×
Booster vaccination strategy: Necessity, Immunization Objectives, Immunization Strategy...
https://doi.org/10.1002/jmv.27590
Journal of Medical Virology; Meng H, Mao J et. al.

Jan 15th, 2022 - At present, the global COVID-19 epidemic has not been completely controlled, and epidemic prevention and control still face severe challenges. As there is no specific treatment for COVID-19, promoting roll-out vaccinations and building herd immunity are still the most effective and economic measures to control the COVID-19 pandemic. However, the neutralizing antibody level in the recipients dec...

Immunotherapy Outcomes in HPV-Associated Head and Neck Cancer Fuel Investigative Efforts
https://www.onclive.com/view/immunotherapy-outcomes-in-hpv-associated-head-and-neck-cancer-fuel-investigative-efforts

Jan 14th, 2022 - Promising data from studies evaluating immunotherapy and cellular therapy for patients with head and neck cancers associated with human papilloma virus (HPV) have helped to widen the treatment landscape. However, many clinical questions remain unanswered as to the appropriate sequencing for the trials. Additionally, investigators have looked to the success in this patient population to develop ...

Adjudicating the logistics of COVID-19 vaccine boosters from a global perspective.
https://doi.org/10.1080/21645515.2021.2020572
Human Vaccines & Immunotherapeutics; Priyanka , Choudhary OP et. al.

Jan 14th, 2022 - The emergence of the novel SARS-CoV-2 variants has led to the advocation of COVID-19 vaccine boosters by many countries. The reasons cited for the booster vaccination, such as waning immunity, immune escape due to viral evolution and suboptimal responses in immunocompromised individuals, need to be cautiously weighed against possible risks, including immune-mediated side effects, vaccine hesita...

Aging-related cell type-specific pathophysiologic immune responses that exacerbate dise...
https://doi.org/10.1111/acel.13544
Aging Cell; Hou Y, Zhou Y et. al.

Jan 14th, 2022 - Coronavirus disease 2019 (COVID-19) is especially severe in aged patients, defined as 65 years or older, for reasons that are currently unknown. To investigate the underlying basis for this vulnerability, we performed multimodal data analyses on immunity, inflammation, and COVID-19 incidence and severity as a function of age. Our analysis leveraged age-specific COVID-19 mortality and laboratory...

Rapid cytokine release assays for analysis of SARS-CoV-2-specific T cells in whole blood.
https://doi.org/10.1093/infdis/jiac005
The Journal of Infectious Diseases; Törnell A, Grauers Wiktorin H et. al.

Jan 14th, 2022 - Waning of IgG antibodies against SARS-CoV-2 complicates diagnosis of past infection. Durability of T cell memory against SARS-CoV-2 remains unclear, and most current T cell protocols are unsuited for large-scale automation. Whole blood samples from 31 patients with verified past COVID-19 and 46 controls, out of which 40 received SARS-CoV-2 vaccine were stimulated with peptides spanning the nucl...

Of vascular defense, hemostasis, cancer, and platelet biology: an evolutionary perspect...
https://doi.org/10.1007/s10555-022-10019-5
Cancer Metastasis Reviews; Menter DG, Afshar-Kharghan V et. al.

Jan 14th, 2022 - We have established considerable expertise in studying the role of platelets in cancer biology. From this expertise, we were keen to recognize the numerous venous-, arterial-, microvascular-, and macrovascular thrombotic events and immunologic disorders are caused by severe, acute-respiratory-syndrome coronavirus 2 (SARS-CoV-2) infections. With this offering, we explore the evolutionary connect...

Don't Expect Much From COVID Vax in This Patient Group
https://www.medpagetoday.com/rheumatology/generalrheumatology/96649

Jan 13th, 2022 - Patients with ANCA-associated vasculitis (AAV) did not mount durable antibody responses to the SARS-CoV-2 Delta variant after the standard two-dose regimen of the Pfizer-BioNTech vaccine -- and for those taking rituximab (Rituxan) as maintenance therapy, even a third dose wasn't much help. For those not on the B-cell depleting agent, however, third doses did provide enough of a boost to neutral...

Natural immunity boosters as therapeutic interventions in the era of COVID-19 pandemic.
https://doi.org/10.2174/1871530322666220110113028
Endocrine, Metabolic & Immune Disorders Drug Targets; Noureen S, Rehman K et. al.

Jan 13th, 2022 - COVID-19, a pandemic caused by SARS-CoV2 has been spread all over the world and is responsible for serious fatalities. SARS-CoV2 is included in the family of β-coronavirus that affects pulmonary gas exchange and triggers cytokines storm. Vigorous inflammation, hyper-coagulation, a decrease in lymphocytic count and an increase in neutrophilic count are observed in the second week after the onset...

A pilot study for the evaluation of an interferon-gamma release assay (IGRA) to measure...
https://doi.org/10.1128/jcm.02199-21
Journal of Clinical Microbiology; Barreiro P, Sanz JC et. al.

Jan 13th, 2022 - Background: Assessment of T-cell responses to SARS-CoV-2 antigens may be of value to determine long-lasting protection to breakthrough infections or reinfections. Interferon-gamma release assay is a validated method to test cellular immunity in mycobacterial infections and has been proposed for patients with SARS-CoV-2 infection or vaccination. Methods: Quantitative IgG to spike and qualitative...

Seroconversion following COVID-19 vaccination: Can we optimize protective response in C...
https://doi.org/10.1093/cei/uxab015
Clinical and Experimental Immunology; Baker D, MacDougall A et. al.

Jan 13th, 2022 - Although there is an ever-increasing number of disease-modifying treatments for relapsing multiple sclerosis (MS), few appear to influence COVID-19 severity. There is concern about the use of anti-CD20-depleting monoclonal antibodies, due to the apparent increased risk of severe disease following SARS-CoV-2 infection and inhibition of protective anti-COVID-19 vaccine responses. These antibodies...

Evidence of SARS-CoV-2 Symptomatic Reinfection in Four Health Care Professionals from t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743858
International Journal of Infectious Diseases : IJID : Off... Gargouri S, Souissi A et. al.

Jan 13th, 2022 - Since the onset of the COVID-19 pandemic, cases of reinfection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported, raising additional public health concerns. SARS-CoV-2 reinfection was assessed in healthcare workers in Tunisia, as they are at the greatest exposure to infection by different variants. We conducted whole-genome sequencing of the viral RNA from...

SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic t...
https://doi.org/10.1371/journal.pone.0262169
PloS One; Havervall S, Jernbom Falk A et. al.

Jan 13th, 2022 - Current SARS-CoV-2 serological assays generate discrepant results, and the longitudinal characteristics of antibodies targeting various antigens after asymptomatic to mild COVID-19 are yet to be established. This longitudinal cohort study including 1965 healthcare workers, of which 381 participants exhibited antibodies against the SARS-CoV-2 spike antigen at study inclusion, reveal that these a...

Effectiveness of Covid-19 Vaccines over a 9-Month Period in North Carolina.
https://doi.org/10.1056/NEJMoa2117128
The New England Journal of Medicine; Lin DY, Gu Y et. al.

Jan 13th, 2022 - The duration of protection afforded by coronavirus disease 2019 (Covid-19) vaccines in the United States is unclear. Whether the increase in postvaccination infections during the summer of 2021 was caused by declining immunity over time, the emergence of the B.1.617.2 (delta) variant, or both is unknown. We extracted data regarding Covid-19-related vaccination and outcomes during a 9-month peri...

Pre-omicron Study: Vaccines Offer 8 Months of Protection From COVID Hospitalization
https://www.medscape.com/viewarticle/966504

Jan 13th, 2022 - (Reuters Health) - A North Carolina study of the waning effectiveness of the three COVID-19 vaccines given in the United States shows that although protection against illness from the novel coronavirus fades after six to eight months, protection against hospitalization and death remains high, especially with the two messenger RNA vaccines. Among early-2021 recipients of the Pfizer and Moderna m...

South Korea Authorizes Novavax COVID-19 Vaccine, Imports Pfizer Pills
https://www.medscape.com/viewarticle/966454

Jan 13th, 2022 - SEOUL (Reuters) - South Korea is turning to additional pharmaceutical tools as it looks to pre-empt a surge of COVID-19 omicron infections, authorising the use of Novavax Inc's vaccine on Wednesday and preparing to distribute the first of Pfizer's antiviral pills. At least 21,000 of Pfizer's antiviral pills, called Paxlovid, will arrive in South Korea on Thursday, with another 10,000 more expec...

Induction of robust cellular and humoral immunity against SARS-CoV-2 after a third dose...
https://doi.org/10.1038/s41564-021-01046-z 10.1016/S0140-6736(21)00947-8 10.1056/NEJMoa2034577 10.1038/s41586-021-03739-1 10.1038/s41586-020-2598-9 10.1016/j.kint.2021.06.025 10.1056/NEJMoa2114255 10.1016/0895-4356(94)90129-5 10.4049/jimmunol.1500598 10.1093/bioinformatics/btw191
Nature Microbiology; Romero-Olmedo AJ, Schulz AR et. al.

Jan 12th, 2022 - Here we compared SARS-CoV-2-specific antibody and T-cell responses between older adults (>80 years old, n = 51) and a younger control group (20-53 years old, n = 46) after receiving two doses of BNT162b2. We found that responses in older adults were generally lower, and we identified 10% low-/non-responders. After receiving a third vaccination with BNT162b2, 4 out of 5 low-/non-responders showe...

Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vac...
https://doi.org/10.1038/s41467-021-27649-y 10.1038/s41586-020-2012-7
Nature Communications; Koerber N, Priller A et. al.

Jan 12th, 2022 - Anti-viral immunity continuously declines over time after SARS-CoV-2 infection. Here, we characterize the dynamics of anti-viral immunity during long-term follow-up and after BNT162b2 mRNA-vaccination in convalescents after asymptomatic or mild SARS-CoV-2 infection. Virus-specific and virus-neutralizing antibody titers rapidly declined in convalescents over 9 months after infection, whereas vir...

Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine...
https://doi.org/10.1038/s41467-021-27761-z 10.1056/NEJMoa2034577 10.1056/NEJMoa2027906 10.1038/s41586-020-2521-4 10.1016/j.smim.2018.10.010 10.1038/nri.2016.90 10.1056/NEJMc2103916 10.1056/NEJMoa2028436 10.1001/jama.2021.3341 10.1136/bmj.n308 10.1056/NEJMc2102017 10.1126/sciimmunol.abi6950 10.1038/s41586-020-2380-z 10.1172/JCI140965 10.1016/j.medj.2021.02.001 10.1038/s41591-021-01377-8 10.1371/journal.ppat.1009772 10.1016/S0140-6736(21)00947-8 10.1038/s41591-020-0913-5
Nature Communications; Faro-Viana J, Bergman ML et. al.

Jan 12th, 2022 - While mRNA vaccines are administrated worldwide in an effort to contain the COVID-19 pandemic, the heterogeneity of the humoral immune response they induce at the population scale remains unclear. Here, in a prospective, longitudinal, cohort-study, including 1245 hospital care workers and 146 nursing home residents scheduled for BNT162b2 vaccination, together covering adult ages from 19 to 99 y...

Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by publ...
https://doi.org/10.1038/s41467-021-27669-8
Nature Communications; Wu D, Kolesnikov A et. al.

Jan 12th, 2022 - T cells play a vital role in combatting SARS-CoV-2 and forming long-term memory responses. Whereas extensive structural information is available on neutralizing antibodies against SARS-CoV-2, such information on SARS-CoV-2-specific T-cell receptors (TCRs) bound to their peptide-MHC targets is lacking. Here we determine the structures of a public and a private TCR from COVID-19 convalescent pati...

Evaluating In Silico the Potential Health and Environmental Benefits of Houseplant Vola...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751036
International Journal of Environmental Research and Publi... Roviello V, Scognamiglio PL et. al.

Jan 12th, 2022 - The practice of spending time in green areas to gain the health benefits provided by trees is well known, especially in Asia, as 'forest bathing', and the consequent protective and experimentally detectable effects on the human body have been linked to the biogenic volatile organic compounds released by plants. Houseplants are common in houses over the globe and are particularly appreciated for...