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Humoral responses after inactivated COVID-19 vaccination in individuals with and withou...
https://doi.org/10.1002/jmv.28055
Journal of Medical Virology; Jia M, Wang X et. al.

Aug 10th, 2022 - We evaluated and compared humoral immune responses after inactivated COVID-19 vaccination among naïve individuals, asymptomatically infected individuals, and recovered patients with varying severity. In this multicenter, prospective cohort study, blood samples from 666 participants were collected before and after two doses of inactivated COVID-19 vaccination. Among 392 SARS-CoV-2-naïve individu...

Male reproductive health after 3 months from SARS-CoV-2 infection: a multicentric study.
https://doi.org/10.1007/s40618-022-01887-3
Journal of Endocrinological Investigation; Paoli D, Pallotti F et. al.

Aug 10th, 2022 - While SARS-CoV-2 infection appears not to be clinically evident in the testes, indirect inflammatory effects and fever may impair testicular function. To date, few long-term data of semen parameters impairment after recovery and comprehensive andrological evaluation of recovered patients has been published. The purpose of this study was to investigate whether SARS-CoV-2 infection affect male re...

The spike receptor-binding motif G496S substitution determines the replication fitness ...
https://doi.org/10.1080/22221751.2022.2111977
Emerging Microbes & Infections; Liang R, Ye ZW et. al.

Aug 10th, 2022 - AbstractThe replication and pathogenicity of SARS-CoV-2 Omicron BA.2 is comparable to that of BA.1 in experimental animal models. However, BA.2 has rapidly emerged to overtake BA.1 to become the predominant circulating SARS-CoV-2 variant worldwide. Here, we compared the replication fitness of BA.1 and BA.2 in cell culture and in the Syrian hamster model of COVID-19. Using a reverse genetics app...

Plasma metabolome and cytokine profile reveal glycylproline modulating antibody fading ...
https://doi.org/10.1073/pnas.2117089119
Proceedings of the National Academy of Sciences of the Un... Yang Z, Wu D et. al.

Aug 10th, 2022 - The COVID-19 pandemic has incurred tremendous costs worldwide and is still threatening public health in the "new normal." The association between neutralizing antibody levels and metabolic alterations in convalescent patients with COVID-19 is still poorly understood. In the present work, we conducted absolutely quantitative profiling to compare the plasma cytokines and metabolome of ordinary co...

SARS-CoV-2 Spike Protein Vaccine-Induced Immune Imprinting Reduces Nucleocapsid Protein...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355782
Journal of Immunology Research; Delgado JF, Vidal-Pla M et. al.

Aug 9th, 2022 - Immune imprinting or original antigenic sin (OAS) is the process by which the humoral memory response to an antigen can inhibit the response to new epitopes of that antigen originating from a second encounter with the pathogen. Given the situation of the COVID-19 pandemic, multiple vaccines have been developed against SARS-CoV-2 infection. These vaccines are directed to the spike protein (S pro...

Exosomal Vaccine Loading T Cell Epitope Peptides of SARS-CoV-2 Induces Robust CD8+ T Ce...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346304
International Journal of Nanomedicine; Shen AR, Jin XX et. al.

Aug 9th, 2022 - Current vaccines for the SARS-CoV-2 virus mainly induce neutralizing antibodies but overlook the T cell responses. This study aims to generate an exosomal vaccine carrying T cell epitope peptides of SARS-CoV-2 for the induction of CD8+ T cell response. Thirty-one peptides presented by HLA-A0201 molecule were conjugated to the DMPE-PEG-NHS molecules, and mixed with DSPE-PEG to form the peptide-P...

IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SAR...
https://doi.org/10.1084/jem.20220849
The Journal of Experimental Medicine; Hale M, Netland J et. al.

Aug 9th, 2022 - Humoral immunity to SARS-CoV-2 can be supplemented with polyclonal sera from convalescent donors or an engineered monoclonal antibody (mAb) product. While pentameric IgM antibodies are responsible for much of convalescent sera's neutralizing capacity, all available mAbs are based on the monomeric IgG antibody subtype. We now show that IgM mAbs derived from immune memory B cell receptors are pot...

Comparison of Persistent Symptoms Following SARS-CoV-2 Infection by Antibody Status in ...
https://doi.org/10.1097/INF.0000000000003653
The Pediatric Infectious Disease Journal; Messiah SE, Hao T et. al.

Aug 9th, 2022 - The prevalence of long-term symptoms of coronavirus disease 2019 (COVID-19) in nonhospitalized pediatric populations in the United States is not well described. The objective of this analysis was to examine the presence of persistent COVID symptoms in children by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody status. Data were collected between October 2020 and May 2022 f...

New-onset dermatomyositis following SARS-CoV-2 infection and vaccination: a case-based ...
https://doi.org/10.1007/s00296-022-05176-3
Rheumatology International; Holzer MT, Krusche M et. al.

Aug 9th, 2022 - Dermatomyositis is a rare, type I interferon-driven autoimmune disease, which can affect muscle, skin and internal organs (especially the pulmonary system). In 2021, we have noted an increase in new-onset dermatomyositis compared to the years before the SARS-CoV-2 pandemic in our center. We present four cases of new-onset NXP2 and/or MDA5 positive dermatomyositis shortly after SARS-CoV-2 infect...

Immunogenicity After a Heterologous BNT262b2 Versus Homologous Booster in Kidney Transp...
https://doi.org/10.1097/TP.0000000000004260
Transplantation Medina-Pestana J, Almeida Viana L et. al.

Aug 9th, 2022 - Comparative studies of third heterologous doses following the CoronaVac vaccine against coronavirus disease 2019 (COVID-19) in kidney transplant recipients are lacking. This prospective, single-center cohort study included kidney transplant recipients without previous COVID-19. Patients received a third heterologous (BNT162b2 mRNA) or homologous dose at least 4 wk after 2 doses of the CoronaVac...

Antibody affinity and cross-variant neutralization of SARS-CoV-2 Omicron BA.1, BA.2 and...
https://doi.org/10.1038/s41467-022-32298-w
Nature Communications; Bellusci L, Grubbs G et. al.

Aug 9th, 2022 - There is limited knowledge on durability of neutralization capacity and antibody affinity maturation generated following two versus three doses of SARS-CoV-2 mRNA vaccines in naïve versus convalescent individuals (hybrid immunity) against the highly transmissible Omicron BA.1, BA.2 and BA.3 subvariants. Virus neutralization titers against the vaccine-homologous strain (WA1) and Omicron sublinea...

Efficacy and impact of SARS-CoV-2 vaccination on cancer treatment for breast cancer pat...
https://doi.org/10.1007/s10549-022-06693-2
Breast Cancer Research and Treatment; Terada M, Kondo N et. al.

Aug 9th, 2022 - Vaccination is an essential strategy to prevent infection in the SARS-CoV-2 pandemic. However, there are concerns about vaccine efficacy and the impact of vaccination on cancer treatment. Additionally, the emergence of novel variants may affect vaccination efficacy. This multi-center, prospective, observational study investigated the efficacy and impact of vaccination against SARS-CoV-2 variant...

Immunogenicity and safety of a SARS-CoV-2 inactivated vaccine (CoronaVac) co-administer...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343811
Vaccine Shenyu W, Xiaoqian D et. al.

Aug 7th, 2022 - Studies are needed for evidence of inactivated COVID-19 vaccine co-administered with influenza vaccine. A randomized, open-label, controlled study was conducted in Zhejiang Province, China. Eligible healthy adults aged 18-59 years underwent randomization at a ratio of 1:1:2 to receive inactivated quadrivalent influenza vaccine (IIV4) either concomitantly with the first (C1 subgroup) or the seco...

Potential of Antibody Pair Targeting Conserved Antigenic Sites in Diagnosis of SARS-CoV...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347178
Journal of Virological Methods; Wang S, Wu Y et. al.

Aug 7th, 2022 - Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has become disaster for human society. As the pandemic becomes more regular, we should develop more rapid and accurate detection methods to achieve early diagnosis and treatment. Antigen detection methods based on spike protein has great potential, however, it has not been effectively developed, probably due to the torturing conformationa...

Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and e...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349033
EBioMedicine Hawman DW, Meade-White K et. al.

Aug 7th, 2022 - In late 2021, the SARS-CoV-2 Omicron (B.1.1.529) variant of concern (VoC) was reported with many mutations in the viral spike protein that were predicted to enhance transmissibility and allow viral escape of neutralizing antibodies. Within weeks of the first report of B.1.1.529, this VoC has rapidly spread throughout the world, replacing previously circulating strains of SARS-CoV-2 and leading ...

Quantitative Analysis of Vertical Transmission of Maternal SARS-CoV-2 Antibodies to Neo...
https://doi.org/10.1093/jpids/piac065
Journal of the Pediatric Infectious Diseases Society; Golan N, Ashkenazi S et. al.

Aug 6th, 2022 - Serum antibody levels to SARS-CoV-2 in infants born to mothers who had received 2 doses of the BNT2b2 vaccine during pregnancy correlated positively with increasing gestational age at vaccination (P < .01) and negatively with increasing time from vaccination (P < .01), with a significant drop in infants aged >60 days (P = .045).

Serosurvey in SARS-CoV-2 inactivated vaccine-elicited neutralizing antibodies against a...
https://doi.org/10.1002/jmv.28049
Journal of Medical Virology; Zou L, Zhang H et. al.

Aug 6th, 2022 - Various variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been emerging and circulating in different parts of the world. Millions of vaccine doses have been administered globally, which reduces the morbidity and mortality of COVID-19 efficiently. Here we assess the immune responses of individuals after two shots of BBIBP-CorV or CoronaVac inactivated vaccine. We meas...

COVID-19 Vaccination and Remdesivir are Associated With Protection From New or Increase...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343962
Transplant International : Official Journal of the Europe... Killian JT, Houp JA et. al.

Aug 6th, 2022 - Alloimmune responses in kidney transplant (KT) patients previously hospitalized with COVID-19 are understudied. We analyzed a cohort of 112 kidney transplant recipients who were hospitalized following a positive SARS-CoV-2 test result during the first 20 months of the COVID-19 pandemic. We found a cumulative incidence of 17% for the development of new donor-specific antibodies (DSA) or increase...

Longitudinal determination of BNT162b2 vaccine induced strongly binding SARS-CoV-2 IgG ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339977
Vaccine Korodi M, Horváth I et. al.

Aug 6th, 2022 - Mass vaccination against the disease caused by the novel coronavirus (COVID-19) was a crucial step in slowing the spread of SARS-CoV-2 in 2021. Even in the face of new variants, it still remains extremely important for reducing hospitalizations and COVID-19 deaths. In order to better understand the short- and long-term dynamics of humoral immune response, we present a longitudinal analysis of p...

Immunogenicity and safety of an inactivated SARS-CoV-2 vaccine (Sinopharm BBIBP-CorV) c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334936
Vaccine Chen H, Huang Z et. al.

Aug 6th, 2022 - The safety and immunogenicity of the coadministration of an inactivated SARS-CoV-2 vaccine (Sinopharm BBIBP-CorV), quadrivalent split-virion inactivated influenza vaccine (IIV4), and 23-valent pneumococcal polysaccharide vaccine (PPV23) in adults in China is unknown. In this open-label, non-inferiority, randomised controlled trial, participants aged ≥ 18 years were recruited from the community....