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People living with HIV easily lose their immune response to SARS-CoV-2: result from a c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485113
BMC Infectious Diseases; Liu Y, Xiao Y et. al.

Oct 3rd, 2021 - To date, whether the immune response for SARS-CoV-2 infection among people living with HIV(PLWH) is different from HIV-naïve individuals is still not clear. In this cohort study, COVID-19 patients admitted to hospitals in Wuhan between January 15 and April 1, 2020, were enrolled. Patients were categorized into PLWH and HIV-naïve group. All patients were followed up regularly (every 15 days) unt...

Suppressive Monocytes Impair MAIT Cells Response via IL-10 in Patients with Severe COVI...
https://doi.org/10.4049/jimmunol.2100228
Journal of Immunology (Baltimore, Md. : 1950); Yang Q, Wen Y et. al.

Aug 29th, 2021 - Immune cell responses are strikingly altered in patients with severe coronavirus disease 2019 (COVID-19), but the immunoregulatory process in these individuals is not fully understood. In this study, 23 patients with mild and 22 patients with severe COVID-19 and 6 asymptomatic carriers of COVID-19 were enrolled, along with 44 healthy controls (HC). Peripheral immune cells in HC and patients wit...

Anti-SARS-CoV-2 IgG levels in relation to disease severity of COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426683
Journal of Medical Virology; Yan X, Chen G et. al.

Aug 18th, 2021 - The durability of infection-induced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity has crucial implications for reinfection and vaccine effectiveness. However, the relationship between coronavirus disease 2019 (COVID-19) severity and long-term anti-SARS-CoV-2 immunoglobulin G (IgG) antibody level is poorly understood. Here, we measured the longevity of SARS-CoV-2-specific...

Summary report of seven cases of COVID-19 infection in renal transplant recipients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352666
Transplant Immunology; Wang T, Qiu T et. al.

Aug 14th, 2021 - The coronavirus disease 2019 (COVID-19) has swept the world, posing a serious threat to people's lives and health. Several cases of COVID-19 infection in renal transplant recipients (RTRs) have been reported, but the treatment and prognosis have not been fully elucidated. We followed-up with RTRs infected with SARS-CoV2 in our center and classified them as five clinical types-asymptomatic, mild...

Transmission dynamics of SARS-CoV-2 in a mid-size city of China.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353423
BMC Infectious Diseases; Zhao H, Lu X et. al.

Aug 12th, 2021 - An outbreak of pneumonia, COVID-19 associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan city and then rapidly spread to other cities. Wenzhou is located approximately 900 km from Wuhan, which was experiencing an outbreak that was severe at the time but is considered modest as the epidemic became a pandemic. We described the epidemiological characteri...

A discussion on the minimum required number of tests in two common pooling test methods...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365137
Epidemiology and Infection; Cheng CH, Chow CL et. al.

Aug 4th, 2021 - Pooling of samples in detecting the presence of virus is an effective and efficient strategy in screening carriers in a large population with low infection rate, leading to reduction in cost and time. There are a number of pooling test methods, some being simple and others being complicated. In such pooling tests, the most important parameter to decide is the pool or group size, which can be op...

Understanding the immunological aspects of SARS-CoV-2 causing COVID-19 pandemic: A ther...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378842
Clinical Immunology (Orlando, Fla.); Das A, Roy S et. al.

Jul 26th, 2021 - In December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a novel variant of coronavirus has emerged from Wuhan in China and has created havoc impulses across the world with a larger number of fatalities. At the same time, studies are on roll to discover potent vaccine against it or repurposing of approved drugs which are widely adopted are under trial to eradicate the SAR...

The impact of recent chemotherapy on immunity in 2 COVID-19 cases with gastrointestinal...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154490
Medicine Ju Z, Yang J et. al.

May 26th, 2021 - Coronavirus disease 2019 (COVID-19) is a rapidly emerging infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2. Currently, more than 100 million cases of COVID-19 have been confirmed worldwide, with over 2.4 million mortalities. The pandemic affects people of all ages but older individuals and those with severe chronic illnesses, including cancer patients, ar...

Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are feature...
https://doi.org/10.1371/journal.ppat.1009229
PLoS Pathogens; Te N, Rodon J et. al.

May 25th, 2021 - While MERS-CoV (Middle East respiratory syndrome Coronavirus) provokes a lethal disease in humans, camelids, the main virus reservoir, are asymptomatic carriers, suggesting a crucial role for innate immune responses in controlling the infection. Experimentally infected camelids clear infectious virus within one week and mount an effective adaptive immune response. Here, transcription of immune ...

Epidemiological and clinical features of SARS-CoV-2 cluster infection in Anhui Province...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110625
International Journal of Infectious Diseases : IJID : Off... Wu J, Chen X et. al.

May 14th, 2021 - COVID-19 has spread worldwide and become a pandemic. We report the epidemiological and clinical characteristics of cluster infections. Data of clustered cases were retrieved from the public health emergency monitoring information system of China. We analyzed the incubation period, generation gap, secondary attack rate, and viral load in various grouped cases. A total of 60 COVID-19 infection cl...

Characterisation of asymptomatic patients and efficacy of preventive measures for SARS-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111874
BMJ Open; Masarone M, Vaccaro E et. al.

May 12th, 2021 - The SARS-CoV-2 pandemic has infected millions of people and has caused more than 2.30 million deaths worldwide to date. Several doubts arise about the role of asymptomatic carriers in virus transmission. During the first epidemic outbreak in Italy a large screening with nasopharyngeal swab (NS) was performed in those who were considered 'suspect' for infection. To report the results of the SARS...

Value of anal swabs for SARS-COV-2 detection: a literature review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100643
International Journal of Medical Sciences; Wang Y, Chen X et. al.

May 11th, 2021 - Facing the unprecedented global public health crisis caused by coronavirus disease 2019 (COVID-19), nucleic acid tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the gold standard for diagnosing COVID-19. The asymptomatic carriers were not suspected of playing a significant role in the ongoing pandemic, and universal nucleic acid screening in close contacts of confirme...

Performance of SARS-CoV-2 rapid antigen test compared with real-time RT-PCR in asymptom...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088036
International Journal of Infectious Diseases : IJID : Off... Peña M, Ampuero M et. al.

May 5th, 2021 - Screening, testing and contact tracing plays a pivotal role in control of the COVID-19 pandemic. To enable this it is necessary to increase the testing capacity. This study compared a SARS-CoV-2 rapid antigen test (RAT) and RT-PCR in 842 asymptomatic individuals from Tarapacá, Chile. A sensitivity of 69.86%, specificity of 99.61%, PPV of 94.44% and NPP of 97.22% with Ct values (Ct > 27) that we...

Effectiveness of personal protective health behaviour against COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082215
BMC Public Health; Lio CF, Cheong HH et. al.

May 1st, 2021 - Novel coronavirus disease 2019 (COVID-19) has become a pandemic, and over 80 million cases and over 1.8 million deaths were reported in 2020. This highly contagious virus is spread primarily via respiratory droplets from face-to-face contact and contaminated surfaces as well as potential aerosol spread. Over half of transmissions occur from presymptomatic and asymptomatic carriers. Although sev...

Sense and sensitivity: can an inaccurate test be better than no test at all?
https://doi.org/10.1136/medethics-2021-107234
Journal of Medical Ethics; Pugh J, Wilkinson D et. al.

Apr 7th, 2021 - The UK government has put lateral flow antigen tests (LFATs) at the forefront of its strategy to scale-up testing in the coronavirus pandemic. However, evidence from a pilot trial using an LFAT to identify asymptomatic infections in the community suggested that the test missed over half of the positive cases in the tested population. This raises the question of whether it can be ethical to use ...

First Detection of Severe Acute Respiratory Syndrome Coronavirus 2 on the Surfaces of T...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004146
International Journal of Environmental Research and Publi... Montagna MT, De Giglio O et. al.

Apr 4th, 2021 - A Coronavirus disease (COVID-19), caused by a new virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spreads via direct contact through droplets produced by infected individuals. The transmission of this virus can also occur via indirect contact if objects and surfaces are contaminated by secretions from individuals with COVID-19 or asymptomatic carriers. Environmental c...

What was the Prevalence of COVID-19 in Asymptomatic Patients Undergoing Orthopaedic Sur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277266
Clinical Orthopaedics and Related Research; Gutman MJ, Patel MS et. al.

Mar 16th, 2021 - Many patients with coronavirus disease 2019 (COVID-19) are asymptomatic. The prevalence of COVID-19 in orthopaedic populations will vary depending on the time and place where the sampling is performed. The idea that asymptomatic carriers play a role is generalizable but has not been studied in large populations of patients undergoing elective orthopaedic surgery. We therefore evaluated this top...

Systematic screening on admission for SARS-CoV-2 to detect asymptomatic infections.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912536
Antimicrobial Resistance and Infection Control; Stadler RN, Maurer L et. al.

Mar 1st, 2021 - The proportion of asymptomatic carriers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains elusive and the potential benefit of systematic screening during the SARS-CoV-2-pandemic is controversial. We investigated the proportion of asymptomatic inpatients who were identified by systematic screening for SARS-CoV-2 upon hospital admission. Our analysis revealed that systemati...

Ultra-rapid detection of SARS-CoV-2 in public workspace environments.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904170
PloS One; Yaren O, McCarter J et. al.

Feb 25th, 2021 - Managing the pandemic caused by SARS-CoV-2 requires new capabilities in testing, including the possibility of identifying, in minutes, infected individuals as they enter spaces where they must congregate in a functioning society, including workspaces, schools, points of entry, and commercial business establishments. Here, the only useful tests (a) require no sample transport, (b) require minima...

SARS-CoV-2 viral shedding characteristics and potential evidence for the priority for f...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899334
PloS One; Yuan C, Wang H et. al.

Feb 23rd, 2021 - This study aimed to identify the specimen type that has high positivity and its proper sampling time for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing to promote diagnostic efficiency. All SARS-CoV-2-infected patients with a laboratory-confirmed diagnosis in Zhoushan City were followed up for viral shedding in respiratory tract specimens and faecal samples. Positivity was...