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A reappraisal of the diagnostic and therapeutic management of uncommon histologies of p... Preview
The Oncologist; Ponzoni M, Govi S et. al.

Jul 2nd, 2013 - Lymphoma is the most common malignancy arising in the ocular adnexa, which includes conjunctiva, lachrymal gland, lachrymal sac, eyelids, orbit soft tissue, and extraocular muscles. Ocular adnexal lymphoma (OAL) accounts for 1%-2% of non-Hodgkin lymphoma and 5%-15% of extranodal lymphoma. Histology, stage, and primary localizations are the most important variables influencing the natural histor...

Lymphoma of the eyelid. Preview
Survey of Ophthalmology; Svendsen FH, Heegaard S

Nov 29th, 2016 - Lymphoma of the eyelid constitutes 5% of ocular adnexal lymphoma. In previously published cases, 56% of lymphomas of the eyelid are of B-cell origin and 44% are of T-cell origin. The most frequent B-cell lymphomas are extranodal marginal zone lymphoma (27 cases-14%) and diffuse large B-cell lymphoma (18 cases-9%). T-cell lymphomas are most frequently mycosis fungoides (25 cases-13%), extranodal...

Outcomes of primary lymphoma of the ocular adnexa (orbital lymphoma) treated with radio... Preview
Clinical Oncology (Royal College of Radiologists (Great Britain)); Woolf DK, Kuhan H et. al.

Dec 2nd, 2014 - Low-grade ocular adnexal lymphoma is a rare disease and often treated with local radiotherapy to varying doses. Most previously reported studies have a very heterogeneous patient population and treatments. We report the outcomes from a 10 year cohort of patients at our institution treated with primary radiation therapy. We analysed a retrospective case series of patients with stage IE low-grade...

FDA approves Cablivi® (caplacizumab-yhdp), the first Nanobody®-based medicine, for adults with acquired thrombotic thrombocytopenic purpura (aTTP)

Feb 5th, 2019 - The U.S. Food and Drug Administration (FDA) has approved Cablivi® (caplacizumab-yhdp) in combination with plasma exchange and immunosuppression for the treatment of acquired thrombotic thrombocytopenic purpura (aTTP) in adults. Cablivi is the first FDA approved therapy specifically indicated for the treatment of aTTP.

Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review a... Preview
BMJ (Clinical Research Ed.); Bekiari E, Kitsios K et. al.

Apr 19th, 2018 - To evaluate the efficacy and safety of artificial pancreas treatment in non-pregnant outpatients with type 1 diabetes. Systematic review and meta-analysis of randomised controlled trials. Medline, Embase, Cochrane Library, and grey literature up to 2 February 2018. Randomised controlled trials in non-pregnant outpatients with type 1 diabetes that compared the use of any artificial pancreas syst...

Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors:... Preview
BMJ (Clinical Research Ed.); Wei L, Lai EC et. al.

Apr 9th, 2019 - To investigate the incidence of new onset type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors (dutasteride or finasteride) for long term treatment of benign prostatic hyperplasia. Population based cohort study. UK Clinical Practice Research Datalink (CPRD; 2003-14) and Taiwanese National Health Insurance Research Database (NHIRD; 2002-12). Men in the CPRD who received duta...

Evaluation of Outpatient Cardiac Stress Testing After Emergency Department Encounters f... Preview
Annals of Emergency Medicine; Natsui S, Sun BC et. al.

Apr 8th, 2019 - Professional guidelines recommend 72-hour cardiac stress testing after an emergency department (ED) evaluation for possible acute coronary syndrome. There are limited data on actual compliance rates and effect on patient outcomes. Our aim is to describe rates of completion of noninvasive cardiac stress testing and associated 30-day major adverse cardiac events. We conducted a retrospective anal...

Screening for Breast Cancer in Average-Risk Women: A Guidance Statement From the Americ... Preview
Annals of Internal Medicine; Qaseem A, Lin JS et. al.

Apr 8th, 2019 - The purpose of this guidance statement is to provide advice to clinicians on breast cancer screening in average-risk women based on a review of existing guidelines and the evidence they include. This guidance statement is derived from an appraisal of selected guidelines from around the world that address breast cancer screening, as well as their included evidence. All national guidelines publis...

A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Bac... Preview
Annals of Emergency Medicine; Friedman BW, Irizarry E et. al.

Apr 4th, 2019 - Patients with low back pain are often treated with nonsteroidal anti-inflammatory drugs and skeletal muscle relaxants. We compare functional outcomes and pain among patients with acute low back pain who were randomized to a 1-week course of ibuprofen plus placebo versus ibuprofen plus 1 of 3 skeletal muscle relaxants: baclofen, metaxalone, and tizanidine. This was a randomized, double-blind, pa...

Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally a... Preview
Lancet (London, England); Mok TSK, Wu YL et. al.

Apr 3rd, 2019 - First-line pembrolizumab monotherapy improves overall and progression-free survival in patients with untreated metastatic non-small-cell lung cancer with a programmed death ligand 1 (PD-L1) tumour proportion score (TPS) of 50% or greater. We investigated overall survival after treatment with pembrolizumab monotherapy in patients with a PD-L1 TPS of 1% or greater. This randomised, open-label, ph...

Dose-Adjusted EPOCH-R Compared With R-CHOP as Frontline Therapy for Diffuse Large B-Cel... Preview
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology; Bartlett NL, Wilson WH et. al.

Apr 2nd, 2019 - Alliance/CALGB 50303 (NCT00118209), an intergroup, phase III study, compared dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (DA-EPOCH-R) with standard rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) as frontline therapy for diffuse large B-cell lymphoma. Patients received six cycles of DA-EPOCH-R or R-CHOP. The prima...

Survival in Out-of-Hospital Cardiac Arrest After Standard Cardiopulmonary Resuscitation... Preview
Circulation Riva G, Ringh M et. al.

Mar 31st, 2019 - Survival in Out-of-Hospital Cardiac Arrest After Standard Cardiopulmonary Resuscitation or Chest Compressions Only Before Arrival of Emergency Medical Services: Nationwide Study During Three Guideline Periods.|2019|Riva G,Ringh M,Jonsson M,Svensson L,Herlitz J,|

Imported Toxin-Producing Cutaneous Diphtheria - Minnesota, Washington, and New Mexico, ... Preview
MMWR. Morbidity and Mortality Weekly Report; Griffith J, Bozio CH et. al.

Mar 28th, 2019 - From September 2015 to March 2018, CDC confirmed four cases of cutaneous diphtheria caused by toxin-producing Corynebacterium diphtheriae in patients from Minnesota (two), Washington (one), and New Mexico (one). All patients had recently returned to the United States after travel to countries where diphtheria is endemic. C. diphtheriae infection was not clinically suspected in any of the patien...

Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update... Preview
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Nicolle LE, Gupta K et. al.

Mar 20th, 2019 - Asymptomatic bacteriuria (ASB) is a common finding in many populations, including healthy women and persons with underlying urologic abnormalities. The 2005 guideline from the Infectious Diseases Society of America recommended that ASB should be screened for and treated only in pregnant women or in an individual prior to undergoing invasive urologic procedures. Treatment was not recommended for...

Psychosis with Methylphenidate or Amphetamine in Patients with ADHD. Preview
The New England Journal of Medicine; Moran LV, Ongur D et. al.

Mar 20th, 2019 - The prescription use of the stimulants methylphenidate and amphetamine for the treatment of attention deficit-hyperactivity disorder (ADHD) has been increasing. In 2007, the Food and Drug Administration mandated changes to drug labels for stimulants on the basis of findings of new-onset psychosis. Whether the risk of psychosis in adolescents and young adults with ADHD differs among various stim...

Long-term Prescription Opioid Utilization, Substance Use Disorders, and Opioid Overdose... Preview
The Journal of Trauma and Acute Care Surgery; Bell TM, Raymond J et. al.

Mar 19th, 2019 - Injured adolescents have a 56% increased risk of developing a substance use disorder (SUD) within 3 years of their injury. The transition from medical prescription opioid use to nonmedical use in adolescent trauma patients has not been longitudinally studied long-term. The aim of this study is to describe 5-year patterns of opioid use in a cohort of injured adolescents as well as the proportion...

Association of Daily Aspirin Therapy With Risk of Hepatocellular Carcinoma in Patients ... Preview
JAMA Internal Medicine; Lee TY, Hsu YC et. al.

Mar 17th, 2019 - Antiviral therapy cannot erase hepatocellular carcinoma (HCC) risk in patients with chronic hepatitis B, and it is not indicated for most hepatitis B virus (HBV) carriers. Another effective way of reducing HCC risk needs to be developed. Aspirin may prevent cancer development, but clinical evidence in patients with HBV-related HCC remains limited. To investigate the association of daily aspirin...

Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Pati... Preview
The New England Journal of Medicine; Mack MJ, Leon MB et. al.

Mar 16th, 2019 - Among patients with aortic stenosis who are at intermediate or high risk for death with surgery, major outcomes are similar with transcatheter aortic-valve replacement (TAVR) and surgical aortic-valve replacement. There is insufficient evidence regarding the comparison of the two procedures in patients who are at low risk. We randomly assigned patients with severe aortic stenosis and low surgic...

Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Dis... Preview
JAMA Zhong VW, Van Horn L et. al.

Mar 15th, 2019 - Cholesterol is a common nutrient in the human diet and eggs are a major source of dietary cholesterol. Whether dietary cholesterol or egg consumption is associated with cardiovascular disease (CVD) and mortality remains controversial. To determine the associations of dietary cholesterol or egg consumption with incident CVD and all-cause mortality. Individual participant data were pooled from 6 ...

Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With A... Preview
JAMA Mark DB, Anstrom KJ et. al.

Mar 14th, 2019 - Catheter ablation is more effective than drug therapy in restoring sinus rhythm in patients with atrial fibrillation (AF), but its incremental effect on long-term quality of life (QOL) is uncertain. To determine whether catheter ablation is more beneficial than conventional drug therapy for improving QOL in patients with AF. An open-label randomized clinical trial of catheter ablation vs drug t...