcomes of Cardiac Screening in Adolescent Soccer Players. Preview
The New England Journal of Medicine; Malhotra A, Dhutia H et. al.

Aug 8th, 2018 - Reports on the incidence and causes of sudden cardiac death among young athletes have relied largely on estimated rates of participation and varied methods of reporting. We sought to investigate the incidence and causes of sudden cardiac death among adolescent soccer players in the United Kingdom. From 1996 through 2016, we screened 11,168 adolescent athletes with a mean (±SD) age of 16.4±1.2 y...

Safety and Side Effects of Rifampin versus Isoniazid in Children. Preview
The New England Journal of Medicine; Diallo T, Adjobimey M et. al.

Aug 1st, 2018 - The treatment of latent infection with Mycobacterium tuberculosis is important in children because of their vulnerability to life-threatening forms of tuberculosis disease. The current standard treatment - 9 months of isoniazid - has been associated with poor adherence and toxic effects, which have hampered the effectiveness of the drug. In adults, treatment with 4 months of rifampin has been s...

A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus. Preview
The New England Journal of Medicine; Fenske W, Refardt J et. al.

Aug 1st, 2018 - The indirect water-deprivation test is the current reference standard for the diagnosis of diabetes insipidus. However, it is technically cumbersome to administer, and the results are often inaccurate. The current study compared the indirect water-deprivation test with direct detection of plasma copeptin, a precursor-derived surrogate of arginine vasopressin. From 2013 to 2017, we recruited 156...

Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction. Preview
Journal of the American College of Cardiology; Levy B, Clere-Jehl R et. al.

Jul 6th, 2018 - Vasopressor agents could have certain specific effects in patients with cardiogenic shock (CS) after myocardial infarction, which may influence outcome. Although norepinephrine and epinephrine are currently the most commonly used agents, no randomized trial has compared their effects, and intervention data are lacking. The goal of this paper was to compare in a prospective, double-blind, multic...

Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2-Po... Preview
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology; Giordano SH, Temin S et. al.

Jun 25th, 2018 - Purpose To update evidence-based guideline recommendations for practicing oncologists and others on systemic therapy for patients with human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer to 2018. Methods An Expert Panel conducted a targeted systematic literature review (for both systemic treatment and CNS metastases) and identified 622 articles. Outcomes of interest ...

Association between diabetes and subsequent Parkinson disease: A record-linkage cohort ... Preview
Neurology De Pablo-Fernandez E, Goldacre R et. al.

Jun 14th, 2018 - To investigate the association between type 2 diabetes mellitus (T2DM) and subsequent Parkinson disease (PD). Linked English national Hospital Episode Statistics and mortality data (1999-2011) were used to conduct a retrospective cohort study. A cohort of individuals admitted for hospital care with a coded diagnosis of T2DM was constructed, and compared to a reference cohort. Subsequent PD risk...

Association of Long-Term Risk of Respiratory, Allergic, and Infectious Diseases With Re... Preview
JAMA Otolaryngology-- Head & Neck Surgery; Byars SG, Stearns SC et. al.

Jun 7th, 2018 - Surgical removal of adenoids and tonsils to treat obstructed breathing or recurrent middle-ear infections remain common pediatric procedures; however, little is known about their long-term health consequences despite the fact that these lymphatic organs play important roles in the development and function of the immune system. To estimate long-term disease risks associated with adenoidectomy, t...

Immunochemotherapy With Obinutuzumab or Rituximab for Previously Untreated Follicular L... Preview
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology; Hiddemann W, Barbui AM et. al.

Jun 1st, 2018 - Purpose The GALLIUM study ( ClinicalTrials.gov identifier: NCT01332968) showed that obinutuzumab (GA101; G) significantly prolonged progression-free survival (PFS) in previously untreated patients with follicular lymphoma relative to rituximab (R) when combined with cyclophosphamide (C), doxorubicin, vincristine (V), and prednisone (P; CHOP); CVP; or bendamustine. This report focuses on the imp...