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Management of Post-Infectious Anosmia and Hyposmia: A Systematic Review.
https://doi.org/10.1177/00034894221118186
The Annals of Otology, Rhinology, and Laryngology; Nag AK, Saltagi AK et. al.

Aug 13th, 2022 - Anosmia and hyposmia significantly affect patients' quality of life and have many etiologies, including trauma, inflammatory conditions including chronic rhinosinusitis, neoplasm, and viral infections, such as rhinovirus and SARS-CoV-2. Our purpose was to establish whether a consensus exists regarding optimal management of olfactory dysfunction and to provide insight into the treatment of anosm...

Seroprevalence and longevity of SARS-CoV-2 nucleocapsid antigen-IgG among health care w...
https://doi.org/10.1371/journal.pone.0272818
PloS One; Alasmari F, Mukahal M et. al.

Aug 13th, 2022 - Seroprevalence of SARS-CoV-2 IgG among health care workers (HCWs) is crucial to inform infection control programs. Conflicting reports have emerged on the longevity of SARS-CoV-2 IgG. Our objective is to describe the prevalence of SARS-CoV-2 IgG in HCWs and perform 8 months longitudinal follow-up (FU) to assess the duration of detectable IgG. In addition, we aim to explore the risk factors asso...

Post-COVID-19 neuropsychiatric manifestations among COVID-19 survivors suffering from m...
https://doi.org/10.1186/s10194-022-01468-y
The Journal of Headache and Pain; Magdy R, Elmazny A et. al.

Aug 13th, 2022 - The burden of post-coronavirus disease (COVID)-19 symptoms has been increasing and is of great concern in patients with pre-existing chronic medical conditions.This study aimed to delineate the post-COVID-19 neuropsychiatric symptoms among migraine patients compared to the non-migraine control group. Two groups, each of 204 COVID-19 survivors, were enrolled in the study after 3 months of severe...

Comorbidity of long COVID and psychiatric disorders after a hospitalisation for COVID-1...
https://doi.org/10.1136/jnnp-2021-328516
Journal of Neurology, Neurosurgery, and Psychiatry; Gasnier M, Choucha W et. al.

Aug 12th, 2022 - Long COVID is a major public health issue. Whether long COVID is comorbid with psychiatric disorders remains unclear. Here, we investigate the association between long COVID, psychiatric symptoms and psychiatric disorders. Cross-sectional. Bicêtre Hospital, France, secondary care. One hundred seventy-seven patients admitted in intensive care unit during acute phase and/or reporting long COVID c...

COCOS trial: COrticosteroids for COVID-19-induced loss of Smell-protocol for a single-c...
https://doi.org/10.1136/bmjopen-2021-060416
BMJ Open; Schepens EJA, Boek WM et. al.

Aug 11th, 2022 - Hyposmia and anosmia are common in COVID-19. Most patients regain normal smell within 4 weeks, but severe loss of smell persists roughly in 20% after 2 months and may last up to a year or longer. These persistent smell disorders greatly influence daily life. It is hypothesised that COVID-19 induces inflammation around the olfactory nerve and in the olfactory pathway, leading to smell disorders....

Neurological symptoms and signs associated with COVID-19 in pediatric patients: a singl...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351517
Medicine Sener Okur D

Aug 11th, 2022 - There is insufficient evidence on SARS-CoV-2 induced neurological effects. Studies on CNS involvement during COVID-19 in children are limited. This study aims to identify and manage the neurological signs and symptoms in COVID-19-infected pediatric patients during follow up and plan future follow-ups. Children diagnosed COVID-19 and hospitalized in the pediatric pandemic services, between March...

Post-COVID syndrome: A prospective study in a tertiary hospital of Nepal.
https://doi.org/10.1371/journal.pone.0272636
PloS One; Shah S, Bhattarai SR et. al.

Aug 11th, 2022 - The post-coronavirus disease 2019 (COVID-19) syndrome is defined as the persistence of symptoms after viral clearance and the emergence of new symptoms after a few months following recovery from COVID-19. This study aimed to assess the prevalence of post-COVID-19 syndrome and the risk factors that contribute to its development. This study was conducted prospectively in Tribhuvan University Teac...

Effect of Sodium Gluconate on Decreasing Elevated Nasal Calcium and Improving Olfactory...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364068
American Journal of Rhinology & Allergy; Abdelazim MH, Abdelazim AH

Aug 10th, 2022 - COVID-19 has been associated with temporary olfactory dysfunction in many infected patients. Calcium plays a great role in the olfaction process with negative feedback for the olfaction transmission. Many reports demonstrated calcium elevation in the nasal secretions with a negative effect on olfaction. Sodium gluconate is a water-soluble salt with a chemical structure that lends to act as a hi...

Molecular mechanisms involved in anosmia induced by SARS-CoV-2, with a focus on the tra...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358639
Archives of Virology; Karimian A, Behjati M et. al.

Aug 9th, 2022 - Since 2020, SARS-CoV-2 has caused a pandemic virus that has posed many challenges worldwide. Infection with this virus can result in a number of symptoms, one of which is anosmia. Olfactory dysfunction can be a temporary or long-term viral complication caused by a disorder of the olfactory neuroepithelium. Processes such as inflammation, apoptosis, and neuronal damage are involved in the develo...

Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational coh...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352274
Lancet (London, England); Ballering AV, van Zon SKR et. al.

Aug 8th, 2022 - Patients often report various symptoms after recovery from acute COVID-19. Previous studies on post-COVID-19 condition have not corrected for the prevalence and severity of these common symptoms before COVID-19 and in populations without SARS-CoV-2 infection. We aimed to analyse the nature, prevalence, and severity of long-term symptoms related to COVID-19, while correcting for symptoms present...

Neurological manifestations of SARS-CoV-2 infections: towards quantum dots based manage...
https://doi.org/10.1080/1061186X.2022.2110252
Journal of Drug Targeting; Almasi F, Mohammadipanah F

Aug 4th, 2022 - Developing numerous nanotechnological designed tools to monitor the existence of SARS-CoV-2, and modifying its interactions address the global needs for efficient remedies required for the management of COVID-19. Herein, through a multidisciplinary outlook encompassing different fields such as the pathophysiology of SARS-CoV-2, analysis of symptoms, and statistics of neurological complications ...

Omicron Better at Invading Young Noses Than Other Variants; Smell Loss May Predict Memory Issues
https://www.medscape.com/viewarticle/978454

Aug 3rd, 2022 - (Reuters) -- The following is a summary of some recent studies on COVID-19. They include research that warrants further study to corroborate the findings and that has yet to be certified by peer review. Childrens' Noses Defend Less Well Against Omicron The Omicron variant may be more efficient at infecting children through the nose than previous versions of the coronavirus, a small study sugges...

Modelling of a triage scoring tool for SARS-COV-2 PCR testing in health-care workers: d...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9341161
BMC Infectious Diseases; Hohl HT, Froeschl G et. al.

Aug 2nd, 2022 - Numerous scoring tools have been developed for assessing the probability of SARS-COV-2 test positivity, though few being suitable or adapted for outpatient triage of health care workers. We retrospectively analysed 3069 patient records of health care workers admitted to the COVID-19 Testing Unit of the Ludwig-Maximilians-Universität of Munich between January 27 and September 30, 2020, for real-...

COVID-19 and olfactory dysfunction: a looming wave of dementia?
https://doi.org/10.1152/jn.00255.2022
Journal of Neurophysiology; Kay LM

Jul 28th, 2022 - Olfactory dysfunction is a hallmark symptom of COVID-19 disease resulting from the SARS-CoV-2 virus. The cause of the sudden and usually temporary anosmia that most people suffer from COVID-19 is likely entirely peripheral - inflammation and other damage caused by the virus in the sensory epithelium inside the upper recesses of the nasal cavity can damage or prevent chemicals from properly acti...

SARS-CoV-2 in a tropical area of Colombia, a remarkable conversion of presymptomatic to...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321267
BMC Infectious Diseases; Martínez C, Serrano-Coll H et. al.

Jul 27th, 2022 - The ability of SARS-CoV-2 to remain in asymptomatic individuals facilitates its dissemination and makes its control difficult. To establish a cohort of asymptomatic individuals, change to the symptomatic status, and determine the most frequent clinical manifestations.  METHODS: Between April 9 and August 9, 2020, molecular diagnosis of SARS-CoV-2 infection was confirmed in 154 asymptomatic peop...

Clinical-epidemiological variation in patients treated in the first and second wave of ...
https://doi.org/10.1016/j.ijid.2022.07.045
International Journal of Infectious Diseases : IJID : Off... Valladares-Garrido MJ, Failoc-Rojas VE et. al.

Jul 26th, 2022 - To identify differences in the clinical and epidemiological characteristics of patients seen during the first and second waves of COVID-19 in the EsSalud-Lambayeque health care network, Peru. Analytical cross-sectional study in 53,912 patients attended during the first and second waves of COVID-19. Cluster analysis based on Clustering Large Applications (CLARA) was applied to clinical-epidemiol...

Symptoms and risk factors for long COVID in non-hospitalized adults.
https://doi.org/10.1038/s41591-022-01909-w
Nature Medicine; Subramanian A, Nirantharakumar K et. al.

Jul 26th, 2022 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is associated with a range of persistent symptoms impacting everyday functioning, known as post-COVID-19 condition or long COVID. We undertook a retrospective matched cohort study using a UK-based primary care database, Clinical Practice Research Datalink Aurum, to determine symptoms that are associated with confirmed SARS-C...

Revealing the mystery of persistent smell loss in Long COVID patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305264
International Journal of Biological Sciences; Park JW, Wang X et. al.

Jul 26th, 2022 - COVID-19 is hopefully approaching its end in many countries as herd immunity develops and weaker strains of SARS-CoV-2 dominate. However, a new concern occurs over the long-term effects of COVID-19, collectively called "Long COVID", as some symptoms of the nervous system last even after patients recover from COVID-19. This review focuses on studies of anosmia, i.e., impairment of smell, which i...

Intensive Olfactory Training in Post-COVID-19 Patients: A Multicenter Randomized Clinic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309586
American Journal of Rhinology & Allergy; Pires ÍAT, Steffens ST et. al.

Jul 23rd, 2022 - Olfactory dysfunction (OD)-including anosmia and hyposmia-is a common symptom of COVID-19. Previous studies have identified olfactory training (OT) as an important treatment for postinfectious OD; however, little is known about its benefits and optimizations after SARS-CoV-2 infection. This study aimed to assess whether olfactory training performance can be optimized using more fragrances over ...

Therapeutic Approaches to the Neurologic Manifestations of COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302225
Neurotherapeutics : the Journal of the American Society F... Graham EL, Koralnik IJ et. al.

Jul 22nd, 2022 - As of May 2022, there have been more than 527 million infections with severe acute respiratory disease coronavirus type 2 (SARS-CoV-2) and over 6.2 million deaths from Coronavirus Disease 2019 (COVID-19) worldwide. COVID-19 is a multisystem illness with important neurologic consequences that impact long-term morbidity and mortality. In the acutely ill, the neurologic manifestations of COVID-19 ...