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Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567423
Neuromolecular Medicine; Koh SS, Ooi SC et. al.

Oct 17th, 2020 - Ergothioneine (ET) is a naturally occurring antioxidant that is synthesized by non-yeast fungi and certain bacteria. ET is not synthesized by animals, including humans, but is avidly taken up from the diet, especially from mushrooms. In the current study, we elucidated the effect of ET on the hCMEC/D3 human brain endothelial cell line. Endothelial cells are exposed to high levels of the cholest...

Effects of Antimalarial Drugs on Neuroinflammation-Potential Use for Treatment of COVID...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448719
Molecular Neurobiology; Ong WY, Go ML et. al.

Oct 1st, 2020 - To evaluate and compare the efficacy of National Early Warning Score, National Early Warning Score 2, Rapid Emergency Medicine Score, Confusion, Respiratory rate, Blood pressure, Age 65 score, and quick Sepsis-related Organ Failure Assessment on predicting in-hospital death in patients with coronavirus disease 2019. A retrospective, observational study. Single center, West Campus of Wuhan Union...

Cerebral Microhemorrhage and Purpuric Rash in COVID-19: The Case for a Secondary Microa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348608
Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association; Shoskes A, Migdady I et. al.

Sep 11th, 2020 - Since the emergence of Coronavirus Disease 19 (COVID-19) pandemic, multiple neurologic complications in infected patients have been reported. Despite these reports, the mechanism of COVID-19 nervous system injury is not well understood. We report the case of a COVID-19 patient with diffuse microhemorrhages on brain MRI, positive anticardiolipin antibodies, and purpuric rash with biopsy showing ...

COVID-19 associated with encephalomyeloradiculitis and positive anti-aquaporin-4 antibo...
https://doi.org/10.1177/1352458520949988
Multiple Sclerosis (Houndmills, Basingstoke, England); Corrêa DG, de Souza Lima FC et. al.

Sep 10th, 2020 - Neurologic complications are being recognized as important outcomes of coronavirus disease 2019 (COVID-19). Pathogenesis is varied and incompletely understood, and may include neuroinvasion, indirect post-infectious neuroinflammation, and cerebrovascular pathologies. We present a case of COVID-19-related encephalomyeloradiculitis with clinical and magnetic resonance imaging characteristics of n...

Critical illness-associated cerebral microbleeds in severe COVID-19 infection.
https://doi.org/10.1016/j.clinimag.2020.08.029
Clinical Imaging; Gupta NA, Lien C et. al.

Sep 10th, 2020 - Neurologic complications of COVID-19 infection have been recently described and include dizziness, headache, loss of taste and smell, stroke, and encephalopathy. Brain MRI in these patients have revealed various findings including ischemia, hemorrhage, inflammation, and demyelination. In this article, we report a case of critical illness-associated cerebral microbleeds identified on MRI in a pa...

Neurological injuries in COVID-19 patients: direct viral invasion or a bystander injury...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465881
Journal of Neurovirology; Azizi SA, Azizi SA

Sep 2nd, 2020 - A subset of patients with coronavirus 2 disease (COVID-19) experience neurological complications. These complications include loss of sense of taste and smell, stroke, delirium, and neuromuscular signs and symptoms. The etiological agent of COVID-19 is SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), an RNA virus with a glycoprotein-studded viral envelope that uses ACE2 (angiotensi...

A Double-Edged Sword: Neurologic Complications and Mortality in Extracorporeal Membrane...
https://doi.org/10.3174/ajnr.A6728
AJNR. American Journal of Neuroradiology; Masur J, Freeman CW et. al.

Aug 26th, 2020 - In this clinical case series, we report our experience to date with neurologic complications of extracorporeal membrane oxygenation therapy for COVID-19 Acute Respiratory Distress Syndrome. We have found an unexpectedly increased rate of complications as demonstrated by neuroimaging compared with meta-analysis data in extracorporeal membrane oxygenation therapy for all Acute Respiratory Distres...

Neurologic complications of COVID-19.
https://doi.org/10.3949/ccjm.87a.ccc058
Cleveland Clinic Journal of Medicine; Hassett CE, Gedansky A et. al.

Aug 25th, 2020 - Human coronaviruses, including SARS-CoV-2, have the ability for neurotropism. Commonly reported neurologic complications of SARS-CoV-2 infections include encephalopathy, neuromuscular disorders, and acute cerebrovascular disorders. Other complications, such as postinfectious demyelination, encephalitis, and seizures, occur less often, but are probably under-reported given the lack of diagnostic...

Bilateral Basal Ganglia Hemorrhage in a Patient with Confirmed COVID-19.
https://doi.org/10.3174/ajnr.A6712
AJNR. American Journal of Neuroradiology; Daci R, Kennelly M et. al.

Aug 20th, 2020 - Bilateral basal ganglia hemorrhage is exceedingly rare. To our knowledge, our patient is the first reported case of a confirmed coronavirus disease 2019 (COVID-19) patient who had bilateral basal ganglia hemorrhage. In the absence of other risk factors for bilateral deep cerebral involvement, we suspect that COVID-19 may be contributing to these rare pathologies. Most published data represent a...

COVID-19-Associated Cytotoxic Lesions of the Corpus Callosum.
https://doi.org/10.3174/ajnr.A6713
AJNR. American Journal of Neuroradiology; Gaur P, Dixon L et. al.

Aug 20th, 2020 - There are very limited published data on the neurologic complications associated with coronavirus disease 2019 (COVID-19) in the pediatric population. Here we present the first 2 pediatric cases of presumed COVID-19 related cytotoxic lesions of the corpus callosum. Similar to reports in adults, these cases suggest that the COVID-19 infection in children may rarely mediate a hyperinflammatory re...

Editors' note: Neurologic complications of coronavirus infections.
https://doi.org/10.1212/WNL.0000000000010221
Neurology Ganesh A, Galetta S

Aug 19th, 2020 - Editors' note: Neurologic complications of coronavirus infections.|2020|Ganesh A,Galetta S,|

Reader response: Neurologic complications of coronavirus infections.
https://doi.org/10.1212/WNL.0000000000010229
Neurology Steyger PS, Kujawa SG et. al.

Aug 19th, 2020 - Reader response: Neurologic complications of coronavirus infections.|2020|Steyger PS,Kujawa SG,Shinobu LA,|

Cytotoxic Lesion of the Corpus Callosum in an Adolescent with Multisystem Inflammatory ...
https://doi.org/10.3174/ajnr.A6755
AJNR. American Journal of Neuroradiology; Lin J, Lawson EC et. al.

Aug 19th, 2020 - Multisystem inflammatory syndrome in children is a recently described complication in the late phase of Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection involving systemic hyperinflammation and multiorgan dysfunction. The extent of its clinical picture is actively evolving and has yet to be fully elucidated. While neurologic manifestations of SARS-CoV-2 are well-described ...

Cerebral venous thrombosis: A typical presentation of COVID-19 in the young.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245247
Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association; Klein DE, Libman R et. al.

Jul 21st, 2020 - Identify clinical and radiographic features of venous infarct as a presenting feature of COVID-19 in the young. SARS-CoV-2 infection causes hypercoagulability and inflammation leading to venous thrombotic events (VTE). Although elderly patients with comorbidities are at higher risk, COVID-19 may also cause VTE in a broader patient population without these risks. Neurologic complications and man...

Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301053
BMC Neurology; Farhadian S, Glick LR et. al.

Jun 19th, 2020 - COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-...

Atypical Deep Cerebral Vein Thrombosis with Hemorrhagic Venous Infarction in a Patient ...
https://doi.org/10.3174/ajnr.A6642
AJNR. American Journal of Neuroradiology; Chougar L, Mathon B et. al.

Jun 19th, 2020 - There is growing evidence that Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has a neurotropic and neuroinvasive potential. In particular, neurologic complications associated with the infection by SARS-CoV-2 include strokes that may result from a dysregulated inflammatory response to the infection. We report an atypical deep cerebral vein thrombosis complicated with hemorrhagic v...

Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alteration...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454059
Emerging Infectious Diseases; Benameur K, Agarwal A et. al.

Jun 3rd, 2020 - There are few detailed investigations of neurologic complications in severe acute respiratory syndrome coronavirus 2 infection. We describe 3 patients with laboratory-confirmed coronavirus disease who had encephalopathy and encephalitis develop. Neuroimaging showed nonenhancing unilateral, bilateral, and midline changes not readily attributable to vascular causes. All 3 patients had increased c...

Neurologic manifestations in hospitalized patients with COVID-19: The ALBACOVID registry.
https://doi.org/10.1212/WNL.0000000000009937
Neurology Romero-Sánchez CM, Díaz-Maroto I et. al.

Jun 2nd, 2020 - The coronavirus disease 2019 (COVID-19) has spread worldwide since December 2019. Neurologic symptoms have been reported as part of the clinical spectrum of the disease. We aimed to determine whether neurologic manifestations are common in hospitalized patients with COVID-19 and to describe their main characteristics. We systematically reviewed all patients diagnosed with COVID-19 admitted to t...

COVID-19 and SARS-Cov-2 Infection: Pathophysiology and Clinical Effects on the Nervous ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255736
World Neurosurgery; Abboud H, Abboud FZ et. al.

May 31st, 2020 - Coronavirus disease 2019 (COVID-19) is an infectious disease caused by SARS-Cov-2, resulting in severe acute respiratory syndrome, with high potential of spreading and infecting humans worldwide. Since December 2019, when the virus was identified in humans, the literature on COVID-19 has grown exponentially and extrarespiratory symptoms including neurologic symptoms are increasingly highlighted...

Novel coronavirus disease 2019 (COVID-19) and neurodegenerative disorders.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261984
Dermatologic Therapy; Singh AK, Bhushan B et. al.

May 15th, 2020 - During the last few months, the whole humanity is experiencing largest and most severe sudden influx of COVID-19 outbreak caused by the novel coronavirus (CoV) originated from Wuhan, China. According to the WHO reports, total 3 862 676 positive cases and 265 961 deaths have been recorded worldwide due to COVID-19 infection as of May 9, 2020. CoVs are a large family of viruses (enveloped, single...