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Platelet Function in Viral Immunity and SARS-CoV-2 Infection.
https://doi.org/10.1055/s-0041-1726033
Seminars in Thrombosis and Hemostasis; Allaoui A, Khawaja AA et. al.

Apr 14th, 2021 - Platelets, as nonnucleated blood components, are classically recognized for their pivotal role in hemostasis. In recent years, however, accumulating evidence points to a nonhemostatic role for platelets, as active participants in the inflammatory and immune responses to microbial organisms in infectious diseases. This stems from the ability of activated platelets to secrete a plethora of immuno...

Reinfection of SARS-CoV-2 - analysis of 23 cases from the literature.
https://doi.org/10.1080/23744235.2021.1905174
Infectious Diseases (London, England); Roberts AT, Piani F et. al.

Apr 14th, 2021 - The duration of immunity after infection from SARS-CoV-2 conferring protection from subsequent COVID-19 episodes is not yet fully understood. We reviewed the literature for cases of documented reinfection. A comprehensive computerized search in PubMed, through 15 December 2020, using the following terms in combination: COVID-19, SARS-CoV-2, reinfection, reactivation, recurrence. To exclude case...

Longitudinal Peripheral Blood Transcriptional Analysis Reveals Molecular Signatures of ...
https://doi.org/10.4049/jimmunol.2001325
Journal of Immunology (Baltimore, Md. : 1950); Yan Q, Li P et. al.

Apr 13th, 2021 - Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with some patients developing severe illness or even death. Disease severity has been associated with increased levels of proinflammatory cytokines and lymphopenia. To elucidate the atlas of peripheral immune response and pathways that might lead to immunopath...

EXPRESS: Performance characteristics of five SARS-CoV-2 serological assays: clinical ut...
https://doi.org/10.1177/00045632211012728
Annals of Clinical Biochemistry; Heffernan E, Kennedy L et. al.

Apr 13th, 2021 - SARS-CoV-2 which causes Coronavirus disease (COVID-19) continues to cause significant morbidity and mortality. The diagnosis of acute infection relies on RT-PCR based viral detection. The objective of this study was to evaluate the optimal serological testing strategy for anti-SARS-CoV-2 antibodies which provides an important indicator of prior infection and potential short-term immunity. The s...

SARS‑CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domai...
https://doi.org/10.1080/21645515.2021.1901545
Human Vaccines & Immunotherapeutics; Pollet J, Chen WH et. al.

Apr 13th, 2021 - There is an urgent need for an accessible and low-cost COVID-19 vaccine suitable for low- and middle-income countries. Here, we report on the development of a SARS-CoV-2 receptor-binding domain (RBD) protein, expressed at high levels in yeast (Pichia pastoris), as a suitable vaccine candidate against COVID-19. After introducing two modifications into the wild-type RBD gene to reduce yeast-deriv...

UK COVID-19 Update: Latest on Antibodies, 'Reassuring' Immune Response in Older People from Pfizer and AZ Vaccines
https://www.medscape.com/viewarticle/949241

Apr 13th, 2021 - These are the UK coronavirus stories you need to know about today. Around Half of UK Population Have Antibodies Around 1 in 2 people in the UK would have tested positive for antibodies against SARS-CoV-2 towards the end of last month, latest figures suggested. The latest infection survey by the Office for National Statistics (ONS) found that as of March 28, the estimated positive antibody perce...

Rapid lateral flow tests for the detection of SARS-CoV-2 neutralizing antibodies.
https://doi.org/10.1080/14737159.2021.1913123
Expert Review of Molecular Diagnostics; Wang JJ, Zhang N et. al.

Apr 12th, 2021 - Background: Rapid Lateral Flow Test (LFT) has been broadly utilized in detection or diagnosis of numerous disease-related antigens and antibodies. It is the most popular format of point-of-care test (POCT) and quickest and easiest way to detect a targeted molecule. In the combat against COVID-19 pandemic, hundreds of POCTs have been developed and are commercially available now. They are designe...

US Colleges Divided Over Requiring Student Vaccinations
https://www.medscape.com/viewarticle/949205

Apr 12th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Stickers for the campus community are seen at the vaccination site on the campus of Georgia Tech in Atlanta. U.S. colleges hoping for a return to normalcy next fall are weighing how far they should go in urging students to get the COVID-19 vaccine, including whether they should — or legally can ...

Factors affecting nurses' intention to accept the COVID-9 vaccine: A cross-sectional st...
https://doi.org/10.1111/phn.12907
Public Health Nursing (Boston, Mass.); Rabi R, Maraqa B et. al.

Apr 12th, 2021 - To measure COVID-19 vaccine acceptance and related factors to undercover nurses' concerns and fears. A cross-sectional study. The study included 639 nurses; 83% were women and 80% under 50 years. A self-administered questionnaire was used. It included demographic characteristics, COVID-19-related fears and concerns, COVID-19 vaccine perceived benefits, and intention toward getting the vaccine. ...

UNRAVELING THE THREAD OF UNCONTROLLED IMMUNE RESPONSE IN COVID-19 AND STEMI: AN EMERGIN...
https://doi.org/10.1152/ajpheart.00934.2020
American Journal of Physiology. Heart and Circulatory Phy... Rios-Navarro C, de Dios E et. al.

Apr 12th, 2021 - The outbreak of severe acute respiratory syndrome coronavirus 2 that first emerged in Wuhan in December 2019 has resulted in the devastating pandemic of coronavirus disease 2019, creating an emerging need for knowledge sharing. Meanwhile, myocardial infarction is and will probably remain the foremost cause of death in the western world throughout the coming decades. Severe deregulation of the i...

The microbiota-mediated dietary and nutritional interventions for COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032598
Clinical Immunology (Orlando, Fla.); Gasmi A, Tippairote T et. al.

Apr 12th, 2021 - Worldwide, scientists are looking for specific treatment for COVID-19. Apart from the antiviral approach, the interventions to support healthy immune responses to the virus are feasible through diet, nutrition, and lifestyle approaches. This narrative review explores the recent studies on dietary, nutritional, and lifestyle interventions that influence the microbiota-mediated immunomodulatory e...

SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040523
Lancet (London, England); Hall VJ, Foulkes S et. al.

Apr 12th, 2021 - Increased understanding of whether individuals who have recovered from COVID-19 are protected from future SARS-CoV-2 infection is an urgent requirement. We aimed to investigate whether antibodies against SARS-CoV-2 were associated with a decreased risk of symptomatic and asymptomatic reinfection. A large, multicentre, prospective cohort study was done, with participants recruited from publicly ...

Native Health Providers Drive Alaska's Vaccination Success Story
https://www.medscape.com/viewarticle/949116

Apr 12th, 2021 - ANCHORAGE, Alaska (Reuters) - Despite its sprawling geography and often-inhospitable climate, Alaska ranks among the top U.S. states for getting COVID-19 vaccine into the arms of its residents, and its indigenous population has played a major role in that achievement. With a history and culture deeply shaped by deadly outbreaks of disease that have periodically ravaged remote corners of their s...

J&J Pause Magnifies Worry About COVID-19 Vaccine Hesitancy
https://www.medscape.com/viewarticle/949236

Apr 12th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's  Coronavirus Resource Center. The news today that states are being asked to pause administration of the Johnson & Johnson COVID-19 vaccine is bringing new fears of vaccine hesitancy that could push back the nation's goal for herd immunity. The Centers for Disease Control and Prevention (CDC) and the US Food and Drug Adminis...

Fibrinolysis Shutdown in COVID-19-Associated Coagulopathy: A Crosstalk among Immunity, ...
https://doi.org/10.1016/j.jamcollsurg.2021.03.003
Journal of the American College of Surgeons; Walsh MM, Khan R et. al.

Apr 11th, 2021 - Fibrinolysis Shutdown in COVID-19-Associated Coagulopathy: A Crosstalk among Immunity, Coagulation, and Specialists in Medicine and Surgery.|2021|Walsh MM,Khan R,Kwaan HC,Neal MD,|

Herd Immunity and COVID-19: 5 Things to Know
https://www.medscape.com/viewarticle/949145

Apr 11th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. After more than a year of living with COVID-19, the United States is beginning to see a light at the end of the tunnel. More than 3 million shots are administered every day. With over 74 million people fully vaccinated — more than 22% of the population — the nation is steadily building its immun...

Traditional Chinese exercise potential role as prevention and adjuvant therapy in patie...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017910
Complementary Therapies in Clinical Practice; Yang S, Liu T et. al.

Apr 11th, 2021 - The epidemic situation of COVID-19 is a great public health emergency worldwide characterized by fastest spreading, widest infection range and the mostly difficult to prevent and control in recent years. According to medical experience, traditional Chinese exercises (TCE) have been applied for COVID-19 prevention, adjuvant treatment or rehabilitation, and achieved some curative effects. They ca...

Vaccinated Fauci Discusses His Own List of Dos, Don'ts
https://www.medscape.com/viewarticle/949144

Apr 11th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Anthony Fauci, MD, the director of the National Institute of Allergy and Infectious Diseases, said his behavior hasn't changed much now that he's fully vaccinated against COVID-19, according to Insider. Fauci hosts small gatherings at his home but still won't go to crowded indoor locations where...

Antigenic cartography reveals complexities of genetic determinants that lead to antigen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980451
Proceedings of the National Academy of Sciences of the Un... Kendra JA, Tohma K et. al.

Apr 10th, 2021 - Noroviruses are the predominant cause of acute gastroenteritis, with a single genotype (GII.4) responsible for the majority of infections. This prevalence is characterized by the periodic emergence of new variants that present substitutions at antigenic sites of the major structural protein (VP1), facilitating escape from herd immunity. Notably, the contribution of intravariant mutations to cha...