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Management of Post-Infectious Anosmia and Hyposmia: A Systematic Review.
https://doi.org/10.1177/00034894221118186
The Annals of Otology, Rhinology, and Laryngology; Nag AK, Saltagi AK et. al.

Aug 13th, 2022 - Anosmia and hyposmia significantly affect patients' quality of life and have many etiologies, including trauma, inflammatory conditions including chronic rhinosinusitis, neoplasm, and viral infections, such as rhinovirus and SARS-CoV-2. Our purpose was to establish whether a consensus exists regarding optimal management of olfactory dysfunction and to provide insight into the treatment of anosm...

Post-COVID-19 neuropsychiatric manifestations among COVID-19 survivors suffering from m...
https://doi.org/10.1186/s10194-022-01468-y
The Journal of Headache and Pain; Magdy R, Elmazny A et. al.

Aug 13th, 2022 - The burden of post-coronavirus disease (COVID)-19 symptoms has been increasing and is of great concern in patients with pre-existing chronic medical conditions.This study aimed to delineate the post-COVID-19 neuropsychiatric symptoms among migraine patients compared to the non-migraine control group. Two groups, each of 204 COVID-19 survivors, were enrolled in the study after 3 months of severe...

Neurological symptoms and signs associated with COVID-19 in pediatric patients: a singl...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351517
Medicine Sener Okur D

Aug 11th, 2022 - There is insufficient evidence on SARS-CoV-2 induced neurological effects. Studies on CNS involvement during COVID-19 in children are limited. This study aims to identify and manage the neurological signs and symptoms in COVID-19-infected pediatric patients during follow up and plan future follow-ups. Children diagnosed COVID-19 and hospitalized in the pediatric pandemic services, between March...

COCOS trial: COrticosteroids for COVID-19-induced loss of Smell-protocol for a single-c...
https://doi.org/10.1136/bmjopen-2021-060416
BMJ Open; Schepens EJA, Boek WM et. al.

Aug 11th, 2022 - Hyposmia and anosmia are common in COVID-19. Most patients regain normal smell within 4 weeks, but severe loss of smell persists roughly in 20% after 2 months and may last up to a year or longer. These persistent smell disorders greatly influence daily life. It is hypothesised that COVID-19 induces inflammation around the olfactory nerve and in the olfactory pathway, leading to smell disorders....

Effect of Sodium Gluconate on Decreasing Elevated Nasal Calcium and Improving Olfactory...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364068
American Journal of Rhinology & Allergy; Abdelazim MH, Abdelazim AH

Aug 10th, 2022 - COVID-19 has been associated with temporary olfactory dysfunction in many infected patients. Calcium plays a great role in the olfaction process with negative feedback for the olfaction transmission. Many reports demonstrated calcium elevation in the nasal secretions with a negative effect on olfaction. Sodium gluconate is a water-soluble salt with a chemical structure that lends to act as a hi...

Long COVID headache.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340759
The Journal of Headache and Pain; Tana C, Bentivegna E et. al.

Aug 2nd, 2022 - Headache is among the most frequent symptoms persisting or newly developing after coronavirus disease 2019 (COVID-19) as part of the so-called long COVID syndrome. The knowledge on long COVID headache is still limited, however growing evidence is defining the features of this novel condition, in particular regarding clinical characteristics, some pathophysiological mechanisms and first treatmen...

COVID-19 and olfactory dysfunction: a looming wave of dementia?
https://doi.org/10.1152/jn.00255.2022
Journal of Neurophysiology; Kay LM

Jul 28th, 2022 - Olfactory dysfunction is a hallmark symptom of COVID-19 disease resulting from the SARS-CoV-2 virus. The cause of the sudden and usually temporary anosmia that most people suffer from COVID-19 is likely entirely peripheral - inflammation and other damage caused by the virus in the sensory epithelium inside the upper recesses of the nasal cavity can damage or prevent chemicals from properly acti...

Intensive Olfactory Training in Post-COVID-19 Patients: A Multicenter Randomized Clinic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309586
American Journal of Rhinology & Allergy; Pires ÍAT, Steffens ST et. al.

Jul 23rd, 2022 - Olfactory dysfunction (OD)-including anosmia and hyposmia-is a common symptom of COVID-19. Previous studies have identified olfactory training (OT) as an important treatment for postinfectious OD; however, little is known about its benefits and optimizations after SARS-CoV-2 infection. This study aimed to assess whether olfactory training performance can be optimized using more fragrances over ...

COVID-19 and Parkinson's Disease: Possible Links in Pathology and Therapeutics.
https://doi.org/10.1007/s12640-022-00540-4
Neurotoxicity Research; Tiwari S, Yadav N et. al.

Jul 14th, 2022 - The outbreak of SARs-CoV-2 with emerging new variants is leading to global health crisis and has brought a major concern for patients with comorbidities. Parkinson's disease (PD) is a motor neurodegenerative disease involving various metabolic and psychological ailments along with the common occurrence of hyposmia as observed in COVID-19 patients. In addition, the observed surplus inflammatory ...

Long-term outcome after COVID-19 infection in multiple sclerosis: a nation-wide multice...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350009
European Journal of Neurology; Bsteh G, Assar H et. al.

Jun 26th, 2022 - Long-term outcome after COVID-19 in patients with multiple sclerosis (pwMS) is scarcely studied and controlled data are lacking. To compare long-term outcome after COVID-19 in pwMS to a matched control group of pwMS without COVID-19. We included pwMS with PCR-confirmed diagnosis of COVID-19 and ≥6 months of follow-up available and, as a control group, pwMS matched 1:1 for age, sex, disability l...

Noninvasive Brain Stimulation Promising for COVID-Related Smell Loss
https://www.medscape.com/viewarticle/976167

Jun 24th, 2022 - Noninvasive brain stimulation may help restore a sense of smell in patients with chronic anosmia or hyposmia related to COVID-19, early research suggests. Results of a small, double-blind, sham-controlled study showed anodal transcranial direct current stimulation (A-tDCS) combined with olfactory training (OT) provided notable and durable improvement in seven patients with persistent COVID-19–r...

Olfactory outcomes in Zika virus-associated Guillain-Barré syndrome.
https://doi.org/10.1111/ene.15444
European Journal of Neurology; Lazarini F, Lannuzel A et. al.

Jun 15th, 2022 - Zika virus (ZIKV) infection has been associated with Guillain-Barré syndrome (GBS). However, little is known about the consequence of ZIKV infection on olfaction in humans. Immediately before the COVID-19 outbreak, we prospectively investigated the olfactory capacities of 19 patients with ZIKV-associated GBS from the French West Indies and compared them to nine controls from the same population...

Olfactory dysfunction in COVID-19, new insights from a cohort of 353 patients: The ANOS...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347548
Journal of Medical Virology; Mercier J, Osman M et. al.

Jun 8th, 2022 - Olfactory disorders (OD) pathogenesis, underlying conditions, and prognostic in coronavirus disease 2019 (COVID-19) remain partially described. ANOSVID is a retrospective study in Nord Franche-Comté Hospital (France) that included COVID-19 patients from March 1 2020 to May 31 2020. The aim was to compare COVID-19 patients with OD (OD group) and patients without OD (no-OD group). A second analys...

Neurological and Mental Health Symptoms Associated with Post-COVID-19 Disability in a S...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998950
International Journal of Environmental Research and Publi... Cacciatore M, Raggi A et. al.

Apr 13th, 2022 - Recent studies suggest that COVID-19 survivors may experience long-term health consequences: in particular, neurological and mental health symptoms might be associated with long-term negative outcomes. This study is a secondary analysis of a larger cohort study and aims to determine the extent to which neurological and mental health sequelae are associated with survivors' disability. Participan...

Performance of formal smell testing and symptom screening for identifying SARS-CoV-2 in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004758
PloS One; Keck JW, Bush M et. al.

Apr 13th, 2022 - Altered sense of smell is a commonly reported COVID-19 symptom. The performance of smell testing to identify SARS-CoV-2 infection status is unknown. We measured the ability of formal smell testing to identify SARS-CoV-2 infection and compared its performance with symptom screening. A convenience sample of emergency department patients with COVID-19 symptom screening participated in smell testin...

Long-Term Smell Loss in COVID-19 Tied to Damage in the Brain's Olfactory Bulb
https://www.medscape.com/viewarticle/972005

Apr 12th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Patients with COVID-19, especially those with an altered sense of smell, have significantly more axon and microvasculopathy damage in the brain's olfactory tissue versus non-COVID patients. These new findings from a post-mortem study may explain long-term loss of smell in some patients with the ...

Efficacy of topical steroids for the treatment of olfactory disorders caused by COVID-1...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9111649
Clinical Otolaryngology : Official Journal of ENT-UK ; Of... Kim DH, Kim SW et. al.

Mar 31st, 2022 - The aim of this study was to assess the effect of topical steroids on acute-onset olfactory dysfunction in patients infected with COVID-19. Systematic review and meta-analysis of cohort studies. Patients infected with COVID-19. PubMed, Embase, the Web of Science, SCOPUS, Cochrane database and Google Scholar were searched for articles up to September 2021. We analysed studies comparing the impro...

A tool for the psychophysical assessment of olfactory dysfunction in patients with COVI...
https://doi.org/10.1177/01455613221084062
Ear, Nose, & Throat Journal; Kim KS, Min HJ

Mar 30th, 2022 - Numerous studies have reported that patients with coronavirus disease 2019 (COVID-19) experience alterations in the sense of smell. Therefore, there is an increased need for a psychophysical evaluation tool for olfactory dysfunction in patients with COVID-19 without increasing the risk of virus spread. We applied a single-use sniffing-bead system, which consisted of small beads and a disposable...

Persisting olfactory dysfunction in post-COVID-19 is associated with gustatory impairme...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942205
PloS One; Hintschich CA, Fischer R et. al.

Mar 24th, 2022 - Olfactory and gustatory disorders are prominent symptoms of acute COVID-19. Although both senses recover in many patients within weeks to months, persistency has been described in up to 60%. However up to now most reports on the course of chemosensitive disorders after COVID-19 are not based on psychophysical testing but only on subjective patients' ratings. In this study we assessed both olfac...

One-year cognitive follow-up of COVID-19 hospitalized patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9111730
European Journal of Neurology; Ferrucci R, Dini M et. al.

Mar 15th, 2022 - Cognitive dysfunction has been observed following recovery from COVID-19. To the best of our knowledge, however, no study has assessed the progression of cognitive impairment after 1 year. The aim was to assess cognitive functioning at 1 year from hospital discharge, and eventual associations with specific clinical variables. Seventy-six patients (aged 22-74 years) who had been hospitalized for...