×
Introduction to Special Issue: Impacts of the COVID-19 Pandemic on LGBTQ+ Health and We...
https://doi.org/10.1080/00918369.2020.1868182
Journal of Homosexuality; Drabble LA, Eliason MJ

Jan 13th, 2021 - This special issue on the impacts of COVID-19 on LGBTQ+ health and well-being reports findings from nine articles with varied study designs, including data from multiple countries and all segments of LGBTQ+ communities. Key findings included the observation that pre-COVID mental health disparities predispose LGBTQ+ people to poorer outcomes; that technological communication aids are essential i...

Proteolytic Activation of SARS-CoV-2 Spike at the S1/S2 Boundary: Potential Role of Pro...
https://doi.org/10.1021/acsinfecdis.0c00701
ACS Infectious Diseases; Tang T, Jaimes JA et. al.

Jan 12th, 2021 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses its spike (S) protein to mediate viral entry into host cells. Cleavage of the S protein at the S1/S2 and/or S2' site(s) is associated with viral entry, which can occur at either the cell plasma membrane (early pathway) or the endosomal membrane (late pathway), depending on the cell type. Previous studies show that SARS-CoV-2 ...

Low Clinical Performance of "Isopollo COVID19 detection kit" (Monitor, South Korea) for...
https://doi.org/10.1016/j.ijid.2020.12.088
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases; Freire-Paspuel B, Garcia-Bereguiain MA

Jan 12th, 2021 - Multiple molecular kits are available for SARS-CoV-2 diagnosis worldwide, lot of them lacking of proper clinical evaluation due to the emergency caused by COVID-19 pandemic, particularly at developing countries. We evaluated the clinical performance of "Isopollo COVID19 detection kit" (Monitor, South Korea) for RT-LAMP SARS-CoV-2 diagnosis using SARS-CoV-2 RT-PCR protocol as a gold standard. 22...

Don't Expect a Conclusion From WHO's China Visit, Says Expert
https://www.medscape.com/viewarticle/943892

Jan 11th, 2021 - SINGAPORE (Reuters) - Expectations should be "very low" that a World Health Organization team of experts tasked with investigating the origins of the COVID-19 pandemic will reach a conclusion from their trip to China this month, a health expert affiliated with the WHO said. "I would be inclined to set the expectations of a conclusion very low for this visit," Dr. Dale Fisher, chair of the Globa...

Misinformation about COVID-19: evidence for differential latent profiles and a strong a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789893
BMC Public Health; Agley J, Xiao Y

Jan 8th, 2021 - The global spread of coronavirus disease 2019 (COVID-19) has been mirrored by diffusion of misinformation and conspiracy theories about its origins (such as 5G cellular networks) and the motivations of preventive measures like vaccination, social distancing, and face masks (for example, as a political ploy). These beliefs have resulted in substantive, negative real-world outcomes but remain lar...

Torn Between Caution and Compassion: a Dilemma for Clinicians from Black and Minority E...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790470
Journal of Racial and Ethnic Health Disparities; Shah N, Ahmed IM et. al.

Jan 8th, 2021 - The wide disparity in coronavirus disease (COVID-19)-related death rates based upon the ethnic origin is well established by now. The higher incidence of COVID-19 deaths amongst the healthcare staff belonging to black and minority ethnic (BAME) communities living in the United Kingdom has generated a great deal of concern and anxiety in clinicians. Public Health England (PHE) has outlined mitig...

Phosphorylation of influenza A virus NS1 at serine 205 mediates its viral polymerase-en...
https://doi.org/10.1128/JVI.02369-20
Journal of Virology; Patil A, Anhlan D et. al.

Jan 7th, 2021 - Influenza A virus (IAV) non-structural protein 1 (NS1) is a protein with multiple functions that are regulated by phosphorylation. Phospho-proteomic screening of H1N1-infected cells identified NS1 to be phosphorylated at serine 205 in intermediate stages of the viral life cycle. Interestingly, S205 is one of six amino acid changes in NS1 of post-pandemic H1N1 viruses currently circulating in hu...

Sinovac Vaccine Shows 78% Efficacy in Brazilian Trial, Details Sparse
https://www.medscape.com/viewarticle/943724

Jan 6th, 2021 - SAO PAULO (Reuters) - A COVID-19 vaccine developed by China's Sinovac Biotech was 78% effective in a late-stage Brazilian trial and entirely prevented severe cases, a source said on Thursday, boosting Chinese efforts to catch up with Western vaccine makers. The announced efficacy, closely watched by developing countries counting on the vaccine to begin mass inoculations, was weaker than prelimi...

Spectrum of Clinicopathologic Findings in COVID-19-induced Skin Lesions: Demonstration ...
https://doi.org/10.1097/PAS.0000000000001634
The American Journal of Surgical Pathology; Garrido Ruiz MC, Santos-Briz Á et. al.

Jan 5th, 2021 - The novel coronavirus disease (COVID-19) is a rapidly spreading pandemic, secondary to severe acute respiratory syndrome coronavirus 2. The severity and the little knowledge that we have of the disease have made us focus mostly on the respiratory symptoms. As we bend the curve, other findings reported in association with COVID-19 become of importance for specialists to recognize. We describe th...

COVID-19 and the revival of passive immunization: Antibody therapy for inhibiting SARS-...
https://doi.org/10.1111/bph.15359
British Journal of Pharmacology; Levi-Schaffer F, de Marco A

Jan 5th, 2021 - The COVID-19 pandemic urged both scientific community and health care companies to undertake an unprecedented effort with the aim of understanding the molecular mechanisms of SARS-CoV-2 infection and developing effective therapeutic solutions. The peculiar immune response triggered by such virus, that seems to last only few months, induced to look for alternatives such as passive immunization i...

Different aspects of convalescent plasma therapy for COVID-19 treatment; a critical rev...
https://doi.org/10.1080/08923973.2020.1863983
Immunopharmacology and Immunotoxicology; Khadka S, Nisar S et. al.

Dec 28th, 2020 - The novel coronavirus disease (COVID-19) has been declared a pandemic by the World Health Organization (WHO) and is ominously threatening the survival of humankind on the whole planet. With a quick spread of the outbreak from its origin, Wuhan, China, to almost all over the world, it has affected more than seven million people to date, hence it has devastated every part of the infrastructural s...

Herbal medicine, a reliable support in COVID therapy.
https://doi.org/10.1080/15321819.2020.1862867
Journal of Immunoassay & Immunochemistry; Grigore A, Cord D et. al.

Dec 28th, 2020 - At present, specific therapies for COVID-19 are not well established, being certain only that the immune system plays a decisive role in the initiation and progression of the disease. Plants have given and continue to give compounds with great efficiency and low toxicity, some of them being a starting point for extremely effective synthetic substances. Although herbal remedies are used mainly f...

New Gains in COVID-19 Science 1 Year Into the Pandemic
https://www.medscape.com/viewarticle/943187

Dec 23rd, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. This time last year, hospitals in Wuhan, China, reported the first cases of pneumonia of unknown origin; it seemed unlikely at the time that a small number of patients coughing with shortness of breath would mark the beginning of a global pandemic that would kill more than 1. 7 million people in...

May the analysis of 1918 influenza pandemic give hints to imagine the possible magnitud...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753514
Journal of Translational Medicine; Scarpa R, Caso F et. al.

Dec 23rd, 2020 - In 1918 an unknown infectious agent spread around the world infecting over one-third of the general population and killing almost 50 million people. Many countries were at war, the First World War. Since Spain was a neutral country and Spanish press could report about the infection without censorship, this condition is commonly remembered as "Spanish influenza". This review examines several asp...

Impacts of lockdown during the SARS-CoV-2 pandemic on patients presenting with cervicof...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485545
The British Journal of Oral & Maxillofacial Surgery; Dawoud BES, Kent P et. al.

Dec 22nd, 2020 - The SARS-CoV-2 pandemic caused unprecedented disruption to primary and secondary healthcare services. Our aim was to explore whether the pandemic had had any impact on patients presenting with cervicofacial infections (CFI) of odontogenic origin to secondary care and management. Comparative analysis was carried out evaluating prospective and retrospective consecutively admitted patients with a ...

Myocardial injury in severe COVID-19 is similar to pneumonias of other origin: results ...
https://doi.org/10.1002/ehf2.13136
ESC Heart Failure References; Jirak P, Larbig R et. al.

Dec 22nd, 2020 - COVID-19, a respiratory viral disease causing severe pneumonia, also affects the heart and other organs. Whether its cardiac involvement is a specific feature consisting of myocarditis, or simply due to microvascular injury and systemic inflammation, is yet unclear and presently debated. Because myocardial injury is also common in other kinds of pneumonias, we investigated and compared such occ...

The effect of angiotensin-converting enzyme levels on Covid-19 susceptibility and sever...
https://doi.org/10.1093/ije/dyaa229
International Journal of Epidemiology; Butler-Laporte G, Nakanishi T et. al.

Dec 22nd, 2020 - There has been uncertainty about the safety or benefit of angiotensin-converting enzyme (ACE) inhibitors during the Covid-19 pandemic. We used Mendelian randomization using genetic determinants of serum-ACE levels to test whether decreased ACE levels increase susceptibility to SARS-CoV-2 infection or Covid-19 severity, while reducing potential bias from confounding and reverse causation in obse...

Manufacturing of convalescent plasma of COVID-19 patients: Aspects of quality.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755199
PloS One; Hähnel V, Peterhoff D et. al.

Dec 22nd, 2020 - The ongoing coronavirus disease 2019 (COVID-19) pandemic emerged in December 2019. Convalescent plasma represents a promising COVID-19 treatment. Here, we report on the manufacturing of a plasma-based product containing antibodies specific to SARS-CoV-2 obtained from recently recovered COVID-19 patients. Convalescent plasma donors were screened as follows: 1) previously confirmed SARS-CoV-2 inf...

Significant reduction in the visits to the emergency room department during the COVID-1...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769364
Medicine Kastritis E, Tsitsimpis K et. al.

Dec 22nd, 2020 - COVID-19 pandemic caused a major crisis, affecting and straining health care systems, including some very advanced ones. The pandemic may have also indirectly affected access to health care for patients with other conditions, not related to COVID-19, even in countries not overwhelmed by an outbreak.We analyzed and compared visits to the emergency room (ER) department during the same calendar pe...

Comparative insight into the genomic landscape of SARS-CoV-2 and identification of muta...
https://doi.org/10.1002/jmv.26744
Journal of Medical Virology REFERENCES; Mishra D, Suri GS et. al.

Dec 21st, 2020 - The analyses of 2325 severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genomes revealed 107, 162, and 65 nucleotide substitutions in the coding region of SARS-CoV-2 from the three continents America, Europe, and Asia, respectively. Of these nucleotide substitutions 58, 94, and 37 were nonsynonymous types mostly present in the Nsp2, Nsp3, Spike, and ORF9. A continent-specific phylogra...