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Bioequivalents lamotrigine, levetiracetam control new-onset focal seizures equally well
https://www.mdedge.com/clinicalneurologynews/article/191088/epilepsy-seizures/bioequivalents-lamotrigine-levetiracetam
Michele G. Sullivan, Clinical Neurology News

Dec 13th, 2018 - NEW ORLEANS – Bioequivalent generic formulations of levetiracetam and lamotrigine reduced seizures by a similar extent over 2 years in a retrospective study of patients with newly diagnosed focal epilepsy. Michele G.

Rural teleprescribing for opioid use disorder shows success
https://www.mdedge.com/clinicalneurologynews/article/191087/addiction-medicine/rural-teleprescribing-opioid-use-disorder
Thomas R. Collins, Clinical Neurology News

Dec 13th, 2018 - BONITA SPRINGS, FLA. – Clinician shortages and alarming opioid overdose rates are prompting rural health care centers to turn to telemedicine for delivering treatments for opioid use disorder (OUD).

Brazil sees first live birth from deceased-donor uterus transplant
https://www.mdedge.com/obgyn/article/191086/surgery/brazil-sees-first-live-birth-deceased-donor-uterus-transplant
Kari Oakes

Dec 13th, 2018 - For the first time, a woman gave birth to a live infant after receiving a uterus transplanted from a deceased donor. The healthy 2,550-g infant girl was born in December 2017 via a planned cesarean delivery at about 36 weeks’ gestation.

Parental leave for residents
https://www.mdedge.com/rheumatology/article/190995/career/parental-leave-residents

Dec 13th, 2018 - Leave policies for residents who become new parents are uneven, often ignored by training boards, and provide less time off than similar policies for faculty physicians. Also today, exercise is important for patients with sickle cell, COPD patients are experiencing a risk in non-TB mycobacteria infections, and how to be an influencer on social media.

Psilocybin yields encouraging results in addiction studies
https://www.mdedge.com/familypracticenews/article/191071/mental-health/psilocybin-yields-encouraging-results-addiction
Thomas R. Collins, Family Practice News

Dec 12th, 2018 - BONITA SPRINGS, FLA. – Small but tantalizing studies are showing benefits from treatment with psilocybin, the psychedelic substance, for alcohol and cocaine addiction, according to findings presented at the annual meeting of the American Academy of Addiction Psychiatry.

Be judicious with empiric antibiotics for febrile neutropenia
https://www.mdedge.com/familypracticenews/article/191058/antimicrobial-resistant-infections/be-judicious-empiric
M. Alexander Otto, Family Practice News

Dec 12th, 2018 - SAN FRANCISCO – Empiric antibiotic therapy for febrile neutropenia, a common and life-threatening complication of chemotherapy, hasn’t really changed much in 20 years, according to Alison Freifeld, MD, director of the section of oncology infectious diseases at the University of Nebraska, Omaha. luchschen/Thinkstock Antibiotic resistance has become a major problem over that time.

Home-based exercise for PAD tops supervised treadmill exercise
https://www.mdedge.com/internalmedicine/article/191047/pad-and-claudication/home-based-exercise-pad-tops-supervised/page/0/1

Dec 12th, 2018 - Requirements for CMS coverage of supervised exercise for symptomatic PAD *The exercise program must consist of 12 weeks of thrice-weekly sessions. *It has to be prescribed by a physician following a face-to-face meeting with the patient during which the physician provides education on cardiovascular risk prevention.

Cannabis May Help UC Patients: Gastro Endo News Report
https://www.medpagetoday.com/gastroenterology/generalgastroenterology/76868

Dec 12th, 2018 - Patients with moderate ulcerative colitis may benefit from cannabis, according to a new study that reported a decrease in disease activity index in patients who used the drug. A recent analysis found that consuming probiotics may contribute to small intestinal bacterial overgrowth and metabolic acidosis, which can cause "brain fog" in some patients. Machine learning technology may help improve ...

CABG surpasses PCI for diabetics out to 7.5 years
https://www.mdedge.com/endocrinology/article/191034/diabetes/cabg-surpasses-pci-diabetics-out-75-years
Mitchel L. Zoler

Dec 12th, 2018 - CHICAGO – Patients with diabetes who underwent coronary artery bypass grafting had significantly better survival than patients with diabetes who underwent percutaneous coronary intervention after a median 7. 5 years of follow-up.

Partial- and whole-breast irradiation very close in efficacy
https://www.mdedge.com/oncologypractice/article/191032/breast-cancer/partial-and-whole-breast-irradiation-very-close/page/0/1

Dec 12th, 2018 - Study details Dr. Vicini and colleagues enrolled in their trial 4,216 women with stage 0-II breast cancer who had undergone lumpectomy.

Risks Tied to Dementia in Female Military Veterans
https://www.medpagetoday.com/neurology/dementia/76881

Dec 12th, 2018 - Female military veterans who had traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), or depression were more likely to develop dementia than female veterans without these conditions, researchers reported. Having a TBI increased dementia risk in female veterans by 50%, while PTSD increased it by almost 80%, and depression increased it by almost 70%, according to Kristine Yaffe, ...

No matter the valve, protective device cuts post-TAVR stroke risk
https://www.mdedge.com/cardiology/article/191030/interventional-cardiology-surgery/no-matter-valve-protective-device-cuts
Jim Kling

Dec 12th, 2018 - SAN DIEGO – A retrospective study and combined meta-analysis of patients undergoing transcatheter aortic valve replacement (TAVR) confirms the protective effect of the Sentinel cerebral embolic protection (CEP) device, regardless of the valve type used, on periprocedural stroke and mortality. Jim Kling/MDedge News Dr.

Vitamin D and Schizophrenia; 007 and Alcohol Abuse
https://www.medpagetoday.com/psychiatry/generalpsychiatry/76880

Dec 12th, 2018 - Newborns with vitamin D deficiency may face higher risk for schizophrenia later in life, a Danish case-control study indicated. "The next step is to conduct randomized clinical trials of vitamin D supplements in pregnant women who are vitamin D deficient, in order to examine the impact on child brain development and risk of neurodevelopmental disorders such as autism and schizophrenia," said st...

Challenges in managing chronic pelvic pain in women
https://www.mdedge.com/obgyn/article/191023/opioid-resource-center/challenges-managing-chronic-pelvic-pain-women/page/0/1

Dec 12th, 2018 - What are the levels of evidence for centralized pain treatment? Available pharmacotherapeutic agents have modest benefit, possibly because the population of pain patients is heterogeneous, with various underlying mechanisms of pain. And, Dr.

Prostatectomy Beats Active Surveillance Long Term -- or Does It?
https://www.medpagetoday.com/urology/prostatecancer/76873

Dec 12th, 2018 - Long-term follow-up of prostate cancer patients randomized to radical prostatectomy or active surveillance (a.k.a. "watchful waiting") showed a substantial and statistically significant survival advantage for the surgical procedure, Swedish researchers said. Specifically, among participants in the Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4) followed for up to 29 years, patients w...

Suicidal Thoughts, Attempts Common With Atopic Dermatitis
https://www.medpagetoday.com/dermatology/atopy/76878

Dec 12th, 2018 - Atopic dermatitis appears to put patients at higher risk for having suicidal thoughts and attempting suicide, a systematic review and meta-analysis found. When compared with individuals who did not have atopic dermatitis, patients with the condition had a 36% greater chance of attempting suicide (pooled odds ratio 1.36, 95% CI 1.09-1.70), and they also had a 44% greater chance of having suicida...

More data link severe sleep apnea and aggressive melanoma
https://www.mdedge.com/internalmedicine/article/190998/sleep-medicine/more-data-link-severe-sleep-apnea-and-aggressive
Heidi Splete, Internal Medicine News

Dec 12th, 2018 - Severe sleep-disordered breathing was significantly associated with more aggressive skin cancer in a study of 443 adults. Dlumen/Thinkstock Sleep-disordered breathing (SDB) has been associated with increased cancer risk and mortality, but no large studies have examined the association in specific cancers, wrote Miguel Angel Martinez-Garcia, MD, of La Fe University and Polytechnic Hospital, Vale.

Comparison of reference Infliximab and a Biosimilar (CT-P13) in Crohn's Disease
https://www.medpagetoday.com/gastroenterology/inflammatoryboweldisease/76875

Dec 12th, 2018 - Action Points This large French cohort study demonstrates that the biosimilar CT-P13 is equivalent in terms of efficacy and safety to that of infliximab in infliximab-naive patients with Crohn's disease. Note that according to editorialists, the results suggest that switching to biosimilars should not cause concerns about effectiveness or safety, and the choice between products could be made on...

MAIA: Daratumumab plus len-dex improves myeloma PFS
https://www.mdedge.com/oncologypractice/article/190989/multiple-myeloma/maia-daratumumab-plus-len-dex-improves-myeloma-pfs
Neil Osterweil, Oncology Practice

Dec 12th, 2018 - SAN DIEGO – Patients with newly diagnosed multiple myeloma who were ineligible for transplant had a 44% reduction in the risk of disease progression or death when they were treated with the anti-CD38 monoclonal antibody daratumumab (Darzalex) added to lenalidomide (Revlimid) and dexamethasone, compared with lenalidomide-dexamethasone alone, an interim analysis from the MAIA trial showed. Among.

Uterine tissue extraction: An update, with a look at tools and techniques
https://www.mdedge.com/obgyn/article/190986/surgery/uterine-tissue-extraction-update-look-tools-and-techniques/page/0/1

Dec 12th, 2018 - Morcellation decisions Dr. Falcone pointed out that, at the Cleveland Clinic, morcellation is not performed in postmenopausal women, and for several other contraindications, including a history of >2 years of tamoxifen therapy; history of pelvic radiation; history of childhood retinoblastoma; personal history of hereditary leiomyomatosis or renal cell carcinoma; and the presence of a cancer-pos.