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Employing a systematic approach to biobanking and analyzing clinical and genetic data f...
https://doi.org/10.1038/s41431-020-00793-7 10.1038/sdata.2016.18 10.1056/NEJMoa2001017 10.1038/s41431-020-0691-z 10.1186/s13742-015-0047-8 10.1093/bioinformatics/17.6.520 10.2307/2528823 10.1038/s41431-020-0636-6 10.1016/S2213-2600(20)30117-X 10.1172/JCI137244 10.1111/jth.14768 10.1053/j.gastro.2020.03.055 10.1053/j.gastro.2020.05.069 10.1016/S2213-2600(20)30076-X 10.1038/s41569-020-0360-5 10.3389/fmed.2020.00347 10.14218/JCTH.2020.00018 10.1021/acschemneuro.0c00460 10.1016/j.cmi.2020.04.040 10.1038/nrg.2017.52 10.1038/nmeth.3440 10.1038/nrg.2017.38 10.1038/s42256-020-0180-7 10.1038/s41467-019-13929-1 10.1038/ng.1083
European Journal of Human Genetics : EJHG; Daga S, Fallerini C et. al.

Jan 18th, 2021 - Within the GEN-COVID Multicenter Study, biospecimens from more than 1000 SARS-CoV-2 positive individuals have thus far been collected in the GEN-COVID Biobank (GCB). Sample types include whole blood, plasma, serum, leukocytes, and DNA. The GCB links samples to detailed clinical data available in the GEN-COVID Patient Registry (GCPR). It includes hospitalized patients (74.25%), broken down into ...

Smell Status in Children Infected with SARS-CoV-2.
https://doi.org/10.1002/lary.29403
The Laryngoscope BIBLIOGRAPHY; Rusetsky Y, Meytel I et. al.

Jan 14th, 2021 - This study aimed to evaluate the olfactory status in children with laboratory confirmed SARS-CoV-2 using subjective and psychophysical methods. Prospective clinical cross-sectional study. This is a prospective clinical cross-sectional study of 79 children with COVID-19. The 21st item of SNOT-22 questionnaire and odor identification test were used for smell assessment. Children were examined twi...

Prevalence and 6-month recovery of olfactory dysfunction: a multicentre study of 1363 C...
https://doi.org/10.1111/joim.13209
Journal of Internal Medicine References; Lechien JR, Chiesa-Estomba CM et. al.

Jan 6th, 2021 - To investigate prevalence and recovery of olfactory dysfunction (OD) in COVID-19 patients according to the disease severity. From 22 March to 3 June 2020, 2581 COVID-19 patients were identified from 18 European hospitals. Epidemiological and clinical data were extracted at baseline and within the 2-month post-infection. The prevalence of OD was significantly higher in mild form (85.9%) compared...

The Association of "Loss of Smell" to COVID-19: A Systematic Review and Meta-Nnalysis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604015
The American Journal of the Medical Sciences; Aziz M, Goyal H et. al.

Dec 22nd, 2020 - The presence of olfactory dysfunction or "loss of smell" has been reported as an atypical symptom in patients with coronavirus disease 2019 (COVID-19). We performed a systematic review and meta-analysis of the available literature to evaluate the prevalence of "loss of smell" in COVID-19 as well as its utility for prognosticating the disease severity. An exhaustive search of the PubMed/Medline,...

Alteration of Smell and Taste in Asymptomatic and Symptomatic COVID-19 Patients in Sici...
https://doi.org/10.1177/0145561320981447
Ear, Nose, & Throat Journal; Bianco MR, Modica DM et. al.

Dec 22nd, 2020 - Alteration of smell and taste has been reported in patients with coronavirus disease 2019 (COVID-19). The incidence and clinical-symptomatic manifestation of COVID-19 is different between northern and southern Italy. This study aims to evaluate the onset of alteration of smell and taste in asymptomatic and symptomatic patients in Sicily (extreme south of Italy). This prospective cross-sectional...

Efficacy of corticosteroid therapy in the treatment of long- lasting olfactory disorder...
https://doi.org/10.4193/Rhin20.515
Rhinology Vaira LA, Hopkins C et. al.

Dec 8th, 2020 - The growing number of COVID-19 patients with long-lasting olfactory disorders makes it necessary to identify ef- fective treatments that enhance the spontaneous recovery of olfactory function. Multicentre randomised case-control study that involved 18 patients with COVID-19 related anosmia or severe hyposmia for more than 30 days. Nine patients were prescribed systemic prednisone and nasal irri...

Covid-19 infection-induced neuromyelitis optica: a case report.
https://doi.org/10.1080/00207454.2020.1860036
The International Journal of Neuroscience; Batum M, Kisabay Ak A et. al.

Dec 7th, 2020 - Acute respiratory syndrome coronavirus-2 (Covid-19) can infect the respiratory system, as well as the central, peripheral nervous system, and muscles, leading to neurological symptoms and signs. The most common neurological symptoms are dizziness, headache, impaired consciousness, ataxia, hypogosis, hyposmia, neuralgia, and myalgia. The most common neurological diseases are acute cerebrovascula...

Taste and Smell Impairment in Critically Ill Patients With COVID-19: An Intensive Care ...
https://doi.org/10.1177/0145561320977464
Ear, Nose, & Throat Journal; Sayın P, Altınay M et. al.

Dec 1st, 2020 - To determine taste and smell impairment rates in patients with coronavirus disease 2019 (COVID-19) who were hospitalized in the intensive care unit (ICU). Between March 2020 and May 2020, patients with COVID-19 hospitalized in the ICU were enrolled in this study. Upon discharge, patients were telephoned and asked to complete a survey related to taste and smell impairment. Characteristics were c...

Skin Manifestations Associated with COVID-19: Current Knowledge and Future Perspectives.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801998
Dermatology (Basel, Switzerland); Genovese G, Moltrasio C et. al.

Nov 24th, 2020 - Coronavirus disease-19 (COVID-19) is an ongoing global pandemic caused by the "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2), which was isolated for the first time in Wuhan (China) in December 2019. Common symptoms include fever, cough, fatigue, dyspnea and hypogeusia/hyposmia. Among extrapulmonary signs associated with COVID-19, dermatological manifestations have been increasin...

Prevalence of Olfactory Dysfunction in Coronavirus Disease 2019 (COVID-19): A Meta-anal...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753439
The Laryngoscope; Saniasiaya J, Islam MA et. al.

Nov 21st, 2020 - Olfactory dysfunction has been observed as one of the clinical manifestations in COVID-19 patients. We aimed to conduct a systematic review and meta-analysis to estimate the overall pooled prevalence of olfactory dysfunction in COVID-19 patients. Systematic review and meta-analyses. PubMed, Scopus, Web of Science, Embase, and Google Scholar databases were searched to identify studies published ...

Clinical and molecular characterization of COVID-19 hospitalized patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673557
PloS One; Benetti E, Giliberti A et. al.

Nov 18th, 2020 - Clinical and molecular characterization by Whole Exome Sequencing (WES) is reported in 35 COVID-19 patients attending the University Hospital in Siena, Italy, from April 7 to May 7, 2020. Eighty percent of patients required respiratory assistance, half of them being on mechanical ventilation. Fiftyone percent had hepatic involvement and hyposmia was ascertained in 3 patients. Searching for comm...

Attributes of dysgeusia and anosmia of coronavirus disease 2019 (COVID-19) in hospitali...
https://doi.org/10.1111/odi.13713
Oral Diseases REFERENCES; Samaranayake LP, Fakhruddin KS et. al.

Nov 11th, 2020 - While chemosensory dysfunctions, dysgeusia and anosmia/hyposmia, are recognized as distinctive symptoms of COVID-19, their temporality of presentation and association with the patient age, gender, disease severity, and comorbidities has been sparsely studied. Hence, we evaluated the latter associations of chemosensory dysfunction, in hospitalized COVID-19 patients in the United Arab Emirates (U...

Olfactory Dysfunction in a Mexican Population Outside of COVID-19 Pandemic: Prevalence ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649040
Current Allergy and Asthma Reports; Castillo-López IY, Govea-Camacho LH et. al.

Nov 8th, 2020 - To study the prevalence of olfactory loss and its associated factors in a Mexican population a cross-sectional analytical study based on a population interviewed about health, epidemiologic aspects, and sense of smell (tested with four scents: rose, banana, perfume, and gas) was conducted to evaluate olfactory detection, memory, and identification. Levels of sense of smell perception were deter...

Headache associated with COVID-19: Frequency, characteristics and association with anos...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645592
Cephalalgia : an International Journal of Headache; Rocha-Filho PAS, Magalhães JE

Nov 4th, 2020 - To assess the frequency and characteristics of headache in patients with COVID-19 and whether there is an association between headache and anosmia and ageusia. This was a cross-sectional study. Consecutive patients admitted to hospital with COVID-19, confirmed by reverse transcription polymerase chain reaction (RT-PCR) technique, were assessed by neurologists. Seventy-three patients were includ...

Environmental Issues and Neurological Manifestations Associated with COVID-19 Pandemic:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663018
International Journal of Environmental Research and Publi... Bellocchio L, Bordea IR et. al.

Nov 3rd, 2020 - Coronavirus (SARS-CoV-2) emerged in China in December 2019 and rapidly caused a global health pandemic. Current evidence seems to suggest a possible link with ecosystem disequilibrium and even air pollution. The primary manifestations affect respiratory and circulatory systems, but neurological features are also being reported through case reports and case series. We summarize neurological symp...

Objective evaluation of odor loss in COVID-19 and other suspected cases.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556258
American Journal of Otolaryngology; Seden N, Yiğit E et. al.

Oct 20th, 2020 - COVID-19 is a pandemic disease known with one of the symptoms is sudden onset anosmia. This symptom sometimes may be the only sign of the disease, therefore it must be research widely. We aim to evaluate odor dysfunction in COVID-19 patients objectively and safely without any risk of transmitting the disease. The odor threshold test was performed on 105 patients hospitalized at the XXXX Trainin...

Update on Neurological Manifestations of SARS-CoV-2.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673884
The Western Journal of Emergency Medicine; Valiuddin HM, Kalajdzic A et. al.

Oct 14th, 2020 - Severe acute respiratory syndrome coronavirus 2, the source of COVID-19, causes numerous clinical findings including respiratory and gastrointestinal findings. Evidence is now growing for increasing neurological symptoms. This is thought to be from direct in-situ effects in the olfactory bulb caused by the virus. Angiotensin-converting enzyme 2 receptors likely serve as a key receptor for cell ...

Parkinsonism as a Third Wave of the COVID-19 Pandemic?
https://doi.org/10.3233/JPD-202211
Journal of Parkinson's Disease; Beauchamp LC, Finkelstein DI et. al.

Sep 28th, 2020 - Since the initial reports of COVID-19 in December 2019, the world has been gripped by the disastrous acute respiratory disease caused by the SARS-CoV-2 virus. There are an ever-increasing number of reports of neurological symptoms in patients, from severe (encephalitis), to mild (hyposmia), suggesting the potential for neurotropism of SARS-CoV-2. This Perspective investigates the hypothesis tha...

Early recovery patterns of olfactory disorders in COVID-19 patients; a clinical cohort ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489267
American Journal of Otolaryngology; Amer MA, Elsherif HS et. al.

Sep 26th, 2020 - A rapidly evolving evidence suggests that smell dysfunction is a common symptom in COVID-19 infection with paucity of data on its duration and recovery rate. Delineate the different patterns of olfactory disorders recovery in patients with COVID-19. This cross-sectional cohort study included 96 patients with olfactory complaint confirmed to be COVID-19 positive with recent onset of anosmia. All...

Association of subjective olfactory dysfunction and 12-item odor identification testing...
https://doi.org/10.1002/alr.22688
International Forum of Allergy & Rhinology References; Prajapati DP, Shahrvini B et. al.

Sep 23rd, 2020 - Acute loss of smell and taste are well-recognized symptoms of coronavirus disease 2019 (COVID-19), yet the correlation between self-reported and psychophysical olfactory function remains unclear. Understanding the reliability of self-reported smell loss in ambulatory cases can assess the utility of this screening measure. A prospective, longitudinal study evaluating patient-reported and measure...