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Patterns and clinical outcomes of olfactory and gustatory disorders in six months: Pros...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481118
American Journal of Otolaryngology; Teaima AA, Salem OM et. al.

Oct 10th, 2021 - This study aims to comprehensively evaluate olfactory and gustatory dysfunctions during the COVID-19 pandemic regarding onset, course, associated symptoms, prognosis and relation to patients' demographics, treatment received and other symptoms. This is a prospective study conducted on patients proven to be infected with COVID-19 and with olfactory/gustatory dysfunction symptoms. Detailed histor...

Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
https://doi.org/10.1212/CON.0000000000000992 10.1159/000453066 10.1056/NEJMoa2002032 10.1016/j.jinf.2020.02.018 10.1016/j.ijid.2020.04.086 10.1212/WNL.0000000000010979 10.1007/s00405-020-05965-1 10.1016/j.cmi.2020.05.017 10.1126/sciadv.abc5801 10.1212/WNL.0000000000010806 10.1212/WNL.0000000000009850 10.1002/acn3.51210 10.1148/radiol.2020202040 10.1186/s13054-020-03200-1 10.1016/j.ijid.2020.03.062 10.1016/j.bbi.2020.05.012 10.1111/epi.16612 10.1111/bpa.12889 10.1056/NEJMc2019373 10.1111/nan.12662 10.1016/S1474-4422(20)30308-2 10.1016/j.jneuroim.2020.577326 10.1148/radiol.2020201187 10.1212/NXI.0000000000000789 10.12659/AJCR.925641 10.1212/WNL.0000000000010250 10.1111/ene.14491 10.1007/s00415-020-09951-9 10.1093/brain/awaa240 10.1101/2020.04.16.20068148 10.1212/NXI.0000000000000797 10.4103/0028-3886.299174 10.1590/0004-282X20200186 10.1136/bcr-2020-239597 10.1007/s00401-020-02166-2 10.2217/fca-2020-0082 10.1590/0004-282X20190162 10.1056/NEJMc2033369 10.1128/JVI.00404-18 10.1136/svn-2020-000431 10.1056/NEJMcp2009575 10.1016/j.jstrokecerebrovasdis.2020.105434 10.1212/WNL.0000000000010537 10.1161/STROKEAHA.120.030940 10.1101/2020.07.21.20159376 10.1177/1971400921988925 10.3389/fneur.2020.610648 10.1111/jth.14849 10.1007/s00059-020-04909-z 10.1093/eurheartj/ehaa288 10.1016/j.jstrokecerebrovasdis.2020.105016 10.1126/scitranslmed.abd3876 10.1016/j.tins.2020.10.009 10.1016/j.bbi.2020.07.007 10.1007/s13760-020-01497-x 10.1007/s00415-020-09934-w 10.1007/s00415-020-09997-9 10.1016/j.pediatrneurol.2020.07.017 10.1007/s00415-020-10145-6 10.1259/bjrcr.20200098 10.1056/NEJMc2009191 10.1007/s00415-020-10124-x 10.1212/WNL.0000000000009700 10.1212/WNL.0000000000009619 10.1002/mus.27003 10.3174/ajnr.A6711 10.1002/mus.27105 10.3201/eid2607.200445 10.7759/cureus.10686 10.1212/WNL.0000000000010640 10.1136/thoraxjnl-2020-215818 10.1111/andr.12839 10.1007/s15010-020-01524-2 10.3855/jidc.13224 10.1002/jmv.26169 10.1038/s41586-021-03207-w 10.1001/jamaneurol.2020.2687 10.1002/ana.26065 10.1038/d41586-020-02706-6 10.1001/jama.2021.7517 10.1056/NEJMoa2105385 10.1212/WNL.0000000000009520
Continuum (Minneapolis, Minn.); Nath A

Oct 9th, 2021 - This article describes the spectrum of neurologic complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, their underlying pathology and pathogenic mechanisms, gaps in knowledge, and current therapeutic strategies. COVID-19 is the clinical syndrome caused by the novel coronavirus SARS-CoV-2. It can affect the entire neuraxis, and presentations in th...

New Data Shed Light on COVID-19's Debilitating Second Act
https://www.medscape.com/viewarticle/960271

Oct 6th, 2021 - NEW YORK (Reuters Health) - A large review of electronic health records by Boston-based researchers has revealed 33 phenotypes that are indicative of long COVID-19 among people who contracted the virus but did not need hospital care. Many of the phenotypes - such as alopecia, anosmia, fatigue, shortness of breath and chest pain - have been well documented as signs and symptoms of post-acute seq...

Neuropsychiatric manifestations of COVID-19, potential neurotropic mechanisms, and ther...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482959
Translational Psychiatry; Han Y, Yuan K et. al.

Oct 2nd, 2021 - The coronavirus disease 2019 (COVID-19) pandemic has caused large-scale economic and social losses and worldwide deaths. Although most COVID-19 patients have initially complained of respiratory insufficiency, the presence of neuropsychiatric manifestations is also reported frequently, ranging from headache, hyposmia/anosmia, and neuromuscular dysfunction to stroke, seizure, encephalopathy, alte...

COVID-19 and anosmia: The story so far.
https://doi.org/10.1177/01455613211048998
Ear, Nose, & Throat Journal; Meng X, Pan Y

Oct 1st, 2021 - The pandemic has affected over 182 million coronavirus disease 2019 (COVID-19) cases worldwide. Accumulated evidence indicates that anosmia is one of the significant characteristics of COVID-19 with a high prevalence. However, many aspects of COVID-19-induced anosmia are still far from being fully understood. The purpose of this review is to summarize recent developments in COVID-19-induced ano...

Secondary household transmission of SARS-CoV-2 among children and adolescents: Clinical...
https://doi.org/10.1002/ppul.25711
Pediatric Pulmonology; Afonso ET, Marques SM et. al.

Oct 1st, 2021 - To evaluate the secondary attack rate (SAR) in children and adolescents, contacts of essential activities workers who were infected by SARS-CoV-2; and to describe associated clinical and epidemiological data. A cross-sectional study conducted in children and adolescents aged 5 to 19 years of age, that were household contacts of parents and other relatives who were infected by SARS-CoV-2 in the ...

Myasthenia gravis and covid-19 in pregnancy: a review of the literature and case series...
https://doi.org/10.1080/14767058.2021.1973418
The Journal of Maternal-fetal & Neonatal Medicine : the O... Neykova KK, Milanova M et. al.

Sep 29th, 2021 - The aim of our study was to investigate the interrelations of symptoms, clinical outcomes and treatment regimens in pregnant women, diagnosed with myasthenia gravis and superimposed COVID-19 infection. We conducted an observational retrospective study between August, 2020 and July, 2021. Five patients with preexisting MG and superimposed COVID- infection were included in our study. We investiga...

Longitudinal Analysis of Inflammatory Response to SARS-CoV-2 in the Upper Respiratory T...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476983
Journal of Clinical Immunology; Vu DL, Martinez-Murillo P et. al.

Sep 29th, 2021 - SARS-CoV-2 infection leads to high viral loads in the upper respiratory tract that may be determinant in virus dissemination. The extent of intranasal antiviral response in relation to symptoms is unknown. Understanding how local innate responses control virus is key in the development of therapeutic approaches. SARS-CoV-2-infected patients were enrolled in an observational study conducted at t...

Vitamin A Nasal Drops Trialled for COVID-19 Anosmia
https://www.medscape.com/viewarticle/959757

Sep 29th, 2021 - A new study will consider whether vitamin A can help those who have lost their sense of smell after having COVID-19. The 12-week Apollo trial will treat people who have experienced smell loss or an altered sense of smell as a result of viral infections with nasal drops containing the vitamin, the University of East Anglia (UEA) said in a statement. The university said research from Germany had ...

Evolving phenotypes of non-hospitalized patients that indicate long COVID.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474909
BMC Medicine; Estiri H, Strasser ZH et. al.

Sep 28th, 2021 - For some SARS-CoV-2 survivors, recovery from the acute phase of the infection has been grueling with lingering effects. Many of the symptoms characterized as the post-acute sequelae of COVID-19 (PASC) could have multiple causes or are similarly seen in non-COVID patients. Accurate identification of PASC phenotypes will be important to guide future research and help the healthcare system focus i...

Quantitative Analysis of the Olfactory System in COVID-19: An MR Imaging Study.
https://doi.org/10.3174/ajnr.A7278
AJNR. American Journal of Neuroradiology; Altunisik E, Baykan AH et. al.

Sep 25th, 2021 - Anosmia or hyposmia, often accompanied by changes in taste, is recognized as a common symptom that can assist in the diagnosis of coronavirus disease 2019 (COVID-19). The pathogenesis of olfactory dysfunction in COVID-19 is not yet fully understood. MR imaging represents a useful anatomic imaging method for the evaluation of olfactory dysfunction associated with varying etiologies, including vi...

Altered smell and taste: Anosmia, parosmia and the impact of long Covid-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462678
PloS One; Burges Watson DL, Campbell M et. al.

Sep 25th, 2021 - Qualitative olfactory (smell) dysfunctions are a common side effect of post-viral illness and known to impact quality of life and health status. Evidence is emerging that taste and smell loss are common symptoms of Covid-19 that may emerge and persist long after initial infection. The aim of the present study was to document the impact of post Covid-19 alterations to taste and smell. We conduct...

Is Early COVID-19 in Kidney Transplant Recipients Concerning Enough to Halt Transplanta...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403672
Transplantation Proceedings; Meshram HS, Kute VB et. al.

Sep 25th, 2021 - Limited data exist on the incidence and outcome of early coronavirus disease 2019 (COVID-19) in kidney transplantation recipients (KTR). A retrospective multicenter research study was conducted across 12 centers in India. We explored the symptomatology, demographic, laboratory findings, and outcome of COVID-19 within 30 days of transplantation. The outcome was compared with the overall KTR and ...

A Systematic Review of Imaging Studies in Olfactory Dysfunction Secondary to COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403662
Academic Radiology; Keshavarz P, Haseli S et. al.

Sep 23rd, 2021 - Hyposmia/anosmia is common among patients with coronavirus disease-2019 (COVID-19). Various imaging modalities have been used to assess olfactory dysfunction in COVID-19. In this systematic review, we sought to categorize and summarize the imaging data in COVID-19-induced anosmia. Eligible articles were included after a comprehensive review using online databases including Google scholar, Scopu...

French General Practitioners Frequently See Patients with Long-COVID.
https://doi.org/10.3122/jabfm.2021.05.210142
Journal of the American Board of Family Medicine : JABFM; Davin-Casalena B, Lutaud R et. al.

Sep 19th, 2021 - A second epidemic has appeared among some patients infected with COVID-19 persistent disorders, commonly called "long COVID syndrome." Our study sought to identify the proportion of French GPs dealing with patients with potential long COVID syndrome and their symptoms in an online cross-sectional questionnaire-based survey among a representative national panel of GPs. The majority (53.8%) repor...

Electrophysiological and olfactometric evaluation of long-term COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449286
Physiological Reports; Mazzatenta A, Montagnini C et. al.

Sep 19th, 2021 - COVID-19 is a public health emergency with cases increasing globally. Its clinical manifestations range from asymptomatic and acute respiratory disease to multiple organ dysfunction syndromes and effects of COVID-19 in the long term. Interestingly, regardless of variant, all COVID-19 share impairment of the sense of smell and taste. We would like to report, as far as we know, the first comprehe...

COVID-Q: Validation of the first COVID-19 questionnaire based on patient-rated symptom ...
https://doi.org/10.1111/ijcp.14829
International Journal of Clinical Practice; Spinato G, Fabbris C et. al.

Sep 13th, 2021 - The aim of the present study was to develop and validate the CoronaVirus-Disease-2019 (COVID-19) Questionnaire (COVID-Q), a novel symptom questionnaire specific for COVID-19 patients, to provide a comprehensive evaluation that may be helpful for physicians, and evaluate the questionnaire's performance in identifying subjects at higher risk of testing positive. Consecutive non-hospitalised adult...

Assessment of balance after recovery from Covid-19 disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405449
Auris, Nasus, Larynx; Yılmaz O, Mutlu BÖ et. al.

Sep 11th, 2021 - To answer the question whether balance related systems have been affected in adults who recovered from Covid-19 disease. This is the first case-control study to assess balance objectively and quantitatively in Covid-19 disease. Thirty-seven patients who recovered from Covid-19 disease and 30 healthy controls were compared using Dizziness Handicap Inventory (DHI), Computerized Dynamic Posturogra...

COVID-19 Screening by Anti-SARS-CoV-2 Antibody Seropositivity: Clinical and Epidemiolog...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431502
International Journal of Environmental Research and Publi... Macedo-Ojeda G, Muñoz-Valle JF et. al.

Sep 11th, 2021 - Developing countries have reported lower molecular diagnostic testing levels due to a lack of resources. Therefore, antibody tests represent an alternative to detect exposure to SARS-CoV-2 and analyze possible risk factors. We aimed to describe and compare the clinical-epidemiological characteristics and the quality of food intake in Mexican individuals with a positive or negative test to antib...

Practical Considerations for Identifying and Managing ILD in Breast Cancer
https://www.onclive.com/view/practical-considerations-for-identifying-and-managing-ild-in-breast-cancer

Sep 8th, 2021 - Mark D. Pegram, MD: In the case of trastuzumab deruxtecan, which is the drug most likely to be associated with ILD [interstitial lung disease] among the drugs that we use for HER2-positive metastatic breast cancer, the all-grade incidence is around 15% in the DESTINY-Breast01 registrational trial that won FDA approval. That’s the latest data sweep from mid-2020. Of those, however, there were 2....