Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine; Clark CL, Gibson TA et. al.
Feb 6th, 2019 - An estimated 1.2 million annual emergency department (ED) visits for syncope/ near syncope occur in the United States. Cardiac biomarkers are frequently obtained during the ED evaluation, but the prognostic value of index high-sensitivity troponin (hscTnT) and Natriuretic Peptide (NT-proBNP) are unclear. The objective of this study was to determine if hscTnT and NT-proBNP drawn in the ED are in...
Annals of Internal Medicine; Brutcher RE, Kurihara C et. al.
Feb 5th, 2019 - The use of compounded topical pain creams has increased dramatically, yet their effectiveness has not been well evaluated. To determine the efficacy of compounded creams for chronic pain. Randomized controlled trials of 3 interventions. (ClinicalTrials.gov: NCT02497066). Military treatment facility. 399 patients with localized pain classified by each patient's treating physician as neuropathic ...
JAMA Pediatrics; Leddy JJ, Haider MN et. al.
Feb 4th, 2019 - Sport-related concussion (SRC) is a significant public health problem without an effective treatment. To assess the effectiveness of subsymptom threshold aerobic exercise vs a placebo-like stretching program prescribed to adolescents in the acute phase of recovery from SRC. This multicenter prospective randomized clinical trial was conducted at university concussion centers. Male and female ado...
JAMA Onland W, Cools F et. al.
Jan 30th, 2019 - Dexamethasone initiated after the first week of life reduces the rate of death or bronchopulmonary dysplasia (BPD) but may cause long-term adverse effects in very preterm infants. Hydrocortisone is increasingly used as an alternative, but evidence supporting its efficacy and safety is lacking. To assess the effect of hydrocortisone initiated between 7 and 14 days after birth on death or BPD in ...
Annals of Internal Medicine; Wussler D, Kozhuharov N et. al.
Jan 29th, 2019 - The MEESSI-AHF (Multiple Estimation of risk based on the Emergency department Spanish Score In patients with AHF) score was developed to predict 30-day mortality in patients presenting with acute heart failure (AHF) to emergency departments (EDs) in Spain. Whether it performs well in other countries is unknown. To externally validate the MEESSI-AHF score in another country. Prospective cohort s...
JAMA Internal Medicine; Stefan MS, Shieh MS et. al.
Jan 28th, 2019 - Although professional society guidelines discourage use of empirical antibiotics in the treatment of asthma exacerbation, high antibiotic prescribing rates have been recorded in the United States and elsewhere. To determine the association of antibiotic treatment with outcomes among patients hospitalized for asthma and treated with corticosteroids. Retrospective cohort study of data of 19 811 a...
Circulation January CT, Wann LS et. al.
Jan 28th, 2019 - 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation.|2019|January CT,Wann LS,Calkins H,Chen LY,Cigarroa JE,|
Annals of Emergency Medicine; Thiruganasambandamoorthy V, Sivilotti MLA et. al.
Jan 25th, 2019 - The prevalence of pulmonary embolism among patients with syncope is understudied. In accordance with a recent study with an exceptionally high pulmonary embolism prevalence, some advocate evaluating all syncope patients for pulmonary embolism, including those with another clear cause for their syncope. We seek to evaluate the pulmonary embolism prevalence among emergency department (ED) patient...
JAMA Psychiatry; Choi KW, Chen CY et. al.
Jan 23rd, 2019 - Increasing evidence shows that physical activity is associated with reduced risk for depression, pointing to a potential modifiable target for prevention. However, the causality and direction of this association are not clear; physical activity may protect against depression, and/or depression may result in decreased physical activity. To examine bidirectional relationships between physical act...
JAMA Zheng SL, Roddick AJ
Jan 23rd, 2019 - The role for aspirin in cardiovascular primary prevention remains controversial, with potential benefits limited by an increased bleeding risk. To assess the association of aspirin use for primary prevention with cardiovascular events and bleeding. PubMed and Embase were searched on Cochrane Library Central Register of Controlled Trials from the earliest available date through November 1, 2018....
PLoS Medicine; Gordon A, Gresh L et. al.
Jan 23rd, 2019 - Zika virus (ZIKV) emerged in northeast Brazil in 2015 and spread rapidly across the Americas, in populations that have been largely exposed to dengue virus (DENV). The impact of prior DENV infection on ZIKV infection outcome remains unclear. To study this potential impact, we analyzed the large 2016 Zika epidemic in Managua, Nicaragua, in a pediatric cohort with well-characterized DENV infectio...
JAMA Neurology; Bourcier R, Goyal M et. al.
Jan 22nd, 2019 - Reperfusion is a key factor for clinical outcome in patients with acute ischemic stroke (AIS) treated with endovascular thrombectomy (EVT) for large-vessel intracranial occlusion. However, data are scarce on the association between the time from onset and reperfusion results. To analyze the rate of reperfusion after EVT started at different intervals after symptom onset in patients with AIS. We...
Annals of Internal Medicine; Jorge A, Wallace ZS et. al.
Jan 22nd, 2019 - Patients with end-stage renal disease (ESRD) due to lupus nephritis (LN) have high rates of premature death. To assess the potential effect on survival of renal transplant among patients with ESRD due to LN (LN-ESRD) in the United States. Nationwide cohort study. United States Renal Data System, the national database of nearly all patients with ESRD. Patients with incident LN-ESRD who were wait...
Circulation Thiruganasambandamoorthy V, Rowe BH et. al.
Jan 21st, 2019 - The optimal duration of cardiac rhythm monitoring following emergency department (ED) presentation for syncope is poorly described. We sought to describe the incidence and time to arrhythmia occurrence to inform decisions regarding duration of monitoring based on ED risk-stratification. We conducted a prospective cohort study enrolled adult (≥ 16 years) patients presenting within 24-hours of sy...
Gastroenterology Mahadevan U, Robinson C et. al.
Jan 19th, 2019 - Inflammatory Bowel Disease in Pregnancy Clinical Care Pathway: A Report From the American Gastroenterological Association IBD Parenthood Project Working Group.|2019|Mahadevan U,Robinson C,Bernasko N,Boland B,Chambers C,|
JAMA Oncology; Ramsey SD, Unger JM et. al.
Jan 17th, 2019 - Universal screening of patients with newly diagnosed cancer for hepatitis B virus (HBV), hepatitis C virus (HCV), and HIV is not routine in oncology practice, and experts disagree about whether universal screening should be performed. To estimate the prevalence of HBV, HCV, and HIV infection among persons with newly diagnosed cancer. Multicenter prospective cohort study of patients with newly d...
JAMA Brown JWL, Coles A et. al.
Jan 16th, 2019 - Within 2 decades of onset, 80% of untreated patients with relapsing-remitting multiple sclerosis (MS) convert to a phase of irreversible disability accrual termed secondary progressive MS. The association between disease-modifying treatments (DMTs), and this conversion has rarely been studied and never using a validated definition. To determine the association between the use, the type of, and ...
JAMA Burt RK, Balabanov R et. al.
Jan 16th, 2019 - Hematopoietic stem cell transplantation (HSCT) represents a potentially useful approach to slow or prevent progressive disability in relapsing-remitting multiple sclerosis (MS). To compare the effect of nonmyeloablative HSCT vs disease-modifying therapy (DMT) on disease progression. Between September 20, 2005, and July 7, 2016, a total of 110 patients with relapsing-remitting MS, at least 2 rel...
JAMA Costello SP, Hughes PA et. al.
Jan 16th, 2019 - High-intensity, aerobically prepared fecal microbiota transplantation (FMT) has demonstrated efficacy in treating active ulcerative colitis (UC). FMT protocols involving anaerobic stool processing methods may enhance microbial viability and allow efficacy with a lower treatment intensity. To assess the efficacy of a short duration of FMT therapy to induce remission in UC using anaerobically pre...
JAMA Internal Medicine; Goodwin JS, Nishi S et. al.
Jan 14th, 2019 - Use of the Shared Decision-Making Visit for Lung Cancer Screening Among Medicare Enrollees.|2019|Goodwin JS,Nishi S,Zhou J,Kuo YF,|