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Hypocalcemia in COVID-19: Prevalence, clinical significance and therapeutic implications.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041474
Reviews in Endocrine & Metabolic Disorders; di Filippo L, Doga M et. al.

Apr 13th, 2021 - COVID-19 extra-pulmonary features include several endocrine manifestations and these are becoming strongly clinically relevant in patients affected influencing disease severity and outcomes.At the beginning of COVID-19 pandemic no population data on calcium levels in patients affected were available and in April 2020 a first case of severe acute hypocalcemia in an Italian patient with SARS-CoV-...

Male bias in ACE2 basic science research: Missed opportunity for discovery in the time ...
https://doi.org/10.1152/ajpregu.00356.2020
American Journal of Physiology. Regulatory, Integrative A... Stanic B, Maddox S et. al.

Apr 13th, 2021 - Throughout the world, including the United States, men have worse outcomes from COVID-19 than women. SARS-CoV-2, the causative virus of the COVID-19 pandemic, uses angiotensin-converting-enzyme-2 (ACE2) to gain cellular entry. ACE2 is a member of the renin-angiotensin-system (RAS) and plays an important role in counteracting the harmful effects mediated by the angiotensin-type-1-receptor. There...

Impact of the presence of heart disease, cardiovascular medications and cardiac events ...
https://doi.org/10.5603/CJ.a2021.0034
Cardiology Journal; Cabezón Villalba G, Amat-Santos IJ et. al.

Apr 12th, 2021 - Cardiovascular risk factors and usage of cardiovascular medication are prevalent among coronavirus disease 2019 (COVID-19) patients. Little is known about the cardiovascular implications of COVID-19. The goal herein, was to evaluate the prognostic impact of having heart disease (HD) and taking cardiovascular medications in a population diagnosed of COVID-19 who required hospitalization. Also, w...

The COVID-19 pandemic: challenges providing supportive care to those with cardiovascula...
https://doi.org/10.1097/SPC.0000000000000552
Current Opinion in Supportive and Palliative Care; Hill L, Lambrinou E et. al.

Apr 12th, 2021 - COVID-19 has permeated the very essence of human existence and society and disrupted healthcare systems. The attrition stemming from this highly contagious disease particularly affects those rendered vulnerable by age and infirmity, including those with underlying cardiovascular disease. This article critically reviews how best to integrate supportive care into the management of those affected....

AstraZeneca's Diabetes Drug Farxiga Fails in COVID-19 Study
https://www.medscape.com/viewarticle/949115

Apr 12th, 2021 - (Reuters) - Data from a late-stage study to test if AstraZeneca's diabetes drug Farxiga could treat patients hospitalised with COVID-19 and at risk of developing serious complications fell short of its main goals, the drugmaker said on Monday. The Farxiga data did not achieve statistical significance in cutting the risk of the disease worsening and death in such patients, the Anglo-Swedish drug...

OPTIMIZING THE POTENTIAL FOR TELEHEALTH IN CARDIOVASCULAR CARE (IN THE ERA OF COVID-19)...
https://doi.org/10.1016/j.amjmed.2021.03.007
The American Journal of Medicine; Patel P, Dhindsa D et. al.

Apr 12th, 2021 - Before the COVID-19 pandemic, use of telehealth services had been limited in cardiovascular care. Potential benefits of telehealth include improved access to care, more efficient care management, reduced costs, the ability to assess patients within their homes while involving key caretakers in medical decisions, maintaining social distancing, and increased patient satisfaction. Challenges inclu...

COVID-19 and hypertension: Is there a role for dsRNA and activation of Toll-like recept...
https://doi.org/10.1016/j.vph.2021.106861
Vascular Pharmacology; Dela Justina V, Giachini FR et. al.

Apr 12th, 2021 - The virus responsible for the coronavirus disease of 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidences suggest that COVID-19 could trigger cardiovascular complications in apparently healthy patients. Coronaviruses are enveloped positive-strand RNA viruses acting as a pathogen-associated molecular pattern (PAMP)/ danger-associated molecular patterns (...

Advances in Clinical Cardiology 2020: A Summary of Key Clinical Trials.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040014
Advances in Therapy; Kearney A, Linden K et. al.

Apr 12th, 2021 - Despite the challenge of a global pandemic, 2020 has been an invaluable year in cardiology research with numerous important clinical trials published or presented virtually at major international meetings. This article aims to summarise these trials and place them in clinical context. The authors reviewed clinical trials presented at major cardiology conferences during 2020 including the Americ...

Cardiovascular rna markers and artificial intelligence may improve covid-19 outcome: po...
https://doi.org/10.1093/cvr/cvab094
Cardiovascular Research; Badimon L, Robinson EL et. al.

Apr 11th, 2021 - The coronavirus disease 2019 (COVID-19) pandemic has been as unprecedented as unexpected, affecting more than 105 million people worldwide as of February 8th, 2020 and causing more than 2.3 million deaths according the World Health Organization. Not only affecting the lungs and provoking acute respiratory distress, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is able to infect m...

Statin and outcomes of coronavirus disease 2019 (COVID-19): A systematic review, meta-a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910652
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD; Hariyanto TI, Kurniawan A

Apr 11th, 2021 - One of the comorbidities associated with severe outcome and mortality of COVID-19 is dyslipidemia. Statin is one of the drugs which is most commonly used for the treatment of dyslipidemic patients. This study aims to analyze the association between statin use and composite poor outcomes of COVID-19. We systematically searched the PubMed and Europe PMC database using specific keywords related to...

Characterisation of cardiac pathology in 23 autopsies of lethal COVID-19.
https://doi.org/10.1002/cjp2.212
The Journal of Pathology. Clinical Research; Haslbauer JD, Tzankov A et. al.

Apr 10th, 2021 - While coronavirus disease 2019 (COVID-19) primarily affects the respiratory tract, pathophysiological changes of the cardiovascular system remain to be elucidated. We performed a retrospective cardiopathological analysis of the heart and vasculature from 23 autopsies of COVID-19 patients, comparing the findings with control tissue. Myocardium from autopsies of COVID-19 patients was categorised ...

Safety of treatment with chloroquine and hydroxychloroquine: A ten-year systematic revi...
https://doi.org/10.1016/j.ejim.2021.03.028
European Journal of Internal Medicine; Edington FLB, Gadellha SR et. al.

Apr 9th, 2021 - To estimate the incidence rate ratio (IRR) of adverse events (AE) in chloroquine or hydroxychloroquine users. We systematically reviewed randomized controlled trials (RCTs), using MEDLINE (2010-2020) and EMBASE (2010-2020) databases, reporting AE in chloroquine or hydroxychloroquine users during treatment for lupus, rheumatoid arthritis, malaria and COVID-19. The protocol for this systematic re...

Ultraviolet A Radiation and COVID-19 Deaths in the USA with replication studies in Engl...
https://doi.org/10.1111/bjd.20093
The British Journal of Dermatology; Cherrie M, Clemens T et. al.

Apr 9th, 2021 - Understanding factors impacting deaths from COVID-19 is of the highest priority. Seasonal variation in environmental meteorological conditions affects the incidence of many infectious diseases and may also affect COVID-19. Ultraviolet A (UVA) radiation induces release of cutaneous photolabile nitric oxide (NO) impacting the cardiovascular system and metabolic syndrome, both COVID-19 risk factor...

Comprehensive Review of Cardiovascular Involvement in COVID-19.
https://doi.org/10.4037/aacnacc2021302
AACN Advanced Critical Care; Macale Cajanding RJ

Apr 9th, 2021 - COVID-19 has emerged as one of the most devastating and clinically significant infectious diseases of the last decade. It has reached global pandemic status at an unprecedented pace and has placed significant demands on health care systems worldwide. Although COVID-19 primarily affects the lungs, epidemiologic reports have shown that the disease affects other vital organs of the body, including...

Scientific Hypothesis for Treatment of COVID-19's Lung Lesions by Adjusting ACE/ACE2 Im...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032553
Cardiovascular Toxicology; Ferrara F, Vitiello A

Apr 9th, 2021 - In March 2019 began the global pandemic COVID-19 caused by the new Coronavirus SARS-CoV-2. The first cases of SARS-CoV-2 infection occurred in November-19 in Wuhan, China. The preventive measures taken did not prevent the rapid spread of the virus to all countries around the world. To date, there are about 2.54 million deaths, effective vaccines are in clinical trials. SARS-CoV-2 uses the ACE-2...

Linked electronic health records for research on a nationwide cohort of more than 54 mi...
https://doi.org/10.1136/bmj.n826
BMJ (Clinical Research Ed.); Wood A, Denholm R et. al.

Apr 8th, 2021 - To describe a novel England-wide electronic health record (EHR) resource enabling whole population research on covid-19 and cardiovascular disease while ensuring data security and privacy and maintaining public trust. Data resource comprising linked person level records from national healthcare settings for the English population, accessible within NHS Digital's new trusted research environment...

Global Perspectives on Improving Chronic Disease Prevention and Management in Diverse S...
https://doi.org/10.5888/pcd18.210055
Preventing Chronic Disease; Airhihenbuwa CO, Tseng TS et. al.

Apr 8th, 2021 - The Centers for Disease Control and Prevention (CDC) define chronic diseases as conditions that last 1 year or more and that require ongoing medical attention or limit activities of daily living, or both (1). Chronic diseases may be influenced by a combination of genetics, lifestyle and social behaviors, health care system factors, community influences, and environmental determinants of health ...

Atypical Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in...
https://doi.org/10.2174/1573396317666210406153302
Current Pediatric Reviews; Βenou S, Ladhani S et. al.

Apr 7th, 2021 - In December 2019, a local outbreak of pneumonia presented in Wuhan (China), and quickly identified to be caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The disease caused by SARS-CoV-2 was named COVID-19 and was soon declared as pandemic because of the millions of infections and thousands of deaths worldwide. Children infected with SARS-CoV-2 usuall...

Post-Discharge Thromboembolic Outcomes and Mortality of Hospitalized COVID-19 Patients:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032474
Blood Giannis D, Allen S et. al.

Apr 7th, 2021 - Thromboembolic events including venous thromboembolism (VTE), arterial thromboembolism (ATE), and mortality from sub-clinical thrombotic events occur frequently in COVID-19 inpatients. Whether the risk extends post-discharge has been controversial. Our prospective registry included consecutive COVID-19 patients hospitalized within our multihospital system from March 1st - May 31st 2020. We capt...