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Meta-analysis of Diagnostic Performance of Serology Tests for COVID-19: Impact of Assay...
https://doi.org/10.1080/22221751.2020.1826362
Emerging Microbes & Infections; Wang H, Ai J et. al.

Sep 23rd, 2020 - Serology detection is recognized for its sensitivity in convalescent patients with COVID-19, in comparison with nucleic acid amplification tests(NAATs), which is considered as the gold standard for diagnosing acute infection. However, when and how serology detection performs the best remains unknown. This article aimed to evaluate the diagnostic accuracy of serologic methods for COVID-19 based ...

Coronavirus (COVID-19) Update: FDA Authorizes First Point-of-Care Antibody Test for COVID-19 | FDA
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-first-point-care-antibody-test-covid-19

Sep 23rd, 2020 - For Immediate Release: September 23, 2020 Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for the first serology (antibody) point-of-care (POC) test for COVID-19. The Assure COVID-19 IgG/IgM Rapid Test Device was first authorized for emergency use by certain labs in July 2020 to help identify individuals with antibodies to SARS-CoV-2, indicating recent o...

Convalescent plasma therapy for B-cell depleted patients with protracted COVID-19 disease.
https://doi.org/10.1182/blood.2020008423
Blood Hueso T, Pouderoux C et. al.

Sep 22nd, 2020 - Anti-CD20 monoclonal antibodies are widely used for the treatment of hematological malignancies or autoimmune disease but may be responsible for a secondary humoral deficiency. In the context of COVID-19 infection, this may prevent the elicitation of a specific SARS-CoV-2-antibody response. We report a series of 17 consecutive patients with profound B-cell lymphopenia and prolonged COVID-19 sym...

Management of pernio-like cutaneous manifestations in children during the outbreak of c...
https://doi.org/10.1111/dth.14312
Dermatologic Therapy; Gallizzi R, Sutera D et. al.

Sep 19th, 2020 - During the outbreak of COVID-19 many pernio-like lesions have been increasingly reported. The aim of the study is to describe our management of these skin manifestations and to evaluate a possible correlation to SARS-CoV-2 infection. All patients underwent clinical and laboratory tests to detect a possible underlying connective disease and also to specific SARS-CoV-2 investigations such as orop...

Systemic complement activation is associated with respiratory failure in COVID-19 hospi...
https://doi.org/10.1073/pnas.2010540117
Proceedings of the National Academy of Sciences of the United States of America; Holter JC, Pischke SE et. al.

Sep 18th, 2020 - Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is hypothesized to be driven by an overreacting innate immune response, where the complement system is a key player. In this prospective cohort study of 39 hospitalized coronavirus disease COVID-19 patients, we describe systemic complement activation and its association with development of respiratory fail...

Kawasaki-like disease in children with COVID-19.
https://doi.org/10.1007/s00296-020-04701-6
Rheumatology International; Akca UK, Kesici S et. al.

Sep 16th, 2020 - Children with Coronavirus disease 2019 (COVID-19) are being reported to have manifestations of hyperinflammatory states and/or Kawasaki-like disease. In this study, we investigated children with typical and atypical Kawasaki disease (KD) likely to be associated with COVID-19. We have reported four children with Kawasaki-like disease probably associated with COVID-19. The clinical features were ...

SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from don...
https://doi.org/10.1111/trf.16101
Transfusion Gniadek TJ, Thiede JM et. al.

Sep 16th, 2020 - The transfer of passive immunity with convalescent plasma is a promising strategy for treatment and prevention of COVID-19, but donors with a history of non-severe disease are serologically heterogenous. The relationship between SARS-Cov-2 antigen binding activity and neutralization activity in this population of donors has not been defined. Convalescent plasma units from 47 individuals with a ...

Symptomatic pericardial effusion in the setting of asymptomatic COVID-19 infection: A c...
https://doi.org/10.1097/MD.0000000000022093
Medicine Amoozgar B, Kaushal V et. al.

Sep 14th, 2020 - Infection with the severe acute respiratory coronavirus disease 2019 (COVID-19) has been shown to cause multi-organ involvement including cardiopulmonary serosal layers infection and inflammation. As a result, pericarditis and pericardial effusion may occur with or without COVID-19 related respiratory signs. Due to limitations in sensitivity and specificity of current COVID-19 diagnostic studie...

Clinical performance of four immunoassays for antibodies to SARS-CoV-2, including a pro...
https://doi.org/10.1016/j.jcv.2020.104633
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology; Marlet J, Petillon C et. al.

Sep 14th, 2020 - The aim of the present study was to evaluate the clinical performance of four SARS-CoV-2 immunoassays and their contribution in routine care for the diagnosis of COVID-19, in order to benefit of robust data before their extensive use. The clinical performance of Euroimmun ELISA SARS-CoV-2 IgG, Abbott SARS-CoV-2 IgG, Wantai SARS-CoV-2 Ab ELISA, and DiaPro COVID-19 IgG confirmation were evaluated...

Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19:Serologi...
https://doi.org/10.1093/cid/ciaa1343
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Hanson KE, Caliendo AM et. al.

Sep 12th, 2020 - The availability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serologic testing has rapidly increased. Current assays use a variety of technologies, measure different classes of immunoglobulin or immunoglobulin combinations and detect antibodies directed against different portions of the virus. The overall accuracy of these tests, however, has not been well-defined. The Infec...

SARS-CoV-2 seroprevalence and asymptomatic viral carriage in healthcare workers: a cros...
https://doi.org/10.1136/thoraxjnl-2020-215414
Thorax Shields A, Faustini SE et. al.

Sep 12th, 2020 - To determine the rates of asymptomatic viral carriage and seroprevalence of SARS-CoV-2 antibodies in healthcare workers. A cross-sectional study of asymptomatic healthcare workers undertaken on 24/25 April 2020. University Hospitals Birmingham NHS Foundation Trust (UHBFT), UK. 545 asymptomatic healthcare workers were recruited while at work. Participants were invited to participate via the UHBF...

Serological Assays Estimate Highly Variable SARS-CoV-2 Neutralizing Antibody Activity i...
https://doi.org/10.1128/JCM.02005-20
Journal of Clinical Microbiology; Luchsinger LL, Ransegnola B et. al.

Sep 12th, 2020 - The development of neutralizing antibodies (nAb) against SARS-CoV-2, following infection or vaccination, is likely to be critical for the development of sufficient population immunity to drive cessation of the COVID19 pandemic. A large number of serologic tests, platforms and methodologies are being employed to determine seroprevalence in populations to select convalescent plasmas for therapeut...

COVID-19 Viral and Serology Testing in New York City Health Care Workers.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499487
American Journal of Clinical Pathology; Racine-Brzostek SE, Yang HS et. al.

Sep 11th, 2020 - COVID-19 Viral and Serology Testing in New York City Health Care Workers.|2020|Racine-Brzostek SE,Yang HS,Chadburn A,Orlander D,An A,|

Comparative Clinical Evaluation of the Roche Elecsys and Abbott SARS-CoV-2 Serology ass...
https://doi.org/10.5858/arpa.2020-0499-SA
Archives of Pathology & Laboratory Medicine; Tan SS, Saw S et. al.

Sep 9th, 2020 - The use of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological tests detect antibodies in the host, contributing to the identification of individuals who have been exposed to Coronavirus Disease 2019 (COVID-19). To critically evaluate two commercially available SARS-CoV-2 serology tests. A total of 333 unique, non-duplicated serum samples obtained from COVID-19 patients (n=...

Testing for SARS-CoV-2 (COVID-19): A General Review.
https://www.ncbi.nlm.nih.gov/pubmed/32900007
Rhode Island Medical Journal (2013); Tang EW, Bobenchik AM et. al.

Sep 9th, 2020 - The rampant COVID-19 pandemic has strained the testing capabilities of healthcare centers across the country. Several nucleic acid and serologic assays are available or currently being developed to meet the growing demand for large-scale testing. This review summarizes the developments of commonly used testing methods and their strategic use in clinical diagnosis and epidemiologic surveillance....

Ultra-sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Und...
https://doi.org/10.1093/clinchem/hvaa213
Clinical Chemistry; Ogata AF, Maley AM et. al.

Sep 8th, 2020 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over 21 million people worldwide since August 16, 2020. Compared to PCR and serology tests, SARS-CoV-2 antigen assays are underdeveloped, despite their potential to identify active infection and monitor disease progression. We used Single Molecule Array (Simoa) assays to quantitatively detect SARS-CoV-2 spike, S1 subunit,...

Multi-system inflammatory syndrome in children & adolescents (MIS-C): A systematic revi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417920
Paediatric Respiratory Reviews; Radia T, Williams N et. al.

Sep 6th, 2020 - Multisystem Inflammatory Syndrome in Children (MIS-C) is a new phenomenon reported worldwide with temporal association with Covid-19. The objective of this paper is to evaluate reported cases in children and adolescents. From 1726 papers, 35 documented papers related to MIS-C cases identified 783 individual cases of MIS-C between March-June 2020; with 55% being male (n = 435) and a median age o...

Two serological approaches for detection of antibodies to SARS-CoV-2 in different scena...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417941
Diagnostic Microbiology and Infectious Disease; Hoste ACR, Venteo A et. al.

Sep 5th, 2020 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than 8 million people worldwide, becoming a pandemic. Detecting antibodies against SARS-CoV-2 is of utmost importance and a good indicator of exposure and circulation of the virus within the general population. Two serological tools based on a double recognition assay [enzyme-linked immunosorbent assay (DR-ELISA) an...

Unexpected diagnosis of COVID-19-associated disorders by SARS-CoV-2-specific serology.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402112
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology; Péré H, Védie B et. al.

Sep 5th, 2020 - Facing the ongoing pandemic caused by SARS-CoV-2, there is an urgent need for serological assays identifying individuals with on-going infection as well as past coronavirus infectious disease 2019 (COVID-19). We herein evaluated the analytical performances of the CE IVD-labeled Abbott SARS-CoV-2 IgG assay (Des Plaines, IL, USA) carried out with the automated Abbott Architect™ i2000 platform at ...

Seroprevalence of SARS-CoV-2 antibodies among healthy blood donors in Karachi, Pakistan.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444608
Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for HaemApheresis; Younas A, Waheed S et. al.

Sep 1st, 2020 - Covid-19 spread through blood transfusion has not yet been reported. Despite the prevailing pandemic, there are no recommendations available as yet for testing SARS-CoV-2 antibodies as part of blood screening. To determine the seroprevalence of SAR-CoV-2 antibodies, its clinical significance and to identify if total antibodies(IgA, IgM, IgG) should be tested or just the specific IgG antibodies ...