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Effectiveness and safety of noninvasive positive pressure ventilation in the treatment ...
https://doi.org/10.1007/s11739-020-02562-2
Internal and Emergency Medicine; Faraone A, Beltrame C et. al.

Nov 22nd, 2020 - The role of noninvasive positive pressure ventilation (NIPPV) in COVID-19 patients with acute hypoxemic respiratory failure (AHRF) is uncertain, as no direct evidence exists to support NIPPV use in such patients. We retrospectively assessed the effectiveness and safety of NIPPV in a cohort of COVID-19 patients consecutively admitted to the COVID-19 general wards of a medium-size Italian hospita...

Characteristics of Clinically Asymptomatic Patients with SARS-CoV-2 Infections, Case Se...
https://doi.org/10.1017/S1049023X20001466
Prehospital and Disaster Medicine; Goldenfeld M, Nir-Paz R et. al.

Nov 17th, 2020 - Up until now, there is much debate about the role of asymptomatic patients and pauci-symptomatic patients in severe acute respiratory syndrome novel coronavirus 2 (SARS-CoV-2) transmission, and little is known about the kinetics of viral ribonucleic acid (RNA) shedding in these populations. This article aims to describe key features and the nature of asymptomatic and pauci-symptomatic SARS-CoV-...

Coronavirus (COVID-19) Update: November 17, 2020 | FDA
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-november-17-2020

Nov 17th, 2020 - For Immediate Release: November 17, 2020 The U.S. Food and Drug Administration today announced the following actions taken in its ongoing response effort to the COVID-19 pandemic: Today, the FDA reaffirmed its commitment to transparency around the EUA process and shared updates on its plan to provide more information about the agency’s decisions to issue, revise or revoke EUAs for drugs and bio...

SARS-CoV-2 Diagnostics, From Serology to Spit
https://www.medscape.com/viewarticle/940204

Nov 15th, 2020 - Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. This transcript has been edited for clarity. Hello. I'm Paul Auwaerter with Medscape Infectious Diseases, speaking virtually from IDWeek with another segment on Chasing the Sun, the 24-hour COVID-19 overview that was a tremendous effort by so many. One of the more interesting segments — and one with many quest...

SARS-CoV-2 Diagnostics, From Serology to Spit
https://www.staging.medscape.com/viewarticle/940204

Nov 15th, 2020 - Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. This transcript has been edited for clarity. Hello. I'm Paul Auwaerter with Medscape Infectious Diseases, speaking virtually from IDWeek with another segment on Chasing the Sun, the 24-hour COVID-19 overview that was a tremendous effort by so many. One of the more interesting segments — and one with many quest...

Efficacy of pragmatic same-day ring prophylaxis for adult individuals exposed to SARS-C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662450
BMJ Open; Smit M, Marinosci A et. al.

Nov 13th, 2020 - Lopinavir/ritonavir (LPV/r) has been proposed as repurposed drugs for pre-exposure and postexposure prophylaxis as well as therapy of COVID-19. Coronavirus postexposure prophylaxis (COPEP) trial aims at assessing their efficacy as postexposure ring-prophylaxis among adults exposed to SARS-CoV-2. COPEP is a two-arm open-label cluster-randomised trial conducted in three cantons of Switzerland. As...

Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658256
Nature Communications; Tosif S, Neeland MR et. al.

Nov 12th, 2020 - Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptomatic infections, but the underlying immunological differences remain unclear. Here, we describe clinical features, virology, longitudinal cellular, and cytokine immune profile, SARS-CoV-2-specific serology and salivary antibody responses in a family of two parents wi...

SARS-CoV-2 seroprevalence and antibody kinetics among health care workers in a Spanish ...
https://doi.org/10.1093/infdis/jiaa696
The Journal of Infectious Diseases; Moncunill G, Mayor A et. al.

Nov 11th, 2020 - At the COVID-19 pandemic peak in Spain, prevalence of SARS-CoV-2 infection in a cohort of 578 randomly selected health care workers (HCW) from Hospital Clínic de Barcelona was 11.2%. A follow-up survey one month later (April-May 2020) measured infection by rRT-PCR and IgM, IgA, IgG to the receptor-binding domain of the spike protein by Luminex. Antibody kinetics, including IgG subclasses, was a...

Coronavirus (COVID-19) Update: FDA Authorizes First Test that Detects Neutralizing Antibodies from Recent or Prior SARS-CoV-2 Infection | FDA
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-first-test-detects-neutralizing-antibodies-recent-or

Nov 6th, 2020 - For Immediate Release: November 06, 2020 Español Today, the U.S. Food and Drug Administration authorized the first serology test that detects neutralizing antibodies from recent or prior SARS-CoV-2 infection, which are antibodies that bind to a specific part of a pathogen and have been observed in a laboratory setting to decrease SARS-CoV-2 viral infection of cells. The FDA issued an emergency ...

SARS-CoV-2 Cysteine-like Protease Antibodies Can Be Detected in Serum and Saliva of COV...
https://doi.org/10.4049/jimmunol.2000842
Journal of Immunology (Baltimore, Md. : 1950); Martínez-Fleta P, Alfranca A et. al.

Nov 5th, 2020 - Currently, there is a need for reliable tests that allow identification of individuals that have been infected with SARS-CoV-2 even if the infection was asymptomatic. To date, the vast majority of the serological tests for SARS-CoV-2-specific Abs are based on serum detection of Abs to either the viral spike glycoprotein (the major target for neutralizing Abs) or the viral nucleocapsid protein t...

SARS-CoV-2 seroprevalence and transmission risk factors among high-risk close contacts:...
https://doi.org/10.1016/S1473-3099(20)30833-1
The Lancet. Infectious Diseases; Ng OT, Marimuthu K et. al.

Nov 5th, 2020 - The proportion of asymptomatic carriers and transmission risk factors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among household and non-household contacts remains unclear. In Singapore, extensive contact tracing by the Ministry of Health for every diagnosed COVID-19 case, and legally enforced quarantine and intensive health surveillance of close contacts provided a rare op...

A high-throughput Anti-SARS-CoV-2 IgG testing platform for COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605757
Journal of Virological Methods; Du J, Chu E et. al.

Nov 5th, 2020 - Serology tests for detecting the antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can identify previous infection and help to confirm the presence of current infection. The aim of this study was to evaluate the performances of a newly developed high throughput immunoassay for anti-SARS-CoV-2 IgG antibody detection. Clinical agreement studies were performed in 107 COVID...

Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598362
The American Journal of Medicine; Mahajan S, Srinivasan R et. al.

Nov 1st, 2020 - A seroprevalence study can estimate the percentage of people with SARS-CoV-2 antibodies in the general population, however, most existing reports have used a convenience sample, which may bias their estimates. We sought a representative sample of Connecticut residents, aged ≥18 years and residing in non-congregate settings, who completed a survey between June 4 and June 23, 2020 and underwent s...

How useful is serology for COVID-19?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591945
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases; Raoult D

Nov 1st, 2020 - How useful is serology for COVID-19?|2020|Raoult D,|

SARS-CoV-2 infection among hospital workers of one of the most severely affected instit...
https://doi.org/10.1017/ice.2020.1303
Infection Control and Hospital Epidemiology; Pérez-García F, Pérez-Zapata A et. al.

Oct 29th, 2020 - To analyze the impact of SARS-CoV-2 pandemic in workers of a hospital located in one of the most affected areas in Spain. Cross-sectional study performed between March and May 2020 over all workers of a secondary hospital in Madrid, Spain. We employed as diagnostic tests PCR (for symptomatic individuals) and serology (for both PCR-negative symptomatic workers and asymptomatic workers). We analy...

Serological cross-reaction and co-infection of dengue and COVID-19 in Asia: Experience ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585717
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases; Masyeni S, Santoso MS et. al.

Oct 29th, 2020 - Similar symptoms and laboratory findings between dengue and coronavirus disease 2019 (COVID-19) pose a diagnostic challenge in some dengue-endemic countries in Asia. In this study, we reported three cases of suspected COVID-19-dengue co-infection in hospitals of Bali, Indonesia. Serological data demonstrated that patients with positive results on dengue virus (DENV) NS1 antigen and anti-dengue ...

Adapting to the Coronavirus Pandemic: Building and Incorporating a Diagnostic Pipeline ...
https://doi.org/10.1002/cyto.a.24248
Cytometry. Part A : the Journal of the International Society for Analytical Cytology Literature Cited; Russell E, Agua-Doce A et. al.

Oct 29th, 2020 - In March 2020, with lockdown due to the coronavirus pandemic underway, the Francis Crick Institute (the Crick) regeared its research laboratories into clinical testing facilities. Two pipelines were established, one for polymerase chain reaction and the other for Serology. This article discusses the Cricks Flow Cytometry Science Technology Platform (Flow STP) role in setting up the Serology pip...

Delayed acute myocarditis and COVID-19-related multisystem inflammatory syndrome.
https://doi.org/10.1002/ehf2.13047
ESC Heart Failure References; Nicol M, Cacoub L et. al.

Oct 27th, 2020 - Precise descriptions of coronavirus disease 2019 (COVID-19)-related cardiac damage as well as underlying mechanisms are scarce. We describe clinical presentation and diagnostic workup of acute myocarditis in a patient who had developed COVID-19 syndrome 1 month earlier. A healthy 40-year-old man suffered from typical COVID-19 symptoms. Four weeks later, he was admitted because of fever and tons...

Unexpected high frequency of unspecific reactivities by testing pre-epidemic blood spec...
https://doi.org/10.1002/jmv.26628
Journal of Medical Virology REFERENCES; Mboumba Bouassa RS, Péré H et. al.

Oct 27th, 2020 - We aimed to evaluate the rates of false-positive test results of three rapid diagnostic tests (RDTs) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immunoglobulin G (IgG) and IgM detection. Two serum panels from patients hospitalized in Paris, France, and from patients living in Bangui, Central African Republic, acquired before the 2019 COVID-19 outbreak, were tested ...

Comparison of admission chest computed tomography and lung ultrasound performance for d...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543736
European Journal of Radiology; Colombi D, Petrini M et. al.

Oct 22nd, 2020 - Chest computed tomography (CT) is considered a reliable imaging tool for COVID-19 pneumonia diagnosis, while lung ultrasound (LUS) has emerged as a potential alternative to characterize lung involvement. The aim of the study was to compare diagnostic performance of admission chest CT and LUS for the diagnosis of COVID-19. We included patients admitted to emergency department between February 21...