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The COVID-19 Serology Studies Workshop: Recommendations and Challenges.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309808
Immunity Lerner AM, Eisinger RW et. al.

Jul 1st, 2020 - The development, validation, and appropriate application of serological assays to detect antibodies to SARS-CoV-2 are essential to determining seroprevalence of this virus in the United States and globally and in guiding government leadership and the private sector on back-to-work policies. An interagency working group of the US Department of Health and Human Services convened a virtual worksho...

Dynamic of SARS-CoV-2 RT-PCR positivity and seroprevalence among high-risk health care ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316468
The Journal of Hospital Infection; Martin C, Montesinos I et. al.

Jun 30th, 2020 - Staff members from Covid-19 highly exposed units were invited to participate in a six month study of SARS-CoV-2 carriage and seroprevalence. The results of Day 1 and Day 15 visits show that 41 SARS-CoV-2 infections were confirmed by RT-PCR and/or serology in 326 participants (overall infection rate=12.6%). Having co-morbidity or symptoms at the time of collection was a risk factor for infection...

Validation of a commercially available SARS-CoV-2 serological immunoassay.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320699
Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases; Meyer B, Torriani G et. al.

Jun 30th, 2020 - To validate the diagnostic accuracy of a Euroimmun SARS-CoV-2 IgG and IgA immunoassay for COVID-19. In this unmatched (1:2) case-control validation study, we used sera of 181 laboratory-confirmed SARS-CoV-2 cases and 326 controls collected before SARS-CoV-2 emergence. Diagnostic accuracy of the immunoassay was assessed against a whole spike protein-based recombinant immunofluorescence assay (rI...

Diagnostic strategies for SARS-CoV-2 infection and interpretation of microbiological re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315992
Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases; Caruana G, Croxatto A et. al.

Jun 30th, 2020 - To face the current COVID-19 pandemic, diagnostic tools are essential. It is recommended to use real-time RT-PCR for RNA viruses in order (i) to perform a rapid and accurate diagnostic, (ii) to guide patient care and management and (iii) to guide epidemiological strategies. Further studies are warranted to define the role of serological diagnosis and a possible correlation between serological r...

Coronavirus (COVID-19) Update: Daily Roundup June 26, 2020 | FDA
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-daily-roundup-june-26-2020

Jun 26th, 2020 - For Immediate Release: June 26, 2020 The U.S. Food and Drug Administration today announced the following actions taken in its ongoing response effort to the COVID-19 pandemic: As part of FDA’s effort to protect consumers, the agency issued a warning letter to one company for selling fraudulent COVID-19 products. The company, Curativa Bay Corporation, offers Hypochlorous Skin Spray, a topical hy...

COVID-19 Update: New Tx Guidelines, More Infections
https://www.medscape.com/viewarticle/933077

Jun 25th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Here are the coronavirus stories Medscape's editors around the globe think you need to know about today: US Guidelines Add Dexamethasone Recommendations The National Institutes of Health COVID-19 Treatment Guidelines Panel has added a recommendation to prescribe dexamethasone for COVID-19 patien...

Antibody tests for identification of current and past infection with SARS-CoV-2.
https://doi.org/10.1002/14651858.CD013652
The Cochrane Database of Systematic Reviews References; Deeks JJ, Dinnes J et. al.

Jun 25th, 2020 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and resulting COVID-19 pandemic present important diagnostic challenges. Several diagnostic strategies are available to identify current infection, rule out infection, identify people in need of care escalation, or to test for past infection and immune response. Serology tests to detect the presence of antibodies to SARS-CoV...

COVID-19 in 7 multiple sclerosis patients in treatment with ANTI-CD20 therapies.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295509
Multiple Sclerosis and Related Disorders; Meca-Lallana V, Aguirre C et. al.

Jun 25th, 2020 - In December 2019, the first cases of SARS-CoV-2 infection were detected in Wuhan. Within two months, it had begun to spread around the world in what became an unprecedented pandemic. Patients with Multiple Sclerosis (MS) in a state of immunosuppression may be considered at risk for complications in the COVID-19 pandemic, although there is increasing evidence postulating a possible protective ro...

Coronavirus May Have Infected 10 Times More Americans Than Reported, CDC Says
https://www.medscape.com/viewarticle/932980

Jun 25th, 2020 - WASHINGTON (Reuters) - Government experts believe more than 20 million Americans could have contracted the coronavirus, 10 times more than official counts, indicating many people without symptoms have or have had the disease, senior administration officials said. The estimate, from the Centers for Disease Control and Prevention, is based on serology testing used to determine the presence of ant...

Prevalence of Sars-Cov-2 Infection in Health Workers (HWs) and Diagnostic Test Performa...
https://doi.org/10.3390/ijerph17124417
International Journal of Environmental Research and Public Health; Lahner E, Dilaghi E et. al.

Jun 24th, 2020 - (1) Background: Health workers (HWs) are at high risk of acquiring SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infections. Therefore, health authorities further recommend screening strategies for SARS-CoV-2 infection in exposed or high-risk HWs. Nevertheless, to date, the best/optimal method to screen HWs for SARS-CoV-2 infection is still under debate, and data on the prevalenc...

Efficacy of Serology Testing in Predicting Reinfection in Patients with SARS-CoV-2.
https://doi.org/10.1017/dmp.2020.216
Disaster Medicine and Public Health Preparedness; Chaturvedi R, Naidu R et. al.

Jun 23rd, 2020 - In many parts of the United States, SARS-CoV-2 cases have reached peak infection rates, prompting administrators to create protocols to resume elective cases. As elective procedures and surgeries get scheduled, ASCs must implement some form of widespread testing in order to ensure the safety of both the ASC staff as well as the patients being seen. The CDC recently announced the approval of new...

COVID-19 infections among Healthcare Workers in an Infectious Diseases specialized sett...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301109
The Journal of Hospital Infection; Fusco FM, Pisaturo M et. al.

Jun 22nd, 2020 - We performed a surveillance study for COVID-19 in March-April 2020 among asymptomatic HCWs in a specialized Infectious Diseases hospital in Naples, Italy. All HCWs underwent two rounds of molecular and serology testing for SARS-CoV-2. 115 HCWs were tested: two infections were identified by PT-PCR and two HCWs were SARS-CoV-2 IgG seropositive. The overall prevalence of current or probable-previo...

Serology-positive but minimally symptomatic COVID-19 may still cause lung injury and lu...
https://doi.org/10.5588/ijtld.20.0197
The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease; Wang JY, Chang SY et. al.

Jun 19th, 2020 - Serology-positive but minimally symptomatic COVID-19 may still cause lung injury and lung function impairment.|2020|Wang JY,Chang SY,Huang YW,Chang SC,|blood,diagnosis,pathology,diagnostic imaging,virology,diagnosis,pathology,

Certain COVID-19 Serology/Antibody Tests Should Not Be Used - Letter to Clinical Laboratory Staff and Health Care Providers | FDA
https://www.fda.gov/medical-devices/letters-health-care-providers/certain-covid-19-serologyantibody-tests-should-not-be-used-letter-clinical-laboratory-staff-and

The U.S. Food and Drug Administration (FDA) recommends that clinical laboratories and health care providers stop using COVID-19 antibody tests that are listed on FDA’s “removed” test list, found on the FDA’s FAQs on Testing for SARS-CoV-2 webpage.  The “removed” test list includes tests where significant clinical performance problems were identified that cannot be or have not been addressed by ...

Coronavirus (COVID-19) Update: FDA Revokes Emergency Use Authorization for Chembio Antibody Test | FDA
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-revokes-emergency-use-authorization-chembio-antibody-test

Jun 18th, 2020 - For Immediate Release: June 16, 2020 Español Today, the U.S. Food and Drug Administration revoked the emergency use authorization (EUA) of the Chembio Diagnostic System, Inc. (Chembio) DPP COVID-19 IgM/IgG System, a SARS-CoV-2 antibody test, due to performance concerns with the accuracy of the test. Antibody tests, a type of serological test, can help provide information on a person’s and popul...

Coronavirus Parties Are a Bad Idea
https://www.medscape.com/viewarticle/932443

Jun 17th, 2020 - Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. COVID-19 parties? The idea of intentionally exposing individuals to COVID-19 has been proposed. It is an idea with historical precedent—chicken pox parties, rubella parties, and even smallpox parties had the goal of intentionally exposing people to a virus. So, why should people resist the temptation to intent...

CMR and serology to diagnose COVID-19 infection with primary cardiac involvement.
https://doi.org/10.1093/ehjci/jeaa169
European Heart Journal Cardiovascular Imaging; Gravinay P, Issa N et. al.

Jun 16th, 2020 - CMR and serology to diagnose COVID-19 infection with primary cardiac involvement.|2020|Gravinay P,Issa N,Girard D,Camou F,Cochet H,|

SARS-CoV-2 shedding and seroconversion among passengers quarantined after disembarking ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292581
The Lancet. Infectious Diseases; Hung IF, Cheng VC et. al.

Jun 16th, 2020 - A cruise ship is a closed-off environment that simulates the basic functioning of a city in terms of living conditions and interpersonal interactions. Thus, the Diamond Princess cruise ship, which was quarantined because of an onboard outbreak of COVID-19 in February, 2020, provides an opportunity to define the shedding pattern of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and...

Chilblains in children in the time of Covid-19: new evidence with serology assay.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323211
Pediatric Dermatology; Colonna C, Spinelli F et. al.

Jun 13th, 2020 - In a previous report in Pediatric Dermatology, we described chilblains-like lesions in four pediatric patients. From April 18 to May 10, 2020, 45 children presented to our Pediatric Dermatology department with similar acral lesions. The clinical appearance ranged from red to violaceous macules and dusky, purpuric plaques on the heels, soles and lateral margin of the feet, often accompanied by p...

Cardiac MRI of Children with Multisystem Inflammatory Syndrome (MIS-C) Associated with ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294821
Radiology Blondiaux E, Parisot P et. al.

Jun 9th, 2020 - This case series examines cardiac MRI findings in four children and adolescents admitted to intensive care in April 2020 for multisystem inflammatory syndrome and Kawasaki disease-like features related to COVID-19. Acute myocarditis occurred less than 1 week after onset of fever and gastrointestinal symptoms. Physical examination showed rash and cheilitis/conjunctivitis. All patients recovered ...