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Angiotensin-converting enzyme 2 (ACE2) receptor and SARS-CoV-2: Potential therapeutic t...
https://doi.org/10.1016/j.ejphar.2020.173455
European Journal of Pharmacology; Sharifkashani S, Bafrani MA et. al.

Aug 3rd, 2020 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta coronavirus that uses the human angiotensin-converting enzyme 2 (ACE2) receptor as a point of entry. The present review discusses the origin and structure of the virus and its mechanism of cell entry followed by the therapeutic potentials of strategies directed towards SARS-CoV2-ACE2 binding, the renin-angiotensin system, an...

A palindromic RNA sequence as a common breakpoint contributor to copy-choice recombinat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394270
Archives of Virology; Gallaher WR

Aug 1st, 2020 - Much remains unknown concerning the origin of the novel pandemic coronavirus that has raged across the globe since emerging in Wuhan of Hubei province, near the center of the People's Republic of China, in December of 2019. All current members of the family Coronaviridae have arisen by a combination of incremental adaptive mutations, against the backdrop of many recombinational events throughou...

SARS-CoV-2 jumping the species barrier: zoonotic lessons from SARS, MERS and recent adv...
https://doi.org/10.1016/j.tmaid.2020.101830
Travel Medicine and Infectious Disease; Dhama K, Patel SK et. al.

Aug 1st, 2020 - Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome - Coronavirus-2) of the family Coronaviridae, appeared in China in December 2019. This disease was declared as posing Public Health International Emergency by World Health Organization on January 30, 2020, attained the status of a very high-risk category on February 29, and now having a pandemic status ...

SARS-CoV-2: characteristics and current advances in research.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387805
Virology Journal; Yang Y, Xiao Z et. al.

Jul 30th, 2020 - Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection has spread rapidly across the world and become an international public health emergency. Both SARS-CoV-2 and SARS-CoV belong to subfamily Coronavirinae in the family Coronaviridae of the order Nidovirales and they are classified as the SARS-like species while belong to different cluster. Besides, viral structure, epidemiology ch...

Coronavirus disease- COVID-19: New perceptives towards epidemic to pandemic.
https://doi.org/10.1080/1061186X.2020.1803885
Journal of Drug Targeting; S B S, A MST et. al.

Jul 29th, 2020 - The sudden outbreak and uncontrolled spread of the novel Coronavirus Disease 2019 (COVID-19) has shocked the world to a degree never seen before. Due to the wide spread transmission of the virus, the number of infected cases worldwide has surpassed 16,421,958 and global death toll has spiked upto 6,52,308 from December 2019 to 27, July 2020. The virus has been labeled as a pandemic by the WHO. ...

Predictors of Mortality in Adults Admitted with COVID-19: Retrospective Cohort Study fr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390589
The Western Journal of Emergency Medicine; Chilimuri S, Sun H et. al.

Jul 29th, 2020 - Rapid spread of coronavirus disease 2019 (COVID-19) in the United States, especially in New York City (NYC), led to a tremendous increase in hospitalizations and mortality. There is very limited data available that associates outcomes during hospitalization in patients with COVID-19. In this retrospective cohort study, we reviewed the health records of patients with COVID-19 who were admitted f...

Advances and challenges in the prevention and treatment of COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378666
International Journal of Medical Sciences; Han YJ, Ren ZG et. al.

Jul 27th, 2020 - Since the end of 2019, a new type of coronavirus pneumonia (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been spreading rapidly throughout the world. Previously, there were two outbreaks of severe coronavirus caused by different coronaviruses worldwide, namely Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the Middle East Respiratory Syn...

SARS-CoV-2 Whole Genome Amplification and Sequencing for Effective Population-Based Sur...
https://doi.org/10.1093/clinchem/hvaa187
Clinical Chemistry; Harilal D, Ramaswamy S et. al.

Jul 26th, 2020 - With the gradual reopening of economies and resumption of social life, robust surveillance mechanisms should be implemented to control the ongoing COVID-19 pandemic. Unlike RT-qPCR, SARS-CoV-2 whole genome sequencing (cWGS) has the added advantage of identifying cryptic origins of the virus, and the extent of community-based transmissions versus new viral introductions, which can in turn influe...

Reliability of self-sampling for accurate assessment of respiratory virus viral and imm...
https://doi.org/10.1093/infdis/jiaa451
The Journal of Infectious Diseases; Waghmare A, Krantz EM et. al.

Jul 24th, 2020 - The SARS-CoV-2 pandemic demonstrates the need for accurate and convenient approaches to diagnose and therapeutically monitor respiratory viral infections. We demonstrated that self-sampling with foam swabs is well-tolerated and provides quantitative viral output concordant with flocked swabs. Using longitudinal home-based self-sampling, we demonstrate nasal cytokine levels correlate and cluster...

The Origin of COVID-19 and Why It Matters.
https://doi.org/10.4269/ajtmh.20-0849
The American Journal of Tropical Medicine and Hygiene; Morens DM, Breman JG et. al.

Jul 23rd, 2020 - The COVID-19 pandemic is among the deadliest infectious diseases to have emerged in recent history. As with all past pandemics, the specific mechanism of its emergence in humans remains unknown. Nevertheless, a large body of virologic, epidemiologic, veterinary, and ecologic data establishes that the new virus, SARS-CoV-2, evolved directly or indirectly from a β-coronavirus in the sarbecovirus ...

Transmission route and introduction of pandemic SARS-CoV-2 between China, Italy, and Sp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404595
Journal of Medical Virology REFERENCES; Nabil B, Sabrina B et. al.

Jul 22nd, 2020 - We present a phylodynamic and phylogeographic analysis of this new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus in this report. A tree of maximum credibility was constructed using the 72 entire genome sequences of this virus, from the three countries (China, Italy, and Spain) available as of 26 March 2020 on the GISAID reference frame. To schematize the current SARS-CoV-2 ...

N-linked glycan sites on the influenza NA head domain are required for efficient IAV in...
https://doi.org/10.1128/JVI.00874-20
Journal of Virology; Östbye H, Gao J et. al.

Jul 21st, 2020 - N-linked glycans commonly contribute to secretory protein folding, sorting and signaling. For enveloped viruses such as the influenza A virus (IAV), the addition of large N-linked glycans can also prevent access to epitopes on the surface antigens hemagglutinin (HA or H) and neuraminidase (NA or N). Sequence analysis showed that in the NA head domain of H1N1 IAVs three N-linked glycosylation si...

SARS-CoV-2 in pregnancy: characteristics and outcomes of hospitalized and non-hospitali...
https://doi.org/10.1080/14767058.2020.1793320
The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians; Barbero P, Mugüerza L et. al.

Jul 19th, 2020 - There is little evidence about how novel coronavirus (SARS-CoV-2) affects pregnant women and their newborns. Comparisons with other members of the coronavirus family responsible for severe acute respiratory syndrome (SARS) have been done to predict maternal and neonatal outcomes; however, more information is required to establish clinical patterns, disease evolution and pregnancy prognosis in t...

Virology, pathogenesis, diagnosis and in-line treatment of COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366121
European Journal of Pharmacology; Samudrala PK, Kumar P et. al.

Jul 19th, 2020 - SARS-CoV-2, a newly emerged pathogen in December 2019, marked as one of the highly pathogenic Coronavirus, and altogether this is the third coronavirus attack that crossed the species barrier. As of 1st July 2020, it is spreading around 216 countries, areas or territories, and a total of 10,185,374 and 503,862 confirmed cases and death reports, respectively. The SARS-CoV-2 virus entered into th...

Tracing and analysis of 288 early SARS-CoV-2 infections outside China: A modeling study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367442
PLoS Medicine; Pinotti F, Di Domenico L et. al.

Jul 17th, 2020 - In the early months of 2020, a novel coronavirus disease (COVID-19) spread rapidly from China across multiple countries worldwide. As of March 17, 2020, COVID-19 was officially declared a pandemic by the World Health Organization. We collected data on COVID-19 cases outside China during the early phase of the pandemic and used them to predict trends in importations and quantify the proportion o...

Epidemiological characteristics of the COVID-19 outbreak in a secondary hospital in Spain.
https://doi.org/10.1016/j.ajic.2020.07.014
American Journal of Infection Control; Giesen C, Diez-Izquierdo L et. al.

Jul 14th, 2020 - In 2019 Chinese authorities alerted of the appearance of a cluster of cases of unknown pneumonia related to a new type of coronavirus. Spain is among the most affected countries. Our aim is to describe the cases of COVID-19 at Infanta Sofía University Hospital (Madrid), a public secondary hospital that increased its hospital beds to provide assistance during the outbreak. Retrospective descript...

Broad and differential animal ACE2 receptor usage by SARS-CoV-2.
https://doi.org/10.1128/JVI.00940-20
Journal of Virology; Zhao X, Chen D et. al.

Jul 12th, 2020 - The COVID-19 pandemic has caused an unprecedented global public health and economy crisis. The origin and emergence of its causal agent, SARS-CoV-2, in the human population remains mysterious, although bat and pangolin were proposed to be the natural reservoirs. Strikingly, comparing to the SARS-CoV-2-like CoVs identified in bats and pangolins, SARS-CoV-2 harbors a polybasic furin cleavage site...

Conspiracy Beliefs Are Associated with Lower Knowledge and Higher Anxiety Levels Regard...
https://doi.org/10.3390/ijerph17144915
International Journal of Environmental Research and Public Health; Sallam M, Dababseh D et. al.

Jul 11th, 2020 - The world has been afflicted heavily by the burden of coronavirus disease 2019 (COVID-19) that overwhelmed health care systems and caused severe economic and educational deficits, in addition to anxiety among the public. The main aim of this study was to evaluate the mutual effects of belief that the pandemic was the result of a conspiracy on knowledge and anxiety levels among students at the U...

Natural transmission of bat-like SARS-CoV-2PRRA variants in COVID-19 patients.
https://doi.org/10.1093/cid/ciaa953
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Wong YC, Lau SY et. al.

Jul 10th, 2020 - SARS-CoV-2 contains the furin cleavage PRRA motif in the S1/S2 region, which enhances viral pathogenicity but is absent in closely related bat and pangolin coronaviruses. It remains unknown if bat-like coronaviral variants without PRRA (ΔPRRA) can establish natural infection in humans. Here, we developed a duplex digital PCR assay to examine ΔPRRA variants in Vero-E6-propagated isolates, human ...

Evolving geographic diversity in SARS-CoV2 and in silico analysis of replicating enzyme...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344048
Journal of Translational Medicine; Chitranshi N, Gupta VK et. al.

Jul 10th, 2020 - Severe acute respiratory syndrome (SARS) has been initiating pandemics since the beginning of the century. In December 2019, the world was hit again by a devastating SARS episode that has so far infected almost four million individuals worldwide, with over 200,000 fatalities having already occurred by mid-April 2020, and the infection rate continues to grow exponentially. SARS coronavirus 2 (SA...