Jan 13th, 2022 - Little is known about the safety of SARS-CoV-2 vaccination in patients with rheumatic musculoskeletal disease (RMD). We evaluated the occurrence of adverse events following immunization (AEFI) in RMD patients and heathy subjects who received anti-SARS-CoV-2 mRNA vaccine. We performed a telephone interview collecting any adverse event (AE) following immunization (AEFI) that occurred in RMD patie...

Jan 11th, 2022 - Several reports linked the use of repurposed drugs such as hydroxychloroquine (HCQ), azithromycin, lopinavir/ritonavir, and favipiravir with QT interval prolongation in patients with SARS-CoV2 infection. Little is known about the risk factors for QT interval prolongation in this population. We sought to describe the prevalence and identify the main risk factors associated with clinically signif...

Jan 10th, 2022 - High concentrations of ivermectin demonstrated antiviral activity against SARS-CoV-2 in vitro. Aim of this study was to assess safety and efficacy of high-dose ivermectin in reducing viral load in individuals with early SARS-CoV-2 infection. Randomised, double-blind, multicentre, phase II, dose-finding, proof-of-concept clinical trial. Participants: adults recently diagnosed with asymptomatic/o...

Jan 8th, 2022 - The use of Hydroxychloroquine (HCQ) prophylaxis has been recommended by the National task force constituted by the Indian Council of Medical Research (ICMR) for the prevention of corona virus disease 2019 (COVID-19) among healthcare workers (HCWs). However, this recommendation was based essentially on the preclinical data and limited clinical experience. The aim of this study was to evaluate th...

Jan 8th, 2022 - The COVID-19 pandemic is one of the greatest threats to human health in the 21st century with more than 257 million cases and over 5.17 million deaths reported worldwide (as of November 23, 2021. Various agents were initially proclaimed to be effective against SARS-CoV-2, the etiological agent of COVID-19. Hydroxychloroquine, lopinavir/ritonavir, and ribavirin are all examples of therapeutic ag...

Jan 4th, 2022 - During the early stages of the coronavirus disease 2019 (COVID-19) pandemic, a marked increase in sudden cardiac death (SCD) was observed. The p.S1103Y-SCN5A common variant, present in ∼8% of individuals of African descent, may be a circumstance-dependent, SCD-predisposing, pro-arrhythmic polymorphism in the setting of hypoxia-induced acidosis or QT-prolonging drug use. To ascertain the effects...

Jan 3rd, 2022 - Fabrice Barlesi, MD ECOG performance status, cancer type, and type of prior therapy received can predict risk for clinical worsening or death in patients with cancer who contract the coronavirus disease 2019 (COVID-19), according to new findings from the Gustave Roussy Institute in Paris, France. ECOG performance statuses of more than 1 and hematological malignancies were the [most influentia...

Jan 1st, 2022 - since SAR-COV- 2 infection emerged and spread worldwide, little is known about its impact on people living with HIV. We performed a single-center retrospective study in order to describe the potential particularities and risk factors for respiratory failure in that population. this single-center retrospective study included patients infected with HIV whose current follow up is run in this cente...

Dec 30th, 2021 - To report on the clinical, laboratory and radiological findings of adolescents who presented during the SARS-CoV-2 surge with symptoms of COVID-19, did not test positive for the infection and were diagnosed with e-cigarette and vaping product use associated lung injury (EVALI). A retrospective review of 12 cases of EVALI admitted to the Bristol Meyers Squibb Children's Hospital between February...

Dec 30th, 2021 - The polymorphism L412F in TLR3 has been associated with several infectious diseases. However, the mechanism underlying this association is still unexplored. Here, we show that the L412F polymorphism in TLR3 is a marker of severity in COVID-19. This association increases in the sub-cohort of males. Impaired macroautophagy/autophagy and reduced TNF/TNFα production was demonstrated in HEK293 cells...

Dec 27th, 2021 - Note that some links may require registration or subscription. New CDC guidance recommends that vaccinated and boosted healthcare staff no longer quarantine after high-risk exposures and shortens the isolation time for those testing positive, if asymptomatic. New York state saw a fourfold increase in COVID-19 hospitalizations among children over the past 3 weeks, about half of which involved ki...

Dec 27th, 2021 - Healthcare workers (HCW) are among the highest risk groups for acquisition of COVID-19 due to occupational exposures. The WHIP COVID-19 study aimed to evaluate the safety and efficacy of hydroxychloroquine (HCQ) as chemoprophylaxis for SARS-CoV-2 infection in this population. HCW, first responders and other occupationally high-risk participants were enrolled in a randomized, placebo-controlled ...

Dec 23rd, 2021 - Objective: To assess the effect of chloroquine and hydroxychloroquine on cytokine release syndrome (CRS) in adult patients with coronavirus disease 2019 (COVID-19) having mild to moderate symptoms.Methods: This blinded, placebo-controlled, randomized study was conducted in the Department of Medicine, Pak Emirates Military Hospital Rawalpindi, from June 1-15, 2020. A total of 150 hospitalized pa...

Dec 22nd, 2021 - The recent coronavirus disease 2019 (COVID-19) pandemic has warranted the need to investigate potential therapies or prophylaxis against this infectious respiratory disease. There is emerging evidence about the potential role of nutrients on COVID-19 in addition to using medications such as hydroxychloroquine and azithromycin. This scoping review aims to explore the literature evaluating the ef...

Dec 17th, 2021 - Hospitalised patients with coronavirus disease 2019 (COVID-19) have a high mortality rate. There are an increasing number of published randomised controlled trials for anti-inflammatory, anti-viral and other treatments. The European Respiratory Society Living Guidelines for the Management of Hospitalised Adults with COVID-19 were published recently, providing recommendations on appropriate phar...

Dec 16th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. A significant number of patients with rheumatic diseases modified the schedules of their immunomodulatory or immunosuppressive medications in response to receiving or preparing to receive doses of a COVID-19 vaccine, many of which were not consistent with the American College of Rheumatology's (...

Dec 16th, 2021 - We aimed to describe the use of drugs with apparent efficacy in ambulatory patients with confirmed COVID-19 and the relationship of Google Trends searches with prescriptions and the total number of COVID-19 cases in Mexico City. Between March 2020 and February 2021, we surveyed 350 patients confirmed to have COVID-19 across 3 hospitals in Mexico City for their ambulatory prescriptions. We analy...

Dec 8th, 2021 - Several repurposed drugs such as hydroxychloroquine (HCQ) have been investigated for treatment of COVID-19, but none was confirmed to be efficacious. While in vitro studies have demonstrated antiviral properties of HCQ, data from clinical trials were conflicting regarding its benefit for COVID-19 treatment. Drugs that limit viral replication may be beneficial in the earlier course of the diseas...

Dec 8th, 2021 - To analyse the frequency and characteristics of post-COVID-19 syndrome in patients with primary Sjögren's syndrome (pSS) affected by acute SARS-CoV-2 infection. By the first week of April 2021, all centres included in the Big Data Sjögren Consortium were contacted asking for patients included in the Registry diagnosed with SARSCoV-2 infection according to the ECDC guidelines. According to the N...

Dec 7th, 2021 - Hydroxychloroquine had attracted significant attention in the initial phases of the COVID-19 pandemic but current recommendations do not support its use. However, the evidence against its use as pre-exposure prophylaxis have been of low to moderate quality and have been limited by high risk of bias. Following institutional ethics committee approval, healthcare workers (n = 1294) completing thei...