×
Interventions for the treatment of persistent post-COVID-19 olfactory dysfunction.
https://doi.org/10.1002/14651858.CD013876.pub2
The Cochrane Database of Systematic Reviews; O'Byrne L, Webster KE et. al.

Jul 23rd, 2021 - Olfactory dysfunction is an early and sensitive marker of COVID-19 infection. Although self-limiting in the majority of cases, when hyposmia or anosmia persists it can have a profound effect on quality of life. Little guidance exists on the treatment of post-COVID-19 olfactory dysfunction, however several strategies have been proposed from the evidence relating to the treatment of post-viral an...

Correlations Between Olfactory Psychophysical Scores and SARS-CoV-2 Viral Load in COVID...
https://doi.org/10.1002/lary.29777
The Laryngoscope; Vaira LA, Deiana G et. al.

Jul 22nd, 2021 - The aim of this study was to evaluate the correlations between the severity and duration of olfactory dysfunctions (OD), assessed with psychophysical tests, and the viral load on the rhino-pharyngeal swab determined with a direct method, in patients affected by coronavirus disease 2019 (COVID-19). Prospective cohort study. Patients underwent psychophysical olfactory assessment with Connecticut ...

Predictive factors of smell recovery in a clinical series of 288 coronavirus disease 20...
https://doi.org/10.1111/ene.14994
European Journal of Neurology; Saussez S, Sharma S et. al.

Jun 23rd, 2021 - The aim was to evaluate potential predictive factors of smell recovery in a clinical series of 288 patients presenting olfactory dysfunction (OD) related to coronavirus disease 2019 (COVID-19). Potential correlations were sought between epidemiological, clinical and immunological characteristics of patients and the persistence of OD at 60 days. COVID-19 positive patients presenting OD were pros...

New Data on COVID-19's Cognitive Fallout
https://www.medscape.com/viewarticle/953478

Jun 21st, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Patients hospitalized with COVID-19 experience cognitive and behavioral problems post-discharge, new research shows. Investigators found cognitive changes, depression, and posttraumatic stress disorder (PTSD) in infected patients, both in the subacute phase and 10 months after hospital discharge...

Gender Differences in the Presentation and Outcomes of Hospitalized Patients With COVID...
https://doi.org/10.12788/jhm.3594
Journal of Hospital Medicine; Biolè C, Bianco M et. al.

Jun 16th, 2021 - Gender-related differences in COVID-19 clinical presentation, disease progression, and mortality have not been adequately explored. We analyzed the clinical profile, presentation, treatments, and outcomes of patients according to gender in the HOPE-COVID-19 International Registry. Among 2,798 enrolled patients, 1,111 were women (39.7%). Male patients had a higher prevalence of cardiovascular ri...

Clinical profile and factors associated with COVID-19 in Yaounde, Cameroon: A prospecti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115782
PloS One; Fouda Mbarga N, Epee E et. al.

May 13th, 2021 - A year after the COVID-19 pandemic started, there are still few scientific reports on COVID-19 in Africa. This study explores the clinical profiles and factors associated with COVID-19 in Cameroon. In this prospective cohort study, we followed patients admitted for suspicion of COVID-19 at Djoungolo Hospital between 01st April and 31st July 2020. Patients were categorised by age groups and dise...

The outcome of olfactory impairment in patients with otherwise paucisymptomatic coronav...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111181
The Journal of Laryngology and Otology; Jalessi M, Bagheri SH et. al.

Apr 23rd, 2021 - This study aimed to measure the duration and recovery rate of olfactory loss in patients complaining of recent smell loss as their prominent symptom during the coronavirus disease 2019 outbreak. This was a prospective telephone follow-up observational study of 243 participants who completed an online survey that started on 12 March 2020. After a mean of 5.5 months from the loss of smell onset, ...

Through The Back Door: Expiratory Accumulation of SARS-Cov-2 in the Olfactory Mucosa as...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040411
International Journal of Medical Sciences; Pipolo C, Bulfamante AM et. al.

Apr 17th, 2021 - Introduction: SARS-CoV-2 is a respiratory virus supposed to enter the organism through aerosol or fomite transmission to the nose, eyes and oropharynx. It is responsible for various clinical symptoms, including hyposmia and other neurological ones. Current literature suggests the olfactory mucosa as a port of entry to the CNS, but how the virus reaches the olfactory groove is still unknown. Bec...

Hyposmia Is Associated with Reduced Cognitive Function in COVID-19: First Preliminary R...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089429
Dementia and Geriatric Cognitive Disorders; Pirker-Kees A, Platho-Elwischger K et. al.

Apr 15th, 2021 - Hyposmia is frequently reported as an initial symptom in coronavirus disease 2019 (COVID-19). As hyposmia accompanies cognitive impairment in several neurological disorders, we aimed to study whether hyposmia represents a clinical biomarker for both neurological involvement and cognitive impairment in mild CO-VID-19. We aimed to study whether olfactory dysfunction (OD) represents a clinical bio...

Neurological manifestations as the predictors of severity and mortality in hospitalized...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960879
BMC Neurology; Amanat M, Rezaei N et. al.

Mar 18th, 2021 - The reports of neurological symptoms are increasing in cases with coronavirus disease 2019 (COVID-19). This multi-center prospective study was conducted to determine the incidence of neurological manifestations in hospitalized cases with COVID-19 and assess these symptoms as the predictors of severity and death. Hospitalized males and females with COVID-19 who aged over 18 years were included i...

Neuro-COVID-19 is more than anosmia: clinical presentation, neurodiagnostics, therapies...
https://doi.org/10.1097/WCO.0000000000000930 10.1002/jmv.26624. 10.1016/j.bbi.2020.12.022. 10.1136/postgradmedj-2020-138791. 10.1093/cid/ciab003.
Current Opinion in Neurology; Schweitzer F, Kleineberg NN et. al.

Mar 13th, 2021 - To provide an overview on current knowledge of neurological symptoms and complications of COVID-19, and to suggest management concepts. Headache, dizziness, excessive tiredness, myalgia, anosmia/hyposmia, and ageusia/dysgeusia are common nonspecific neurological manifestations during early COVID-19 disease found in the majority of patients. Less frequent but more severe and specific neurologica...

Neurological outcome and quality of life 3 months after COVID-19: A prospective observa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250725
European Journal of Neurology; Rass V, Beer R et. al.

Mar 9th, 2021 - To assess neurological manifestations and health-related quality of life (QoL) 3 months after COVID-19. In this prospective, multicenter, observational cohort study we systematically evaluated neurological signs and diseases by detailed neurological examination and a predefined test battery assessing smelling disorders (16-item Sniffin Sticks test), cognitive deficits (Montreal Cognitive Assess...

Pediatric Inflammatory Multisystem Syndrome Tied to Ongoing Otolaryngologic Problems
https://www.medscape.com/viewarticle/946801

Mar 4th, 2021 - NEW YORK (Reuters Health) - Pediatric inflammatory multisystem syndrome temporally associated with COVID-19 disease (PIMS-TS) is associated with a variety of disorders affecting voice, swallowing and smell and taste, which may be long-lasting, according to researchers based in the U.K. In a letter in JAMA Otolaryngology-Head and Neck Surgery, Dr. Ryan C. T. Cheong of Great Ormond Street Hospita...

COVID-19 and Neurology - An Emerging Association.
https://doi.org/10.2174/1871526521666210218202226
Infectious Disorders Drug Targets; Gupta A, Yadav P et. al.

Feb 20th, 2021 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, which is a cause of the ongoing pandemic, has the potential to infect the nervous system and causing neurological manifestations. However, patients with primarily neurological symptoms are often overlooked and tested later. We aim to summarise all the neurological manifestations which are reported so far to aid in early diagnos...

Type 2 diabetes mellitus impaired nasal immunity and increased the risk of hyposmia in ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826056
International Immunopharmacology; Zhao Y, Liu Y et. al.

Feb 19th, 2021 - In patients with COVID-19,type 2 diabetes mellitus (T2DM) can impair the function of nasal-associated lymphoid tissue (NALT) and result in olfactory dysfunction. Exploring the causative alterations of T2DM within the nasal mucosa and NALT could provide insight into the pathogenic mechanisms and bridge the gap between innate immunity and adaptive immunity for virus clearance. Here, we designed a...

Clinical and laboratory characteristics in outpatient diagnosis of COVID-19 in healthca...
https://doi.org/10.1136/jclinpath-2020-206797
Journal of Clinical Pathology; Porto LC, Costa CH et. al.

Feb 12th, 2021 - This study aimed to identify the symptoms associated with early stage SARS-CoV-2 (COVID-19) infections in healthcare professionals (HCPs) using both clinical and laboratory data. A total of 1297 patients, admitted between 18 March and 8 April 2020, were stratified according to their risk of developing COVID-19 using their responses to a questionnaire designed to evaluate symptoms and risk condi...

Covid-19 in outpatients-Is fever a useful indicator for SARS-CoV-2 infection?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857607
PloS One; Schneider A, Kirsten H et. al.

Feb 4th, 2021 - Understanding mild to moderate symptoms of coronavirus disease 2019 (Covid-19) is important in order to identify active cases early and thus counteract transmission. In March 2020, Leipzig University Hospital established an outpatient clinic for patients potentially infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Confirmed cases with mild to moderate symptoms self-is...

18F-FDG brain PET hypometabolism in patients with long COVID.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837643
European Journal of Nuclear Medicine and Molecular Imaging; Guedj E, Campion JY et. al.

Jan 28th, 2021 - In the context of the worldwide outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), some patients report functional complaints after apparent recovery from COVID-19. This clinical presentation has been referred as "long COVID." We here present a retrospective analysis of 18F-FDG brain PET of long COVID patients from the same center with a biologically confirmed diagnosis o...

Loss of smell and taste in COVID-19 infection in adolescents.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804378
International Journal of Pediatric Otorhinolaryngology; Kumar L, Kahlon N et. al.

Jan 22nd, 2021 - To study the prevalence, clinical course and outcomes of olfactory and taste dysfunction in COVID-19 positive adolescents. This prospective study was carried out from May to August 2020. The adolescents, aged 10-19 years, who were detected COVID-19 positive by RT-PCR with mild to moderate disease were included in the study. The following epidemiological and clinical outcomes were studied: age, ...

Otorhinolaryngological manifestations of coronavirus disease 2019: a prospective review...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925986
The Journal of Laryngology and Otology; Bhatta S, Gandhi S et. al.

Jan 19th, 2021 - To evaluate otorhinolaryngological manifestations of coronavirus disease 2019 infection and the time required for their resolution. A prospective analysis was conducted of coronavirus disease 2019 patients presenting from 1 April 2020 to 30 July 2020. The otorhinolaryngological manifestations were evaluated based on patient history. The time required for symptom resolution was evaluated separat...