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Smell and Taste Dysfunction in Patients With COVID-19: A Systematic Review and Meta-ana...
https://doi.org/10.1016/j.mayocp.2020.05.030
Mayo Clinic Proceedings; Agyeman AA, Chin KL et. al.

Aug 5th, 2020 - To estimate the prevalence of olfactory and gustatory dysfunctions (OGDs) among patients infected with novel coronavirus disease 2019 (COVID-19). A systematic review was conducted by searching MEDLINE, EMBASE, and the preprint server MedRxiv from their inception until May 11, 2020, using the terms anosmia or hyposmia or dysosmia or olfactory dysfunction or olfaction disorder or smell dysfunctio...

Co‑expression of peripheral olfactory receptors with SARS‑CoV‑2 infection mediators: Po...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388840
International Journal of Molecular Medicine; Kerslake R, Hall M et. al.

Jul 24th, 2020 - Severe acute respiratory syndrome (SARS) coronavirus‑2 (SARS‑CoV‑2) enters into human host cells via mechanisms facilitated mostly by angiotensin‑converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). New loss of smell (anosmia/hyposmia) is now recognized as a COVID‑19 related symptom, which may be caused by SARS‑CoV‑2 infection and damage of the olfactory receptor (OR) cells...

Prospective study in 355 patients with suspected COVID-19 infection. Value of cough, su...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404620
The Laryngoscope; Martin-Sanz E, Riestra J et. al.

Jul 20th, 2020 - To evaluate the incidence of certain symptoms in a population of health workers exposed to COVID-19 patients. A case-control study was conducted at a tertiary care hospital from March 1 to April 7, 2020. Health workers with suspected COVID-19 infection were included. The presence of COVID-19 was detected by using real-time-PCR methods. Positive and negative RT-PCR patients were used as case and...

Assessment of neurological manifestations in hospitalized patients with COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405467
European Journal of Neurology; Luigetti M, Iorio R et. al.

Jul 18th, 2020 - The objective of this study is to assess the neurological manifestations in a series of consecutive SARS-CoV-2 positive patients, comparing their frequency with a population hospitalized in the same period for flu/respiratory symptoms, finally not related to SARS-CoV-2. We retrospectively enrolled patients with flu-respiratory symptoms admitted to Fondazione Policlinico Gemelli hospital from Ma...

Neurological manifestations of COVID-19: a systematic review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356133
Critical Care (London, England); Nepal G, Rehrig JH et. al.

Jul 14th, 2020 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global spread of coronavirus disease (COVID-19). Our understanding of the impact this virus has on the nervous system is limited. Our review aims to inform and improve decision-making among the physicians treating COVID-19 by presenting a systematic analysis of the neurological manifestations experienced within ...

COVID-19 Pulmonary and Olfactory Dysfunctions: Is the Chemokine CXCL10 the Common Denom...
https://doi.org/10.1177/1073858420939033
The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry; Oliviero A, de Castro F et. al.

Jul 13th, 2020 - COVID-19 is an ongoing viral pandemic that emerged from East Asia and quickly spread to the rest of the world. SARS-CoV-2 is the virus causing COVID-19. Acute respiratory distress syndrome (ARDS) is definitely one of the main clinically relevant consequences in patients with COVID-19. Starting from the earliest reports of the COVID-19 pandemic, two peculiar neurological manifestations (namely, ...

Olfactory Dysfunction in COVID-19 Patients: Prevalence and Prognosis for Recovering Sen...
https://doi.org/10.1177/0194599820943530
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery; D'Ascanio L, Pandolfini M et. al.

Jul 13th, 2020 - While olfactory dysfunction associated with coronavirus disease 2019 (COVID-19) has attracted considerable interest, few studies have tracked outcomes at serial time points or beyond 2 weeks. Furthermore, data are conflicting regarding whether COVID-19 severity correlates with degree of olfactory dysfunction. This prospective case-control study analyzed prevalence and severity of subjective los...

Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection.
https://doi.org/10.1212/WNL.0000000000010282
Neurology Méndez-Guerrero A, Laespada-García MI et. al.

Jul 7th, 2020 - To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome. Patient data were obtained from medical records from the "Hospital Universitario 12 de Octubre" in Madrid, Spain. [123I]-ioflupane dopamine transporter single-photon emission CT (DaT-SPECT) images were acquired 4 hours after a single dose o...

Neurosensory dysfunction: a diagnostic marker of early COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323654
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases; Liang Y, Xu J et. al.

Jul 2nd, 2020 - To detailly described the neurosensory dysfunction, including hyposmia, hypogeusia and tinnitus, in patients with COVID-19. Clinical characteristics and oropharyngeal swabs were obtained from 86 patients with COVID-19 hospitalized in Guangzhou Eighth People's Hospital. Chronological analysis method was used to detailly clarify the neurosensory dysfunction. The cycle threshold (Ct) values were u...

Oral ulceration and blistering in patients with COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317274
Evidence-based Dentistry; Sinadinos A, Shelswell J

Jun 27th, 2020 - Design Case series.Introduction The most common signs and symptoms of SARS-CoV-2 infection include headache, sore throat, hyposmia, hypogeusia, diarrhoea, dyspnoea and pneumonia. Dermatological manifestations have also been reported but few authors have documented oral signs and symptoms. Methods Three cases are reported where oral ulceration or blistering is found in patients with confirmed or...

The diagnostic value of detecting sudden smell loss among asymptomatic COVID-19 patient...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282761
Auris, Nasus, Larynx; Kang YJ, Cho JH et. al.

Jun 19th, 2020 - The newly emerged coronavirus disease 19 (COVID-19), is threatening the world. Olfactory or gustatory dysfunction is reported as one of the symptoms worldwide. As reported so far, different clinical features have been reported according to outbreak sites and gender; most of the patients, who complained of anosmia or hyposmia, were Europeans. We had a fast review for novel articles about COVID-1...

Diagnosing COVID-19 in the Emergency Department: A Scoping Review of Clinical Examinati...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323136
Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine References; Carpenter CR, Mudd PA et. al.

Jun 16th, 2020 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as a global pandemic in early 2020 with rapidly evolving approaches to diagnosing the clinical illness called coronavirus disease (COVID-19). The primary objective of this scoping review is to synthesize current research of the diagnostic accuracy of history, physical examination, routine laboratory tests, real-time reverse tr...

SARS-CoV-2 infection in patients with autoimmune rheumatic diseases in northeast Italy:...
https://doi.org/10.1016/j.jaut.2020.102502
Journal of Autoimmunity; Zen M, Fuzzi E et. al.

Jun 12th, 2020 - Whether patients with autoimmune rheumatic diseases (ARD) have a higher risk for SARS-CoV-2 infection (COVID-19) and how SARS-CoV-2 pandemic impacts on adherence to therapy has not been fully elucidated. We assessed the rate and clinical presentation of COVID-19, and adherence to therapy in a large cohort of patients with ARD followed-up in a tertiary University-Hospital in Northeast Italy. Bet...

Taste and Smell Impairment in COVID-19: An AAO-HNS Anosmia Reporting Tool-Based Compara...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284454
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery; Sayin İ, Yaşar KK et. al.

Jun 9th, 2020 - To identify the taste and smell impairment in coronavirus disease 2019 (COVID-19)-positive subjects and compare the findings with COVID-19-negative subjects using the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) Anosmia Reporting Tool. Tertiary referral center/COVID-19 pandemic hospital. Comparative study. After power analysis, 128 subjects were divided into 2 groups accor...

COVID-19 and SARS-Cov-2 Infection: Pathophysiology and Clinical Effects on the Nervous ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255736
World Neurosurgery; Abboud H, Abboud FZ et. al.

May 31st, 2020 - Coronavirus disease 2019 (COVID-19) is an infectious disease caused by SARS-Cov-2, resulting in severe acute respiratory syndrome, with high potential of spreading and infecting humans worldwide. Since December 2019, when the virus was identified in humans, the literature on COVID-19 has grown exponentially and extrarespiratory symptoms including neurologic symptoms are increasingly highlighted...

Psychophysical Olfactory Tests and Detection of COVID-19 in Patients With Sudden Onset ...
https://doi.org/10.1177/0145561320929169
Ear, Nose, & Throat Journal; Lechien JR, Cabaraux P et. al.

May 28th, 2020 - To investigate the coronavirus disease 2019 (COVID-19) status of patients with initial sudden olfactory anosmia (ISOA) through nasopharyngeal swabs for reverse transcription-polymerase chain reaction (RT-PCR) analysis and to explore their olfactory dysfunctions with psychophysical olfactory evaluation. A total of 78 ISOA patients were recruited from April 6, 2020, to April 10, 2020, through a p...

The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specia...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204734
Journal of the Neurological Sciences; Román GC, Spencer PS et. al.

May 28th, 2020 - A comprehensive review of the neurological disorders reported during the current COVID-19 pandemic demonstrates that infection with SARS-CoV-2 affects the central nervous system (CNS), the peripheral nervous system (PNS) and the muscle. CNS manifestations include: headache and decreased responsiveness considered initial indicators of potential neurological involvement; anosmia, hyposmia, hypoge...

Severe acute respiratory syndrome coronavirus 2 is penetrating to dementia research.
https://doi.org/10.2174/1567202617666200522220509
Current Neurovascular Research; Bostanciklioglu M

May 22nd, 2020 - 1. Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus infectious disease 2019 (COVID-19), which was first reported in Wuhan, China, in late December, 2019. Despite the tremendous efforts to control the disease, SARS-CoV-2 has infected 1,5 million people and caused the death of more than a hundred thousand people across the globe as of writing. Recently,...

Olfactory Dysfunction and Sinonasal Symptomatology in COVID-19: Prevalence, Severity, T...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240313
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery; Speth MM, Singer-Cornelius T et. al.

May 19th, 2020 - Olfactory dysfunction (OD)-hyposmia or anosmia-is a symptom of coronavirus disease 2019 (COVID-19), caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We sought to better determine prevalence, severity, and timing of OD in COVID-19 relative to other sinonasal and pulmonary symptoms. Prospective, cross-sectional. Regional/cantonal hospital. In total, 1...

Neurological manifestations of COVID-19 and other coronavirus infections: A systematic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227498
Clinical Neurology and Neurosurgery; Montalvan V, Lee J et. al.

May 18th, 2020 - Increasing research reports neurological manifestations of COVID-19 patients. SARS-CoV-2 shares homology with other human coronaviruses that have also had nervous system involvement. To review the neurological aspects of SARS-cov2 and other coronavirus, including transmission pathways, mechanisms of invasion into the nervous system, and mechanisms of neurological disease. We conducted a systema...