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Anti-Omicron Vax Coming; Blood Crisis Is Here; Elevators Recalled for Safety Issue
https://www.medpagetoday.com/infectiousdisease/covid19/96623

Jan 12th, 2022 - Note that some links may require registration or subscription. Current coronavirus vaccines may have to be reformulated to make sure they're effective against Omicron and other variants to come, the World Health Organization said. (Reuters) In related news, Pfizer is planning to manufacture 50 million to 100 million doses of an Omicron-specific COVID-19 vaccine. (Washington Post) The Red Cross ...

Initial findings of universal screening for SARS-CoV-2 in women admitted for delivery i...
https://doi.org/10.1080/01443615.2021.2011179
Journal of Obstetrics and Gynaecology : the Journal of Th... Maraj H, Bhattacharjee D et. al.

Jan 9th, 2022 - We describe the prevalence of overall and asymptomatic SARS-CoV-2 infection in pregnant women admitted for delivery at three maternity units in North Wales. This was a prospective, multicentre cohort study of universal testing for SARS-CoV-2 infection offered to all pregnant women admitted for delivery. Four hundred and seventy-five women were tested by reverse transcription-polymerase chain re...

China's Yuzhou locks down 1.1 million residents on COVID fears
https://www.reuters.com/article/us-health-coronavirus-china/chinas-yuzhou-locks-down-1-1-million-residents-on-covid-fears-idUSKBN2JE0OT

Jan 4th, 2022 - BEIJING (Reuters) -A Chinese city has locked down its 1.1 million residents after reports of new coronavirus cases as officials rushed to contain even small outbreaks just over four weeks before the Winter Olympics begin. The curbs in the city of Yuzhou, in the central province of Henan, are similar to those imposed for nearly two weeks in the industrial hub of Xian, which has become China’s la...

Diagnostic techniques for COVID-19: A mini-review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684097
Journal of Virological Methods; Wu X, Chen Q et. al.

Dec 22nd, 2021 - COVID-19, a new respiratory infectious disease, was first reported at the end of 2019, in Wuhan, China. Now, COVID-19 is still causing major loss of human life and economic productivity in almost all countries around the world. Early detection, early isolation, and early diagnosis of COVID-19 patients and asymptomatic carriers are essential to blocking the spread of the pandemic. This paper bri...

Asymptomatic detection of SARS-CoV-2 among cancer patients receiving infusional anti-ca...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8646446
Cancer Medicine; Shaya J, Cabal A et. al.

Oct 29th, 2021 - Little is known regarding the rate and clinical outcomes of asymptomatic carriers of SARS-CoV-2 among patients with cancer. Detection of asymptomatic carriers is important in this population given the use of myelosuppressive and immunomodulating therapies. Understanding the asymptomatic carrier rate will help to develop mitigation strategies in this high-risk cohort. Retrospective cohort analys...

People living with HIV easily lose their immune response to SARS-CoV-2: result from a c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485113
BMC Infectious Diseases; Liu Y, Xiao Y et. al.

Oct 3rd, 2021 - To date, whether the immune response for SARS-CoV-2 infection among people living with HIV(PLWH) is different from HIV-naïve individuals is still not clear. In this cohort study, COVID-19 patients admitted to hospitals in Wuhan between January 15 and April 1, 2020, were enrolled. Patients were categorized into PLWH and HIV-naïve group. All patients were followed up regularly (every 15 days) unt...

Suppressive Monocytes Impair MAIT Cells Response via IL-10 in Patients with Severe COVI...
https://doi.org/10.4049/jimmunol.2100228
Journal of Immunology (Baltimore, Md. : 1950); Yang Q, Wen Y et. al.

Aug 29th, 2021 - Immune cell responses are strikingly altered in patients with severe coronavirus disease 2019 (COVID-19), but the immunoregulatory process in these individuals is not fully understood. In this study, 23 patients with mild and 22 patients with severe COVID-19 and 6 asymptomatic carriers of COVID-19 were enrolled, along with 44 healthy controls (HC). Peripheral immune cells in HC and patients wit...

Anti-SARS-CoV-2 IgG levels in relation to disease severity of COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426683
Journal of Medical Virology; Yan X, Chen G et. al.

Aug 18th, 2021 - The durability of infection-induced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity has crucial implications for reinfection and vaccine effectiveness. However, the relationship between coronavirus disease 2019 (COVID-19) severity and long-term anti-SARS-CoV-2 immunoglobulin G (IgG) antibody level is poorly understood. Here, we measured the longevity of SARS-CoV-2-specific...

Summary report of seven cases of COVID-19 infection in renal transplant recipients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352666
Transplant Immunology; Wang T, Qiu T et. al.

Aug 14th, 2021 - The coronavirus disease 2019 (COVID-19) has swept the world, posing a serious threat to people's lives and health. Several cases of COVID-19 infection in renal transplant recipients (RTRs) have been reported, but the treatment and prognosis have not been fully elucidated. We followed-up with RTRs infected with SARS-CoV2 in our center and classified them as five clinical types-asymptomatic, mild...

Transmission dynamics of SARS-CoV-2 in a mid-size city of China.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353423
BMC Infectious Diseases; Zhao H, Lu X et. al.

Aug 12th, 2021 - An outbreak of pneumonia, COVID-19 associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan city and then rapidly spread to other cities. Wenzhou is located approximately 900 km from Wuhan, which was experiencing an outbreak that was severe at the time but is considered modest as the epidemic became a pandemic. We described the epidemiological characteri...

A discussion on the minimum required number of tests in two common pooling test methods...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365137
Epidemiology and Infection; Cheng CH, Chow CL et. al.

Aug 4th, 2021 - Pooling of samples in detecting the presence of virus is an effective and efficient strategy in screening carriers in a large population with low infection rate, leading to reduction in cost and time. There are a number of pooling test methods, some being simple and others being complicated. In such pooling tests, the most important parameter to decide is the pool or group size, which can be op...

Understanding the immunological aspects of SARS-CoV-2 causing COVID-19 pandemic: A ther...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378842
Clinical Immunology (Orlando, Fla.); Das A, Roy S et. al.

Jul 26th, 2021 - In December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a novel variant of coronavirus has emerged from Wuhan in China and has created havoc impulses across the world with a larger number of fatalities. At the same time, studies are on roll to discover potent vaccine against it or repurposing of approved drugs which are widely adopted are under trial to eradicate the SAR...

The impact of recent chemotherapy on immunity in 2 COVID-19 cases with gastrointestinal...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154490
Medicine Ju Z, Yang J et. al.

May 26th, 2021 - Coronavirus disease 2019 (COVID-19) is a rapidly emerging infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2. Currently, more than 100 million cases of COVID-19 have been confirmed worldwide, with over 2.4 million mortalities. The pandemic affects people of all ages but older individuals and those with severe chronic illnesses, including cancer patients, ar...

Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are feature...
https://doi.org/10.1371/journal.ppat.1009229
PLoS Pathogens; Te N, Rodon J et. al.

May 25th, 2021 - While MERS-CoV (Middle East respiratory syndrome Coronavirus) provokes a lethal disease in humans, camelids, the main virus reservoir, are asymptomatic carriers, suggesting a crucial role for innate immune responses in controlling the infection. Experimentally infected camelids clear infectious virus within one week and mount an effective adaptive immune response. Here, transcription of immune ...

Epidemiological and clinical features of SARS-CoV-2 cluster infection in Anhui Province...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110625
International Journal of Infectious Diseases : IJID : Off... Wu J, Chen X et. al.

May 14th, 2021 - COVID-19 has spread worldwide and become a pandemic. We report the epidemiological and clinical characteristics of cluster infections. Data of clustered cases were retrieved from the public health emergency monitoring information system of China. We analyzed the incubation period, generation gap, secondary attack rate, and viral load in various grouped cases. A total of 60 COVID-19 infection cl...

Characterisation of asymptomatic patients and efficacy of preventive measures for SARS-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111874
BMJ Open; Masarone M, Vaccaro E et. al.

May 12th, 2021 - The SARS-CoV-2 pandemic has infected millions of people and has caused more than 2.30 million deaths worldwide to date. Several doubts arise about the role of asymptomatic carriers in virus transmission. During the first epidemic outbreak in Italy a large screening with nasopharyngeal swab (NS) was performed in those who were considered 'suspect' for infection. To report the results of the SARS...

Value of anal swabs for SARS-COV-2 detection: a literature review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100643
International Journal of Medical Sciences; Wang Y, Chen X et. al.

May 11th, 2021 - Facing the unprecedented global public health crisis caused by coronavirus disease 2019 (COVID-19), nucleic acid tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the gold standard for diagnosing COVID-19. The asymptomatic carriers were not suspected of playing a significant role in the ongoing pandemic, and universal nucleic acid screening in close contacts of confirme...

Performance of SARS-CoV-2 rapid antigen test compared with real-time RT-PCR in asymptom...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088036
International Journal of Infectious Diseases : IJID : Off... Peña M, Ampuero M et. al.

May 5th, 2021 - Screening, testing and contact tracing plays a pivotal role in control of the COVID-19 pandemic. To enable this it is necessary to increase the testing capacity. This study compared a SARS-CoV-2 rapid antigen test (RAT) and RT-PCR in 842 asymptomatic individuals from Tarapacá, Chile. A sensitivity of 69.86%, specificity of 99.61%, PPV of 94.44% and NPP of 97.22% with Ct values (Ct > 27) that we...

Effectiveness of personal protective health behaviour against COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082215
BMC Public Health; Lio CF, Cheong HH et. al.

May 1st, 2021 - Novel coronavirus disease 2019 (COVID-19) has become a pandemic, and over 80 million cases and over 1.8 million deaths were reported in 2020. This highly contagious virus is spread primarily via respiratory droplets from face-to-face contact and contaminated surfaces as well as potential aerosol spread. Over half of transmissions occur from presymptomatic and asymptomatic carriers. Although sev...

Sense and sensitivity: can an inaccurate test be better than no test at all?
https://doi.org/10.1136/medethics-2021-107234
Journal of Medical Ethics; Pugh J, Wilkinson D et. al.

Apr 7th, 2021 - The UK government has put lateral flow antigen tests (LFATs) at the forefront of its strategy to scale-up testing in the coronavirus pandemic. However, evidence from a pilot trial using an LFAT to identify asymptomatic infections in the community suggested that the test missed over half of the positive cases in the tested population. This raises the question of whether it can be ethical to use ...