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Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma.
https://doi.org/10.1056/NEJMoa1805762
The New England Journal of Medicine; Dimopoulos MA, Dytfeld D et. al.

Nov 7th, 2018 - The immunostimulatory monoclonal antibody elotuzumab plus lenalidomide and dexamethasone has been shown to be effective in patients with relapsed or refractory multiple myeloma. The immunomodulatory agent pomalidomide plus dexamethasone has been shown to be effective in patients with multiple myeloma that is refractory to lenalidomide and a proteasome inhibitor. Patients with multiple myeloma t...

Screening for Intimate Partner Violence, Elder Abuse, and Abuse of Vulnerable Adults: U...
https://doi.org/10.1001/jama.2018.14741
JAMA , Curry SJ et. al.

Oct 25th, 2018 - Intimate partner violence (IPV) and abuse of older or vulnerable adults are common in the United States but often remain undetected. In addition to the immediate effects of IPV, such as injury and death, there are other health consequences, many with long-term effects, including development of mental health conditions such as depression, posttraumatic stress disorder, anxiety disorders, substan...

Influenza and Tdap Vaccination Coverage Among Pregnant Women - United States, April 2018.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188122
MMWR. Morbidity and Mortality Weekly Report; Kahn KE, Black CL et. al.

Sep 27th, 2018 - Vaccinating pregnant women with influenza and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines can reduce the risk for influenza and pertussis for themselves and their infants. The Advisory Committee on Immunization Practices (ACIP) recommends that all women who are or might be pregnant during the influenza season receive influenza vaccine, which can be adminis...

Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis.
https://doi.org/10.1056/NEJMoa1800149
The New England Journal of Medicine; Chitnis T, Arnold DL et. al.

Sep 12th, 2018 - Treatment of patients younger than 18 years of age with multiple sclerosis has not been adequately examined in randomized trials. We compared fingolimod with interferon beta-1a in this population. In this phase 3 trial, we randomly assigned patients 10 to 17 years of age with relapsing multiple sclerosis in a 1:1 ratio to receive oral fingolimod at a dose of 0.5 mg per day (0.25 mg per day for ...

Intrauterine Device Expulsion After Postpartum Placement: A Systematic Review and Meta-...
https://doi.org/10.1097/AOG.0000000000002822
Obstetrics and Gynecology; Jatlaoui TC, Whiteman MK et. al.

Sep 11th, 2018 - To estimate expulsion rates among women with postpartum intrauterine device (IUD) placement by timing of insertion, IUD type, and delivery method. We searched PubMed, Cochrane Library, and ClinicalTrials.gov from 1974 to May 2018. We searched databases for any published studies that examined postpartum placement of a copper IUD or levonorgestrel intrauterine system and reported counts of expuls...

Oral steroids for resolution of otitis media with effusion in children (OSTRICH): a dou...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099122
Lancet (London, England); Francis NA, Cannings-John R et. al.

Aug 28th, 2018 - Children with persistent hearing loss due to otitis media with effusion are commonly managed by surgical intervention. A safe, cheap, and effective medical treatment would enhance treatment options. Underpowered, poor-quality trials have found short-term benefit from oral steroids. We aimed to investigate whether a short course of oral steroids would achieve acceptable hearing in children with ...

Outcomes of Cardiac Screening in Adolescent Soccer Players.
https://doi.org/10.1056/NEJMoa1714719
The New England Journal of Medicine; Malhotra A, Dhutia H et. al.

Aug 8th, 2018 - Reports on the incidence and causes of sudden cardiac death among young athletes have relied largely on estimated rates of participation and varied methods of reporting. We sought to investigate the incidence and causes of sudden cardiac death among adolescent soccer players in the United Kingdom. From 1996 through 2016, we screened 11,168 adolescent athletes with a mean (±SD) age of 16.4±1.2 y...

Labor Induction versus Expectant Management in Low-Risk Nulliparous Women.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186292
The New England Journal of Medicine; Grobman WA, Rice MM et. al.

Aug 8th, 2018 - The perinatal and maternal consequences of induction of labor at 39 weeks among low-risk nulliparous women are uncertain. In this multicenter trial, we randomly assigned low-risk nulliparous women who were at 38 weeks 0 days to 38 weeks 6 days of gestation to labor induction at 39 weeks 0 days to 39 weeks 4 days or to expectant management. The primary outcome was a composite of perinatal death ...

A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus.
https://doi.org/10.1056/NEJMoa1803760
The New England Journal of Medicine; Fenske W, Refardt J et. al.

Aug 1st, 2018 - The indirect water-deprivation test is the current reference standard for the diagnosis of diabetes insipidus. However, it is technically cumbersome to administer, and the results are often inaccurate. The current study compared the indirect water-deprivation test with direct detection of plasma copeptin, a precursor-derived surrogate of arginine vasopressin. From 2013 to 2017, we recruited 156...

Safety and Side Effects of Rifampin versus Isoniazid in Children.
https://doi.org/10.1056/NEJMoa1714284
The New England Journal of Medicine; Diallo T, Adjobimey M et. al.

Aug 1st, 2018 - The treatment of latent infection with Mycobacterium tuberculosis is important in children because of their vulnerability to life-threatening forms of tuberculosis disease. The current standard treatment - 9 months of isoniazid - has been associated with poor adherence and toxic effects, which have hampered the effectiveness of the drug. In adults, treatment with 4 months of rifampin has been s...

Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2-Po...
https://doi.org/10.1200/JCO.2018.79.2697
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology; Giordano SH, Temin S et. al.

Jun 25th, 2018 - Purpose To update evidence-based guideline recommendations for practicing oncologists and others on systemic therapy for patients with human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer to 2018. Methods An Expert Panel conducted a targeted systematic literature review (for both systemic treatment and CNS metastases) and identified 622 articles. Outcomes of interest ...

Association of Long-Term Risk of Respiratory, Allergic, and Infectious Diseases With Re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145787
JAMA Otolaryngology-- Head & Neck Surgery; Byars SG, Stearns SC et. al.

Jun 7th, 2018 - Surgical removal of adenoids and tonsils to treat obstructed breathing or recurrent middle-ear infections remain common pediatric procedures; however, little is known about their long-term health consequences despite the fact that these lymphatic organs play important roles in the development and function of the immune system. To estimate long-term disease risks associated with adenoidectomy, t...

ACOG Committee Opinion No. 742: Postpartum Pain Management.
https://doi.org/10.1097/AOG.0000000000002683
Obstetrics and Gynecology;

May 21st, 2018 - Pain and fatigue are the most common problems reported by women in the early postpartum period. Pain can interfere with a woman's ability to care for herself and her infant. Untreated pain is associated with a risk of greater opioid use, postpartum depression, and development of persistent pain. Nonpharmacologic and pharmacologic therapies are important components of postpartum pain management....

Birth Outcomes for Pregnant Women with HIV Using Tenofovir-Emtricitabine.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984044
The New England Journal of Medicine; Rough K, Seage GR et. al.

Apr 25th, 2018 - In a previous trial of antiretroviral therapy (ART) involving pregnant women with human immunodeficiency virus (HIV) infection, those randomly assigned to receive tenofovir, emtricitabine, and ritonavir-boosted lopinavir (TDF-FTC-LPV/r) had infants at greater risk for very premature birth and death within 14 days after delivery than those assigned to receive zidovudine, lamivudine, and ritonavi...

Change in Overweight from Childhood to Early Adulthood and Risk of Type 2 Diabetes.
https://doi.org/10.1056/NEJMoa1713231
The New England Journal of Medicine; Bjerregaard LG, Jensen BW et. al.

Apr 4th, 2018 - Childhood overweight is associated with an increased risk of type 2 diabetes in adulthood. We investigated whether remission of overweight before early adulthood reduces this risk. We conducted a study involving 62,565 Danish men whose weights and heights had been measured at 7 and 13 years of age and in early adulthood (17 to 26 years of age). Overweight was defined in accordance with Centers ...

Two-Year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure.
https://doi.org/10.1056/NEJMoa1800866
The New England Journal of Medicine; Mehra MR, Goldstein DJ et. al.

Mar 12th, 2018 - In an early analysis of this trial, use of a magnetically levitated centrifugal continuous-flow circulatory pump was found to improve clinical outcomes, as compared with a mechanical-bearing axial continuous-flow pump, at 6 months in patients with advanced heart failure. In a randomized noninferiority and superiority trial, we compared the centrifugal-flow pump with the axial-flow pump in patie...

Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervent...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876881
JAMA Berwanger O, Santucci EV et. al.

Mar 11th, 2018 - The effects of loading doses of statins on clinical outcomes in patients with acute coronary syndrome (ACS) and planned invasive management remain uncertain. To determine if periprocedural loading doses of atorvastatin decrease 30-day major adverse cardiovascular events (MACE) in patients with ACS and planned invasive management. Multicenter, double-blind, placebo-controlled, randomized clinica...

Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842359
BMJ (Clinical Research Ed.); Pasternak B, Inghammar M et. al.

Mar 9th, 2018 - To investigate whether oral fluoroquinolone use is associated with an increased risk of aortic aneurysm or dissection. Nationwide historical cohort study using linked register data on patient characteristics, filled prescriptions, and cases of aortic aneurysm or dissection. Sweden, July 2006 to December 2013. 360 088 treatment episodes of fluoroquinolone use (78%ciprofloxacin) and propensity sc...

Effect of Bag-Mask Ventilation vs Endotracheal Intubation During Cardiopulmonary Resusc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838565
JAMA Jabre P, Penaloza A et. al.

Feb 27th, 2018 - Bag-mask ventilation (BMV) is a less complex technique than endotracheal intubation (ETI) for airway management during the advanced cardiac life support phase of cardiopulmonary resuscitation of patients with out-of-hospital cardiorespiratory arrest. It has been reported as superior in terms of survival. To assess noninferiority of BMV vs ETI for advanced airway management with regard to surviv...

Effect of Meropenem-Vaborbactam vs Piperacillin-Tazobactam on Clinical Cure or Improvem...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838656
JAMA Kaye KS, Bhowmick T et. al.

Feb 27th, 2018 - Meropenem-vaborbactam is a combination carbapenem/beta-lactamase inhibitor and a potential treatment for severe drug-resistant gram-negative infections. To evaluate efficacy and adverse events of meropenem-vaborbactam in complicated urinary tract infection (UTI), including acute pyelonephritis. Phase 3, multicenter, multinational, randomized clinical trial (TANGO I) conducted November 2014 to A...