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SARS-CoV-2 Gastrointestinal Shedding in Hospitalized Children.
https://doi.org/10.1542/hpeds.2021-006304
Hospital Pediatrics; Tam I, McNamara C et. al.

Jan 15th, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory virus that can cause gastrointestinal (GI) symptoms, with studies demonstrating detection of stool viral RNA weeks after respiratory tract clearance. It is unknown if children who test negative for SARS-CoV-2 on a nasopharyngeal (NP) swab may be shedding the virus in their stool. To measure the prevalence of SARS-CoV-...

Development and Validation of a Novel At-home Smell Assessment.
https://doi.org/10.1001/jamaoto.2021.3994
JAMA Otolaryngology-- Head & Neck Surgery; Gupta S, Kallogjeri D et. al.

Jan 14th, 2022 - Current tools for diagnosis of olfactory dysfunction (OD) are costly, time-consuming, and often require clinician administration. To develop and validate a simple screening assessment for OD using common household items. This fully virtual diagnostic study included adults with self-reported OD from any cause throughout the US. Data were collected from December 2020 to April 2021 and analyzed fr...

In COVID-19, NLRP3 inflammasome genetic variants are associated with critical disease a...
https://doi.org/10.1038/s41380-021-01431-4 10.1007/s00296-021-04843-1 10.1038/s41577-021-00588-x 10.1161/ATVBAHA.120.314515 10.1038/s41392-021-00679-0 10.1186/s41232-020-00146-3 10.1101/2021.03.06.21252796 10.1084/jem.20202413 10.1084/jem.20201707 10.1038/s41577-019-0165-0 10.1007/s10875-019-00638-z 10.1186/1741-7015-10-66 10.1186/1741-7015-11-64 10.1007/s12035-013-8425-7 10.1186/s12974-016-0539-1 10.2471/BLT.20.257758 10.1016/s0166-4328(01)00297-2 10.2307/41410402 10.1108/EBR-11-2018-0203 10.3390/brainsci10090645 10.5498/wjp.v11.i1.1 10.3389/fimmu.2020.01021 10.3389/fimmu.2020.01518 10.1038/s41467-021-25015-6 10.1038/s41586-020-2588-y 10.3390/cancers12123822 10.1177/0846537120913033 10.1513/AnnalsATS.202005-418FR 10.1038/nrd4422 10.2337/db12-0420 10.2337/db12-1115 10.2147/DMSO.S222053 10.1016/j.gene.2013.07.082 10.3389/fimmu.2013.00050 10.1016/j.metabol.2017.06.002 10.1007/s12020-017-1343-0 10.2174/1389201019666180808162011 10.1038/s41598-020-63469-8 10.3389/fimmu.2020.570251 10.1016/j.cytogfr.2020.08.003 10.3389/fmolb.2021.671363 10.1038/s41586-020-2700-3 10.1038/srep39075 10.1111/imr.12886 10.1515/revneuro.1993.4.4.407 10.1093/ajcn/42.6.1179 10.1186/s10194-021-01306-7 10.1016/s0149-7634(88)80004-6 10.1111/bph.15189 10.1128/iai.28.3.771-776.1980 10.1177/0885066619889322 10.1007/s11011-019-00403-6 10.1089/jir.2012.0031 10.3389/fimmu.2019.01426 10.3389/fimmu.2021.708149 10.3389/fimmu.2020.607734 10.14336/AD.2020.0601 10.3389/fragi.2020.602108 10.1038/nri.2016.90
Molecular Psychiatry; Maes M, Tedesco Junior WLD et. al.

Jan 14th, 2022 - In coronavirus disease (COVID-19), the nucleotide-binding domain, leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome is activated in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Acute infections are accompanied by a sickness symptom complex (SSC) which is highly conserved and protects against infections and hyperinflammation. Th...

Perception, Prevalence, and Prediction of Severe Infection and Post-acute Sequelae of C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743283
The American Journal of the Medical Sciences; Knight DRT, Munipalli B et. al.

Jan 13th, 2022 - The aim of the study was to assess, characterize, and describe the prevalence and predicting factors of patient-reported severe coronavirus disease 2019 (COVID-19) infection and post-acute sequelae of COVID-19 (PASC). We prospectively surveyed patients who received care in our outpatient clinic for COVID-19 from March 13, 2020, through August 17, 2020, and then retrospectively reviewed their el...

Morbidity, Clinical Course and Vaccination against SARS-CoV-2 Virus in Patients with Du...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744807
International Journal of Environmental Research and Publi... Wasilewska E, Sobierajska-Rek A et. al.

Jan 12th, 2022 - Background: Patients with Duchenne muscular dystrophy (DMD) may be at higher risk of a severe course of COVID-19. The aim of the study was to evaluate: (1) the incidence and course of COVID-19 infection in DMD patients; (2) the vaccination status of DMD patients; and (3) COVID-19 related anxiety among DMD families. Materials and Methods: The study was conducted during an online symposium for DM...

Therapeutic Status of Famotidine in COVID-19 Patients: A Review.
https://doi.org/10.2174/1871526522666220107125511
Infectious Disorders Drug Targets; Mohseni M, Raissi V et. al.

Jan 8th, 2022 - The novel coronavirus, SARS-coV-2, which emerged in Wuhan in November 2019, has increasingly spread worldwide. More than 272 million cases of infection have been identified. COVID-19 affects 223 countries and territories across the world. The principal target of the SARS-CoV-2 infection is the lower respiratory tract. Series of moderate to non-specific severe clinical signs and symptoms that ap...

Symptoms COVID 19 Positive Vapers Compared to COVID 19 Positive Non-vapers.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744181
Journal of Primary Care & Community Health; McFadden DD, Bornstein SL et. al.

Jan 7th, 2022 - The purpose of the present study was to assess and describe the severity of symptoms reported by Covid-19 positive patients who vaped (smoked e-cigarettes) when compared to those who did not vape or smoke at the time of the diagnosis of Covid-19. Patients from this study are from a well-characterized patient cohort collected at Mayo Clinic between March 1, 2020 and February 28, 2021; with confi...

Serum Sodium, Patient Symptoms, and Clinical Outcomes in Hospitalized Patients with COV...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744185
Journal of Primary Care & Community Health; Yen TE, Kim A et. al.

Jan 7th, 2022 - Disorders of serum sodium (SNa) are common in hospitalized patients with COVID-19 and may reflect underlying disease severity. However, the association of SNa with patient-reported outcomes is not clear. The Brigham and Women's Hospital COVID-19 Registry is a prospective cohort study of consecutively admitted adult patients with confirmed SARS-CoV-2 infection (n = 809). We examined the associat...

Taste Dysfunction May Linger After COVID-19
https://www.medpagetoday.com/infectiousdisease/covid19/96549

Jan 6th, 2022 - Taste dysfunction may linger after acute COVID-19 infection and may not necessarily be a consequence of olfactory dysfunction, a cross-sectional study in Italy showed. In a group of people who reported losing their sense of taste for months after they had COVID, 42% were found to have true hypogeusia, reported Paolo Boscolo-Rizzo, MD, of the University of Trieste in Italy, and co-authors. Most ...

Healthcare Workers 'Most Likely to Report Long COVID Symptoms'
https://www.medscape.com/viewarticle/966151

Jan 6th, 2022 - Health and social care staff are in the top three most likely employment groups to report symptoms of long COVID, new data suggests. More than 1.2 million people in the UK were estimated to have symptoms of long COVID in the 4 weeks up until December 6, 2021, according to figures from the Office for National Statistics (ONS). That represents a 4.7% increase since the last analysis for October, ...

Coronavirus Disease 2019 (COVID-19) in Children
https://emedicine.medscape.com/article/2500132-overview

Jan 6th, 2022 - Practice Essentials Coronavirus disease 2019 (COVID-19) is an illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In the United States and throughout the world, fewer cases of COVID-19 have been reported in children than in adults. Whereas children comprise about 22% of the US population, more than 17% of all cases of COVID-19 reported to the Centers for Disease Cont...

Coronavirus Disease 2019 (COVID-19) in Children
https://emedicine.medscape.com/article/2500132-print

Jan 6th, 2022 - Coronavirus disease 2019 (COVID-19) is an illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In the United States and throughout the world, fewer cases of COVID-19 have been reported in children than in adults. Whereas children comprise about 22% of the US population, more than 17% of all cases of COVID-19 reported to the Centers for Disease Control and Prevention (...

Coronavirus Disease 2019 (COVID-19) in Children
http://emedicine.medscape.com/article/2500132-overview

Jan 6th, 2022 - Practice Essentials Coronavirus disease 2019 (COVID-19) is an illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In the United States and throughout the world, fewer cases of COVID-19 have been reported in children than in adults. Whereas children comprise about 22% of the US population, more than 17% of all cases of COVID-19 reported to the Centers for Disease Cont...

Covid-19: pharmacotherapeutic insights on various curative approaches in terms of vulne...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722419
Inflammopharmacology Kaur R, Singh S et. al.

Jan 5th, 2022 - A novel coronavirus disease (COVID-19), caused by a severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), was discovered in Wuhan, China, in December 2019, and the world has suffered from a pandemic. As of 22nd March 2020, at least 185 countries worldwide had been affected by COVID-19. SARS-CoV-2, leading to COVID-19 pneumonia, infects cells through ACE-2 receptors. The disease has diff...

Headache, anosmia, ageusia and other neurological symptoms in COVID-19: a cross-section...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721484
The Journal of Headache and Pain; Sampaio Rocha-Filho PA, Albuquerque PM et. al.

Jan 5th, 2022 - Neurological symptoms are frequent among patients with COVID-19. Little is known regarding the repercussions of neurological symptoms for patients and how these symptoms are related to one another. To determine whether there is an association between the neurological symptoms in patients with COVID-19, and to characterize the headache. This was a cross-sectional study. All hospital inpatients a...

Using artificial intelligence-based models to predict the risk of mucormycosis among CO...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694789
The Journal of Infection; Syed-Abdul S, Babu AS et. al.

Dec 27th, 2021 - India reported a severe public health challenge not only due to the COVID-19 outbreak but also the increasing number of associated mucormycosis cases since 2021.This study aimed at developing artificial intelligence based models to predict the risk of mucormycosis among the patients at the time of discharge from hospital. The dataset included of 1229 COVID-19 positive patients, and additional 2...

Epidemiological characteristics of COVID-19 travel-associated cases in Vojvodina, Serbi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699980
PloS One; Pustahija T, Ristić M et. al.

Dec 24th, 2021 - Coronavirus disease 2019 (COVID-19) is currently the biggest public health problem worldwide. Intensive international travel and tourism have greatly contributed to its rapid global spreading. This study is the first comprehensive analysis of the epidemiological characteristics and clinical outcomes of the travel-associated COVID-19 cases in Vojvodina, Serbia, from March 6 to December 31, 2020 ...

Stellate ganglion block reduces symptoms of Long COVID: A case series.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653406
Journal of Neuroimmunology; Liu LD, Duricka DL

Dec 19th, 2021 - After recovering from COVID-19, a significant proportion of symptomatic and asymptomatic individuals develop Long COVID. Fatigue, orthostatic intolerance, brain fog, anosmia, and ageusia/dysgeusia in Long COVID resemble "sickness behavior," the autonomic nervous system response to pro-inflammatory cytokines (Dantzer et al., 2008). Aberrant network adaptation to sympathetic/parasympathetic imbal...

Long-Term Follow up of Renal and Other Acute Organ Failure in Survivors of Critical Ill...
https://doi.org/10.1177/08850666211062582
Journal of Intensive Care Medicine; Chand S, Kapoor S et. al.

Dec 18th, 2021 - Little is known about the long-term health sequelae and outcomes of various organ failures in ICU survivors of Covid-19. The aim of our research was to study the characteristics of 120-day ICU survivors of the initial pandemic surge and report their long term (>6 months) outcomes. We conducted a telephone questionnaire-based follow up study of 120- day survivors of Covid-19 admitted to ICUs at ...

Symptoms and management of long COVID: A scoping review.
https://doi.org/10.1111/jocn.16150
Journal of Clinical Nursing; Cha C, Baek G

Dec 17th, 2021 - This scoping review aims to describe published work on the symptoms and management of long COVID conditions. Symptoms and management of COVID-19 have focused on the acute stage. However, long-term consequences have also been observed. A scoping review was performed based on the framework suggested by Arksey and O'Malley. We conducted a literature search to retrieve articles published from May 2...