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High Frequency of SARS-CoV-2 RNAemia and Association With Severe Disease.
https://doi.org/10.1093/cid/ciaa1054
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Hogan CA, Stevens BA et. al.

Sep 23rd, 2020 - Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in blood, also known as RNAemia, has been reported, but its prognostic implications are poorly understood. This study aimed to determine the frequency of SARS-CoV-2 RNA in plasma and its association with coronavirus disease 2019 (COVID-19) clinical severity. An analytical cross-sectional study was performed in a singl...

Association of Red Blood Cell Distribution Width With Mortality Risk in Hospitalized Ad...
https://doi.org/10.1001/jamanetworkopen.2020.22058
JAMA Network Open; Foy BH, Carlson JCT et. al.

Sep 23rd, 2020 - Coronavirus disease 2019 (COVID-19) is an acute respiratory illness with a high rate of hospitalization and mortality. Biomarkers are urgently needed for patient risk stratification. Red blood cell distribution width (RDW), a component of complete blood counts that reflects cellular volume variation, has been shown to be associated with elevated risk for morbidity and mortality in a wide range ...

Risk Factors for Hospitalization, Mechanical Ventilation, or Death Among 10 131 US Vete...
https://doi.org/10.1001/jamanetworkopen.2020.22310
JAMA Network Open; Ioannou GN, Locke E et. al.

Sep 23rd, 2020 - Identifying independent risk factors for adverse outcomes in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can support prognostication, resource utilization, and treatment. To identify excess risk and risk factors associated with hospitalization, mechanical ventilation, and mortality in patients with SARS-CoV-2 infection. This longitudinal cohort study incl...

The Perfect Storm: COVID-19 Health Disparities in US Blacks.
https://doi.org/10.1007/s40615-020-00871-y
Journal of Racial and Ethnic Health Disparities; Phillips N, Park IW et. al.

Sep 23rd, 2020 - Coronavirus disease 2019 (COVID-19) accounts for over 180,000 deaths in the USA. Although COVID-19 affects all racial ethnicities, non-Hispanic Blacks have the highest mortality rates. Evidence continues to emerge, linking the disproportion of contagion and mortality from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a result of adverse social determinants of health. Yet, geneti...

Clinical features and outcomes of adults with COVID-19: A systematic review and pooled ...
https://doi.org/10.1111/ijcp.13725
International Journal of Clinical Practice; Bennett S, Tafuro J et. al.

Sep 23rd, 2020 - The 2019 coronavirus disease (COVID-19) has become a global pandemic and the published literature describing the virus has grown exponentially. We conducted a systematic review of the literature to identify the symptoms, comorbidities present, radiological features and outcomes for adults testing positive for COVID-19 admitted to hospital. The results across multiple studies were numerically po...

Derivation and Validation of a Predictive Score for Disease Worsening in Patients with ...
https://doi.org/10.1055/s-0040-1716544
Thrombosis and Haemostasis; Gerotziafas GT, Sergentanis TN et. al.

Sep 22nd, 2020 - The prospective observational cohort study COMPASS-COVID-19 aimed to develop a risk assessment model for early identification of hospitalized COVID-19 patients at risk for worsening disease. Patients with confirmed COVID-19 (n = 430) hospitalized between March 18 and April 21, 2020 were divided in derivation (n = 310) and validation (n = 120) cohorts. Two groups became evident: (1) good prognos...

Risk of metformin in type 2 diabetes patients with COVID-19: a preliminary retrospectiv...
https://doi.org/10.1111/cts.12897
Clinical and Translational Science; Gao Y, Liu T et. al.

Sep 21st, 2020 - The current outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread across the world. No specific antiviral agents have been adequately evidenced for the treatment of COVID-19. Although metformin has been recommended as a host-directed therapy for COVID-19, there are some opposite views. And the effect of metformin on the disease severity of COVID-19 pa...

Predictors of Outcomes of COVID-19 in Patients with Chronic Liver Disease: US Multi-cen...
https://doi.org/10.1016/j.cgh.2020.09.027
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association; Kim D, Adeniji N et. al.

Sep 20th, 2020 - Chronic liver disease (CLD) represents a major global health burden. We undertook this study to identify the factors associated with adverse outcomes in patients with CLD who acquire the novel coronavirus-2019 (COVID-19). We conducted a multi-center, observational cohort study across 21 institutions in the United States (US) of adult patients with CLD and laboratory-confirmed diagnosis of COVID...

Commentary: The original pandemic-stemming the tide of overweight, diabetes, hypertensi...
https://doi.org/10.1016/j.jtcvs.2020.08.048
The Journal of Thoracic and Cardiovascular Surgery; Wyler von Ballmoos MC, Almassi GH

Sep 19th, 2020 - Commentary: The original pandemic-stemming the tide of overweight, diabetes, hypertension, and dyslipidemia after coronary artery bypass grafting.|2020|Wyler von Ballmoos MC,Almassi GH,|

Risk Factors for COVID-19-associated hospitalization: COVID-19-Associated Hospitalizati...
https://doi.org/10.1093/cid/ciaa1419
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Ko JY, Danielson ML et. al.

Sep 18th, 2020 - Data on risk factors for COVID-19-associated hospitalization are needed to guide prevention efforts and clinical care. We sought to identify factors independently associated with COVID-19-associated hospitalizations. U.S. community-dwelling adults (≥18 years) hospitalized with laboratory-confirmed COVID-19 during March 1-June 23, 2020 were identified from the COVID-19-Associated Hospitalization...

The association between plasma glucose and mortality of COVID-19 in patients without di...
https://doi.org/10.1016/j.diabres.2020.108448
Diabetes Research and Clinical Practice; Huang Y, Guo H et. al.

Sep 18th, 2020 - Coronavirus disease 2019 (COVID-19) which is a novel pneumonia can rapidly progress to acute respiratory distress syndrome, septic shock, and multiple organ dysfunction syndrome. It has appeared in 196 countries around the world. We aimed to clarify the association between plasma glucose and mortality of COVID-19 in patients without diabetes. We performed a retrospective, single-center study of...

Use of DPP4 inhibitors in Italy does not correlate with diabetes prevalence among COVID...
https://doi.org/10.1016/j.diabres.2020.108444
Diabetes Research and Clinical Practice; Strollo R, Maddaloni E et. al.

Sep 18th, 2020 - Use of DPP4 inhibitors in Italy does not correlate with diabetes prevalence among COVID-19 deaths.|2020|Strollo R,Maddaloni E,Dauriz M,Pedone C,Buzzetti R,|

COVID-19 and diabetes: a co-conspiracy?
https://doi.org/10.1016/S2213-8587(20)30315-6
The Lancet. Diabetes & Endocrinology; The Lancet Diabetes Endocrinology

Sep 18th, 2020 - COVID-19 and diabetes: a co-conspiracy?|2020|The Lancet Diabetes Endocrinology ,|

COVID-19 and Diabetes: A Collision and Collusion of Two Diseases.
https://doi.org/10.2337/dbi20-0032
Diabetes Feldman EL, Savelieff MG et. al.

Sep 17th, 2020 - The COVID-19 pandemic has infected over 22.7 million and led to the deaths of 795,000 people worldwide. Diabetes patients are highly susceptible to COVID-19-induced adverse outcomes and complications. The COVID-19 pandemic is superimposing on the preexisting diabetes pandemic to create large and significantly vulnerable COVID-19 diabetes patient populations. This perspective provides an overvie...

Induction of ketosis as a potential therapeutic option to limit hyperglycemia and preve...
https://doi.org/10.1016/j.nut.2020.110967
Nutrition (Burbank, Los Angeles County, Calif.); Sukkar SG, Bassetti M

Sep 17th, 2020 - The severe form of coronavirus disease 19 (COVID-19) is characterized by cytokine storm syndrome (CSS) and disseminated intravascular coagulation (DIC). Diabetes, obesity, and hypertension have, as minor common denominators, chronic low-grade inflammation and high plasma myeloperoxidase levels, which could be linked to pulmonary phagocytic hyperactivation and CSS. The hyperactivation of M1 macr...

Diabetic ketoacidosis in the time of COVID-19 and resource-limited settings: role of su...
https://doi.org/10.1111/pedi.13118
Pediatric Diabetes; Priyambada L, Wolfsdorf JI et. al.

Sep 16th, 2020 - The International Society for Pediatric and Adolescent Diabetes (ISPAD) Clinical Practice Consensus Guidelines 2018 for management of diabetic ketoacidosis (DKA) and the hyperglycemic hyperosmolar state 1, 2 provide comprehensive guidance for management of DKA in young people (Figure 1). Intravenous (IV) infusion of insulin remains the treatment of choice for treating DKA; however, the policy o...

Early experience with critically ill patients with COVID-19 in Montreal.
https://doi.org/10.1007/s12630-020-01816-z
Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie; Cavayas YA, Noël A et. al.

Sep 16th, 2020 - Montreal has been the epicentre of the coronavirus disease (COVID-19) pandemic in Canada. Given the regional disparities in incidence and mortality in the general population, we aimed to describe local characteristics, treatments, and outcomes of critically ill COVID-19 patients in Montreal. A single-centre retrospective cohort of consecutive adult patients admitted to the intensive care unit (...

Impact of cerebrovascular and cardiovascular diseases on mortality and severity of COVI...
https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104949
Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association; Pranata R, Huang I et. al.

Sep 15th, 2020 - We conducted a systematic review and meta-analysis to evaluate the latest evidence on the association between cerebrovascular, and cardiovascular diseases and poor outcome in patients with Coronavirus Disease 2019 (COVID-19) pneumonia. A comprehensive systematic literature search was performed using PubMed, SCOPUS, EuropePMC, and Cochrane Central Database. The outcome of interest was composite ...

Patient characteristics and admitting vital signs associated with COVID-19 related mort...
https://doi.org/10.1017/ice.2020.461
Infection Control and Hospital Epidemiology; Sands K, Wenzel R et. al.

Sep 15th, 2020 - Determine risk factors for mortality among COVID-19 patients admitted to a system of community hospitals in the United States. Retrospective analysis of patient data collected from the routine care of COVID-19 patients. System of more than 180 acute care facilities in the United States. All admitted patients with positive identification of COVID-19 and a documented discharge as of May 12, 2020....

COVID-19 risk and outcomes in patients with substance use disorders: analyses from elec...
https://doi.org/10.1038/s41380-020-00880-7
Molecular Psychiatry; Wang QQ, Kaelber DC et. al.

Sep 15th, 2020 - The global pandemic of COVID-19 is colliding with the epidemic of opioid use disorders (OUD) and other substance use disorders (SUD) in the United States (US). Currently, there is limited data on risks, disparity, and outcomes for COVID-19 in individuals suffering from SUD. This is a retrospective case-control study of electronic health records (EHRs) data of 73,099,850 unique patients, of whom...