Mar 18th, 2023 - In the Vaccine Safety Datalink (VSD), we previously reported no association between COVID-19 vaccination in early pregnancy and spontaneous abortion (SAB). The current study aims to understand how time since vaccine roll-out or other methodologic factors could affect results. Using a case-control design and generalized estimating equations, we estimated the odds ratios (OR) of COVID-19 vaccinat...

Mar 18th, 2023 - Nirmatrelvir-ritonavir (Paxlovid) is recommended to reduce the risk of hospitalization from coronavirus disease 2019 (COVID-19) in pregnancy. Data on use in pregnancy, including prescribing patterns and patient experience (adverse effects, incidence of rebound), are limited. We performed a cross-sectional study in which we surveyed a cohort of vaccinated pregnant or lactating individuals with b...

Mar 18th, 2023 - Food insecurity is an increasingly important public health concern in high-income countries following the 2008 global financial crash, and recently with the COVID-19 pandemic. Food insecurity has been understood as a highly gendered issue, affecting more women than men. As women have more complex nutritional needs because of their menstrual cycle, pregnancy, and breastfeeding, the nutritional i...

Mar 17th, 2023 - Guidelines Summary Numerous clinical guidelines have been issued for COVID-19. The following guidelines have been summarized at Medscape's COVID-19 Clinical Guidelines center: COVID-19 Enforcement Policy for Sterilizers, Disinfectant Devices, and Air Purifiers (FDA, 2020): 2020 COVID-19 guidance for industry and FDA staff OSHA Guidance on Preparing the Workplace for COVID-19 (2020): 2020 guidan...

Mar 17th, 2023 - To examine pregnancy-related mortality ratios before (January 2019-March 2020) and during (April 2020-December 2020 and 2021) the coronavirus disease 2019 (COVID-19) pandemic overall, by race and ethnicity, and by rural-urban classifications using vital records data. Mortality and natality data (2019-2021) were obtained from the Centers for Disease Control and Prevention's WONDER database to es...

Mar 17th, 2023 - This study aimed to examine factors associated with postpartum depression (PPD) symptoms during the COVID-19 pandemic among postpartum women in five countries, a subject that has not been investigated thus far. A multi-country, cross-sectional, online survey was conducted with a convenience sample of 3,523 postpartum women in Brazil, South Korea, Taiwan, Thailand, and the United Kingdom, from J...

Mar 17th, 2023 - Contingency measures due to the COVID-19 pandemic limited access to routine prenatal care for pregnant women, increasing the risk of pregnancy complications due to poor prenatal follow-up, especially in those patients at high obstetric risk. This prompted the implementation and adaptation of telemedicine. We aim to evaluate the maternal and perinatal outcomes of patients who received prenatal c...

Mar 17th, 2023 - This study aimed to investigate the safety of the inactivated COVID-19 vaccines in early pregnant women in view of their adverse-effect profile and associated maternal-fetal complication, as well as to evaluate their immunogenicity. In this prospective observational cohort study, 232 women in their first trimester or those in the periconception period who inadvertently received two doses of ina...

Mar 16th, 2023 - Lutetium Lu 177 vipivotide tetraxetan (Pluvicto) is currently in shortage, according to the FDA, leaving some prostate cancer patients with limited options; the drug's manufacturer Novartis said it's working to increase production. Meanwhile, the FDA expanded the indication for Illuccix for use in selecting patients for lutetium Lu 177 vipivotide tetraxetan, Telix announced. Multiple cancer dru...

Mar 16th, 2023 - Maternal mortality in the U.S. significantly increased in 2021 compared with the previous year, the CDC reported Thursday. A total of 1,205 women died of maternal causes in 2021, compared with 861 in 2020 and 754 in 2019, according to the report from Donna Hoyert, PhD, of the CDC's National Center for Health Statistics. The maternal mortality rate for 2021 was 32.9 deaths per 100,000 live birth...

Mar 16th, 2023 - Vaccine is the cost-effective and reliable public health intervention to combat the emerging COVID-19 pandemic. The vaccination is considered safe and effective at any stage of pregnancy; however, pregnant women show more vaccine hesitation than the general population. This study aims to assess pregnant women's awareness, perception, and acceptability of COVID-19 vaccine attending antenatal cli...

Mar 16th, 2023 - To identify the association between maternal SARS-CoV-2 infection in pregnancy and individual neonatal morbidities and outcomes, particularly longer-term outcomes such as neurodevelopment. Systematic review of outcomes of neonates born to pregnant women diagnosed with a SARS-CoV-2 infection at any stage during pregnancy, including asymptomatic women. MEDLINE, Embase, Global Health, WHOLIS and L...

Mar 15th, 2023 - Note that some links may require subscriptions. The mortality rate of children and teens rose sharply in 2020 and 2021, driven by factors unrelated to COVID-19 itself. (JAMA) Drugmaker Novo Nordisk said it will slash its insulin prices, following a similar recent move by rival Eli Lilly. (Reuters) The Biden administration is having a tough time filling the job of NIH director. (Wall Street Jour...

Mar 14th, 2023 - Objectives: The aim of this study was to explore the impact of the 2020-2022 pandemic on the levels of fear and anxiety in pregnant women and to identify risk and protective factors. Methods: A systematic review was conducted. Electronic databases were consulted for studies published between January 2020 and August 2022. The methodological quality was assessed using a critical appraisal tool fo...

Mar 13th, 2023 - Note that some links may require subscriptions. The takeaway of a recent Cochrane review that masks don't work is an "inaccurate and misleading interpretation," the editor-in-chief of the Cochrane Library said in a statement. A bill to declassify information on the origins of COVID passed the House and is headed to President Biden's desk. (Politico) And the World Health Organization's director-...

Mar 13th, 2023 - Even through the fact that pregnant women are more and more severely infected with COVID-19 disease, there are still doubts about vaccinating these people due to the lack of sufficient evidence base information. So in this systematic review, we decided to study vaccinated and unvaccinated pregnant women regarding maternal, fetal and neonatal complications and outcomes. Between 30 December 2019 ...

Mar 13th, 2023 - After three years of the COVID-19 pandemic, we have learned many aspects of the disease and the virus: its molecular structure, how it infects human cells, the clinical picture at different ages, potential therapies, and the effectiveness of prophylaxis. Research is currently focused on the short- and long-term consequences of COVID-19. We review the available information on the neurodevelopmen...

Mar 12th, 2023 - Health care systems will continue to face unpredictable challenges related to climate change. The COVID-19 pandemic tested the ability of perinatal care systems to respond to extreme disruption. Many childbearing people in the United States opted out of the mainstream choice of hospital birth during the pandemic, leading to a 19.5% increase in community birth between 2019 and 2020. The aim of t...

Mar 11th, 2023 - Potential medium- and long-term neurodevelopmental sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy have not been ruled out. We aimed to systematically review and summarize the evidence regarding the effects of intrauterine exposure to SARS-CoV-2 on infant development and behavior. Scopus, PubMed, Web of Science, CINAHL, and PsycNet databases w...

Mar 11th, 2023 - Objectives: We investigated coronavirus disease 2019 (COVID-19) opinions, experiences, and willingness to accept COVID-19 vaccination during pregnancy at two prenatal clinics in early 2021 and early 2022. Materials and Methods: Paper questionnaires were distributed to pregnant women at prenatal care facilities in Virginia and Florida between January and April 2021 and January and April 2022. Qu...