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Objective evaluation of odor loss in COVID-19 and other suspected cases.
https://doi.org/10.1016/j.amjoto.2020.102761
American Journal of Otolaryngology; Seden N, Yiğit E et. al.

Oct 20th, 2020 - COVID-19 is a pandemic disease known with one of the symptoms is sudden onset anosmia. This symptom sometimes may be the only sign of the disease, therefore it must be research widely. We aim to evaluate odor dysfunction in COVID-19 patients objectively and safely without any risk of transmitting the disease. The odor threshold test was performed on 105 patients hospitalized at the XXXX Trainin...

Update on Neurological Manifestations of SARS-CoV-2.
https://doi.org/10.5811/westjem.2020.8.48839
The Western Journal of Emergency Medicine; Valiuddin HM, Kalajdzic A et. al.

Oct 14th, 2020 - Severe acute respiratory syndrome coronavirus 2, the source of COVID-19, causes numerous clinical findings including respiratory and gastrointestinal findings. Evidence is now growing for increasing neurological symptoms. This is thought to be from direct in-situ effects in the olfactory bulb caused by the virus. Angiotensin-converting enzyme 2 receptors likely serve as a key receptor for cell ...

Parkinsonism as a Third Wave of the COVID-19 Pandemic?
https://doi.org/10.3233/JPD-202211
Journal of Parkinson's Disease; Beauchamp LC, Finkelstein DI et. al.

Sep 28th, 2020 - Since the initial reports of COVID-19 in December 2019, the world has been gripped by the disastrous acute respiratory disease caused by the SARS-CoV-2 virus. There are an ever-increasing number of reports of neurological symptoms in patients, from severe (encephalitis), to mild (hyposmia), suggesting the potential for neurotropism of SARS-CoV-2. This Perspective investigates the hypothesis tha...

Association of subjective olfactory dysfunction and 12-item odor identification testing...
https://doi.org/10.1002/alr.22688
International Forum of Allergy & Rhinology References; Prajapati DP, Shahrvini B et. al.

Sep 23rd, 2020 - Acute loss of smell and taste are well-recognized symptoms of coronavirus disease 2019 (COVID-19), yet the correlation between self-reported and psychophysical olfactory function remains unclear. Understanding the reliability of self-reported smell loss in ambulatory cases can assess the utility of this screening measure. A prospective, longitudinal study evaluating patient-reported and measure...

Identification of Viruses in Patients With Postviral Olfactory Dysfunction by Multiplex...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436707
The Laryngoscope; Tian J, Pinto JM et. al.

Aug 13th, 2020 - To investigate causative viruses in patients with postviral olfactory disorders (PVOD). Case-control study. One hundred fifty-one consecutive patients diagnosed with PVOD were enrolled, and samples from 38 patients who visited the doctor within 3 months of symptom onset were collected and analyzed. Thirty-two individuals who underwent surgery for nasal septal deviation during the same time peri...

Smell and Taste Dysfunction in Patients With COVID-19: A Systematic Review and Meta-ana...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275152
Mayo Clinic Proceedings; Agyeman AA, Chin KL et. al.

Aug 5th, 2020 - To estimate the prevalence of olfactory and gustatory dysfunctions (OGDs) among patients infected with novel coronavirus disease 2019 (COVID-19). A systematic review was conducted by searching MEDLINE, EMBASE, and the preprint server MedRxiv from their inception until May 11, 2020, using the terms anosmia or hyposmia or dysosmia or olfactory dysfunction or olfaction disorder or smell dysfunctio...

Co‑expression of peripheral olfactory receptors with SARS‑CoV‑2 infection mediators: Po...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388840
International Journal of Molecular Medicine; Kerslake R, Hall M et. al.

Jul 24th, 2020 - Severe acute respiratory syndrome (SARS) coronavirus‑2 (SARS‑CoV‑2) enters into human host cells via mechanisms facilitated mostly by angiotensin‑converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). New loss of smell (anosmia/hyposmia) is now recognized as a COVID‑19 related symptom, which may be caused by SARS‑CoV‑2 infection and damage of the olfactory receptor (OR) cells...

Early recovery patterns of olfactory disorders in COVID-19 patients; a clinical cohort ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489267
American Journal of Otolaryngology; Amer MA, Elsherif HS et. al.

Jul 24th, 2020 - A rapidly evolving evidence suggests that smell dysfunction is a common symptom in COVID-19 infection with paucity of data on its duration and recovery rate. Delineate the different patterns of olfactory disorders recovery in patients with COVID-19. This cross-sectional cohort study included 96 patients with olfactory complaint confirmed to be COVID-19 positive with recent onset of anosmia. All...

Prospective study in 355 patients with suspected COVID-19 infection. Value of cough, su...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404620
The Laryngoscope; Martin-Sanz E, Riestra J et. al.

Jul 20th, 2020 - To evaluate the incidence of certain symptoms in a population of health workers exposed to COVID-19 patients. A case-control study was conducted at a tertiary care hospital from March 1 to April 7, 2020. Health workers with suspected COVID-19 infection were included. The presence of COVID-19 was detected by using real-time-PCR methods. Positive and negative RT-PCR patients were used as case and...

Assessment of neurological manifestations in hospitalized patients with COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405467
European Journal of Neurology References; Luigetti M, Iorio R et. al.

Jul 18th, 2020 - The objective of this study was to assess the neurological manifestations in a series of consecutive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients, comparing their frequency with a population hospitalized in the same period for flu/respiratory symptoms, finally not related to SARS-CoV-2. Patients with flu/respiratory symptoms admitted to Fondazione Policlinico G...

Neurological manifestations of COVID-19: a systematic review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356133
Critical Care (London, England); Nepal G, Rehrig JH et. al.

Jul 14th, 2020 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global spread of coronavirus disease (COVID-19). Our understanding of the impact this virus has on the nervous system is limited. Our review aims to inform and improve decision-making among the physicians treating COVID-19 by presenting a systematic analysis of the neurological manifestations experienced within ...

COVID-19 Pulmonary and Olfactory Dysfunctions: Is the Chemokine CXCL10 the Common Denom...
https://doi.org/10.1177/1073858420939033
The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry; Oliviero A, de Castro F et. al.

Jul 13th, 2020 - COVID-19 is an ongoing viral pandemic that emerged from East Asia and quickly spread to the rest of the world. SARS-CoV-2 is the virus causing COVID-19. Acute respiratory distress syndrome (ARDS) is definitely one of the main clinically relevant consequences in patients with COVID-19. Starting from the earliest reports of the COVID-19 pandemic, two peculiar neurological manifestations (namely, ...

Olfactory Dysfunction in COVID-19 Patients: Prevalence and Prognosis for Recovering Sen...
https://doi.org/10.1177/0194599820943530
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery; D'Ascanio L, Pandolfini M et. al.

Jul 13th, 2020 - While olfactory dysfunction associated with coronavirus disease 2019 (COVID-19) has attracted considerable interest, few studies have tracked outcomes at serial time points or beyond 2 weeks. Furthermore, data are conflicting regarding whether COVID-19 severity correlates with degree of olfactory dysfunction. This prospective case-control study analyzed prevalence and severity of subjective los...

Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection.
https://doi.org/10.1212/WNL.0000000000010282
Neurology Méndez-Guerrero A, Laespada-García MI et. al.

Jul 9th, 2020 - To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome. Patient data were obtained from medical records from the Hospital Universitario 12 de Octubre in Madrid, Spain. [123I]-ioflupane dopamine transporter (DaT) SPECT images were acquired 4 hours after a single dose of 185 MBq of 123I-FP-CIT. Qu...

Neurosensory dysfunction: A diagnostic marker of early COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323654
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases; Liang Y, Xu J et. al.

Jul 2nd, 2020 - To describe neurosensory dysfunctions, including hyposmia, hypogeusia, and tinnitus, in patients with COVID-19. Clinical characteristics and oropharyngeal swabs were obtained from 86 patients with COVID-19 hospitalized in Guangzhou Eighth People's Hospital. The chronological analysis method was used to detail neurosensory dysfunction. The cycle threshold (Ct) values were used to approximately i...

Oral ulceration and blistering in patients with COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317274
Evidence-based Dentistry; Sinadinos A, Shelswell J

Jun 27th, 2020 - Design Case series.Introduction The most common signs and symptoms of SARS-CoV-2 infection include headache, sore throat, hyposmia, hypogeusia, diarrhoea, dyspnoea and pneumonia. Dermatological manifestations have also been reported but few authors have documented oral signs and symptoms. Methods Three cases are reported where oral ulceration or blistering is found in patients with confirmed or...

The diagnostic value of detecting sudden smell loss among asymptomatic COVID-19 patient...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282761
Auris, Nasus, Larynx; Kang YJ, Cho JH et. al.

Jun 19th, 2020 - The newly emerged coronavirus disease 19 (COVID-19), is threatening the world. Olfactory or gustatory dysfunction is reported as one of the symptoms worldwide. As reported so far, different clinical features have been reported according to outbreak sites and gender; most of the patients, who complained of anosmia or hyposmia, were Europeans. We had a fast review for novel articles about COVID-1...

Diagnosing COVID-19 in the Emergency Department: A Scoping Review of Clinical Examinati...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323136
Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine References; Carpenter CR, Mudd PA et. al.

Jun 16th, 2020 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as a global pandemic in early 2020 with rapidly evolving approaches to diagnosing the clinical illness called coronavirus disease (COVID-19). The primary objective of this scoping review is to synthesize current research of the diagnostic accuracy of history, physical examination, routine laboratory tests, real-time reverse tr...

SARS-CoV-2 infection in patients with autoimmune rheumatic diseases in northeast Italy:...
https://doi.org/10.1016/j.jaut.2020.102502
Journal of Autoimmunity; Zen M, Fuzzi E et. al.

Jun 12th, 2020 - Whether patients with autoimmune rheumatic diseases (ARD) have a higher risk for SARS-CoV-2 infection (COVID-19) and how SARS-CoV-2 pandemic impacts on adherence to therapy has not been fully elucidated. We assessed the rate and clinical presentation of COVID-19, and adherence to therapy in a large cohort of patients with ARD followed-up in a tertiary University-Hospital in Northeast Italy. Bet...

Taste and Smell Impairment in COVID-19: An AAO-HNS Anosmia Reporting Tool-Based Compara...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284454
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery; Sayin İ, Yaşar KK et. al.

Jun 9th, 2020 - To identify the taste and smell impairment in coronavirus disease 2019 (COVID-19)-positive subjects and compare the findings with COVID-19-negative subjects using the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) Anosmia Reporting Tool. Tertiary referral center/COVID-19 pandemic hospital. Comparative study. After power analysis, 128 subjects were divided into 2 groups accor...