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A unique case of Miller Fisher-Guillain-Barré overlap syndrome in a liver transplant re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456682
Journal of Neurovirology; Ramirez-Sanchez C, Syed R et. al.

Sep 23rd, 2021 - Guillain-Barré syndrome (GBS) is an ascending demyelinating polyneuropathy often associated with recent infection. Miller Fisher syndrome represents a variant with predominant facial and cranial nerve involvement, although Miller Fisher and Guillain-Barré overlap syndromes can occur. Guillain-Barré spectrum syndromes have been thought to be rare among solid organ transplant recipients. We descr...

Allergic reactions and adverse events associated with administration of mRNA-based vacc...
https://doi.org/10.2500/aap.2021.42.210069
Allergy and Asthma Proceedings; Arroliga ME, Dhanani K et. al.

Sep 4th, 2021 - Background: Adverse reactions, including anaphylaxis, to messenger RNA coronavirus disease 2019 (COVID-19) vaccines rarely occur. Because of the need to administer a timely second dose in subjects who reported a reaction to their first dose, a panel of health-care professionals developed a safe triage of the employees and health care providers (EHCP) at a large health-care system to consider ad...

Can Guillain-Barré Syndrome Recur After mRNA COVID Vaccine?
https://www.medpagetoday.com/neurology/generalneurology/94331

Sep 2nd, 2021 - Serious relapse of Guillain-Barré syndrome (GBS) after receiving the Pfizer/BioNtech COVID-19 mRNA vaccine (Comirnaty) was rare, an analysis of medical records in Israel showed. Out of nearly 600 people previously diagnosed with GBS who got the vaccine, one needed brief medical care for relapse afterward, reported Shirley Shapiro Ben David, MD, of Maccabi Healthcare Services in Tel Aviv, and co...

Neurologic Manifestations and Complications of COVID-19.
https://doi.org/10.1146/annurev-med-042320-010427
Annual Review of Medicine; Hensley MK, Markantone D et. al.

Aug 21st, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a global pandemic. Beyond the well-described respiratory manifestations, SARS-CoV-2 may cause a variety of neurologic complications, including headaches, alteration in taste and smell, encephalopathy, cerebrovascular disease, myopathy, psychiatric diseases, and ocular disorders. Herein we describe SARS-CoV-2's mechanism of...

AAN Issues Formal Position Statement on COVID-19 Vaccine
https://www.medpagetoday.com/neurology/generalneurology/93862

Aug 2nd, 2021 - Based on existing evidence, neurologists should recommend COVID-19 vaccination to their patients, a newly released American Academy of Neurology (AAN) paper said. "Barring the rare circumstance of an absolute contraindication to available vaccine formulations, it is the American Academy of Neurology's formal position that eligible patients should be offered the COVID-19 vaccine," wrote Elisabet...

COVID-19 Tied to Acceleration of Alzheimer's Pathology
https://www.medscape.com/viewarticle/955755

Jul 30th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. DENVER ― Certain plasma biomarkers of neuronal damage and neuroinflammation are markedly elevated in hospitalized COVID-19 patients with neurologic symptoms compared to hospitalized COVID-19 patients without such symptoms, a new study shows. These results suggest COVID-19 may accelerate Alzheime...

SARS-CoV-2 Neuronal Invasion and Complications: Potential Mechanisms and Therapeutic Ap...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221594
The Journal of Neuroscience : the Official Journal of The... Swain O, Romano SK et. al.

Jun 25th, 2021 - Clinical reports suggest that the coronavirus disease-19 (COVID-19) pandemic caused by severe acute respiratory syndrome (SARS)-coronavirus-2 (CoV-2) has not only taken millions of lives, but has also created a major crisis of neurologic complications that persist even after recovery from the disease. Autopsies of patients confirm the presence of the coronaviruses in the CNS, especially in the ...

Understanding the Role of Blood Vessels in the Neurologic Manifestations of Coronavirus...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193973
The American Journal of Pathology; Whitmore HAB, Kim LA

Jun 15th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was originally identified as an outbreak in Wuhan, China, toward the end of 2019 and quickly became a global pandemic, with a large death toll. Originally identified as a respiratory disease, similar to previously discovered SARS and Middle East respiratory syndrome (MERS), concern has since been raised about the effects of SARS-CoV-2...

CROI 2021: Neurologic Complications of HIV-1 Infection or COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224246
Topics in Antiviral Medicine; Ances BM, Anderson AM et. al.

Jun 10th, 2021 - The 2021 Conference on Retroviruses and Opportunistic Infections (CROI) featured a timely review of the neurologic complications of COVID-19 as well as new research findings on mechanisms by which SARS-CoV-2 may affect the brain. CROI included new and important findings about the neurologic complications of HIV-1, human polyomavirus 2 (also known as JC Virus), and cryptococcus. New long-term an...

Dementia Diagnosis and Suicide; Head Injury Disability; Complexity of Chronic Pain
https://www.medpagetoday.com/neurology/generalneurology/92857

Jun 1st, 2021 - Death by suicide increased after Alzheimer's or dementia diagnosis, with the highest risk among people 65 to 74 years old and in the first 90 days after diagnosis. (Alzheimer's and Dementia) Cholesterol catabolism and bile acid synthesis may have sex-specific effects on dementia progression. (PLOS Medicine) Blood oxygenation and neurovascular coupling were decreased in the hippocampus compared ...

Postinfectious Neurologic Complications in COVID-19: A Complex Case Report.
https://doi.org/10.2967/jnumed.120.256099
Journal of Nuclear Medicine : Official Publication, Socie... Tiraboschi P, Xhani R et. al.

May 22nd, 2021 - A 40-y-old woman with severe acute respiratory syndrome coronavirus 2 infection developed neurologic manifestations (confusion, agitation, seizures, dyskinesias, and parkinsonism) a few weeks after the onset of severe acute respiratory syndrome. MRI and cerebrospinal fluid analyses were unremarkable, but 18F-FDG PET/CT showed limbic and extralimbic hypermetabolism. A full recovery, alongside 18...

First Report of SARS-CoV-2 Detection in Cerebrospinal Fluid in a Child With Guillain-Ba...
https://doi.org/10.1097/INF.0000000000003146 10.1542/peds.2020-015115 10.1093/tropej/fmaa044
The Pediatric Infectious Disease Journal; Araújo NM, Ferreira LC et. al.

May 16th, 2021 - Underlying mechanisms on the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and neurologic complications are still poorly understood. Cases of Guillain-Barré Syndrome (GBS) have been linked to the SARS-CoV-2 infection as the result of dysregulated immune response with damage in neuronal tissues. In the current report, we present the first pediatric ca...

Neurologic Complications in Hospitalized COVID Patients Common, Deadly
https://www.medscape.com/viewarticle/950937

May 11th, 2021 - Eight in 10 patients hospitalized with COVID-19 develop neurologic complications, and these patients are much more likely to die in hospital compared with their counterparts without neurologic complications, a global study shows. Findings from the Global Consortium Study of Neurologic Dysfunction in COVID-19 (GCS-NeuroCOVID) reveal 82% of hospitalized COVID-19 patients had neurologic manifestat...

COVID-19 as a Cause of Acute Neonatal Encephalitis and Cerebral Cytotoxic Edema.
https://doi.org/10.1097/INF.0000000000003145
The Pediatric Infectious Disease Journal; Fragoso DC, Marx C et. al.

Apr 27th, 2021 - The majority of coronavirus disease 2019 (COVID-19) have been confirmed in adults, with only a few reported cases in children. In the pediatric population, COVID-19 infection appears to be often unremarkable or associated with mild respiratory symptoms. Little is known about neurologic complications related to COVID-19 in newborns. We present a case of severe encephalitis with cytotoxic brain e...

Neurologic Emergencies during the Coronavirus Disease 2019 Pandemic.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995638
Neurologic Clinics; Shulman JG, Ford T et. al.

Apr 27th, 2021 - Although minor neurologic complications of coronavirus disease 2019 are common, life-threatening neurologic emergencies are rare. Acute ischemic stroke, intracerebral hemorrhage, venous sinus thrombosis, seizures, and posterior reversible encephalopathy syndrome have been described. Hospitals have seen significant changes in the volume of patients presenting with neurologic emergencies. We revi...

The Neurology of Long-haul COVID-19
https://www.medscape.com/viewarticle/949779

Apr 22nd, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Long-haul neurologic symptoms of COVID-19 seem to be distinct from neurologic conditions found in acute disease. Among the patient population of long-haulers complaining of brain fog, muscular ache, and other issues, many had mild COVID-19. Much work remains to be done to understand the biologic...

COVID-19 and emerging spinal cord complications: A systematic review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981271
Multiple Sclerosis and Related Disorders; Mondal R, Deb S et. al.

Apr 13th, 2021 - Spinal cord complications associated with coronavirus infectious disease of 2019 (COVID-19) are being widely reported. The purpose of this systematic review was to summarize so far available pieces of evidence documenting de novo novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) mediated spinal cord demyelinating diseases. Indeed, the spinal demyelinating disorders that have been...

Neurologic manifestations in hospitalized patients with COVID-19 in Mexico City.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031187
PloS One; Flores-Silva FD, García-Grimshaw M et. al.

Apr 9th, 2021 - The coronavirus disease 2019 (COVID-19) is a systemic entity that frequently implies neurologic features at presentation and complications during the disease course. We aimed to describe the characteristics and predictors for developing in-hospital neurologic manifestations in a large cohort of hospitalized patients with COVID-19 in Mexico City. We analyzed records from consecutive adult patien...

New Alzheimer's Gene Variants; Cannabis and Surgery; LSD for Cluster Headache?
https://www.medpagetoday.com/neurology/generalneurology/91947

Apr 6th, 2021 - Thirteen new rare gene variants in loci related to synaptic function and neuronal development were associated with Alzheimer's disease. (Alzheimer's and Dementia) In an unusual JAMA op-ed, three members of the FDA's advisory committee reviewing aducanumab took another shot at the controversial Alzheimer's drug candidate, laying out reasons why aducanumab shouldn't be approved. The FDA rejected ...

Neurologic aspects of coronavirus disease of 2019 infection.
https://doi.org/10.1097/QCO.0000000000000731 10.1101/2020.04.19.049254 10.1007/s10571-020-00947-7 10.3390/v12010014 10.1126/sciadv.abc5801 10.1093/bib/bbaa168 10.1186/s13054-020-03218-5 10.1212/NXI.0000000000000893 10.1212/WNL.0000000000010979 10.1177/1747493020959216 10.1056/NEJMc2009787 10.1016/j.jstrokecerebrovasdis.2020.105535 10.1007/s11239-020-02288-0 10.1111/nan.12677 10.1016/j.jstrokecerebrovasdis.2020.105379 10.1093/bib/bbaa168 10.1016/j.bbih.2020.100091 10.1136/bcr-2020-238668
Current Opinion in Infectious Diseases; Hassett CE, Frontera JA

Mar 27th, 2021 - Central and peripheral nervous system manifestations of coronavirus disease 2019 (COVID-19) have been frequently reported and may cause significant morbidity and mortality. This review details the latest evidence on the neuropathogenesis and neurologic complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly reported neurologic complications include toxi...