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Hyposmia Is Associated with Reduced Cognitive Function in COVID-19: First Preliminary R...
https://doi.org/10.1159/000515575
Dementia and Geriatric Cognitive Disorders; Pirker-Kees A, Platho-Elwischger K et. al.

Apr 14th, 2021 - Hyposmia is frequently reported as an initial symptom in coronavirus disease 2019 (COVID-19). As hyposmia accompanies cognitive impairment in several neurological disorders, we aimed to study whether hyposmia represents a clinical biomarker for both neurological involvement and cognitive impairment in mild CO-VID-19. We aimed to study whether olfactory dysfunction (OD) represents a clinical bio...

Neurological manifestations as the predictors of severity and mortality in hospitalized...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960879
BMC Neurology; Amanat M, Rezaei N et. al.

Mar 17th, 2021 - The reports of neurological symptoms are increasing in cases with coronavirus disease 2019 (COVID-19). This multi-center prospective study was conducted to determine the incidence of neurological manifestations in hospitalized cases with COVID-19 and assess these symptoms as the predictors of severity and death. Hospitalized males and females with COVID-19 who aged over 18 years were included i...

Neuro-COVID-19 is more than anosmia: clinical presentation, neurodiagnostics, therapies...
https://doi.org/10.1097/WCO.0000000000000930
Current Opinion in Neurology; Schweitzer F, Kleineberg NN et. al.

Mar 12th, 2021 - To provide an overview on current knowledge of neurological symptoms and complications of COVID-19, and to suggest management concepts. Headache, dizziness, excessive tiredness, myalgia, anosmia/hyposmia, and ageusia/dysgeusia are common nonspecific neurological manifestations during early COVID-19 disease found in the majority of patients. Less frequent but more severe and specific neurologica...

Neurological outcome and quality of life three months after COVID-19: a prospective obs...
https://doi.org/10.1111/ene.14803
European Journal of Neurology; Rass V, Beer R et. al.

Mar 8th, 2021 - To assess neurological manifestations and quality of life (QoL) three months after COVID-19. In this prospective, multicentre, observational cohort study we systematically evaluated neurological signs and diseases by detailed neurological examination and a predefined test battery assessing smelling disorders (16-item Sniffin-Sticks-test), cognitive deficits (Montreal Cognitive Assessment), QoL ...

Pediatric Inflammatory Multisystem Syndrome Tied to Ongoing Otolaryngologic Problems
https://www.medscape.com/viewarticle/946801

Mar 3rd, 2021 - NEW YORK (Reuters Health) - Pediatric inflammatory multisystem syndrome temporally associated with COVID-19 disease (PIMS-TS) is associated with a variety of disorders affecting voice, swallowing and smell and taste, which may be long-lasting, according to researchers based in the U.K. In a letter in JAMA Otolaryngology-Head and Neck Surgery, Dr. Ryan C. T. Cheong of Great Ormond Street Hospita...

COVID-19 and Neurology - An Emerging Association.
https://doi.org/10.2174/1871526521666210218202226
Infectious Disorders Drug Targets; Gupta A, Yadav P et. al.

Feb 19th, 2021 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, which is a cause of the ongoing pandemic, has the potential to infect the nervous system and causing neurological manifestations. However, patients with primarily neurological symptoms are often overlooked and tested later. We aim to summarise all the neurological manifestations which are reported so far to aid in early diagnos...

Type 2 diabetes mellitus impaired nasal immunity and increased the risk of hyposmia in ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826056
International Immunopharmacology; Zhao Y, Liu Y et. al.

Feb 18th, 2021 - In patients with COVID-19,type 2 diabetes mellitus (T2DM) can impair the function of nasal-associated lymphoid tissue (NALT) and result in olfactory dysfunction. Exploring the causative alterations of T2DM within the nasal mucosa and NALT could provide insight into the pathogenic mechanisms and bridge the gap between innate immunity and adaptive immunity for virus clearance. Here, we designed a...

Clinical and laboratory characteristics in outpatient diagnosis of COVID-19 in healthca...
https://doi.org/10.1136/jclinpath-2020-206797
Journal of Clinical Pathology; Porto LC, Costa CH et. al.

Feb 11th, 2021 - This study aimed to identify the symptoms associated with early stage SARS-CoV-2 (COVID-19) infections in healthcare professionals (HCPs) using both clinical and laboratory data. A total of 1297 patients, admitted between 18 March and 8 April 2020, were stratified according to their risk of developing COVID-19 using their responses to a questionnaire designed to evaluate symptoms and risk condi...

Covid-19 in outpatients-Is fever a useful indicator for SARS-CoV-2 infection?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857607
PloS One; Schneider A, Kirsten H et. al.

Feb 3rd, 2021 - Understanding mild to moderate symptoms of coronavirus disease 2019 (Covid-19) is important in order to identify active cases early and thus counteract transmission. In March 2020, Leipzig University Hospital established an outpatient clinic for patients potentially infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Confirmed cases with mild to moderate symptoms self-is...

18F-FDG brain PET hypometabolism in patients with long COVID.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837643
European Journal of Nuclear Medicine and Molecular Imaging; Guedj E, Campion JY et. al.

Jan 27th, 2021 - In the context of the worldwide outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), some patients report functional complaints after apparent recovery from COVID-19. This clinical presentation has been referred as "long COVID." We here present a retrospective analysis of 18F-FDG brain PET of long COVID patients from the same center with a biologically confirmed diagnosis o...

Loss of smell and taste in COVID-19 infection in adolescents.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804378
International Journal of Pediatric Otorhinolaryngology; Kumar L, Kahlon N et. al.

Jan 21st, 2021 - To study the prevalence, clinical course and outcomes of olfactory and taste dysfunction in COVID-19 positive adolescents. This prospective study was carried out from May to August 2020. The adolescents, aged 10-19 years, who were detected COVID-19 positive by RT-PCR with mild to moderate disease were included in the study. The following epidemiological and clinical outcomes were studied: age, ...

Employing a systematic approach to biobanking and analyzing clinical and genetic data f...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811682
European Journal of Human Genetics : EJHG; Daga S, Fallerini C et. al.

Jan 18th, 2021 - Within the GEN-COVID Multicenter Study, biospecimens from more than 1000 SARS-CoV-2 positive individuals have thus far been collected in the GEN-COVID Biobank (GCB). Sample types include whole blood, plasma, serum, leukocytes, and DNA. The GCB links samples to detailed clinical data available in the GEN-COVID Patient Registry (GCPR). It includes hospitalized patients (74.25%), broken down into ...

Otorhinolaryngological manifestations of coronavirus disease 2019: a prospective review...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925986
The Journal of Laryngology and Otology; Bhatta S, Gandhi S et. al.

Jan 18th, 2021 - To evaluate otorhinolaryngological manifestations of coronavirus disease 2019 infection and the time required for their resolution. A prospective analysis was conducted of coronavirus disease 2019 patients presenting from 1 April 2020 to 30 July 2020. The otorhinolaryngological manifestations were evaluated based on patient history. The time required for symptom resolution was evaluated separat...

Smell Status in Children Infected with SARS-CoV-2.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013292
The Laryngoscope; Rusetsky Y, Meytel I et. al.

Jan 14th, 2021 - This study aimed to evaluate the olfactory status in children with laboratory confirmed SARS-CoV-2 using subjective and psychophysical methods. Prospective clinical cross-sectional study. This is a prospective clinical cross-sectional study of 79 children with COVID-19. The 21st item of SNOT-22 questionnaire and odor identification test were used for smell assessment. Children were examined twi...

Prevalence and 6-month recovery of olfactory dysfunction: a multicentre study of 1363 C...
https://doi.org/10.1111/joim.13209
Journal of Internal Medicine References; Lechien JR, Chiesa-Estomba CM et. al.

Jan 6th, 2021 - To investigate prevalence and recovery of olfactory dysfunction (OD) in COVID-19 patients according to the disease severity. From 22 March to 3 June 2020, 2581 COVID-19 patients were identified from 18 European hospitals. Epidemiological and clinical data were extracted at baseline and within the 2-month post-infection. The prevalence of OD was significantly higher in mild form (85.9%) compared...

The Association of "Loss of Smell" to COVID-19: A Systematic Review and Meta-Analysis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604015
The American Journal of the Medical Sciences; Aziz M, Goyal H et. al.

Dec 22nd, 2020 - The presence of olfactory dysfunction or "loss of smell" has been reported as an atypical symptom in patients with coronavirus disease 2019 (COVID-19). We performed a systematic review and meta-analysis of the available literature to evaluate the prevalence of "loss of smell" in COVID-19 as well as its utility for prognosticating the disease severity. An exhaustive search of the PubMed/Medline,...

Alteration of Smell and Taste in Asymptomatic and Symptomatic COVID-19 Patients in Sici...
https://doi.org/10.1177/0145561320981447
Ear, Nose, & Throat Journal; Bianco MR, Modica DM et. al.

Dec 22nd, 2020 - Alteration of smell and taste has been reported in patients with coronavirus disease 2019 (COVID-19). The incidence and clinical-symptomatic manifestation of COVID-19 is different between northern and southern Italy. This study aims to evaluate the onset of alteration of smell and taste in asymptomatic and symptomatic patients in Sicily (extreme south of Italy). This prospective cross-sectional...

Efficacy of corticosteroid therapy in the treatment of long- lasting olfactory disorder...
https://doi.org/10.4193/Rhin20.515
Rhinology Vaira LA, Hopkins C et. al.

Dec 8th, 2020 - The growing number of COVID-19 patients with long-lasting olfactory disorders makes it necessary to identify ef- fective treatments that enhance the spontaneous recovery of olfactory function. Multicentre randomised case-control study that involved 18 patients with COVID-19 related anosmia or severe hyposmia for more than 30 days. Nine patients were prescribed systemic prednisone and nasal irri...

Covid-19 infection-induced neuromyelitis optica: a case report.
https://doi.org/10.1080/00207454.2020.1860036
The International Journal of Neuroscience; Batum M, Kisabay Ak A et. al.

Dec 7th, 2020 - Acute respiratory syndrome coronavirus-2 (Covid-19) can infect the respiratory system, as well as the central, peripheral nervous system, and muscles, leading to neurological symptoms and signs. The most common neurological symptoms are dizziness, headache, impaired consciousness, ataxia, hypogosis, hyposmia, neuralgia, and myalgia. The most common neurological diseases are acute cerebrovascula...

Taste and Smell Impairment in Critically Ill Patients With COVID-19: An Intensive Care ...
https://doi.org/10.1177/0145561320977464
Ear, Nose, & Throat Journal; Sayın P, Altınay M et. al.

Dec 1st, 2020 - To determine taste and smell impairment rates in patients with coronavirus disease 2019 (COVID-19) who were hospitalized in the intensive care unit (ICU). Between March 2020 and May 2020, patients with COVID-19 hospitalized in the ICU were enrolled in this study. Upon discharge, patients were telephoned and asked to complete a survey related to taste and smell impairment. Characteristics were c...