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B cell contribution to immunometabolic dysfunction and impaired immune responses in obe...
https://doi.org/10.1093/cei/uxac079
Clinical and Experimental Immunology; Oleinika K, Slisere B et. al.

Aug 13th, 2022 - Obesity increases the risk of type 2 diabetes mellitus, cardiovascular disease, fatty liver disease, and cancer. It is also linked with more severe complications from infections, including COVID-19, and poor vaccine responses. Chronic, low-grade inflammation and associated immune perturbations play an important role in determining morbidity in people living with obesity. The contribution of B c...

Comparison of Pregnancy and Birth Outcomes Before vs During the COVID-19 Pandemic.
https://doi.org/10.1001/jamanetworkopen.2022.26531
JAMA Network Open; Molina RL, Tsai TC et. al.

Aug 13th, 2022 - Little is known about changes in obstetric outcomes during the COVID-19 pandemic. To assess whether obstetric outcomes and pregnancy-related complications changed during the COVID-19 pandemic. This retrospective cohort study included pregnant patients receiving care at 463 US hospitals whose information appeared in the PINC AI Healthcare Database. The relative differences in birth outcomes, pre...

Sedentary Behavior and Physical Inactivity in the Asia-Pacific Region: Current Challeng...
https://doi.org/10.3390/ijerph19159351
International Journal of Environmental Research and Publi... Annear M

Aug 13th, 2022 - This editorial sets the scene for our Special Issue on the growing problem of sedentary behavior and physical inactivity in the Asia-Pacific region. In many societies, more than 40% of the adult population and growing numbers of children are insufficiently physically active to safeguard their health. This is contributing to high rates of cardiovascular disease, obesity, and other deleterious he...

One-year follow up of vascular intervention trials disrupted by the COVID-19 pandemic: ...
https://doi.org/10.1016/j.carrev.2022.07.018
Cardiovascular Revascularization Medicine : Including Mol... Rymer JA, Kirtane AJ et. al.

Aug 12th, 2022 - The COVID-19 pandemic had an unprecedented impact on cardiovascular clinical research. The decision-making and state of study operations in cardiovascular trials 1-year after interruption has not been previously described. In the spring of 2020, we created a pandemic impact task force to develop a landscape of use case scenarios from 17 device trials of peripheral artery disease (PAD) and coron...

Risk factors for mortality among hospitalized COVID-19 patients in Northern Ethiopia: A...
https://doi.org/10.1371/journal.pone.0271124
PloS One; Abebe HT, Mulugeta A et. al.

Aug 12th, 2022 - COVID-19 is a deadly pandemic caused by an RNA virus that belongs to the family of CORONA virus. To counter the COVID-19 pandemic in resource limited settings, it is essential to identify the risk factors of COVID-19 mortality. This study was conducted to identify the social and clinical determinants of mortality in COVID-19 patients hospitalized in four treatment centers of Tigray, Northern Et...

German Heart Surgery Report 2021: The Annual Updated Registry of the German Society for...
https://doi.org/10.1055/s-0042-1754353
The Thoracic and Cardiovascular Surgeon; Beckmann A, Meyer R et. al.

Aug 11th, 2022 - Based on a longtime voluntary registry, founded by the German Society for Thoracic and Cardiovascular Surgery (GSTCVS) in 1980, well-defined data of all cardiac, thoracic and vascular surgery procedures performed in 78 German heart surgery departments during the year 2021 are analyzed. Under more than extraordinary conditions of the further ongoing worldwide coronavirus disease 2019 (COVID-19) ...

Risk factors of a severe course of pediatric multi-system inflammatory syndrome tempora...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364844
European Journal of Pediatrics; Stasiak A, Perdas E et. al.

Aug 11th, 2022 - Pediatric multi-system inflammatory syndrome temporally associated with COVID-19 (PIMS-TS) is a serious complication of a previous SARS-CoV-2 infection. The disease causes multiple organ failure, but in some patients, a more severe course of the disease is observed. The treatment is multidirectional and depends on the severity and course of the disease, as some patients do not respond to the re...

Regular Fasting Linked to Less Severe COVID: Study
https://www.medscape.com/viewarticle/979036

Aug 10th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Intermittent fasting was not linked with a smaller chance of getting COVID-19, but it was linked with getting a less severe infection, according to the findings of a new study. The study was done on men and women in Utah who were, on average, in their 60s and got COVID before vaccines were avail...

Determinants of COVID-19 Breakthrough Infections and Severity in ChAdOx1 nCoV-19-Vaccin...
https://doi.org/10.4269/ajtmh.22-0172
The American Journal of Tropical Medicine and Hygiene; Kaur U, Bala S et. al.

Aug 9th, 2022 - The current analysis is a part of an ongoing observational study that began in February 2021 in the Sir Sunder Lal Hospital (Varanasi, Uttar Pradesh) in northern India and is expected to continue until June 2022. This analysis aimed to delineate the clinical presentation and risk factors of occurrence and severity of COVID-19 in vaccinated individuals. The study enrolled health-care workers and...

Assessing cardiovascular disease: looking beyond cholesterol.
https://doi.org/10.1097/MED.0000000000000761
Current Opinion in Endocrinology, Diabetes, and Obesity; Kendrick M

Aug 9th, 2022 - The low-density lipoprotein (LDL)-cholesterol level is a weak predictor of developing cardiovascular (CV) disease and can only explain a small proportion of CV risk. It is not used to determine CV risk on either the atherosclerotic cardiovascular disease (ASCVD) calculator in the United States, or the Qrisk3 in the UK.A study in JAMA in 2022 suggested that 'the absolute benefits of statins are ...

Recreation as Rx? Why You Should Prescribe Nature
https://www.medscape.com/viewarticle/978654

Aug 9th, 2022 - Every time I go to the beach, I bring a book but hardly open it. Instead, I look at the waves and listen to the gulls. My eyelids get heavy and my heart rate decreases. My stiff joints relax as I walk along the shore. The fatigue in my feet melts away as they sink in the sand. The beach at Sandy Hook National Recreation Area is one of my happy places. It revives me and reminds me that nature is...

Breastfeeding mobile application for mothers with gestational diabetes mellitus: design...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360707
BMC Public Health; Park S, Kwak E et. al.

Aug 9th, 2022 - Mothers and babies with gestational diabetes have an increased risk of diabetes, obesity, and cardiovascular complications. Breastfeeding is known to help reduce complications in mothers and babies with gestational diabetes. However, the rate of breastfeeding among mothers with gestational diabetes is still low due to various barriers. Therefore, the purpose of this study was to develop a mobil...

The role of cyclophilins in viral infec and the immune response.
https://doi.org/10.1016/j.jinf.2022.08.002
The Journal of Infection; Wu Y, Ma Z et. al.

Aug 8th, 2022 - Cyclophilins (Cyps) are a subgroup of peptidyl-prolyl cis-trans isomerases (PPIases) that contain a highly conserved domain of PPIases. Sixteen Cyps have been identified in humans, among which the functions of five classical Cyp subtypes (CypA, B, C, D, and 40) have been studied in more detail. Cyps are widely expressed in almost all human tissues and are involved in several intracellular signa...

Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356426
Cardiovascular Diabetology; Pretorius E, Venter C et. al.

Aug 7th, 2022 - Fibrin(ogen) amyloid microclots and platelet hyperactivation previously reported as a novel finding in South African patients with the coronavirus 2019 disease (COVID-19) and Long COVID/Post-Acute Sequelae of COVID-19 (PASC), might form a suitable set of foci for the clinical treatment of the symptoms of Long COVID/PASC. A Long COVID/PASC Registry was subsequently established as an online platf...

The Impact of Meteorological Factors and Air Pollutants on Acute Coronary Syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361940
Current Cardiology Reports; Rus AA, Mornoş C

Aug 7th, 2022 - Several studies have found that air pollution and climate change can have an impact on acute coronary syndromes (ACS), the leading cause of death worldwide. We synthesized the latest information about the impact of air pollution and climate change on ACS, the latest data about the pathophysiological mechanisms of meteorological factors and atmospheric pollutants on atherosclerotic disease, and ...

Physical Activity in Cardiac Implantable Electronic Device Recipients During the COVID-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808717
Mayo Clinic Proceedings; Deshmukh AJ, Harrell C et. al.

Aug 7th, 2022 - To characterize the physical activity (PA) level in patients with a cardiac implantable electronic device (CIED) during the coronavirus disease 2019 (COVID-19) pandemic and compare PA level during the pandemic in 2020 with the year 2019. We performed a retrospective analysis of PA activity in individuals implanted with a CIED enrolled in the BIOTRONIK CERTITUDE Registry. Mean daily and weekly P...

Impact of different COVID-19 waves on kidney replacement therapy epidemiology and morta...
https://doi.org/10.1093/ndt/gfac234
Nephrology, Dialysis, Transplantation : Official Publicat... Carriazo S, Aparicio-Madre MI et. al.

Aug 6th, 2022 - Kidney replacement therapy (KRT) confers the highest risk of death from COVID-19. However, most data refer to the early pandemic waves. Whole year analysis in comparison with prior secular trends are scarce. We present the 2020 REMER Madrid KRT registry, corresponding to the Spanish Region hardest hit by COVID-19. In 2020, KRT incidence decreased 12% versus 2019 while KRT prevalence decreased (...

Cardiac Troponin Testing as a Component of Return to Play Cardiac Screening in Young Co...
https://doi.org/10.1161/JAHA.122.025369
Journal of the American Heart Association; Moulson N, Petek BJ et. al.

Aug 6th, 2022 - Background Initial protocols for return to play cardiac testing in young competitive athletes following SARS-CoV-2 infection recommended cardiac troponin (cTn) to screen for cardiac involvement. This study aimed to define the diagnostic yield of cTn in athletes undergoing cardiovascular testing following SARS-CoV-2 infection. Methods and Results This prospective, observational cohort study from...

Long-term Cardiovascular Manifestations and Complications of COVID-19: Spectrum and App...
https://www.ncbi.nlm.nih.gov/pubmed/35930485
Rhode Island Medical Journal (2013); Khetpal V, Berkowitz J et. al.

Aug 6th, 2022 - Survivors of coronavirus disease 2019 (COVID-19) may experience persistent symptoms, abnormal diagnostic test findings, incident disease in specific organ systems, or progression of existing disease. Post-acute COVID-19 syndrome (PACS) is defined by persistent, recurrent, or new symptoms, findings, or diagnoses beyond four weeks after the initial infection. PACS has been characterized as a mult...

Medical and cardio-vascular emergency department visits during the COVID-19 pandemic in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9362706
Clinical Research in Cardiology : Official Journal of The... Slagman A, Pigorsch M et. al.

Aug 6th, 2022 - In this retrospective routine data analysis, we investigate the number of emergency department (ED) consultations during the COVID-19 pandemic of 2020 in Germany compared to the previous year with a special focus on numbers of myocardial infarction and acute heart failure. Aggregated case numbers for the two consecutive years 2019 and 2020 were obtained from 24 university hospitals and 9 non-un...