Molecular Pharmacology; Hammoud S, Wehbe Z et. al.
Oct 21st, 2020 - ACE2 has emerged as a double agent in the COVID-19 ordeal being physiologically protective yet conducive of viral infection. The identification of ACE2 in as many as 72 tissues suggests that extra-pulmonary invasion and damage is likely, which indeed has already been demonstrated by cardiovascular and gastro-intestinal symptoms. On the other hand, identifying ACE2 dysregulation in patients with...
Drugs & Aging; Casucci G, Acanfora D et. al.
Oct 21st, 2020 - This paper presents a brief overview of the complex interaction between age, hypertension, the renin-angiotensin-aldosterone system (RAAS), inflammation, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection. Coronavirus disease 2019 (COVID-19) is more frequent and more severe in comorbid elderly patients, especially those with hypertension, diabetes, obesity, or cardiovascu...
Medicinal Research Reviews REFERENCES; Rufino AT, Costa VM et. al.
Oct 21st, 2020 - Obesity is a global health problem that affects all age groups in both developing and developed countries. In recent years, the prevalence of overweight and obesity has reached pandemic levels, resulting in a dramatic increase in the incidence of various comorbidities, such as cardiovascular diseases, type 2 diabetes, and cancer, consequently leading to massive health and socioeconomic burdens....
Cardiovascular Research; Tanwar V, Adelstein JM et. al.
Oct 21st, 2020 - The coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly grown into a pandemic. According to initial reports, the lungs were thought to be the primary target, but recent case studies have shown its reach can extend to other organs including the heart and blood vessels. The severity of cardiac complications of COVID-19 depends on ...
Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research; Kozłowska E, Brzezińska-Błaszczyk E et. al.
Oct 20th, 2020 - COVID-19 has posed an extraordinary burden on health and the economy worldwide. Patients with cardiovascular diseases are more likely to have severe illness due to COVID-19 and are at increased risk for complications and mortality. We performed a narrative literature review to assess the burden of COVID-19 and cardiovascular morbidity and mortality. Myocardial injury has been reported in 20%-30...
Journal of Cardiovascular Pharmacology; Suvorava T, Kaesemeyer W
Oct 20th, 2020 - Involvement of the vascular endothelium in the complications of COVID-19 is now recognized. Chief among these are pulmonary endotheliitis, cytokine storm, endotoxic shock and cardiovascular collapse. This Perspectives paper is focused on therapeutical strategies to reduce the risk of these complications by targeting the vascular endothelium as a part of the overall treatment of COVID-19.
Metabolism: Clinical and Experimental; Hill MA, Sowers JR et. al.
Oct 20th, 2020 - While substantial evidence points towards obesity and associated cardiometabolic disorders being a major factor for poor outcomes in SARS-CoV2 infections (COVID -19), the complexity of the interplay between these two pandemics is becoming apparent. Indeed, as previously defined, this interaction between obesity and COVID-19 represents a 'syndemic' that requires both current and ongoing attentio...
Journal of Medical Virology; Stratton CW, Tang YW et. al.
Oct 19th, 2020 - The 2019 novel coronavirus disease (COVID-19) now is considered a global public health emergency. One of the unprecedented challenges is defining optimal therapy for those patients with severe pneumonia and systemic manifestations of COVID-19. Optimal therapy should be largely based on the pathogenesis of infections caused by this novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-...
Cardiology in the Young; Santi AD, Aquino P et. al.
Oct 19th, 2020 - The SARS-CoV-2 (COVID-19) pandemic has challenged our initial predictions of its ramifications, both short and long term. Cardiovascular manifestations of COVID-19 in pediatric patients remains a topic of investigation as literature is lacking. We describe new onset atrial fibrillation in a pediatric patient with a history of COVID-19 infection. Understanding of cardiogenic effects of COVID-19 ...
Chest Narain S, Stefanov DG et. al.
Oct 19th, 2020 - Cytokine storm is a marker of COVID-19 illness severity and increased mortality. Immunomodulatory treatments have been repurposed to improve mortality outcomes. To identify if immunomodulatory therapies improve survival in patients with COVID-19 cytokine storm. We conducted a retrospective analysis of electronic health records across the Northwell Health system. COVID-19 patients hospitalized b...
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases; Mohana A, Sulaiman T et. al.
Oct 19th, 2020 - Global healthcare is challenged following the COVID-19 pandemic, since late 2019. Multiple approaches have been performed to relieve the pressure and support existing healthcare. The Saudi Arabian Ministry of Health (MOH) launched an initiative to support the National Healthcare System. Since the 5th of June 2020, 238 outpatient fever clinics were established nationwide. This study aimed to ass...
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases; Abayomi A, Odukoya O et. al.
Oct 19th, 2020 - As COVID-19 continues to spread worldwide with high number of fatalities first in China, then even higher fatalities in Italy, Spain, United Kingdom, United States, and other advanced countries; most African countries with less advanced healthcare systems ironically, continue to experience lower COVID-19 mortality rates. This is even as the pandemic has reached its peak, plateaued or sliding do...
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia; de Sousa GC, de Sousa TC et. al.
Oct 19th, 2020 - An aging global population and accompanying increases in the prevalence of age-related disorders are leading to greater financial, social, and health burdens. Aging-related dementias are one such category of age-related disorders that are associated with progressive loss of physical and cognitive integrity. One proposed preventative measure against risk of aging-related dementia is improving ca...
BMC Cardiovascular Disorders; Gallego-Colon E, Bonaventura A et. al.
Oct 19th, 2020 - The 2020 annual Congress of the European Society of Cardiology (ESC) was the first ever to be held virtually. Under the spotlight of 'the cutting edge of cardiology', exciting and ground-breaking cardiovascular (CV) science was presented both in basic and clinical research. This commentary summarizes essential updates from ESC 2020-The Digital Experience. Despite the challenges that coronavirus...
Psychosomatics Amouri J, Andrews PS et. al.
Oct 18th, 2020 - The COVID-19 pandemic had an unexpected impact on cardiovascular emergencies, particularly STEMI. The France PCI registry and other studies around the world have highlighted a significant decrease in myocardial infarctions arriving at hospital. This decrease is mainly related to patients' fear of coming to the hospital and being contaminated. Although the STEMI revascularisation time targets (...
Neuromolecular Medicine; Koh SS, Ooi SC et. al.
Oct 17th, 2020 - Ergothioneine (ET) is a naturally occurring antioxidant that is synthesized by non-yeast fungi and certain bacteria. ET is not synthesized by animals, including humans, but is avidly taken up from the diet, especially from mushrooms. In the current study, we elucidated the effect of ET on the hCMEC/D3 human brain endothelial cell line. Endothelial cells are exposed to high levels of the cholest...
BMC Geriatrics; Chinnadurai R, Ogedengbe O et. al.
Oct 17th, 2020 - There is a need for more observational studies across different clinical settings to better understand the epidemiology of the novel COVID-19 infection. Evidence on clinical characteristics of COVID-19 infection is scarce in secondary care settings in Western populations. We describe the clinical characteristics of all consecutive COVID-19 positive patients (n = 215) admitted to the acute medic...
Clinical Science (London, England : 1979); Li Q, Grant MB et. al.
Oct 16th, 2020 - The angiotensin-converting enzyme 2 (ACE2) has emerged as a critical regulator of the renin-angiotensin system (RAS), which plays important roles in cardiovascular homeostasis by regulating vascular tone, fluid and electrolyte balance. ACE2 functions as a carboxymonopeptidase hydrolyzing the cleavage of a single C-terminal residue from Angiotensin-II (Ang-II), the key peptide hormone of RAS, to...
Circulation Shah P, deFilippi CR et. al.
Oct 16th, 2020 - Navigating COVID-19 Testing, Special Considerations for the Cardiovascular Clinician.|2020|Shah P,deFilippi CR,Mullins KE,|
Trends in Cardiovascular Medicine; Citro R, Pontone G et. al.
Oct 16th, 2020 - The management of patients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be difficult due to the need for dedicated in-hospital pathways, protective measures for healthcare professionals and isolated beds of intensive care, particularly in areas overwhelmed by wide viral spread. Although pneumonia is the most common clinical manifestation in coronavirus disease 20...