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Incomplete humoral response including neutralizing antibodies in asymptomatic to mild C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787511
Virology Takeshita M, Nishina N et. al.

Jan 15th, 2021 - The pandemic of COVID-19 is still ongoing, and many studies on serum antibodies have been reported, however, there are few studies about asymptomatic and mild patients. In this study, we enrolled 44 COVID-19 patients with relatively mild disease and 48 pre-pandemic controls. We measured serum antibodies against extracellular domain, S1 domain, and receptor-binding domain of Spike and N protein,...

Vitamin D, zinc and glutamine: Synergistic action with OncoTherad immunomodulator in in...
https://doi.org/10.3892/ijmm.2021.4844
International Journal of Molecular Medicine; Name JJ, Vasconcelos AR et. al.

Jan 15th, 2021 - Coronavirus disease 2019 (COVID‑19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), was identified in December, 2019 in Wuhan, China. Since then, it has continued to spread rapidly in numerous countries, while the search for effective therapeutic options persists. Coronaviruses, including SARS‑CoV‑2, are known to suppress and evade the antiviral responses of the host or...

Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune re...
https://doi.org/10.1073/pnas.2021615118 10.1016/j.jmii.2020.05.001 10.1093/cid/ciaa1143 10.1056/NEJMoa2029849
Proceedings of the National Academy of Sciences of the United States of America; Sasisekharan V, Pentakota N et. al.

Jan 15th, 2021 - Immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the current pandemic remains a field of immense interest and active research worldwide. Although the severity of acute infection may depend on the intensity of innate and adaptive immunity, leading to higher morbidity and mortality, the longevity of IgG antibodies, including neutralizing activity to...

Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cel...
https://doi.org/10.4049/jimmunol.2001400
Journal of Immunology (Baltimore, Md. : 1950); Joag V, Wijeyesinghe S et. al.

Jan 14th, 2021 - The magnitude of SARS-CoV-2-specific T cell responses correlates inversely with human disease severity, suggesting T cell involvement in primary control. Whereas many COVID-19 vaccines focus on establishing humoral immunity to viral spike protein, vaccine-elicited T cell immunity may bolster durable protection or cross-reactivity with viral variants. To better enable mechanistic and vaccination...

Identification of SARS-CoV-2 Nucleocapsid and Spike T-cell Epitopes for Assessing T-cel...
https://doi.org/10.1128/JVI.02002-20
Journal of Virology; Lee E, Sandgren K et. al.

Jan 14th, 2021 - Developing optimal T-cell response assays to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is critical for measuring the duration of immunity to this disease and assessing the efficacy of vaccine candidates. These assays need to target conserved regions of SARS-CoV-2 global variants and avoid cross-reactivity to seasonal human coronaviruses. To contribute to this effort, we ...

Severe COVID-19: Immunosuppression or Hyperinflammation?
https://doi.org/10.1097/SHK.0000000000001724
Shock (Augusta, Ga.); Liu Y, Li Y et. al.

Jan 14th, 2021 - The ongoing coronavirus disease 2019 (COVID-19) pandemic has swept over the world and causes thousands of deaths. Although the clinical features of COVID-19 become much clearer than before, there are still further problems with the pathophysiological process and treatments of severe patients. One primary problem is with the paradoxical immune states in severe patients with COVID-19. Studies ind...

Concerns for others increases the likelihood of vaccination against influenza and COVID...
https://doi.org/10.1073/pnas.2007538118
Proceedings of the National Academy of Sciences of the United States of America; Jung H, Albarracín D

Jan 14th, 2021 - Vaccination yields the direct individual benefit of protecting recipients from infectious diseases and also the indirect social benefit of reducing the transmission of infections to others, often referred to as herd immunity This research examines how prosocial concern for vaccination, defined as people's preoccupation with infecting others if they do not vaccinate themselves, motivates vaccina...

Impact of reproduction number on multiwave spreading dynamics of COVID-19 with temporar...
https://doi.org/10.1016/j.ijid.2021.01.018
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases; Shayak B, Sharma MM et. al.

Jan 14th, 2021 - The recent discoveries of phylogenetically confirmed COVID-19 reinfection cases worldwide, together with studies suggesting that antibody titres decrease over time, raise the question of what course the epidemic trajectories may take if immunity were really to be temporary in a significant fraction of the population. The objective of this study is to answer this question. We construct a ground-...

Brazil SARS-CoV-2 Variant Found in UK 'Not One of Concern'
https://www.medscape.com/viewarticle/944185

Jan 14th, 2021 - Editor's note, 16 January 2021: This article was updated with new information from Public Health England. One of two types of variants of the SARS-CoV-2 virus believed to have originated in Brazil has already been detected in the UK, according to a leading virologist. Prof Wendy Barclay/SMC However, Prof Wendy Barclay, chair in influenza virology at Imperial College London, said the one found i...

5 Reasons to Wear a Mask Even After You're Vaccinated
https://www.medscape.com/viewarticle/944200

Jan 14th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. As an emergency physician, Dr. Eugenia South was in the first group of people to receive a covid vaccine. She received her second dose last week  — even before President-elect Joe Biden. Yet South said she's in no rush to throw away her face mask. "I honestly don't think I'll ever go without a m...

COVID-19 Infection Gives Some Immunity, but Virus Can Still Be Spread, Study Finds
https://www.medscape.com/viewarticle/944095

Jan 14th, 2021 - LONDON (Reuters) - People who have had COVID-19 are highly likely to have immunity to it for at least five months, but there is evidence that those with antibodies may still be able to carry and spread the virus, a study of British healthcare workers has found. Preliminary findings by scientists at Public Health England (PHE) showed that reinfections in people who have COVID-19 antibodies from ...

Natural Immunity From COVID-19 'May Last Months'
https://www.medscape.com/viewarticle/944086

Jan 13th, 2021 - Infection with the SARS-CoV-2 virus may provide some immunity for at least 5 months, interim results from a study has found.

What the Blood Supply Shows About COVID-19's Spread
https://www.medscape.com/viewarticle/944035

Jan 12th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. In March, as the Covid-19 pandemic began to shut down major cities in the U. S Since early in the pandemic, scientists have used antibodies to try to estimate the true number of Covid-19 infections in the community, mapping the invisible scale of the pandemic. Some of those studies work a bit li...

Modeling human adaptive immune responses with tonsil organoids.
https://doi.org/10.1038/s41591-020-01145-0
Nature Medicine; Wagar LE, Salahudeen A et. al.

Jan 12th, 2021 - Most of what we know about adaptive immunity has come from inbred mouse studies, using methods that are often difficult or impossible to confirm in humans. In addition, vaccine responses in mice are often poorly predictive of responses to those same vaccines in humans. Here we use human tonsils, readily available lymphoid organs, to develop a functional organotypic system that recapitulates key...

Antibody response to SARS-CoV-2 in infected patients with different clinical outcome.
https://doi.org/10.1002/jmv.26789
Journal of Medical Virology; Anichini G, Gandolfo C et. al.

Jan 11th, 2021 - Data regarding antibody responses to SARS-CoV-2 in patients infected with COVID-19 are not yet available. In this study, we aimed to evaluate serum antibody responses in patients regardless of the outcome. We measured the circulating IgG antibody levels in 60 subjects with a certified history of SARS-CoV-2 infection by using immunoenzymatic, chemiluminescent, and Neutralization assays. Half pat...

SARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 individuals.
https://doi.org/10.1172/JCI145476
The Journal of Clinical Investigation; Kared H, Redd AD et. al.

Jan 11th, 2021 - Characterization of the T cell response in individuals who recover from SARS-CoV-2 infection is critical to understand its contribution to protective immunity. A multiplexed peptide-MHC tetramer approach was used to screen 408 SARS-CoV-2 candidate epitopes for CD8+ T cell recognition in a cross-sectional sample of 30 COVID-19 convalescent individuals. T cells were evaluated using a 28-marker ph...

The Psychiatrist and the Vaccine
https://www.medscape.com/viewarticle/943946

Jan 11th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. When the long-awaited news of a Food and Drug Administration–approved vaccine came on Dec. 11, 2020, my first thought was that I would wait My personal feelings have been influenced by a few things. An article in the New York Times highlighted how New York City vaccinated 5 million people for sm...

Travel Body Rejects Compulsory COVID-19 Shots as Experts Say Herd Immunity Not Close
https://www.medscape.com/viewarticle/943893

Jan 11th, 2021 - PARIS/SYDNEY (Reuters) - The head of a global travel organisation on Monday opposed making COVID-19 vaccinations a requirement for travellers in the fight against the pandemic, despite scepticism about reaching herd immunity this year. Several health experts said during the Reuters Next conference that the mass roll-out of coronavirus vaccines would not result in enough people having immunity t...

The Sensitivity and Costs of Testing for SARS-CoV-2 Infection With Saliva Versus Nasoph...
https://doi.org/10.7326/M20-6569
Annals of Internal Medicine; Bastos ML, Perlman-Arrow S et. al.

Jan 11th, 2021 - Nasopharyngeal swabs are the primary sampling method used for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but they require a trained health care professional and extensive personal protective equipment. To determine the difference in sensitivity for SARS-CoV-2 detection between nasopharyngeal swabs and saliva and estimate the incremental cost per additional SARS-C...

Indonesia Approves China's Sinovac Vaccine as Infections Surge
https://www.medscape.com/viewarticle/943950

Jan 11th, 2021 - JAKARTA (Reuters) - Indonesia gave Sinovac Biotech's COVID-19 vaccine its first emergency use approval outside China on Monday as the world's fourth most populous country launches nationwide inoculations to stem surging infections and deaths. A lack of data and varying efficacy rates reported for the vaccine from different countries could undermine public trust in the rollout, according to publ...