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The COVID-19 epidemic of manuscripts.
https://doi.org/10.1111/jan.14437
Journal of Advanced Nursing; Watson R, Mark M

May 27th, 2020 - In the midst of the novel coronavirus pandemic-referred to as COVID-19-there has been much uncertainty. We remain uncertain about its precise origin, its structure and composition, how best to test for it, or for resulting immunity, whether or not exposure leads to immunity, whether or not disposable surgical masks are effective, why men and some ethnic minorities are more susceptible and just ...

COVID-19 Immunity Passport to Ease Travel Restrictions?
https://doi.org/10.1093/jtm/taaa085
Journal of Travel Medicine; Chen LH, Freedman DO et. al.

May 27th, 2020 - COVID-19 Immunity Passport to Ease Travel Restrictions?|2020|Chen LH,Freedman DO,Visser LG,|

Gaps in Malpractice Insurance Pose Risk for Frontline Physicians, Nurses; More
https://www.medscape.com/viewarticle/931272

May 27th, 2020 - Limited Coverage Working Outside Specialty or State Many doctors and nurses working on the front lines of the coronavirus emergency face an increased malpractice risk without adequate liability coverage,coverage, according to Reuters. While both the federal and state governments have made efforts to limit providers' underlying risk — Washington in the form of the Coronavirus Aid, Relief, and Ec...

Obesity and COVID-19: Immune and metabolic derangement as a possible link to adverse cl...
https://doi.org/10.1152/ajpendo.00198.2020
American Journal of Physiology. Endocrinology and Metabolism; Korakas E, Ikonomidis I et. al.

May 27th, 2020 - Recent reports have shown a strong association between obesity and the severity of COVID-19 infection, even in the absence of other co-morbidities. After infecting the host cells, SARS-CoV-2 may cause a hyper-inflammatory reaction through the excessive release of cytokines, a condition known as "cytokine storm", while inducing lymphopenia and a disrupted immune response. Obesity is associated w...

Animal models of mechanisms of SARS-CoV-2 infection and COVID-19 pathology.
https://doi.org/10.1111/bph.15143
British Journal of Pharmacology; Cleary SJ, Pitchford SC et. al.

May 26th, 2020 - The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 infections has led to substantial unmet need for treatments, many of which will require testing in appropriate animal models of this disease. Vaccine trials are already underway, but there remains an urgent need to find other therapeutic approaches to either target SARS-CoV-2 or the complications arising from viral infection,...

COVID 'Immunity Passport' No More Reliable Than a Coin Flip
https://www.medscape.com/viewarticle/931097

May 26th, 2020 - Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. This transcript has been edited for clarity. Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I'm Dr F. Perry Wilson at the Yale School of Medicine. This week, my Twitter feed is filling up with talk about antibody testing. Wouldn't it be nice to have a simple blood test and kno...

Novavax Launches Its First Coronavirus Vaccine Test on Humans
https://www.medscape.com/viewarticle/931135

May 26th, 2020 - (Reuters) - U.S. biotech company Novavax Inc has joined the race to test coronavirus vaccine candidates on humans and said it was targeting production of over a billion doses of its vaccine candidate next year. The company, which enrolled its first participants on Monday, said it expected preliminary data on safety and indicators of an immune response from the trial in July. The announcement of...

Design of a Novel Multi Epitope-Based Vaccine for Pandemic Coronavirus Disease (COVID-1...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245302
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences; Ahmad S, Navid A et. al.

May 26th, 2020 - The emergence and rapid expansion of the coronavirus disease (COVID-19) require the development of effective countermeasures especially a vaccine to provide active acquired immunity against the virus. This study presented a comprehensive vaccinomics approach applied to the complete protein data published so far in the National Center for Biotechnological Information (NCBI) coronavirus data hub....

Antibody Testing Suggests Coronavirus More Widespread Than Expected in LA County
https://www.medscape.com/viewarticle/931072

May 25th, 2020 - NEW YORK (Reuters Health) - In early April, far more individuals in Los Angeles (LA) County had SARS-CoV-2 antibodies than previously thought, suggesting that confirmed cases don't reveal the true extent of infection in a given community, researchers say. "The findings also suggest that we are far away from herd immunity, and thus we should have a long-term planning horizon in evaluating polici...

Portuguese Resort Town to Test All Residents Ahead of Summer Season
https://www.medscape.com/viewarticle/931058

May 25th, 2020 - CASCAIS, Portugal (Reuters) - A popular beach town near Lisbon plans to be the first in Portugal to test all of its 200,000 residents for coronavirus antibodies to try and help them enjoy as normal a summer season as possible despite the crisis. Born and bred in Cascais, loved for its beaches and golf courses, 57-year-old Marina Lima was one of the first to enter the tiny testing room when the ...

Potential COVID-19 therapeutics from a rare disease: Weaponizing lipid dysregulation to...
https://doi.org/10.1194/jlr.R120000851
Journal of Lipid Research; Sturley S, Rajakumar T et. al.

May 25th, 2020 - The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the death of more than 328,000 persons worldwide in the first 5 months of 2020. Herculean efforts to rapidly design and produce vaccines and other antiviral interventions are ongoing. However, newly evolving viral mutations, the prospect of only temporary immun...

Recommendations for the management of patients with immune-mediated kidney disease duri...
https://doi.org/10.1093/ndt/gfaa112
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association; Anders HJ, Bruchfeld A et. al.

May 23rd, 2020 - The coronavirus disease 2019 (COVID-19) pandemic has created major challenges for all countries around the globe. Retrospective studies have identified hypertension, cardiovascular disease, diabetes and older age as risk factors for high morbidity and mortality from COVID-19. There is a general concern that patients with immune-mediated kidney diseases, namely those on immunosuppressive therapi...

Delayed Primary and Specialty Care: The Coronavirus Disease-2019 Pandemic Second Wave.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248587
Disaster Medicine and Public Health Preparedness; Weinstein E, Ragazzoni L et. al.

May 22nd, 2020 - Time is of the essence to continue the pandemic disaster cycle with a comprehensive post-COVID-19 health care delivery system RECOVERY analysis, plan and operation at the local, regional and state level.The second wave of COVID-19 pandemic response are not the ripples of acute COVID-19 patient clusters that will persist until a vaccine strategy is designed and implemented to effect herd immunit...

New Data on SARS-CoV-2-Reactive T Cells Provide Insights into Immunity
https://www.ashclinicalnews.org/online-exclusives/new-data-sars-cov-2-reactive-t-cells-provide-insights-immunity/

May 22nd, 2020 - Two new studies found that patients with COVID-19, as well as some people who have not been infected with SARS-CoV-2, possess T-cells that target the virus. In the case of those who haven’t had COVID-19, this is likely because they were previously infected with other coronaviruses, such as the common cold. Both studies were able to identify strong T-cell responses to the virus, although they di...

Prevention and treatment of COVID-19 disease by controlled modulation of innate immunity.
https://doi.org/10.1002/eji.202048693
European Journal of Immunology; Schijns V, Lavelle EC

May 21st, 2020 - The recent outbreak of coronavirus disease 2019 (COVID-19), triggered by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an enormous threat to global public health and economies. Human coronaviruses normally cause no or mild respiratory disease but in the past two decades, potentially fatal coronavirus infections have emerged, causing respiratory tract illnesses such as p...

Update on clinical outcomes of women with COVID-19 during pregnancy.
https://doi.org/10.1002/ijgo.13236
International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics; Zeng Y, Lin L et. al.

May 21st, 2020 - Pregnant women have a disproportionately high risk of complications from other types of viral pneumonia; however, little is known about the full impact of coronavirus disease 2019 (COVID-19) in pregnancy. Pregnant women are uniquely susceptible to severe illnesses caused by viral infection, possibly due to the shift from cellular to humoral immunity during pregnancy and the puerperium [1].

COVID-19 Vaccine Won't Be a Slam Dunk
https://www.medscape.com/viewarticle/930986

May 21st, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. A successful vaccine for prevention of SARS-CoV-2 infection will probably need to incorporate T-cell epitopes to induce a long-term memory T-cell immune response to the virus, Mehrdad Matloubian, MD, PhD, predicted at the virtual edition of the American College of Rheumatology's 2020 State-of-th...

The immunologic status of newborns born to SARS-CoV2-infected mothers in Wuhan, China.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211641
The Journal of Allergy and Clinical Immunology; Liu P, Zheng J et. al.

May 21st, 2020 - Immunologic dysfunction due to COVID-19 is closely related to clinical prognosis, and the inflammatory response of pregnant women may affect the directional differentiation and function of fetal immune cells. To analyze the immune status of newborns from mothers with COVID-19 in the third trimester. Along with collecting the clinical data from 51 newborns and their respective mothers, we also r...

A Quarter of Americans Are Hesitant About a Coronavirus Vaccine: Reuters/Ipsos Poll
https://www.medscape.com/viewarticle/930928

May 21st, 2020 - (Reuters) - A quarter of Americans have little or no interest in taking a coronavirus vaccine, a Reuters/Ipsos poll published on Thursday found, with some voicing concern that the record pace at which vaccine candidates are being developed could compromise safety. While health experts say a vaccine to prevent infection is needed to return life to normal, the survey points to a potential trust i...

US FDA Names 27 Coronavirus Antibody Tests No Longer Ok to Be Sold
https://www.medscape.com/viewarticle/930974

May 21st, 2020 - (Reuters) - The U.S. Food and Drug Administration on Thursday identified 27 coronavirus antibody tests that should no longer be sold in the United States, following up on new regulations meant to weed out dubious tests and players that had entered the country under loose rules set in March. That original policy required vendors only to notify the agency that they intended to sell the tests in t...