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Patterns and clinical outcomes of olfactory and gustatory disorders in six months: Pros...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481118
American Journal of Otolaryngology; Teaima AA, Salem OM et. al.

Oct 10th, 2021 - This study aims to comprehensively evaluate olfactory and gustatory dysfunctions during the COVID-19 pandemic regarding onset, course, associated symptoms, prognosis and relation to patients' demographics, treatment received and other symptoms. This is a prospective study conducted on patients proven to be infected with COVID-19 and with olfactory/gustatory dysfunction symptoms. Detailed histor...

Neuropsychiatric manifestations of COVID-19, potential neurotropic mechanisms, and ther...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482959
Translational Psychiatry; Han Y, Yuan K et. al.

Oct 2nd, 2021 - The coronavirus disease 2019 (COVID-19) pandemic has caused large-scale economic and social losses and worldwide deaths. Although most COVID-19 patients have initially complained of respiratory insufficiency, the presence of neuropsychiatric manifestations is also reported frequently, ranging from headache, hyposmia/anosmia, and neuromuscular dysfunction to stroke, seizure, encephalopathy, alte...

Quantitative Analysis of the Olfactory System in COVID-19: An MR Imaging Study.
https://doi.org/10.3174/ajnr.A7278
AJNR. American Journal of Neuroradiology; Altunisik E, Baykan AH et. al.

Sep 25th, 2021 - Anosmia or hyposmia, often accompanied by changes in taste, is recognized as a common symptom that can assist in the diagnosis of coronavirus disease 2019 (COVID-19). The pathogenesis of olfactory dysfunction in COVID-19 is not yet fully understood. MR imaging represents a useful anatomic imaging method for the evaluation of olfactory dysfunction associated with varying etiologies, including vi...

A Systematic Review of Imaging Studies in Olfactory Dysfunction Secondary to COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403662
Academic Radiology; Keshavarz P, Haseli S et. al.

Sep 23rd, 2021 - Hyposmia/anosmia is common among patients with coronavirus disease-2019 (COVID-19). Various imaging modalities have been used to assess olfactory dysfunction in COVID-19. In this systematic review, we sought to categorize and summarize the imaging data in COVID-19-induced anosmia. Eligible articles were included after a comprehensive review using online databases including Google scholar, Scopu...

Impairments in odour detection and hedonic ratings of unpleasant smells in asymptomatic...
https://doi.org/10.1111/ejn.15430
The European Journal of Neuroscience; Walsh-Messinger J, Kaouk S et. al.

Aug 24th, 2021 - Sudden olfactory loss in the absence of concurrent nasal congestion is now a well-recognized symptom of COVID-19. We examined olfaction using standardized objective tests of odour detection, identification and hedonics collected from asymptomatic university students before and as SARS-CoV-2 emerged locally. Olfactory performance of students who were tested when the virus is known to be endemic ...

The Frequency and Clinical Assessment of COVID-19 in Patients With Chronic Rhinosinusitis.
https://doi.org/10.1177/01455613211038070
Ear, Nose, & Throat Journal; Akhlaghi A, Darabi A et. al.

Aug 21st, 2021 - Chronic rhinosinusitis (CRS), as an inflammatory airway disease, could be a risk factor for COVID-19 patients. This study aimed to investigate the frequency and severity of symptoms of COVID-19 in patients with CRS and to assess the association between the status of CRS symptoms and the quality of life (QoL) of the patients. In this observational and cross-sectional study, 207 adult CRS patient...

Neurological symptoms and axonal damage in COVID-19 survivors: are there sequelae?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346772
Immunologic Research; Bozzetti S, Ferrari S et. al.

Aug 8th, 2021 - The persistence of neurological symptoms after SARS-CoV-2 infection, as well as the presence of late axonal damage, is still unknown. We performed extensive systemic and neurological follow-up evaluations in 107 out of 193 consecutive patients admitted to the COVID-19 medical unit, University Hospital of Verona, Italy between March and June 2020. We analysed serum neurofilament light chain (NfL...

Interventions for the treatment of persistent post-COVID-19 olfactory dysfunction.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406942
The Cochrane Database of Systematic Reviews; O'Byrne L, Webster KE et. al.

Jul 23rd, 2021 - Olfactory dysfunction is an early and sensitive marker of COVID-19 infection. Although self-limiting in the majority of cases, when hyposmia or anosmia persists it can have a profound effect on quality of life. Little guidance exists on the treatment of post-COVID-19 olfactory dysfunction, however several strategies have been proposed from the evidence relating to the treatment of post-viral an...

Correlations Between Olfactory Psychophysical Scores and SARS-CoV-2 Viral Load in COVID...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441733
The Laryngoscope; Vaira LA, Deiana G et. al.

Jul 22nd, 2021 - The aim of this study was to evaluate the correlations between the severity and duration of olfactory dysfunctions (OD), assessed with psychophysical tests, and the viral load on the rhino-pharyngeal swab determined with a direct method, in patients affected by coronavirus disease 2019 (COVID-19). Prospective cohort study. Patients underwent psychophysical olfactory assessment with Connecticut ...

Predictive factors of smell recovery in a clinical series of 288 coronavirus disease 20...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444937
European Journal of Neurology; Saussez S, Sharma S et. al.

Jun 23rd, 2021 - The aim was to evaluate potential predictive factors of smell recovery in a clinical series of 288 patients presenting olfactory dysfunction (OD) related to coronavirus disease 2019 (COVID-19). Potential correlations were sought between epidemiological, clinical and immunological characteristics of patients and the persistence of OD at 60 days. COVID-19 positive patients presenting OD were pros...

New Data on COVID-19's Cognitive Fallout
https://www.medscape.com/viewarticle/953478

Jun 21st, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Patients hospitalized with COVID-19 experience cognitive and behavioral problems post-discharge, new research shows. Investigators found cognitive changes, depression, and posttraumatic stress disorder (PTSD) in infected patients, both in the subacute phase and 10 months after hospital discharge...

Gender Differences in the Presentation and Outcomes of Hospitalized Patients With COVID...
https://doi.org/10.12788/jhm.3594
Journal of Hospital Medicine; Biolè C, Bianco M et. al.

Jun 16th, 2021 - Gender-related differences in COVID-19 clinical presentation, disease progression, and mortality have not been adequately explored. We analyzed the clinical profile, presentation, treatments, and outcomes of patients according to gender in the HOPE-COVID-19 International Registry. Among 2,798 enrolled patients, 1,111 were women (39.7%). Male patients had a higher prevalence of cardiovascular ri...

Clinical profile and factors associated with COVID-19 in Yaounde, Cameroon: A prospecti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115782
PloS One; Fouda Mbarga N, Epee E et. al.

May 13th, 2021 - A year after the COVID-19 pandemic started, there are still few scientific reports on COVID-19 in Africa. This study explores the clinical profiles and factors associated with COVID-19 in Cameroon. In this prospective cohort study, we followed patients admitted for suspicion of COVID-19 at Djoungolo Hospital between 01st April and 31st July 2020. Patients were categorised by age groups and dise...

The outcome of olfactory impairment in patients with otherwise paucisymptomatic coronav...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111181
The Journal of Laryngology and Otology; Jalessi M, Bagheri SH et. al.

Apr 23rd, 2021 - This study aimed to measure the duration and recovery rate of olfactory loss in patients complaining of recent smell loss as their prominent symptom during the coronavirus disease 2019 outbreak. This was a prospective telephone follow-up observational study of 243 participants who completed an online survey that started on 12 March 2020. After a mean of 5.5 months from the loss of smell onset, ...

Through The Back Door: Expiratory Accumulation of SARS-Cov-2 in the Olfactory Mucosa as...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040411
International Journal of Medical Sciences; Pipolo C, Bulfamante AM et. al.

Apr 17th, 2021 - Introduction: SARS-CoV-2 is a respiratory virus supposed to enter the organism through aerosol or fomite transmission to the nose, eyes and oropharynx. It is responsible for various clinical symptoms, including hyposmia and other neurological ones. Current literature suggests the olfactory mucosa as a port of entry to the CNS, but how the virus reaches the olfactory groove is still unknown. Bec...

Hyposmia Is Associated with Reduced Cognitive Function in COVID-19: First Preliminary R...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089429
Dementia and Geriatric Cognitive Disorders; Pirker-Kees A, Platho-Elwischger K et. al.

Apr 15th, 2021 - Hyposmia is frequently reported as an initial symptom in coronavirus disease 2019 (COVID-19). As hyposmia accompanies cognitive impairment in several neurological disorders, we aimed to study whether hyposmia represents a clinical biomarker for both neurological involvement and cognitive impairment in mild CO-VID-19. We aimed to study whether olfactory dysfunction (OD) represents a clinical bio...

Neurological manifestations as the predictors of severity and mortality in hospitalized...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960879
BMC Neurology; Amanat M, Rezaei N et. al.

Mar 18th, 2021 - The reports of neurological symptoms are increasing in cases with coronavirus disease 2019 (COVID-19). This multi-center prospective study was conducted to determine the incidence of neurological manifestations in hospitalized cases with COVID-19 and assess these symptoms as the predictors of severity and death. Hospitalized males and females with COVID-19 who aged over 18 years were included i...

Neuro-COVID-19 is more than anosmia: clinical presentation, neurodiagnostics, therapies...
https://doi.org/10.1097/WCO.0000000000000930 10.1002/jmv.26624. 10.1016/j.bbi.2020.12.022. 10.1136/postgradmedj-2020-138791. 10.1093/cid/ciab003.
Current Opinion in Neurology; Schweitzer F, Kleineberg NN et. al.

Mar 13th, 2021 - To provide an overview on current knowledge of neurological symptoms and complications of COVID-19, and to suggest management concepts. Headache, dizziness, excessive tiredness, myalgia, anosmia/hyposmia, and ageusia/dysgeusia are common nonspecific neurological manifestations during early COVID-19 disease found in the majority of patients. Less frequent but more severe and specific neurologica...

Neurological outcome and quality of life 3 months after COVID-19: A prospective observa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250725
European Journal of Neurology; Rass V, Beer R et. al.

Mar 9th, 2021 - To assess neurological manifestations and health-related quality of life (QoL) 3 months after COVID-19. In this prospective, multicenter, observational cohort study we systematically evaluated neurological signs and diseases by detailed neurological examination and a predefined test battery assessing smelling disorders (16-item Sniffin Sticks test), cognitive deficits (Montreal Cognitive Assess...

Pediatric Inflammatory Multisystem Syndrome Tied to Ongoing Otolaryngologic Problems
https://www.medscape.com/viewarticle/946801

Mar 4th, 2021 - NEW YORK (Reuters Health) - Pediatric inflammatory multisystem syndrome temporally associated with COVID-19 disease (PIMS-TS) is associated with a variety of disorders affecting voice, swallowing and smell and taste, which may be long-lasting, according to researchers based in the U.K. In a letter in JAMA Otolaryngology-Head and Neck Surgery, Dr. Ryan C. T. Cheong of Great Ormond Street Hospita...