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The effect of post COVID-19 on gustatory and olfactory function: a preliminary case- co...
https://doi.org/10.1111/odi.14567
Oral Diseases; Livni D, Grinstein-Koren O et. al.

Mar 18th, 2023 - To analyse objective and subjective olfactory / gustatory function in post COVID-19 infection (PCI). Patients with past PCR-confirmed COVID-19 infection and persistent olfactory/gustatory complaints were investigated. Olfactory threshold and identification, gustatory detection, identification and magnitude scaling were tested. 42 PCI subjects were compared to 41 age- and gender-matched controls...

Brain diffusion alterations in patients with COVID-19 pathology and neurological manife...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883079
NeuroImage. Clinical; Caroli A, Capelli S et. al.

Feb 3rd, 2023 - COVID-19 neurological manifestations have been progressively recognized. Among available MRI techniques, diffusion weighted imaging (DWI) shows promise to study microstructure, inflammation, and edema. Previous DWI studies reported alterations in brain diffusivity in COVID-19 patients, as assessed by morphologic evaluation of brain DWI scans only. The aim of this study was to assess and quantif...

Drug-induced olfactory and gustatory dysfunction: Analysis of FDA adverse events report...
https://doi.org/10.1016/j.anl.2022.12.012
Auris, Nasus, Larynx; Debbaneh P, McKinnon L et. al.

Jan 23rd, 2023 - With the COVID-19 pandemic, there is growing interest and research in olfactory and gustatory dysfunction (OGD). Drug-induced dysfunction is an often overlooked etiology. While several medications include smell or taste disturbance as a side effect, there are no publications describing which medications are most frequently implicated. We aim to describe the patterns of these adverse drug reacti...

Substance P and Prokineticin-2 are overexpressed in olfactory neurons and play differen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760596
Brain, Behavior, and Immunity; Schirinzi T, Lattanzi R et. al.

Dec 23rd, 2022 - Persistent olfactory dysfunction (OD) is one of the most complaining and worrying complications of long COVID-19 because of the potential long-term neurological consequences. While causes of OD in the acute phases of the SARS-CoV-2 infection have been figured out, reasons for persistent OD are still unclear. Here we investigated the activity of two inflammatory pathways tightly linked with olfa...

Factors Associated with Self-Reported Post/Long-COVID-A Real-World Data Study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738553
International Journal of Environmental Research and Publi... Thronicke A, Hinse M et. al.

Dec 12th, 2022 - Evidence suggests that Post/Long-COVID (PLC) is associated with a reduced health-related quality of life, however little knowledge exists on the risk factors that contribute to PLC. The objective of this prospective real-world data study was to evaluate factors associated with PLC using national online survey data. Adjusted multivariable regression analyses were performed using the software R. ...

Effects of nasal inflammation on the olfactory bulb.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733073
Journal of Neuroinflammation; LaFever BJ, Imamura F

Dec 11th, 2022 - Sinonasal diseases, such as rhinosinusitis, affect up to 12% of individuals each year which constitutes these diseases as some of the most common medical conditions in the world. Exposure to environmental pathogens and toxicants via the nasal cavity can result in a severe inflammatory state commonly observed in these conditions. It is well understood that the epithelial and neuronal cells linin...

USE OF MOUTHWASH AND DENTIFRICE CONTAINING AN ANTIMICROBIAL PHTHALOCYANINE DERIVATIVE F...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472577
The Journal of Evidence-based Dental Practice; Poleti ML, Gregório D et. al.

Dec 10th, 2022 - This clinical trial aimed to evaluate the use of mouthwash and dentifrice containing an antimicrobial phthalocyanine derivative (APD) to reduce the clinical symptoms in patients with COVID-19. This randomized, triple-blind clinical trial enrolled 134 patients aged 18 years or older who underwent COVID-19 testing through the use of nasopharyngeal swab RT-qPCR in a reference center for the diagno...

Brain fog of post-COVID-19 condition and Chronic Fatigue Syndrome, same medical disorder?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724286
Journal of Translational Medicine; Azcue N, Gómez-Esteban JC et. al.

Dec 7th, 2022 - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is characterized by persistent physical and mental fatigue. The post-COVID-19 condition patients refer physical fatigue and cognitive impairment sequelae. Given the similarity between both conditions, could it be the same pathology with a different precipitating factor? To describe the cognitive impairment, neuropsychiatric symptoms, a...

Physiological discrimination and correlation between olfactory and gustatory dysfunctio...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812235
Physiological Reports; Mazzatenta A

Nov 23rd, 2022 - The spread of the SARS-CoV-2 virus produces a new disease termed COVID-19, the underlying physiological mechanisms of which are still being understood. Characteristic of the infection is the compromising of taste and smell. There is a persistent need to discriminate the dysfunctions and correlation between taste and smell, which are probably epiphenomena of other concealed conditions. Anosmic a...

COVID-19 as a Risk Factor for Alzheimer's Disease.
https://doi.org/10.3233/JAD-220800
Journal of Alzheimer's Disease : JAD; Golzari-Sorkheh M, Weaver DF et. al.

Nov 1st, 2022 - Severe acute respiratory disease coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although a primarily respiratory disease, recent reports indicate that it also affects the central nervous system (CNS). Over 25% of COVID-19 patients report neurological symptoms such as memory loss, anosmia, hyposmia, confusion, and headaches. The neurological outco...

Alleviation of Post-COVID-19 Cognitive Deficits by Treatment with EGb 761®: A Case Series.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523733
The American Journal of Case Reports; Zifko UA, Yacob M et. al.

Sep 27th, 2022 - BACKGROUND Cognitive symptoms persisting longer than 3 months after infection, such as memory loss, or difficulties concentrating, have been reported in up to one-third of patients after COVID-19. Evidence-based therapeutic interventions to treat post-COVID-19 symptoms (also called "Long-COVID symptoms") have not yet been established, and the treating physicians must rely on conjecture to help ...

The Olfactory Nerve: Anatomy and Pathology.
https://doi.org/10.1053/j.sult.2022.04.001
Seminars in Ultrasound, CT, and MR; Ottaiano AC, Freddi TAL et. al.

Sep 19th, 2022 - The human sense of smell is the unique sense through which the olfactory system can identify aromatic molecules within the air and provide a taste sensation. Still, also it plays an essential role in several other functions, warning about environmental safety and even impacts our emotional lives. Recently, olfactory impairment has become an issue of interest due to the COVID-19 pandemic. The dy...

Hyposmia Patterns Separate COVID From Mild Cognitive Impairment
https://www.medscape.com/viewarticle/980901

Sep 15th, 2022 - PHILADELPHIA — In patients with persistent hyposmia after COVID-19 infection, the specific pattern of impaired olfaction can distinguish these patients from normal controls and from individuals with mild cognitive impairment, a study has shown. "We know that overall, 1 in 8 patients, at least, who have had COVID, are going to have persistent olfactory dysfunction," Jennifer Villwock, MD, of the...

Sociodemographic Characteristics and Comorbidities of Patients With Long COVID and Pers...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459661
JAMA Network Open; Mendes Paranhos AC, Nazareth Dias ÁR et. al.

Sep 9th, 2022 - Determining the characteristics, type, and severity of olfactory dysfunction in patients with long COVID is important for the prognosis and potential treatment of the affected population. To describe the sociodemographic and clinical features of patients with long COVID who develop persistent olfactory dysfunction. This cross-sectional study, conducted at a rehabilitation center at a public uni...

Interventions for the treatment of persistent post-COVID-19 olfactory dysfunction.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443431
The Cochrane Database of Systematic Reviews; O'Byrne L, Webster KE et. al.

Sep 6th, 2022 - Olfactory dysfunction is a common consequence of COVID-19 infection and persistent symptoms can have a profound impact on quality of life. At present there is little guidance on how best to treat this condition. A variety of interventions have been suggested to promote recovery, including medication and olfactory training. However, it is uncertain whether any intervention is of benefit. This is...

Natural trajectory of recovery of COVID-19 associated olfactory loss.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355743
American Journal of Otolaryngology; Khan AM, Lee J et. al.

Aug 16th, 2022 - Prevalence of post-viral olfactory loss has increased dramatically due to the frequency and severity of olfactory dysfunction associated with infection by the SARS-CoV-2 virus. To determine the trajectory of COVID-19 olfactory loss over a six-month period. A key secondary objective is to assess predictive factors associated with the recovery of olfaction. Longitudinal repeated-measures study th...

Management of Post-Infectious Anosmia and Hyposmia: A Systematic Review.
https://doi.org/10.1177/00034894221118186
The Annals of Otology, Rhinology, and Laryngology; Nag AK, Saltagi AK et. al.

Aug 13th, 2022 - Anosmia and hyposmia significantly affect patients' quality of life and have many etiologies, including trauma, inflammatory conditions including chronic rhinosinusitis, neoplasm, and viral infections, such as rhinovirus and SARS-CoV-2. Our purpose was to establish whether a consensus exists regarding optimal management of olfactory dysfunction and to provide insight into the treatment of anosm...

Post-COVID-19 neuropsychiatric manifestations among COVID-19 survivors suffering from m...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372973
The Journal of Headache and Pain; Magdy R, Elmazny A et. al.

Aug 13th, 2022 - The burden of post-coronavirus disease (COVID)-19 symptoms has been increasing and is of great concern in patients with pre-existing chronic medical conditions.This study aimed to delineate the post-COVID-19 neuropsychiatric symptoms among migraine patients compared to the non-migraine control group. Two groups, each of 204 COVID-19 survivors, were enrolled in the study after 3 months of severe...

COCOS trial: COrticosteroids for COVID-19-induced loss of Smell-protocol for a single-c...
https://doi.org/10.1136/bmjopen-2021-060416
BMJ Open; Schepens EJA, Boek WM et. al.

Aug 11th, 2022 - Hyposmia and anosmia are common in COVID-19. Most patients regain normal smell within 4 weeks, but severe loss of smell persists roughly in 20% after 2 months and may last up to a year or longer. These persistent smell disorders greatly influence daily life. It is hypothesised that COVID-19 induces inflammation around the olfactory nerve and in the olfactory pathway, leading to smell disorders....

Neurological symptoms and signs associated with COVID-19 in pediatric patients: a singl...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351517
Medicine Sener Okur D

Aug 11th, 2022 - There is insufficient evidence on SARS-CoV-2 induced neurological effects. Studies on CNS involvement during COVID-19 in children are limited. This study aims to identify and manage the neurological signs and symptoms in COVID-19-infected pediatric patients during follow up and plan future follow-ups. Children diagnosed COVID-19 and hospitalized in the pediatric pandemic services, between March...