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Usefulness of Combined Renin-Angiotensin System Inhibitors and Diuretic Treatment In Pa...
https://doi.org/10.1016/j.amjcard.2021.12.004
The American Journal of Cardiology; Palazzuoli A, Tecson KM et. al.

Jan 15th, 2022 - Antecedent use of renin-angiotensin system inhibitors (RASi) prevents clinical deterioration and protects against cardiovascular/thrombotic complications of COVID-19, for indicated patients. Uncertainty exists regarding treatment continuation throughout infection and doing so with concomitant medications. Hence, the purpose of this study is to evaluate the differential effect of RASi continuati...

Risk Factors for COVID-19 Mortality Among People Living with HIV: A Scoping Review.
https://doi.org/10.1007/s10461-022-03578-9 10.1371/journal.pone.0243529 10.1186/s12955-016-0556-x 10.1097/QAD.0000000000002293 10.1186/s12889-021-10296-9 10.1111/hiv.12911 10.1007/s40121-021-00447-1 10.1097/MD.0000000000026573 10.1038/s41598-020-79139-8 10.1097/QAD.0000000000002836 10.1007/s10461-020-02983-2 10.7326/M18-0850 10.1007/s10461-015-1281-x 10.1016/j.jash.2017.06.004 10.1016/S2352-3018(20)30305-2 10.1093/cid/ciaa1198 10.1093/cid/ciaa1793 10.1177/0956462420973106 10.15585/mmwr.mm7022a2 10.1093/cid/ciaa1339 10.7326/M20-3689 10.1093/cid/ciaa1605 10.1093/infdis/jiaa380 10.1101/2020.12.21.20248409v1 10.1097/QAI.0000000000002423 10.1111/hiv.12920 10.7196/SAMJ.2020.v110i11.15249 10.1080/09540121.2021.1936444 10.1093/cid/ciaa635 10.1093/cid/ciaa880 10.1002/jmv.26370 10.1101/2020.11.04.20226118 10.1016/j.jinf.2021.05.020 10.4338/ACI-2016-10-R-0175 10.1111/jrh.12200 10.1007/s10461-020-02895-1 10.1097/QAI.0000000000002815 10.1007/s10461-020-02902-5 10.1136/ejhpharm-2021-eahpconf.224 10.9745/GHSP-D-21-00168 10.1097/QAI.0000000000002570 10.1007/s10461-020-02976-1 10.1016/j.amepre.2021.05.044 10.1002/jia2.25583 10.1097/ADM.0000000000000712 10.1016/j.drugpo.2020.102821
AIDS and Behavior; Varshney K, Ghosh P et. al.

Jan 14th, 2022 - People living with HIV (PLWH) are particularly vulnerable to worsened outcomes of COVID-19. Therefore, the purpose of this work was to provide a scoping review of the literature to assess the risk factors for COVID-19 mortality among PLWH. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR), searches were conducted in PubMe...

Perioperative Cardiovascular Considerations Prior to Elective Noncardiac Surgery in Pat...
https://doi.org/10.1001/jamasurg.2021.6953
JAMA Surgery; Rohatgi N, Smilowitz NR et. al.

Jan 13th, 2022 - Perioperative Cardiovascular Considerations Prior to Elective Noncardiac Surgery in Patients With a History of COVID-19.|2022|Rohatgi N,Smilowitz NR,Reejhsinghani R,|

Cardiac Inflammation Can Be Present After Mild COVID Infection
https://www.medscape.com/viewarticle/966565

Jan 13th, 2022 - Myocardial inflammation is present in a small proportion of patients who have recovered from relatively mild cases of COVID-19 infection, a new study shows. "Our findings suggest that even in patients who have had relatively mild cases of COVID-19, some will have inflammatory changes to the heart, and these changes can be present without any cardiac symptoms," senior author, Paaladinesh Thavend...

Myocardial Inflammation Comes and Goes After COVID Illness
https://www.medpagetoday.com/cardiology/prevention/96628

Jan 12th, 2022 - A minority of people recovering from COVID-19 underwent a brief period of localized myocardial inflammation accompanied by cardiac injury and higher levels of systemic inflammatory blood markers, researchers found. Myocardial inflammation, flagged as focal fluorodeoxyglucose (FDG) uptake on combined PET/MRI scans, was visible in eight out of 47 people more than 2 months after COVID-19 diagnosis...

From the Heart to the Brain: Building Bridges to a Better Future.
https://doi.org/10.1161/STROKEAHA.121.036763
Stroke Elkind MSV

Jan 12th, 2022 - This Presidential Address was delivered at the International Stroke Conference in March 2021, during the coronavirus pandemic. Dr Elkind, the President of the American Heart Association (AHA) at the time, is a vascular neurologist with a research focus on stroke epidemiology. This address interweaves personal reflections on a career in clinical neurology, stroke research, and public health with...

HIV, Aging, and Comorbidities Research in Clinical Cohorts: 3 Lessons Learned Using Exa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751281
Journal of Acquired Immune Deficiency Syndromes (1999); Crane HM, Drumright L

Jan 12th, 2022 - Owing to ongoing improvements in antiretroviral therapy, people with HIV (PWH) are achieving near-normal lifespans with many surviving into middle and old age. Despite this success, PWH have a higher than expected risk of developing non-AIDS comorbidities, multimorbidity, and functional decline at ages younger than those without HIV. As part of the Inter-CFAR (Center for AIDS Research) Symposiu...

Fatty Liver Disease a Long-COVID Symptom After Severe Cases?
https://www.medpagetoday.com/gastroenterology/generalhepatology/96607

Jan 11th, 2022 - A majority of long-COVID patients who had been hospitalized for severe COVID-19 illness had metabolic (dysfunction)-associated fatty liver disease (MAFLD), a retrospective study from Italy found. In an analysis of 235 patients presenting to a post-acute COVID syndrome (PACS) clinic in Italy, 55.3% had MAFLD during follow-up as compared to 37.3% upon their initial hospital admission (P<0.001), r...

Heart-Saving Drone; Drug-Associated Myocarditis; CAR-T Therapy for HF?
https://www.medpagetoday.com/cardiology/prevention/96603

Jan 11th, 2022 - In Sweden, a drone delivered the automated external defibrillator that helped save a man in cardiac arrest. (BBC) Israel logs its first case of myocarditis following Omicron infection, reportedly in a previously healthy man in his 40s who had last received a coronavirus vaccine in August. (Times of Israel) Watch out for subclinical cardiac impairment in people recovering from mild-to-moderate C...

Comorbidities as Risk Factors for Severe Disease in Hospitalized Elderly COVID-19 Patie...
https://doi.org/10.1159/000521000
Gerontology Asai Y, Nomoto H et. al.

Jan 10th, 2022 - Old age is an independent risk factor (RF) for severe COVID-19; evidence for clinico-epidemiological characteristics among elderly COVID-19 patients is scarce. We aimed to analyze clinical and epidemiological characteristics and comorbidities associated with COVID-19 inpatients in age-stratified populations of an elderly COVID-19 cohort. We conducted a retrospective cohort study, using nationwi...

COVID & Childhood Obesity; Phase III Oral Octreotide Success; Anti-Fog Chemicals
https://www.medpagetoday.com/endocrinology/generalendocrinology/96566

Jan 9th, 2022 - According to new CDC research, COVID-19 is a much greater threat to kids with obesity, with the average length of their hospital stay double that of kids without obesity. (Morbidity and Mortality Weekly Report) A new phase III trial found that oral octreotide (Mycapssa) was noninferior to injectable somatostatin receptor ligands for the treatment of patients with acromegaly. (The Lancet Diabete...

Mid-regional proadrenomedullin (MR-proADM), C-reactive protein (CRP) and other biomarke...
https://doi.org/10.1136/jclinpath-2021-207750
Journal of Clinical Pathology; Moore N, Williams R et. al.

Jan 9th, 2022 - There is a lack of biomarkers validated for assessing clinical deterioration in patients with COVID-19 on presentation to secondary or tertiary care. This evaluation looked at the potential clinical application of C reactive protein (CRP), procalcitonin, mid-regional proadrenomedullin (MR-proADM) and white cell count to support prediction of clinical outcomes. 135 patients presenting to Hampshi...

Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits fo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8736331
Reviews in Endocrine & Metabolic Disorders; Mahapatra MK, Karuppasamy M et. al.

Jan 8th, 2022 - Semaglutide, a glucagon like peptide-1 (GLP-1) receptor agonist, is available as monotherapy in both subcutaneous as well as oral dosage form (first approved oral GLP-1 receptor agonist). It has been approved as a second line treatment option for better glycaemic control in type 2 diabetes and currently under scrutiny for anti-obesity purpose. Semaglutide has been proved to be safe in adults an...

CDC: Pfizer Vaccine Blunts Severe COVID Complication in Teens
https://www.medpagetoday.com/infectiousdisease/covid19vaccine/96572

Jan 7th, 2022 - Two doses of Pfizer/BioNTech vaccine bolstered protection against multi-system inflammatory syndrome (MIS-C) in adolescents ages 12 to 18, researchers found. The vaccine was 91% (95% CI 78%-97%) effective in protecting fully vaccinated adolescents against MIS-C, reported Laura Zambrano, PhD, MPH, of the CDC COVID-19 Emergency Response Team, and colleagues. From July to mid-December 2021, when t...

COVID-19 Infection in Pregnancy: A Review.
https://doi.org/10.2174/1871526522666220105111358
Infectious Disorders Drug Targets; Mily SJ, Akter KM et. al.

Jan 7th, 2022 - Coronavirus disease 2019 (COVID-19), which is a highly contagious viral illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a catastrophic effect on the world's demographics, resulting in more than 3.8 million deaths worldwide, and establishing itself as the most serious global health crisis since the 1918 influenza pandemic. Several questions remain unans...

Prevention of atherosclerosis from childhood.
https://doi.org/10.1038/s41569-021-00647-9 10.1001/jamacardio.2021.3508
Nature Reviews. Cardiology; Raitakari O, Pahkala K et. al.

Jan 7th, 2022 - Cardiovascular diseases caused by atherosclerosis do not typically manifest before middle age; however, the disease process begins early in life. Preclinical atherosclerosis can be quantified with imaging methods in healthy populations long before clinical manifestations present. Cohort studies have shown that childhood exposure to risk factors, such as dyslipidaemia, elevated blood pressure an...

Allocating scarce cardiovascular support in a pandemic: ECMO in crisis standards of care.
https://doi.org/10.1136/heartjnl-2021-319193
Heart (British Cardiac Society); Zaidi D, Fedson SE et. al.

Jan 7th, 2022 - Allocating scarce cardiovascular support in a pandemic: ECMO in crisis standards of care.|2022|Zaidi D,Fedson SE,Kirkpatrick JN,|

Adults Meeting Fruit and Vegetable Intake Recommendations - United States, 2019.
https://doi.org/10.15585/mmwr.mm7101a1
MMWR. Morbidity and Mortality Weekly Report; Lee SH, Moore LV et. al.

Jan 7th, 2022 - The 2020-2025 Dietary Guidelines for Americans* advise incorporating more fruits and vegetables into U.S. residents' diets as part of healthy dietary patterns. Adults should consume 1.5-2 cup-equivalents of fruits and 2-3 cup-equivalents of vegetables daily.† A healthy diet supports healthy immune function (1) and helps to prevent obesity, type 2 diabetes, cardiovascular diseases, and some canc...

Jan 7, 2021 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/966213

Jan 7th, 2022 - Please note that the text below is not a full transcript and has not been copyedited. For more insight and commentary on these stories, subscribe to the This Week in Cardiology podcast on Apple Podcasts, Spotify, or your preferred podcast provider. In This Week’s Podcast For the week ending January 7, 2021, John Mandrola, MD comments on the following news and features stories. First, I want to ...

Effect of renin-angiotensin system blocker on COVID-19 in young patients with hypertens...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753108
Journal of Investigative Medicine : the Official Publicat... Kuzeytemiz M, Tenekecioglu E

Jan 7th, 2022 - Hypertension is found frequently in patients with COVID-19 and is often treated with ACE inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). SARS-CoV-2, the pathogen of COVID-19, binds to the receptors of ACE2 to enter the alveolar cells, raising questions on whether these drugs are salutary or harmful with respect to any propensity for COVID-19 or to disease prognosis. We investigated...