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Are diabetes and its medications risk factors for the development of COVID-19? Data fro...
https://doi.org/10.1016/j.numecd.2020.09.028
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD; Silverii GA, Monami M et. al.

Nov 23rd, 2020 - Diabetes mellitus (DM) has been associated with higher incidence of severe cases of COVID-19 in hospitalized patients, but it is unknown whether DM is a risk factor for the overall COVID-19 incidence. The aim of present study was to investigate whether there is an association of DM with COVID-19 prevalence and case fatality, and between different DM medications and risk for COVID-19 infection a...

Pregnant women with severe or critical COVID-19 have increased composite morbidity comp...
https://doi.org/10.1016/j.ajog.2020.11.022
American Journal of Obstetrics and Gynecology; DeBolt CA, Bianco A et. al.

Nov 22nd, 2020 - In March 2020, as community spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) became increasingly prevalent, pregnant women appeared to be equally susceptible to developing Coronavirus Disease 2019 (COVID-19). While the disease course usually appears mild, severe and critical COVID-19 appears to lead to significant morbidity including ICU admission with prolonged hospital s...

Association between Renin-Angiotensin-Aldosterone system inhibitor use and COVID-19 Hos...
https://doi.org/10.1002/ejhf.2060
European Journal of Heart Failure; Savarese G, Benson L et. al.

Nov 22nd, 2020 - Renin-angiotensin-aldosterone-system inhibitors (RAASi) improve outcomes in cardiorenal disease but concerns have been raised over increased risk of incident and death from Covid-19. We investigated the association between use of angiotensin converting enzyme inhibitors (ACEi), angiotensin receptor blockers (ARB) or mineralocorticoid receptor antagonists (MRA) and Covid-19 hospitalization/death...

The Impact of SARS-CoV-2 on Stroke Epidemiology and Care: A Meta-analysis.
https://doi.org/10.1002/ana.25967
Annals of Neurology; Katsanos AH, Palaiodimou L et. al.

Nov 21st, 2020 - Emerging data indicates an increased risk for cerebrovascular events with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and highlights the potential impact of coronavirus disease (COVID-19) on the management and outcomes of acute stroke. We conducteda systematic review and meta-analysis to evaluate the aforementioned considerations. We performed a meta-analysis of observati...

Hypertension, medications, and risk of severe COVID-19: A Massachusetts community-based...
https://doi.org/10.1111/jch.14101
Journal of Clinical Hypertension (Greenwich, Conn.) REFERENCES; Bauer AZ, Gore R et. al.

Nov 21st, 2020 - It remains uncertain whether the hypertension (HT) medications angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) mitigate or exacerbate SARS-CoV-2 infection. We evaluated the association of ACEi and ARB with severe coronavirus disease 19 (COVID-19) as defined by hospitalization or mortality among individuals diagnosed with COVID-19. We investigated whether ...

Association of glycosylated hemoglobin and outcomes in patients with COVID-19 and pre-e...
https://doi.org/10.1097/MD.0000000000023392
Medicine Zhang N, Yun R et. al.

Nov 21st, 2020 - The impact of glycosylated hemoglobin on mortality in patients with coronavirus disease 2019 (COVID-19) and type 2 diabetes (T2D) remains uncertain. In this study, we aim to assess the effect of pre-hospital blood glucose regulation on patients with COVID-19 and pre-existing T2D. All randomized controlled trials (RCTs) and cohort studies of association of glycosylated hemoglobin and outcomes in...

Pneumonia in medical professionals during COVID-19 outbreak in cardiovascular hospital.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674984
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases; Ilic I, Zdravkovic M et. al.

Nov 21st, 2020 - The pandemic of coronavirus associated disease (COVID-19) placed the health care workers at high risk. We investigated clinical and treatment characteristics of infected medical professionals in a cardiovascular hospital. The study was retrospective, conducted in tertiary cardiovascular hospital and included employees with confirmed coronavirus infection. They filled out a questionnaire about h...

Clinical Characteristics and Risk Factors for Fatality and Severity in Patients with Co...
https://doi.org/10.3390/ijerph17228559
International Journal of Environmental Research and Public Health; Lee SG, Park GU et. al.

Nov 21st, 2020 - We aimed to investigate the clinical characteristics and risk factors for fatality and severity in these patients. In this nationwide population-based retrospective study, we investigated the data of 7339 laboratory-confirmed COVID-19 patients, aged ≥ 18 years, using the Korean Health Insurance Review and Assessment Service (HIRA) database. Comorbidities and medications used were identified usi...

The dark side of the spoon - glucose, ketones and COVID-19: a possible role for ketogen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677746
Journal of Translational Medicine; Paoli A, Gorini S et. al.

Nov 21st, 2020 - The novel coronavirus disease (COVID-19) is posing a serious challenge to the health-care systems worldwide, with an enormous impact on health conditions and loss of lives. Notably, obesity and its related comorbidities are strictly related with worse clinical outcomes of COVID-19 disease. Recently, there is a growing interest in the clinical use of ketogenic diets (KDs), particularly in the co...

Factors Associated with Mortality among Hospitalized Patients with COVID-19: A Retrospe...
https://doi.org/10.4269/ajtmh.20-1170
The American Journal of Tropical Medicine and Hygiene; Martins-Filho PR, Antunes de Souza Araújo A et. al.

Nov 20th, 2020 - Information on the risk factors for COVID-19 mortality in low- and middle-income countries is still scarce. In this retrospective cohort study, we analyzed the factors associated with COVID-19 mortality in hospitalized patients in a poor area of Brazil. Logistic regression was used to identify factors independently associated with mortality, including gender, age, and the presence of underlying...

Clinical characteristics of coronavirus disease 2019 (COVID-19) patients in Kuwait.
https://doi.org/10.1371/journal.pone.0242768
PloS One; Alshukry A, Ali H et. al.

Nov 20th, 2020 - This is a retrospective single-center study of 417 consecutive patients with coronavirus disease 2019 (COVID-19) admitted to Jaber Al-Ahmad Hospital in Kuwait between February 24, 2020 and May 24, 2020. In total, 39.3% of patients were asymptomatic, 41% were symptomatic with mild/moderate symptoms, 19.7% were admitted to the intensive care unit (ICU). Most common symptoms in cohort patients wer...

Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675396
Nature Reviews. Cardiology; Gu SX, Tyagi T et. al.

Nov 20th, 2020 - The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive inflammation and respiratory disease, with cytokine storm and acute respiratory distress syndrome implicated in the most severe cases. Thrombotic complications are a major cause of morbidity and mortality in patients wit...

Recent trends for the management of diabetes for older adults in the context of univers...
https://doi.org/10.1093/inthealth/ihaa098
International Health; Arredondo A

Nov 19th, 2020 - To identify trends in the epidemiological and economic burden of diabetes in the elderly. Using the Box-Jenkins method to estimate expected cases for the period 2020-2022, costs were determined with the instrumentation technique. The population base was 4 032 189 older adults diagnosed with diabetes in 2019. Regarding the epidemiological burden, there is an increase of 11-15% (p<0.001). Compari...

ACE-Inhibitors, Angiotensin Receptor Blockers and Endothelial Injury in COVID-19.
https://doi.org/10.1111/joim.13202
Journal of Internal Medicine; Tetlow S, Segiet-Swiecicka A et. al.

Nov 19th, 2020 - COVID-19 is caused by the coronavirus SARS-CoV-2, which uses Angiotensin Converting Enzyme-2 (ACE-2) as a receptor for cellular entry. It is theorized that ACE-inhibitors (ACE-Is) or Angiotensin Receptor Blockers (ARBs) may increase vulnerability to SARS-CoV-2 by up-regulating ACE-2 expression, but ACE-I/ARB discontinuation is associated with clinical deterioration. To determine whether ACE-I a...

M♡THer, a mHealth System to Support Women with Gestational Diabetes Mellitus - Feasibil...
https://doi.org/10.1089/dia.2020.0509
Diabetes Technology & Therapeutics; Varnfield M, Redd C et. al.

Nov 19th, 2020 - Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance first identified during pregnancy. Delays in diagnosis and challenges in management can lead to serious adverse outcomes for the mother and child. As rates of GDM diagnosis increase worldwide, health systems and maternity services have become increasingly strained, especially with new restrictions around in-person care due to...

Incremental Risk of Developing Severe COVID-19 Among Mexican Patients With Diabetes Att...
https://doi.org/10.2337/dc20-2192
Diabetes Care; Sosa-Rubí SG, Seiglie JA et. al.

Nov 19th, 2020 - Diabetes is an important risk factor for severe coronavirus disease 2019 (COVID-19), but little is known about the marginal effect of additional risk factors for severe COVID-19 among individuals with diabetes. We tested the hypothesis that sociodemographic, access to health care, and presentation to care characteristics among individuals with diabetes in Mexico confer an additional risk of hos...

The Impact of Previous History of Bariatric Surgery on Outcome of COVID-19. A Nationwid...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673863
Obesity Surgery; Iannelli A, Bouam S et. al.

Nov 19th, 2020 - To determine the risk of invasive mechanical ventilation and death in obese individuals with a history of bariatric surgery (BS) admitted for COVID-19. All obese inpatients recorded during a hospital stay by the French National Health Insurance were included, and their electronic health data were reviewed retrospectively. Patients who had undergone bariatric surgery comprised the BS group and p...

Pregnancy Outcomes Among Women With and Without Severe Acute Respiratory Syndrome Coron...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677755
JAMA Network Open; Adhikari EH, Moreno W et. al.

Nov 19th, 2020 - Published data suggest that there are increased hospitalizations, placental abnormalities, and rare neonatal transmission among pregnant women with coronavirus disease 2019 (COVID-19). To evaluate adverse outcomes associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy and to describe clinical management, disease progression, hospital admission, place...

Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-1...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674575
Intensive Care Medicine;

Nov 19th, 2020 - To describe acute respiratory distress syndrome (ARDS) severity, ventilation management, and the outcomes of ICU patients with laboratory-confirmed COVID-19 and to determine risk factors of 90-day mortality post-ICU admission. COVID-ICU is a multi-center, prospective cohort study conducted in 138 hospitals in France, Belgium, and Switzerland. Demographic, clinical, respiratory support, adjuncti...

Effect of the COVID-19 Lockdown on Disease Recognition and Utilization of Healthcare Se...
https://doi.org/10.1093/ageing/afaa260
Age and Ageing; Michalowsky B, Hoffmann W et. al.

Nov 18th, 2020 - There is little evidence about the utilization of healthcare services and disease recognition in the older population, which was urged to self-isolate during the COVID-19 lockdowns. We aimed to describe the utilization of physician consultations, specialist referrals, hospital admissions, and the recognition of incident diseases in Germany for this age group during the COVID-19 lockdown. Cross-...