Mar 29th, 2023 - Cardiovascular events were not more likely for recipients of the Pfizer-BioNTech COVID-19 mRNA bivalent booster compared with the original monovalent booster, according to French researchers. Their population-based study found no evidence of an increased risk of cardiovascular events at 21 days among the recipients of the bivalent vaccine versus recipients of the monovalent vaccine, including: ...

Mar 29th, 2023 - In certain groups of men, glucose-6-phosphate dehydrogenase (G6PD) deficiency was linked with an increased likelihood of severe COVID-19, a Veterans Affairs cohort study found. In Black men under 65, for example, those with the common enzyme deficiency had a roughly 1.5-fold higher risk for severe illness (OR 1.47, 95% CI 1.03-2.09), reported Lavannya Pandit, MD, MS, of the Michael E. DeBakey V...

Mar 28th, 2023 - Two groups of long COVID patients -- those hospitalized for acute COVID, and those with mild SARS-CoV-2 infection who weren't hospitalized -- had different neurologic manifestations, prospective data showed. Long COVID patients who were hospitalized with acute infection more frequently had an abnormal neurologic exam (62% vs 37%, P<0.0001) and performed worse on processing speed, attention, and...

Mar 28th, 2023 - Melioidosis, caused by Burkholderia pseudomallei, may be considered a neglected tropical disease which remains underdiagnosed in many geographical areas. Travelers can act as sentinels of disease activity and data from imported cases may help complete the global map of melioidosis. A literature search for imported melioidosis for the period 2016-2022 was performed in PubMed and Google Scholar. ...

Mar 25th, 2023 - Breastfeeding maintains the maternal-fetal immune link after birth, favors the transmission of immunological competence, and is considered an important contributing factor to the development of the babies' immune system. This study aimed to obtain data related to the effects of gestational diabetes on immunoglobulin A (IgA) and cytokines levels in the colostrum, before and during the pandemic o...

Mar 25th, 2023 - To examine the association between pre-existing cardiovascular disorders and the risk of coronavirus disease 2019 (COVID-19) among community-dwelling adults in the United States (US). We analyzed data from the 2021 National Health Interview Survey (NHIS), encompassing 28,848 nationally representative participants aged ≥18. We examined the association by two age groups, younger adults (aged 18-5...

Mar 25th, 2023 - With the rise in prevalence of youth-onset type 2 diabetes (T2DM), it is imperative to understand the clinical burden of the disease and the socioeconomic burden this disease imposes. We review the most recent data on youth-onset T2DM, including its pathophysiology, complications, and treatment. We also review existing data to determine the socioeconomic burden of youth-onset T2DM. The incidenc...

Mar 25th, 2023 - SARS-Cov-2 infection during pregnancy can lead to severe placental lesions characterized by massive perivillous fibrin deposition, histiocytic intervillositis and trophoblast necrosis. Diffuse placental damage of this kind is rare, but can sometimes lead to obstetric complications, such as intrauterine fetal death (IUFD). The objectives of this study were to identify possible predictors of seve...

Mar 24th, 2023 - Type 1 diabetes (T1D) is usually caused by immune-mediated destruction of islet beta-cells, and genetic and environmental factors are thought to trigger autoimmunity. Convincing evidence indicates that viruses are associated with T1D development and progression. During the coronavirus disease 2019(COVID-19) pandemic, cases of hyperglycemia, diabetic ketoacidosis (DKA), and new diabetes increase...

Mar 24th, 2023 - Monkeypox infection is caused by the Orthopoxvirus (OPXV) genus of the Poxviridae family, closely resembling its more famous sibling smallpox. Recently World Health Organization (WHO), have renamed monkeypox as Mpox citing racial concerns, so we will be referring monkeypox as Mpox There has been a recent outbreak in May 2022 when more than 31,800 confirmed and suspected cases of Mpox were ident...

Mar 24th, 2023 - There is consistent evidence that the COVID-19 pandemic is associated with an increased psychosocial burden on children and adolescents and their parents. Relatively little is known about its particular impact on high-risk groups with chronic physical health conditions (CCs). Therefore, the primary aim of the study is to analyze the multiple impacts on health care and psychosocial well-being on...

Mar 24th, 2023 - End-stage renal disease patients on hemodialysis (ESRD) patients are at high risk for contracting COVID-19. In this propensity matched cohort study, we examined the prevalence of COVID-19 in emergency room (ER) patients and examined whether clinical outcomes varied by ESRD status. Patients who visited George Washington University Hospital ER from April 2020 to April 2021 were reviewed for COVID...

Mar 24th, 2023 - Patients undergoing surgery with perioperative COVID-19 are suggested to have worse outcomes, but whether this is COVID-related or due to selection bias remains unclear. We aimed to compare the postoperative outcomes of patients with and without perioperative COVID-19. Patients with perioperative COVID-19 diagnosed within 7 days before or 30 days after surgery between February and July 2020 fro...

Mar 24th, 2023 - Post-COVID-19 condition (PCC) is a complex heterogeneous disorder that has affected the lives of millions of people globally. Identification of potential risk factors to better understand who is at risk of developing PCC is important because it would allow for early and appropriate clinical support. To evaluate the demographic characteristics and comorbidities that have been found to be associa...

Mar 24th, 2023 - The COVID-19 pandemic has profoundly affected health care delivery. In addition to the significant morbidity and mortality associated with acute illness from COVID-19, the indirect impact has been far-reaching, including substantial disruptions in chronic disease care. As a result of pandemic disruptions in health care, vulnerable and minority populations have faced health inequalities. The aim...

Mar 24th, 2023 - Diabetes is a major public health problem in Canada and requires multifactorial, consistent clinical management. The COVID-19 pandemic increased challenges in the management of many chronic ailments, including diabetes. Diabetes was associated with a higher risk of severe illness in the context of COVID-19. Pandemic restrictions also impacted diabetes care continuity, which may have contributed...

Mar 24th, 2023 - Some epidemiological studies have suggested an increase in incidence of type 1 diabetes during the COVID-19 pandemic, however the mechanism(s) behind such an increase have yet to be identified. In this study we aimed to evaluate the possible role of the SARS-CoV-2 virus in the reported increase in the rate of type 1 diabetes. In this observational cohort study using data from the Finnish Pediat...

Mar 23rd, 2023 - SAN FRANCISCO – Gastroenterologists are uniquely positioned to treat obesity, according to a panel of experts convened by the American Gastroenterological Association. “We see this as a field that GI should own,” said Naresh T.

Mar 23rd, 2023 - Populations of different South Asian nations including Bangladesh reportedly have a high risk of developing diabetes in recent years. This study aimed to investigate the differences in the gut microbiome of COVID-19 positive participants with or without T2DM compared with healthy control subjects. Microbiome data of thirty participants with T2DM were compared with twenty-two age-, sex-, and BMI...

Mar 23rd, 2023 - Without access to leptin replacement, patients with generalized lipodystrophy (GL) are at high risk for severe metabolic disease. Although there is a well-established GL registry in Turkey since the early 2000s, leptin replacement treatment was not available until recently. This gave us a unique opportunity to describe the natural history of GL. This study reports on 72 patients with GL (47 fam...