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COVID-19 and emerging spinal cord complications: A systematic review.
https://doi.org/10.1016/j.msard.2021.102917
Multiple Sclerosis and Related Disorders; Mondal R, Deb S et. al.

Apr 12th, 2021 - Spinal cord complications associated with coronavirus infectious disease of 2019 (COVID-19) are being widely reported. The purpose of this systematic review was to summarize so far available pieces of evidence documenting de novo novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) mediated spinal cord demyelinating diseases. Indeed, the spinal demyelinating disorders that have been...

Neurologic manifestations in hospitalized patients with COVID-19 in Mexico City.
https://doi.org/10.1371/journal.pone.0247433
PloS One; Flores-Silva FD, García-Grimshaw M et. al.

Apr 8th, 2021 - The coronavirus disease 2019 (COVID-19) is a systemic entity that frequently implies neurologic features at presentation and complications during the disease course. We aimed to describe the characteristics and predictors for developing in-hospital neurologic manifestations in a large cohort of hospitalized patients with COVID-19 in Mexico City. We analyzed records from consecutive adult patien...

Neurologic aspects of coronavirus disease of 2019 infection.
https://doi.org/10.1097/QCO.0000000000000731
Current Opinion in Infectious Diseases; Hassett CE, Frontera JA

Mar 26th, 2021 - Central and peripheral nervous system manifestations of coronavirus disease 2019 (COVID-19) have been frequently reported and may cause significant morbidity and mortality. This review details the latest evidence on the neuropathogenesis and neurologic complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly reported neurologic complications include toxi...

Bridging the Gap Between Intensivists and Primary Care Clinicians in Extracorporeal Mem...
https://doi.org/10.1001/jamapediatrics.2020.5921
JAMA Pediatrics; Barbaro RP, Brodie D et. al.

Mar 1st, 2021 - Extracorporeal membrane oxygenation (ECMO) is a form of advanced life support that may be used in children with refractory respiratory or cardiac failure. While it is required infrequently, in the US, ECMO is used to support childhood respiratory failure as often as children receive kidney or heart transplants. ECMO is complex, resource intensive, and potentially lifesaving, but it is also asso...

Neurologic complications of myocarditis.
https://doi.org/10.1016/B978-0-12-819814-8.00030-5
Handbook of Clinical Neurology; Block HS

Feb 26th, 2021 - Myocarditis, a nonischemic acquired cardiomyopathy, is an uncommon condition with multiple presentation patterns which may be initially difficult to recognize and may simulate other conditions such as acute myocardial infarction, pericarditis, septicemia, etc. There are four distinct clinical presentation patterns that include: (1) low-grade nonspecific symptoms such as fatigue; (2) symptoms th...

Neurological issues during severe COVID-19 in a tertiary level hospital in Western India.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881741
Neuroscience Letters; Dravid AN, Mane DN et. al.

Feb 16th, 2021 - India has the second largest COVID-19 epidemic in the world as per current estimates. Central and peripheral nervous system involvement in COVID-19 (Neuro COVID-19) has been increasingly identified and reported. This letter is the first report of the spectrum of neurological disorders observed in patients with severe COVID-19 from a resource limited setting like India. Till October 30th 2020, N...

Impact of SARS-CoV-2 Pandemic on "Stroke Code" Imaging Utilization and Yield.
https://doi.org/10.3174/ajnr.A7038
AJNR. American Journal of Neuroradiology; Shatzkes DR, Zlochower AB et. al.

Feb 5th, 2021 - Indirect consequences of the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) pandemic include those related to failure of patients to seek or receive timely medical attention for seemingly unrelated disease. We report our experience with stroke code imaging during the early pandemic months of 2020. Retrospective review of stroke codes during the 2020 pandemic and both 2020 and matc...

Inflammatory Leptomeningeal Cytokines Mediate COVID-19 Neurologic Symptoms in Cancer Pa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833316
Cancer Cell; Remsik J, Wilcox JA et. al.

Jan 28th, 2021 - SARS-CoV-2 infection induces a wide spectrum of neurologic dysfunction that emerges weeks after the acute respiratory infection. To better understand this pathology, we prospectively analyzed of a cohort of cancer patients with neurologic manifestations of COVID-19, including a targeted proteomics analysis of the cerebrospinal fluid. We find that cancer patients with neurologic sequelae of COVI...

Transforaminal Epidural Steroid Injections: A Systematic Review and Meta-Analysis of Ef...
https://www.ncbi.nlm.nih.gov/pubmed/33492919
Pain Physician; Helm Ii S, Harmon PC et. al.

Jan 25th, 2021 - Transforaminal epidural injections have been used since the late 1990s to treat lumbar radicular pain. They have been the subject of considerable attention, with varying conclusions from systematic reviews as to their efficacy. Transforaminal injections have been associated with rare but major complications. Further, the use of transforaminal injections has increased since the passage of the Af...

Neuroimaging Offers Low Yield in Children Positive for SARS-CoV-2.
https://doi.org/10.3174/ajnr.A7022
AJNR. American Journal of Neuroradiology; Orman G, Desai NK et. al.

Jan 8th, 2021 - The coronavirus disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome coronavirus disease 2 (SARS CoV-2) most commonly presents with respiratory disease, but neurologic complications are being reported. We aimed to investigate the rate of positive neuroimaging findings in children positive for SARS-CoV-2 referred for neuroimaging between March 18 and September 30, 2020. W...

Endothelial cell damage is the central part of COVID-19 and a mouse model induced by in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758180
Annals of Diagnostic Pathology; Nuovo GJ, Magro C et. al.

Dec 28th, 2020 - Neurologic complications of symptomatic COVID-19 are common. Brain tissues from 13 autopsies of people who died of COVID-19 were examined. Cultured endothelial and neuronal cells were incubated with and wild type mice were injected IV with different spike subunits. In situ analyses were used to detect SARS-CoV-2 proteins and the host response. In 13/13 brains from fatal COVID-19, pseudovirions ...

COVID-19 Neurologic Fallout Not Limited to the Severely Ill
https://www.medscape.com/viewarticle/942571

Dec 13th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Serious neurologic complications in patients with COVID-19 are not limited to the severely ill, new research confirms. The researchers say more study is needed to characterize the infectious and post-infectious neurologic complications of COVID-19 in diverse patient populations. Lingering Issues...

Comorbidities May Contribute to Neurologic Effects in COVID-19 Patients
https://www.medscape.com/viewarticle/942145

Dec 6th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Neurologic complications from COVID-19 are common in patients with diabetes and hypertension, according to new research presented at the virtual Radiological Society of North America (RSNA) 2020 Annual Meeting. Colbey Freeman "Patients with these conditions may be at higher risk for neurologic c...

Brain Death Evaluation in Children With Suspected or Confirmed Coronavirus Disease 2019.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924933
Pediatric Critical Care Medicine : a Journal of the Socie... Kirschen MP, McGowan N et. al.

Dec 4th, 2020 - To discuss the challenges of conducting a death by neurologic criteria or brain death evaluation in the coronavirus disease 2019 era and provide guidance to mitigate viral transmission risk and maintain patient safety during testing. Not applicable. Not applicable. Children with suspected or confirmed coronavirus disease 2019 who suffer catastrophic brain injury due to one of numerous neurologi...

Cerebral Venous Sinus Thrombosis in the COVID-19 Pandemic.
https://doi.org/10.1097/WNO.0000000000001122
Journal of Neuro-ophthalmology : the Official Journal of ... Medicherla CB, Pauley RA et. al.

Nov 13th, 2020 - Recent studies have noted concern for increased thromboembolic events in the setting of Coronavirus Disease 2019 (COVID-19). Cerebral venous sinus thrombosis (CVST) is a form of thromboembolism that has been observed as a neuro-ophthalmologic complication of COVID-19. Review of the scientific literature. In this article, we report an overview of CVST epidemiology, clinical presentation, diagnos...

COVID-19 Linked to Increased Risk for Parkinson's
https://www.medscape.com/viewarticle/940464

Nov 4th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. One of the neurologic complications of COVID-19 may be the development of Parkinson's disease, new data suggest. "It does not appear to be just an acute condition which you survive or don't survive. There are many people for whom long-term outcomes may be affected," he commented. If such serious...

Cerebral Venous Sinus Thrombosis in the Coronavirus Disease 2019 Pandemic.
https://doi.org/10.1097/WNO.0000000000001122
Journal of Neuro-ophthalmology : the Official Journal of ... Medicherla CB, Pauley RA et. al.

Nov 2nd, 2020 - Recent studies have noted concern for increased thromboembolic events in the setting of Coronavirus Disease 2019 (COVID-19). Cerebral venous sinus thrombosis (CVST) is a form of thromboembolism that has been observed as a neuro-ophthalmologic complication of COVID-19. Review of the scientific literature. In this article, we report an overview of CVST epidemiology, clinical presentation, diagnos...

Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567423
Neuromolecular Medicine; Koh SS, Ooi SC et. al.

Oct 17th, 2020 - Ergothioneine (ET) is a naturally occurring antioxidant that is synthesized by non-yeast fungi and certain bacteria. ET is not synthesized by animals, including humans, but is avidly taken up from the diet, especially from mushrooms. In the current study, we elucidated the effect of ET on the hCMEC/D3 human brain endothelial cell line. Endothelial cells are exposed to high levels of the cholest...

Effects of Antimalarial Drugs on Neuroinflammation-Potential Use for Treatment of COVID...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448719
Molecular Neurobiology; Ong WY, Go ML et. al.

Oct 1st, 2020 - To evaluate and compare the efficacy of National Early Warning Score, National Early Warning Score 2, Rapid Emergency Medicine Score, Confusion, Respiratory rate, Blood pressure, Age 65 score, and quick Sepsis-related Organ Failure Assessment on predicting in-hospital death in patients with coronavirus disease 2019. A retrospective, observational study. Single center, West Campus of Wuhan Union...

Cerebral Microhemorrhage and Purpuric Rash in COVID-19: The Case for a Secondary Microa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348608
Journal of Stroke and Cerebrovascular Diseases : the Offi... Shoskes A, Migdady I et. al.

Sep 11th, 2020 - Since the emergence of Coronavirus Disease 19 (COVID-19) pandemic, multiple neurologic complications in infected patients have been reported. Despite these reports, the mechanism of COVID-19 nervous system injury is not well understood. We report the case of a COVID-19 patient with diffuse microhemorrhages on brain MRI, positive anticardiolipin antibodies, and purpuric rash with biopsy showing ...