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Peripartal anti-SARS-CoV-2-IgA/IgG in asymptomatic pregnant women during regional SARS-...
https://doi.org/10.1515/jpm-2021-0001
Journal of Perinatal Medicine; Häusler S, Weigl M et. al.

Feb 25th, 2021 - The Severe Acute Respiratory Distress Corona Virus 2 (SARS-CoV-2) pandemic poses special challenges for the society and especially the medical staff. Even if a rather mild course is assumed among pregnant women the measures to prevent transmission of the infection are of outstanding importance. To screen asymptomatic pregnant women during admission to our university maternal hospital we focused...

Host-directed therapies for COVID-19.
https://doi.org/10.1097/MCP.0000000000000769
Current Opinion in Pulmonary Medicine; Maeurer M, Ramalho R et. al.

Feb 25th, 2021 - Severe acute respiratory syndrome coronavirus-2-induced hyperinflammation is a major cause of death or end-organ dysfunction in COVID-19 patients. We review adjunct host-directed therapies (HDTs) for COVID-19 management. The use of umbilical cord-derived mesenchymal stem cells as HDT for COVID-19 has been shown to be safe in phase 1 and 2 trials. Trials of anti-interleukin-6 receptor antibodies...

Coronavirus (COVID-19) Update: FDA Continues Important Work to Support Medical Product Development to Address New Virus Variants | FDA
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-continues-important-work-support-medical-product-development-address

Feb 25th, 2021 - For Immediate Release: February 04, 2021 Statement From: Statement Author Leadership Role Acting Commissioner of Food and Drugs - Food and Drug Administration Janet Woodcock M.D. Español As the public health agency responsible for regulating medical products, we must ensure that health care providers have the most up-to-date diagnostics, treatments and vaccines in their toolbox to fight this pa...

SARS-CoV-2 proteins: Are they useful as targets for COVID-19 drugs and vaccines?
https://doi.org/10.2174/1566524021666210223143243
Current Molecular Medicine; Mohammed MEA

Feb 24th, 2021 - The proteins of coronavirus are classified to nonstructural, structural, and accessory. There are 16 nonstructural viral proteins beside their precursors (1a and 1ab polyproteins). The nonstructural proteins are named as nsp1 to nsp16 and they act as enzymes, coenzymes, and binding proteins to facilitate the replication, transcription, and translation of the virus. The structural proteins are b...

The Status of Pediatric Patients With Hematological Malignancy During COVID-19 Pandemic...
https://doi.org/10.1097/MPH.0000000000002133
Journal of Pediatric Hematology/oncology; Wang Z, Shen Y et. al.

Feb 24th, 2021 - Data regarding the epidemiologic characteristics and clinical features of pediatric hematological patients are limited in this corona virus disease 2019 (COVID-19) crisis. We investigated the status of 113 pediatric hematological patients in Wuhan union hospital during the COVID-19 pandemic from January 23 to March 10, 2020. All the patients had routine blood and biochemical examination, as wel...

UK COVID-19 Update: Alert Level Downgraded, 1 in 7 'Have Antibodies'
https://www.medscape.com/viewarticle/946452

Feb 24th, 2021 - These are the UK coronavirus stories you need to know about today. CQC's Nigel Acheson said: "We saw that staff were working hard to provide care to patients in very challenging conditions. "Given the pressure the trust was under, the decision to inspect during this period was a difficult one. However, we had significant concerns from reviewing our own data, the views of healthcare system partn...

SARS-CoV-2 Antibodies Detected in Around 1 in 7 People in England
https://www.medscape.com/viewarticle/946450

Feb 24th, 2021 - High levels of antibodies were detected in people of all ages who received two doses of the Pfizer/BioNTech COVID-19 vaccine, a study preprint has suggested. Antibody prevalence in unvaccinated people was found to vary across the country. The highest rate (16.9%) was seen in London. Black people were also most likely to test positive at 22.4%, followed by Asian individuals at 20%, compared with...

Chloroquine or hydroxychloroquine for prevention and treatment of COVID-19.
https://doi.org/10.1002/14651858.CD013587.pub2
The Cochrane Database of Systematic Reviews; Singh B, Ryan H et. al.

Feb 24th, 2021 - The coronavirus disease 2019 (COVID-19) pandemic has resulted in substantial mortality. Some specialists proposed chloroquine (CQ) and hydroxychloroquine (HCQ) for treating or preventing the disease. The efficacy and safety of these drugs have been assessed in randomized controlled trials. To evaluate the effects of chloroquine (CQ) or hydroxychloroquine (HCQ) for 1) treating people with COVID-...

Association of SARS-CoV-2 Seropositive Antibody Test With Risk of Future Infection.
https://doi.org/10.1001/jamainternmed.2021.0366
JAMA Internal Medicine; Harvey RA, Rassen JA et. al.

Feb 24th, 2021 - Understanding the effect of serum antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on susceptibility to infection is important for identifying at-risk populations and could have implications for vaccine deployment. The study purpose was to evaluate evidence of SARS-CoV-2 infection based on diagnostic nucleic acid amplification test (NAAT) among patients with positive v...

ASH 2020 Meeting Highlights
https://ascopost.com/issues/february-25-2021-supplement-conference-highlights-ash-2020/ash-2020-meeting-highlights/

Feb 24th, 2021 - New Advances and Breakthroughs in Immunotherapy and Precision Medicine for Patients With Blood Cancer The world of hematologic malignancies continues to move forward at a robust pace despite the challenges of the COVID era. Although some areas of clinical trials and basic research suffered short-term stoppages or delays due to the pandemic, the studies presented at the 2020 American Society of ...

Antibody response patterns in COVID-19 patients with different levels of disease severi...
https://doi.org/10.1002/jmv.26899
Journal of Medical Virology; Imai K, Kitagawa Y et. al.

Feb 23rd, 2021 - We analyzed antibody response patterns according to level of disease severity in patients with novel coronavirus disease 2019 (COVID-19) in Japan. We analyzed 611 serum specimens from 231 patients with COVID-19 (mild, 170; severe, 31; critical, 30). IgM and IgG antibodies against nucleocapsid protein (N) and spike 1 protein (S1) were detected by enzyme-linked immunosorbent assays. The peaks of ...

Atypical symptoms, SARS-CoV-2 test results, and immunization rates in 456 residents fro...
https://doi.org/10.1093/ageing/afab050
Age and Ageing; Blain H, Gamon L et. al.

Feb 23rd, 2021 - Frail older persons may have an atypical presentation of COVID-19. The value of rRT-PCR testing for identifying SARS-CoV-2 nursing homes (NH) residents is not known. To determine whether (i) atypical symptoms may predict rRT-PCR results and (ii) rRT-PCR results may predict immunization against SARS-CoV-2 in NH residents. A retrospective longitudinal study. eight NHs with at least ten rRT-PCR-po...

Humoral immunological kinetics of severe acute respiratory syndrome coronavirus 2 infec...
https://doi.org/10.1093/inthealth/ihab005
International Health; Emeribe AU, Abdullahi IN et. al.

Feb 23rd, 2021 - As the coronavirus disease 2019 (COVID-19) pandemic continues to rise and second waves are reported in some countries, serological test kits and strips are being considered to scale up an adequate laboratory response. This study provides an update on the kinetics of humoral immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and performance characteristics ...

A Mobile Unit Overcomes the Challenges to Monoclonal Antibody Infusion for COVID-19 in ...
https://doi.org/10.1111/jgs.17090
Journal of the American Geriatrics Society; Tulledge-Scheitel S, Bell SJ et. al.

Feb 23rd, 2021 - Residents of nursing homes and long-term care facilities are at increased risk for severe coronavirus disease-19 (COVID-19) but may not be able to access monoclonal antibody therapies offered at outpatient infusion centers due to frailty and logistical issues. We describe a mobile monoclonal antibody infusion program for patients with COVID-19 in skilled nursing facilities and provide descripti...

Comparison of SARS-CoV-2 infections in healthcare workers with high and low exposures t...
https://doi.org/10.1080/23744235.2021.1885734
Infectious Diseases (London, England); Handal N, Whitworth J et. al.

Feb 23rd, 2021 - A year into the pandemic, the knowledge of SARS-CoV-2 infection risks among healthcare workers remains limited. In this cross-sectional study, we examined whether healthcare workers with high exposure to Covid-19 patients had a higher risk of SARS-CoV-2 infection than other healthcare workers in a Norwegian University Hospital. We also investigated the prevalence of asymptomatic healthcare work...

SARS-Cov2 variants and convalescent plasma: reality, fallacies, and opportunities.
https://doi.org/10.1172/JCI148832
The Journal of Clinical Investigation; Casadevall A, Henderson J et. al.

Feb 23rd, 2021 - In recent months genomic characterization of pandemic SARS-CoV-2 isolates identified viral variants that are less susceptible to neutralization by convalescent plasma (CP), vaccine-elicited plasma/sera, or SARS-CoV-2 monoclonal antibodies than earlier SARS-CoV-2 strains. In this Viewpoint, Casadevall et al. argue against the causal association made in some press articles between the emergence o...

Retrospective analysis of 426 donors of a convalescent collective after mild COVID-19.
https://doi.org/10.1371/journal.pone.0247665
PloS One; Flieder T, Vollmer T et. al.

Feb 23rd, 2021 - The novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread across the world. The aim of our study was to characterize mild courses and to determine the antibody status for these patients. We initiated an appeal for convalescent plasma donations. 615 people contacted us, and we ultimately included 426 in our analyses, in ...

Liver transplantation performed in a SARS-CoV-2 positive hospitalized recipient using a...
https://doi.org/10.1111/ajt.16548
American Journal of Transplantation : Official Journal Of... Manzia TM, Gazia C et. al.

Feb 23rd, 2021 - The Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 currently affected more than 108 million people worldwide with a fatality rate of 2.2%. Herein, we report the first case of liver transplantation (LT) performed with a liver procured from a SARS-CoV-2 positive donor. The recipient was a 35-years ...

Novavax to Seek EUA for COVID-19 Vaccine as Early as April
https://www.medscape.com/viewarticle/946422

Feb 23rd, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Novavax says it plans to apply for US Food and Drug Administration (FDA) emergency use authorization for its COVID-19 vaccine in the second quarter of the year. Gregory M. Glenn, MD, president of research and development at the Gaithersburg, Maryland-based company, said on a Washington Post live...