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Understanding the immunological aspects of SARS-CoV-2 causing COVID-19 pandemic: A ther...
https://doi.org/10.1016/j.clim.2021.108804
Clinical Immunology (Orlando, Fla.); Das A, Roy S et. al.

Jul 26th, 2021 - In December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a novel variant of coronavirus has recently emerged from Wuhan in China and has created havoc impulses across the world for a larger number of fatalities. At the same time studies are going on to discover vaccine against it or repurposing of approved drugs is widely adopted are under trial to eradicate the SARS-CoV-...

The impact of recent chemotherapy on immunity in 2 COVID-19 cases with gastrointestinal...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154490
Medicine Ju Z, Yang J et. al.

May 26th, 2021 - Coronavirus disease 2019 (COVID-19) is a rapidly emerging infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2. Currently, more than 100 million cases of COVID-19 have been confirmed worldwide, with over 2.4 million mortalities. The pandemic affects people of all ages but older individuals and those with severe chronic illnesses, including cancer patients, ar...

Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are feature...
https://doi.org/10.1371/journal.ppat.1009229
PLoS Pathogens; Te N, Rodon J et. al.

May 25th, 2021 - While MERS-CoV (Middle East respiratory syndrome Coronavirus) provokes a lethal disease in humans, camelids, the main virus reservoir, are asymptomatic carriers, suggesting a crucial role for innate immune responses in controlling the infection. Experimentally infected camelids clear infectious virus within one week and mount an effective adaptive immune response. Here, transcription of immune ...

Epidemiological and clinical features of SARS-CoV-2 cluster infection in Anhui Province...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110625
International Journal of Infectious Diseases : IJID : Off... Wu J, Chen X et. al.

May 14th, 2021 - COVID-19 has spread worldwide and become a pandemic. We report the epidemiological and clinical characteristics of cluster infections. Data of clustered cases were retrieved from the public health emergency monitoring information system of China. We analyzed the incubation period, generation gap, secondary attack rate, and viral load in various grouped cases. A total of 60 COVID-19 infection cl...

Characterisation of asymptomatic patients and efficacy of preventive measures for SARS-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111874
BMJ Open; Masarone M, Vaccaro E et. al.

May 12th, 2021 - The SARS-CoV-2 pandemic has infected millions of people and has caused more than 2.30 million deaths worldwide to date. Several doubts arise about the role of asymptomatic carriers in virus transmission. During the first epidemic outbreak in Italy a large screening with nasopharyngeal swab (NS) was performed in those who were considered 'suspect' for infection. To report the results of the SARS...

Value of anal swabs for SARS-COV-2 detection: a literature review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100643
International Journal of Medical Sciences; Wang Y, Chen X et. al.

May 11th, 2021 - Facing the unprecedented global public health crisis caused by coronavirus disease 2019 (COVID-19), nucleic acid tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the gold standard for diagnosing COVID-19. The asymptomatic carriers were not suspected of playing a significant role in the ongoing pandemic, and universal nucleic acid screening in close contacts of confirme...

Performance of SARS-CoV-2 rapid antigen test compared with real-time RT-PCR in asymptom...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088036
International Journal of Infectious Diseases : IJID : Off... Peña M, Ampuero M et. al.

May 5th, 2021 - Screening, testing and contact tracing plays a pivotal role in control of the COVID-19 pandemic. To enable this it is necessary to increase the testing capacity. This study compared a SARS-CoV-2 rapid antigen test (RAT) and RT-PCR in 842 asymptomatic individuals from Tarapacá, Chile. A sensitivity of 69.86%, specificity of 99.61%, PPV of 94.44% and NPP of 97.22% with Ct values (Ct > 27) that we...

Effectiveness of personal protective health behaviour against COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082215
BMC Public Health; Lio CF, Cheong HH et. al.

May 1st, 2021 - Novel coronavirus disease 2019 (COVID-19) has become a pandemic, and over 80 million cases and over 1.8 million deaths were reported in 2020. This highly contagious virus is spread primarily via respiratory droplets from face-to-face contact and contaminated surfaces as well as potential aerosol spread. Over half of transmissions occur from presymptomatic and asymptomatic carriers. Although sev...

Sense and sensitivity: can an inaccurate test be better than no test at all?
https://doi.org/10.1136/medethics-2021-107234
Journal of Medical Ethics; Pugh J, Wilkinson D et. al.

Apr 7th, 2021 - The UK government has put lateral flow antigen tests (LFATs) at the forefront of its strategy to scale-up testing in the coronavirus pandemic. However, evidence from a pilot trial using an LFAT to identify asymptomatic infections in the community suggested that the test missed over half of the positive cases in the tested population. This raises the question of whether it can be ethical to use ...

First Detection of Severe Acute Respiratory Syndrome Coronavirus 2 on the Surfaces of T...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004146
International Journal of Environmental Research and Publi... Montagna MT, De Giglio O et. al.

Apr 4th, 2021 - A Coronavirus disease (COVID-19), caused by a new virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spreads via direct contact through droplets produced by infected individuals. The transmission of this virus can also occur via indirect contact if objects and surfaces are contaminated by secretions from individuals with COVID-19 or asymptomatic carriers. Environmental c...

What was the Prevalence of COVID-19 in Asymptomatic Patients Undergoing Orthopaedic Sur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277266
Clinical Orthopaedics and Related Research; Gutman MJ, Patel MS et. al.

Mar 16th, 2021 - Many patients with coronavirus disease 2019 (COVID-19) are asymptomatic. The prevalence of COVID-19 in orthopaedic populations will vary depending on the time and place where the sampling is performed. The idea that asymptomatic carriers play a role is generalizable but has not been studied in large populations of patients undergoing elective orthopaedic surgery. We therefore evaluated this top...

Systematic screening on admission for SARS-CoV-2 to detect asymptomatic infections.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912536
Antimicrobial Resistance and Infection Control; Stadler RN, Maurer L et. al.

Mar 1st, 2021 - The proportion of asymptomatic carriers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains elusive and the potential benefit of systematic screening during the SARS-CoV-2-pandemic is controversial. We investigated the proportion of asymptomatic inpatients who were identified by systematic screening for SARS-CoV-2 upon hospital admission. Our analysis revealed that systemati...

Ultra-rapid detection of SARS-CoV-2 in public workspace environments.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904170
PloS One; Yaren O, McCarter J et. al.

Feb 25th, 2021 - Managing the pandemic caused by SARS-CoV-2 requires new capabilities in testing, including the possibility of identifying, in minutes, infected individuals as they enter spaces where they must congregate in a functioning society, including workspaces, schools, points of entry, and commercial business establishments. Here, the only useful tests (a) require no sample transport, (b) require minima...

SARS-CoV-2 viral shedding characteristics and potential evidence for the priority for f...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899334
PloS One; Yuan C, Wang H et. al.

Feb 23rd, 2021 - This study aimed to identify the specimen type that has high positivity and its proper sampling time for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing to promote diagnostic efficiency. All SARS-CoV-2-infected patients with a laboratory-confirmed diagnosis in Zhoushan City were followed up for viral shedding in respiratory tract specimens and faecal samples. Positivity was...

With COVID Vaccinations Comes a Potential Nightmare Scenario
https://www.medscape.com/viewarticle/945433

Feb 10th, 2021 - This transcript has been edited for clarity. Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I'm Dr F. Perry Wilson of the Yale School of Medicine. No one talked about it much, but public health professionals were all aware of a potential nightmare scenario when COVID vaccinations started up in bulk. No, not a slew of severe adverse events; the clinical trials m...

Feasibility and Predictive Performance of a Triage System for Patients with Cancer Duri...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014855
The Oncologist; Fasola G, Pelizzari G et. al.

Feb 5th, 2021 - Triage procedures have been implemented to limit hospital access and minimize infection risk among patients with cancer during the coronavirus disease (COVID-19) outbreak. In the absence of prospective evidence, we aimed to evaluate the predictive performance of a triage system in the oncological setting. This retrospective cohort study analyzes hospital admissions to the oncology and hematolog...

At the Urging of Nursing Homes, a Law Is Amended and COVID Court Claims Are Slowed
https://www.medscape.com/viewarticle/944954

Feb 1st, 2021 - (Reuters) - Garnice Robertson wants accountability for her mother's death from COVID-19 caught while she was living at a Kansas nursing home that allegedly failed to prevent an outbreak of the disease. An unexpected legal hurdle stands in her way. The nursing home argues it has complete legal immunity for lawsuits like Robertson's stemming from COVID-19. It cites recent changes to a 2005 law by...

SARS-CoV-2 infection in asymptomatic healthcare workers at a clinic in Chile.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842995
PloS One; Olmos C, Campaña G et. al.

Jan 29th, 2021 - Asymptomatic SARS-CoV-2 infection of healthcare workers (HCWs) has been reported as a key player in the nosocomial spreading of COVID-19. Early detection of infected HCWs can prevent spreading of the virus in hospitals among HCWs and patients. We conducted a cross-sectional study to determine the asymptomatic infection of HCWs in a private clinic in the city of Santiago, Chile. Our study was co...

Clinical course and challenging management of early COVID-19 infection after heart tran...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816134
BMC Infectious Diseases; Tchana-Sato V, Ancion A et. al.

Jan 22nd, 2021 - There are limited data on Coronavirus disease 2019 (COVID-19) in solid organ transplant patients, especially in heart transplant recipients, with only a few case reports and case series described so far. Heart transplant recipients may be at particular high risk due to their comorbidities and immunosuppressed state. This report describes the clinical course and the challenging management of ear...

Madrid Begins Mass Testing Young People for COVID-19
https://www.medscape.com/viewarticle/944424

Jan 21st, 2021 - MADRID (Reuters) - Health authorities in Madrid began mass testing hundreds of young people for COVID-19 at universities on Wednesday to detect asymptomatic carriers in one of the groups with the highest rates of transmission. With the country in the grip of a third wave of infection, authorities called on young people to attend makeshift medical centres at nine university campuses to take a ra...