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Neuroimaging Offers Low Yield in Children Positive for SARS-CoV-2.
https://doi.org/10.3174/ajnr.A7022
AJNR. American Journal of Neuroradiology; Orman G, Desai NK et. al.

Jan 8th, 2021 - The coronavirus disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome coronavirus disease 2 (SARS CoV-2) most commonly presents with respiratory disease, but neurologic complications are being reported. We aimed to investigate the rate of positive neuroimaging findings in children positive for SARS-CoV-2 referred for neuroimaging between March 18 and September 30, 2020. W...

Endothelial cell damage is the central part of COVID-19 and a mouse model induced by in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758180
Annals of Diagnostic Pathology; Nuovo GJ, Magro C et. al.

Dec 28th, 2020 - Neurologic complications of symptomatic COVID-19 are common. Brain tissues from 13 autopsies of people who died of COVID-19 were examined. Cultured endothelial and neuronal cells were incubated with and wild type mice were injected IV with different spike subunits. In situ analyses were used to detect SARS-CoV-2 proteins and the host response. In 13/13 brains from fatal COVID-19, pseudovirions ...

COVID-19 Neurologic Fallout Not Limited to the Severely Ill
https://www.medscape.com/viewarticle/942571

Dec 13th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Serious neurologic complications in patients with COVID-19 are not limited to the severely ill, new research confirms. The researchers say more study is needed to characterize the infectious and post-infectious neurologic complications of COVID-19 in diverse patient populations. Lingering Issues...

Comorbidities May Contribute to Neurologic Effects in COVID-19 Patients
https://www.medscape.com/viewarticle/942145

Dec 6th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Neurologic complications from COVID-19 are common in patients with diabetes and hypertension, according to new research presented at the virtual Radiological Society of North America (RSNA) 2020 Annual Meeting. Colbey Freeman "Patients with these conditions may be at higher risk for neurologic c...

Brain Death Evaluation in Children With Suspected or Confirmed Coronavirus Disease 2019.
https://doi.org/10.1097/PCC.0000000000002650
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies; Kirschen MP, McGowan N et. al.

Dec 4th, 2020 - To discuss the challenges of conducting a death by neurologic criteria or brain death evaluation in the coronavirus disease 2019 era and provide guidance to mitigate viral transmission risk and maintain patient safety during testing. Not applicable. Not applicable. Children with suspected or confirmed coronavirus disease 2019 who suffer catastrophic brain injury due to one of numerous neurologi...

Cerebral Venous Sinus Thrombosis in the COVID-19 Pandemic.
https://doi.org/10.1097/WNO.0000000000001122
Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society; Medicherla CB, Pauley RA et. al.

Nov 13th, 2020 - Recent studies have noted concern for increased thromboembolic events in the setting of Coronavirus Disease 2019 (COVID-19). Cerebral venous sinus thrombosis (CVST) is a form of thromboembolism that has been observed as a neuro-ophthalmologic complication of COVID-19. Review of the scientific literature. In this article, we report an overview of CVST epidemiology, clinical presentation, diagnos...

COVID-19 Linked to Increased Risk for Parkinson's
https://www.medscape.com/viewarticle/940464

Nov 4th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. One of the neurologic complications of COVID-19 may be the development of Parkinson's disease, new data suggest. At least three case reports have been published of relatively young COVID-19 patients who developed clinical parkinsonism, either in isolation or with other neurologic deficits, withi...

Cerebral Venous Sinus Thrombosis in the Coronavirus Disease 2019 Pandemic.
https://doi.org/10.1097/WNO.0000000000001122
Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society; Medicherla CB, Pauley RA et. al.

Nov 2nd, 2020 - Recent studies have noted concern for increased thromboembolic events in the setting of Coronavirus Disease 2019 (COVID-19). Cerebral venous sinus thrombosis (CVST) is a form of thromboembolism that has been observed as a neuro-ophthalmologic complication of COVID-19. Review of the scientific literature. In this article, we report an overview of CVST epidemiology, clinical presentation, diagnos...

Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567423
Neuromolecular Medicine; Koh SS, Ooi SC et. al.

Oct 17th, 2020 - Ergothioneine (ET) is a naturally occurring antioxidant that is synthesized by non-yeast fungi and certain bacteria. ET is not synthesized by animals, including humans, but is avidly taken up from the diet, especially from mushrooms. In the current study, we elucidated the effect of ET on the hCMEC/D3 human brain endothelial cell line. Endothelial cells are exposed to high levels of the cholest...

Effects of Antimalarial Drugs on Neuroinflammation-Potential Use for Treatment of COVID...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448719
Molecular Neurobiology; Ong WY, Go ML et. al.

Oct 1st, 2020 - To evaluate and compare the efficacy of National Early Warning Score, National Early Warning Score 2, Rapid Emergency Medicine Score, Confusion, Respiratory rate, Blood pressure, Age 65 score, and quick Sepsis-related Organ Failure Assessment on predicting in-hospital death in patients with coronavirus disease 2019. A retrospective, observational study. Single center, West Campus of Wuhan Union...

Cerebral Microhemorrhage and Purpuric Rash in COVID-19: The Case for a Secondary Microa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348608
Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association; Shoskes A, Migdady I et. al.

Sep 11th, 2020 - Since the emergence of Coronavirus Disease 19 (COVID-19) pandemic, multiple neurologic complications in infected patients have been reported. Despite these reports, the mechanism of COVID-19 nervous system injury is not well understood. We report the case of a COVID-19 patient with diffuse microhemorrhages on brain MRI, positive anticardiolipin antibodies, and purpuric rash with biopsy showing ...

COVID-19 associated with encephalomyeloradiculitis and positive anti-aquaporin-4 antibo...
https://doi.org/10.1177/1352458520949988
Multiple Sclerosis (Houndmills, Basingstoke, England); Corrêa DG, de Souza Lima FC et. al.

Sep 10th, 2020 - Neurologic complications are being recognized as important outcomes of coronavirus disease 2019 (COVID-19). Pathogenesis is varied and incompletely understood, and may include neuroinvasion, indirect post-infectious neuroinflammation, and cerebrovascular pathologies. We present a case of COVID-19-related encephalomyeloradiculitis with clinical and magnetic resonance imaging characteristics of n...

Critical illness-associated cerebral microbleeds in severe COVID-19 infection.
https://doi.org/10.1016/j.clinimag.2020.08.029
Clinical Imaging; Gupta NA, Lien C et. al.

Sep 10th, 2020 - Neurologic complications of COVID-19 infection have been recently described and include dizziness, headache, loss of taste and smell, stroke, and encephalopathy. Brain MRI in these patients have revealed various findings including ischemia, hemorrhage, inflammation, and demyelination. In this article, we report a case of critical illness-associated cerebral microbleeds identified on MRI in a pa...

Neurological injuries in COVID-19 patients: direct viral invasion or a bystander injury...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465881
Journal of Neurovirology; Azizi SA, Azizi SA

Sep 2nd, 2020 - A subset of patients with coronavirus 2 disease (COVID-19) experience neurological complications. These complications include loss of sense of taste and smell, stroke, delirium, and neuromuscular signs and symptoms. The etiological agent of COVID-19 is SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), an RNA virus with a glycoprotein-studded viral envelope that uses ACE2 (angiotensi...

A Double-Edged Sword: Neurologic Complications and Mortality in Extracorporeal Membrane...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658835
AJNR. American Journal of Neuroradiology; Masur J, Freeman CW et. al.

Aug 28th, 2020 - In this clinical case series, we report our experience to date with neurologic complications of extracorporeal membrane oxygenation therapy for COVID-19 Acute Respiratory Distress Syndrome. We have found an unexpectedly increased rate of complications as demonstrated by neuroimaging compared with meta-analysis data in extracorporeal membrane oxygenation therapy for all Acute Respiratory Distres...

Bilateral Basal Ganglia Hemorrhage in a Patient with Confirmed COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661071
AJNR. American Journal of Neuroradiology; Daci R, Kennelly M et. al.

Aug 20th, 2020 - Bilateral basal ganglia hemorrhage is exceedingly rare. To our knowledge, our patient is the first reported case of a confirmed coronavirus disease 2019 (COVID-19) patient who had bilateral basal ganglia hemorrhage. In the absence of other risk factors for bilateral deep cerebral involvement, we suspect that COVID-19 may be contributing to these rare pathologies. Most published data represent a...

COVID-19-Associated Cytotoxic Lesions of the Corpus Callosum.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661087
AJNR. American Journal of Neuroradiology; Gaur P, Dixon L et. al.

Aug 20th, 2020 - There are very limited published data on the neurologic complications associated with coronavirus disease 2019 (COVID-19) in the pediatric population. Here we present the first 2 pediatric cases of presumed COVID-19 related cytotoxic lesions of the corpus callosum. Similar to reports in adults, these cases suggest that the COVID-19 infection in children may rarely mediate a hyperinflammatory re...

Cytotoxic Lesion of the Corpus Callosum in an Adolescent with Multisystem Inflammatory ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658840
AJNR. American Journal of Neuroradiology; Lin J, Lawson EC et. al.

Aug 20th, 2020 - Multisystem inflammatory syndrome in children is a recently described complication in the late phase of Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection involving systemic hyperinflammation and multiorgan dysfunction. The extent of its clinical picture is actively evolving and has yet to be fully elucidated. While neurologic manifestations of SARS-CoV-2 are well-described ...

Editors' note: Neurologic complications of coronavirus infections.
https://doi.org/10.1212/WNL.0000000000010221
Neurology Ganesh A, Galetta S

Aug 19th, 2020 - Editors' note: Neurologic complications of coronavirus infections.|2020|Ganesh A,Galetta S,|

Reader response: Neurologic complications of coronavirus infections.
https://doi.org/10.1212/WNL.0000000000010229
Neurology Steyger PS, Kujawa SG et. al.

Aug 19th, 2020 - Reader response: Neurologic complications of coronavirus infections.|2020|Steyger PS,Kujawa SG,Shinobu LA,|