Mar 18th, 2023 - To analyse objective and subjective olfactory / gustatory function in post COVID-19 infection (PCI). Patients with past PCR-confirmed COVID-19 infection and persistent olfactory/gustatory complaints were investigated. Olfactory threshold and identification, gustatory detection, identification and magnitude scaling were tested. 42 PCI subjects were compared to 41 age- and gender-matched controls...

Mar 16th, 2023 - This study aimed to assess the utility of DTI in the detection of olfactory bulb dysfunction in COVID-19-related anosmia. It was performed in 62 patients with COVID-19-related anosmia and 23 controls. The mean diffusivity and fractional anisotropy were calculated by 2 readers. The difference between the fractional anisotropy and mean diffusivity values of anosmic and control olfactory bulbs was...

Feb 14th, 2023 - The hypothesis that long COVID might be related to a functional neurological disorder (FND) remains untested, a systematic review showed. Across 102 long COVID studies, neurologic symptoms were insufficiently characterized to support or refute a diagnosis of FND, reported Tiago Teodoro, MD, PhD, of St. George's Hospital in London, and colleagues. Given the characteristics of the disorder, some ...

Feb 13th, 2023 - This is a Brighton Collaboration case definition of anosmia to be used in the evaluation of adverse events following immunization, and for epidemiologic studies for the assessment of background incidence or hypothesis testing. The case definition was developed by a group of experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) in the context of active development of SAR...

Feb 11th, 2023 - COVID-19 is a contagious infection caused by the SARS-CoV-2 virus, responsible for more than 5 million deaths worldwide, and has been a significant challenge for healthcare systems worldwide. Characterized by multiple manifestations, the most common symptoms are fever, cough, anosmia, ageusia, and myalgia. However, several organs can be affected in more severe cases, causing encephalitis, myoca...

Feb 10th, 2023 - The vast majority of covid-19 patients experience non-severe disease. Nonetheless, long-term symptoms may be common and the impact on quality of life is uncertain. This study aims to examine these aspects in a prospective, longitudinal cohort. Non-hospitalised patients with PCR-confirmed covid-19 were prospectively invited to self-report assessments of background data, symptoms and recovery, il...

Feb 8th, 2023 - The primary target of severe acute respiratory syndrome coronavirus 2 is the respiratory system including the nose and lungs, however, it can also damage the kidneys, cardiovascular system and gastrointestinal system. Many recent reports suggested that severe acute respiratory syndrome coronavirus 2 infections can also affect the central nervous system as well as peripheral nervous system that ...

Feb 5th, 2023 - Deficits in motivational functioning including impairments in reward learning or reward sensitivity are common in psychiatric disorders characterized by anhedonia. Recently, anhedonic symptoms have been exacerbated by the pandemic caused by the Coronavirus disease 2019 (COVID-19) in the general population. The present study examined the putative associations between loss of smell (anosmia) and ...

Feb 1st, 2023 - Clinical manifestations of human coronavirus (HCoV)-related diseases are mostly related to the respiratory system, although secondary complications such as headache, anosmia, ageusia, and myalgia have been reported. HCoV infection and replication in chemosensory cells associated with ageusia and anosmia is poorly understood. Here, we characterized HCoV-OC43 and SARS-CoV-2 infection in two types...

Jan 26th, 2023 - To assess long-term clinical, radiological, and functional follow-up of patients hospitalized for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pneumonia of different grades of severity. Two-hundred-thirty and three patients (Group 1, patients needed invasive mechanical ventilation, n = 69; Group 2, patients needed noninvasive mechanical ventilation, n = 78; Group 3, patients nee...

Jan 24th, 2023 - Amelioration of olfactory and gustatory dysfunction (OGD) disorders has become a common requirement due to COVID-19. Although it's hardly exclusive to COVID-19, OGD's prevalence requires exploration of therapeutic and restorative modalities, on the broadest scale possible. No specific medication or treatment of any noteworthy efficacy exists for OGD. As Part 1 of a three-part article, a narrati...

Jan 23rd, 2023 - With the COVID-19 pandemic, there is growing interest and research in olfactory and gustatory dysfunction (OGD). Drug-induced dysfunction is an often overlooked etiology. While several medications include smell or taste disturbance as a side effect, there are no publications describing which medications are most frequently implicated. We aim to describe the patterns of these adverse drug reacti...

Jan 22nd, 2023 - The coronavirus disease 2019 (COVID-19) pandemic has changed the course of human history and killed millions of people worldwide. Its long-term consequences remain uncertain. This study aimed to describe the short- and long-term symptoms of COVID-19 among individuals in Goiás, central Brazil, who experienced acute mild or non-symptomatic SARS-CoV-2 infection during the first wave of the pandemi...

Jan 17th, 2023 - Practice Essentials Coronavirus disease 2019 (COVID-19) is an illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In the United States and throughout the world, fewer cases of COVID-19 have been reported in children than in adults. Whereas children comprise slightly over 22% of the US population, 17.2% of all cases of COVID-19 reported to the Centers for Disease Cont...

Jan 17th, 2023 - Coronavirus disease 2019 (COVID-19) is an illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In the United States and throughout the world, fewer cases of COVID-19 have been reported in children than in adults. Whereas children comprise slightly over 22% of the US population, 17.2% of all cases of COVID-19 reported to the Centers for Disease Control and Prevention (...

Jan 17th, 2023 - Practice Essentials Coronavirus disease 2019 (COVID-19) is an illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In the United States and throughout the world, fewer cases of COVID-19 have been reported in children than in adults. Whereas children comprise slightly over 22% of the US population, 17.2% of all cases of COVID-19 reported to the Centers for Disease Cont...

Jan 14th, 2023 - Neurological manifestations in patients with COVID-19 have been reported previously as outcomes of the infection. The purpose of current study was to investigate the occurrence of neurological signs and symptoms in COVID-19 patients, in the county of Östergötland in southeastern Sweden. This is a retrospective, observational cohort study. Data were collected between March 2020 and June 2020. In...

Jan 12th, 2023 - Many health outcomes of people who developed long COVID after mild acute SARS-CoV-2 infection resolved 1 year later, an analysis of electronic health records from an Israeli healthcare organization suggested. The risk for most outcomes appeared to decrease between early (30-180 days) and late (180-360 days) time periods after infection, reported Barak Mizrahi, MSc, a computational researcher at...

Jan 12th, 2023 - Long COVID is typically characterized by anosmia and dysgeusia, cognitive impairment, dyspnea, weakness, and palpitations, with younger patients showing greatest improvements at 1 year, according to a nationwide cohort study conducted in Israel. These findings help define long COVID, guiding providers and patients through the recovery process, Barak Mizrahi, MSc, of KI Research Institute, Kfar.

Jan 12th, 2023 - To determine the clinical sequelae of long covid for a year after infection in patients with mild disease and to evaluate its association with age, sex, SARS-CoV-2 variants, and vaccination status. Retrospective nationwide cohort study. Electronic medical records from an Israeli nationwide healthcare organisation. 1 913 234 Maccabi Healthcare Services members of all ages who did a polymerase ch...