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Visualizing Endoscopy- Generated Aerosols with Laser Light Scattering.
https://doi.org/10.1016/j.gie.2022.07.030
Gastrointestinal Endoscopy; Passi M, Stadnytskyi V et. al.

Aug 7th, 2022 - Upper gastrointestinal (GI) endoscopy is speculated to be an aerosol-generating procedure (AGP). Robust evidence exists for aerosol transmission of SARS-CoV-2. The quality of data available confirming aerosol generation during GI endoscopy is limited. We aimed to objectively demonstrate that GI endoscopy is an AGP and illustrate the mechanism by which the greatest risk for aerosolization of dro...

Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble AC...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273060
PloS One; Shoemaker RH, Panettieri RA et. al.

Jul 12th, 2022 - As ACE2 is the critical SARS-CoV-2 receptor, we hypothesized that aerosol administration of clinical grade soluble human recombinant ACE2 (APN01) will neutralize SARS-CoV-2 in the airways, limit spread of infection in the lung, and mitigate lung damage caused by deregulated signaling in the renin-angiotensin (RAS) and Kinin pathways. Here, after demonstrating in vitro neutralization of SARS-CoV...

The dynamics of SARS-CoV-2 infectivity with changes in aerosol microenvironment.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271203
Proceedings of the National Academy of Sciences of the Un... Oswin HP, Haddrell AE et. al.

Jun 29th, 2022 - Understanding the factors that influence the airborne survival of viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in aerosols is important for identifying routes of transmission and the value of various mitigation strategies for preventing transmission. We present measurements of the stability of SARS-CoV-2 in aerosol droplets (∼5 to 10 µm equilibrated radius) over ...

Variation in Use of High-Flow Nasal Cannula and Noninvasive Ventilation Among Patients ...
https://doi.org/10.4187/respcare.09672
Respiratory Care; Garcia MA, Johnson SW et. al.

Jun 8th, 2022 - The use of high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) for hypoxemic respiratory failure secondary to COVID-19 are recommended by critical-care guidelines; however, apprehension about viral particle aerosolization and patient self-inflicted lung injury may have limited use. We aimed to describe hospital variation in the use and clinical outcomes of HFNC and NIV for the mana...

Swab test in biological fluids as predictor of COVID-19 transmission risk during surger...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964243
BMC Surgery; Fabbri N, Pesce A et. al.

Mar 31st, 2022 - The contamination of body fluids by Severe Acute Respiratory Syndrome Coronavirus 2 during surgery is current matter of debate in the scientific literature concerning CoronaVIrus Disease 2019. Surgical guidelines were published during the first wave of the COVID-19 pandemic and recommended to avoid laparoscopic surgery as much as possible, in fear that the chimney effect of high flow intraperit...

Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821864
The AAPS Journal; Kolli AR, Semren TZ et. al.

Feb 9th, 2022 - In vitro screening for pharmacological activity of existing drugs showed chloroquine and hydroxychloroquine to be effective against severe acute respiratory syndrome coronavirus 2. Oral administration of these compounds to obtain desired pulmonary exposures resulted in dose-limiting systemic toxicity in humans. However, pulmonary drug delivery enables direct and rapid administration to obtain h...

Consensus Statement on Urinary Stone Treatment During a Pandemic: A Delphi Process from...
https://doi.org/10.1089/end.2021.0477
Journal of Endourology; Scotland KB, Tailly T et. al.

Jan 13th, 2022 - Introduction: The novel coronavirus disease (COVID-19) pandemic has had a significant impact on the care of patients with urolithiasis. Recommendations and prioritization of endourologic surgical procedures vary among regions, and a comprehensive overall international directive is needed. We used the Delphi method to obtain international consensus on managing urolithiasis patients during the pa...

Tracheostomy in COVID-19 acute respiratory distress syndrome patients and follow-up: A ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694414
PloS One; Evrard D, Jurcisin I et. al.

Dec 23rd, 2021 - Tracheostomy has been proposed as an option to help organize the healthcare system to face the unprecedented number of patients hospitalized for a COVID-19-related acute respiratory distress syndrome (ARDS) in intensive care units (ICU). It is, however, considered a particularly high-risk procedure for contamination. This paper aims to provide our experience in performing tracheostomies on COVI...

Feasibility of a High-Volume Filter Sampler for Detecting SARS-CoV-2 RNA in COVID-19 Pa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767856
Annals of Work Exposures and Health; Wilson AM, Kaur K et. al.

Nov 19th, 2021 - Aerosolization of SARS-CoV-2 by COVID-19 patients can put healthcare workers and susceptible individuals at risk of infection. Air sampling for SARS-CoV-2 has been conducted in healthcare settings, but methods vary widely and there is need for improvement. The objective of this study was to evaluate the feasibility of using a high-volume filter sampler, BioCapture z720, to detect SARS-CoV-2 in ...

Surfaces and Air Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 Using...
https://doi.org/10.1093/infdis/jiab564
The Journal of Infectious Diseases; Lebreil AL, Greux V et. al.

Nov 18th, 2021 - Understanding patterns of environmental contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for infection prevention policies. We screened surfaces and air samples from single-bed intensive-care unit rooms of adult patients with coronavirus disease 2019 (COVID-19) for SARS-CoV-2 RNA and viable viruses. We evidenced viral RNA environmental contamination in ...

Evaluation of Residual Infectivity after SARS-CoV-2 Aerosol Transmission in a Controlle...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582643
International Journal of Environmental Research and Publi... Zupin L, Licen S et. al.

Nov 14th, 2021 - Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is mainly transmitted through respiratory droplets, aerosols, or direct contact with fomites from an infected subject. It has been reported that SARS-CoV-2 is stable and viable in aerosol up to 16 h in controlled laboratory conditions. However, the aerosolization conditions varied a lot between the studies. In this work, an exper...

Association of Sleep-Related Hypoxia With Risk of COVID-19 Hospitalizations and Mortali...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581726
JAMA Network Open; Pena Orbea C, Wang L et. al.

Nov 11th, 2021 - The influence of sleep-disordered breathing (SDB) and sleep-related hypoxemia in SARS-CoV-2 viral infection and COVID-19 outcomes remains unknown. Controversy exists regarding whether to continue treatment for SDB with positive airway pressure given concern for aerosolization with limited data to inform professional society recommendations. To investigate the association of SDB (identified via ...

A Novel Three-Dimensional Robot Arm Steered Camera for Ear Surgery.
https://doi.org/10.1097/SCS.0000000000007858
The Journal of Craniofacial Surgery; Tekin AM, Saadi MA et. al.

Oct 28th, 2021 - Ear surgery requires magnified imaging of anatomical structures from its beginning to achieve safe and successful surgical outcomes. The historical evolution of magnification in otology has developed from monocular to binocular, and to three-dimensional and even to digital in modern times. Current technological advancements pursue high-quality visualization for the best surgical outcomes but al...

Strategy for Safe Bronchoscopy During the COVID-19 Pandemic.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526119
The Annals of Thoracic Surgery; Lim WY, Ng B et. al.

Oct 23rd, 2021 - Aerosol-generating procedures are avoided for patients with coronavirus disease 2019 (COVID-19) to lower the risk of transmission to health care providers. However, when bronchoscopy is indicated, it remains unclear whether the procedure performed while the patient is under general anesthesia leads to contamination of the surroundings and whether standard endoscopy reprocessing methods are effe...

Objective Assessment of Aerosolization During Transnasal Endoscopy: A Systematic Review.
https://doi.org/10.1177/01945998211050632
Otolaryngology--head and Neck Surgery : Official Journal ... Matos S, Sharma A et. al.

Oct 13th, 2021 - The goal of this systematic review is to assimilate the literature on objective assessment of particulate aerosolization during transnasal endoscopic procedures. PubMed and hand-searched articles. The PubMed electronic database was searched using Medical Subject Headings and free-text search terms relating to aerosolization and transnasal endoscopic procedures from inception to November 16, 202...

Rate of COVID-19 Infection in Patients Following Otolaryngology vs Non-otolaryngology O...
https://doi.org/10.1177/01945998211049702
Otolaryngology--head and Neck Surgery : Official Journal ... Workman AD, Varvares MA et. al.

Sep 29th, 2021 - Routine outpatient otolaryngology visits have been identified as potential vectors for increased transmission of COVID-19 relative to other medical encounters. This is in part due to the inability of patients to mask during comprehensive otolaryngology examination and potential propensity for aerosolization during upper airway procedures, including endoscopy and nasopharyngoscopy. Using a match...

VACuum INtubation (VACcIN) box restricts the exhaled air dispersion generated by simula...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475855
Journal of Clinical Monitoring and Computing; Issa R, Urbanowicz R et. al.

Sep 26th, 2021 - The COVID-19 pandemic has caused personal protective equipment shortages worldwide and required healthcare workers to develop novel ways of protecting themselves. Anesthesiologists in particular are exposed to increased risks of contamination when performing interventions such as airway manipulations. We developed and tested an aerosolization protective device which contains aerosols around the...

Clinical Policies and Procedures for Critical Care Transport during a Respiratory Pande...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503069
Prehospital and Disaster Medicine; Leisten DC, Wheeler J et. al.

Sep 23rd, 2021 - The severe acute respiratory syndrome coronavirus disease-2 (SARS-CoV-2) pandemic of 2020-2021 created unprecedented challenges for clinicians in critical care transport (CCT). These CCT services had to rapidly adjust their clinical approaches to evolving patient demographics, a preponderance of respiratory failure, and transport utilization stratagem. Organizations had to develop and implement...

Aerosolization risk during endoscopic transnasal surgery: a prospective qualitative and...
https://doi.org/10.3171/2021.3.JNS204415
Journal of Neurosurgery; Russo F, Valentini M et. al.

Sep 18th, 2021 - The coronavirus disease 2019 (COVID-19) pandemic represents the greatest public health emergency of this century. The primary mode of viral transmission is droplet transmission through direct contact with large droplets generated during breathing, talking, coughing, and sneezing. However, the virus can also demonstrate airborne transmission through smaller droplets (< 5 μm in diameter) generate...

What is the risk of a deadly adenovirus pandemic?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412336
PLoS Pathogens; Kremer EJ

Sep 3rd, 2021 - Many of us had refresher courses in virology, immunology, and epidemiology in 2020, and we were reminded of the fact that Homo sapiens, the wiliest predator on the planet, has been hunting everything that moves for millennia. These repeated interspecies contacts inherently lead to recurrent zoonosis (nonhuman to human) and anthroponosis (human to nonhuman). Given the accelerating changes in our...