×
A high prevalence of potential HIV elite controllers identified over 30 years in Democr...
https://doi.org/10.1016/j.ebiom.2021.103258
EBioMedicine Berg MG, Olivo A et. al.

Mar 6th, 2021 - In-depth analysis of the HIV pandemic at its epicenter in the Congo basin has been hampered by 40 years of political unrest and lack of functional public health infrastructure. In recent surveillance studies (2017-18), we found that the prevalence of HIV in Kinshasa, Democratic Republic of Congo (11%) far exceeded previous estimates. 10,457 participants were screened in Kinshasa with rapid test...

COVID-19 new diagnostics development: novel detection methods for SARS-CoV-2 infection ...
https://doi.org/10.1097/MCP.0000000000000768
Current Opinion in Pulmonary Medicine; Huggett JF, Moran-Gilad J et. al.

Mar 3rd, 2021 - COVID-19 has put the in-vitro-diagnostic community under an unprecedented spotlight, with a global requirement for accurate SARS-CoV-2 tests. This review will outline technological responses to this need and the analytical considerations required for their translation to routine use. SARS-CoV-2 diagnostic solutions directly detect a virus or measure host-derived surrogate markers of infection. ...

Kinetics of Anti-SARS-CoV-2 IgG Antibodies in Hemodialysis Patients Six Months after In...
https://doi.org/10.1681/ASN.2020111618
Journal of the American Society of Nephrology : JASN; Sakhi H, Dahmane D et. al.

Feb 27th, 2021 - The humoral response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the hemodialysis population, including its dynamics over time, remains poorly understood. To analyze initial and long-term humoral responses against SARS-CoV-2 in a hemodialysis population, we retrospectively evaluated findings from SARS-CoV-2 IgG serologic assays targeting the nucleocapsid antigen or s...

Peripartal anti-SARS-CoV-2-IgA/IgG in asymptomatic pregnant women during regional SARS-...
https://doi.org/10.1515/jpm-2021-0001
Journal of Perinatal Medicine; Häusler S, Weigl M et. al.

Feb 25th, 2021 - The Severe Acute Respiratory Distress Corona Virus 2 (SARS-CoV-2) pandemic poses special challenges for the society and especially the medical staff. Even if a rather mild course is assumed among pregnant women the measures to prevent transmission of the infection are of outstanding importance. To screen asymptomatic pregnant women during admission to our university maternal hospital we focused...

Seroprevalence of anti-SARS-CoV-2 IgG among healthcare workers of a large university ho...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902322
BMJ Open; Lombardi A, Mangioni D et. al.

Feb 23rd, 2021 - To assess the seroprevalence of anti-SARS-CoV-2 IgG among health careworkers (HCWs) in our university hospital and verify the risk of acquiring the infection according to work area. Cross-sectional study. Monocentric, Italian, third-level university hospital. All the employees of the hospital on a voluntary base, for a total of 4055 participants among 4572 HCWs (88.7%). Number of anti-SARS-CoV-...

Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate end...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896075
Nature Communications; Becker M, Strengert M et. al.

Feb 20th, 2021 - The humoral immune response to SARS-CoV-2 is a benchmark for immunity and detailed analysis is required to understand the manifestation and progression of COVID-19, monitor seroconversion within the general population, and support vaccine development. The majority of currently available commercial serological assays only quantify the SARS-CoV-2 antibody response against individual antigens, lim...

Safety of disease-modifying treatments in SARS-CoV-2 antibody-positive multiple scleros...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836789
Multiple Sclerosis and Related Disorders; Mallucci G, Zito A et. al.

Feb 20th, 2021 - Coronavirus disease 2019 (COVID-19) raises particular concerns for people with multiple sclerosis (PwMS) on disease-modifying treatments (DMTs), and for physicians caring for them. The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on PwMS receiving DMTs that inhibit immune cell trafficking, such as natalizumab (NTZ) and fingolimod (FTY), remains to be determin...

Performance of SARS-CoV-2 serology tests: Are they good enough?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888604
PloS One; Piec I, English E et. al.

Feb 17th, 2021 - In the emergency of the SARS-CoV-2 pandemic, great efforts were made to quickly provide serology testing to the medical community however, these methods have been introduced into clinical practice without the complete validation usually required by the regulatory organizations. SARS-CoV-2 patient samples (n = 43) were analyzed alongside pre-pandemic control specimen (n = 50), confirmed respirat...

High SARS-CoV-2 Seroprevalence in Healthcare Workers in Bukavu, Eastern Democratic Repu...
https://doi.org/10.4269/ajtmh.20-1526
The American Journal of Tropical Medicine and Hygiene; Mukwege D, Byabene AK et. al.

Feb 16th, 2021 - Among 359 healthcare workers (HCW) employed in Panzi General Referral Hospital located in Bukavu in the Democratic Republic of Congo, 148 (41.2%) tested positive for SARS-CoV-2 antibodies. Thirty-three (22.3%) of the 148 personnel with positive serology reported symptoms evoking a prior COVID-19 illness. None of the infected HCWs reported COVID-related hospitalization, and all of them recovered...

Resuming professional football (soccer) during the COVID-19 pandemic in a country with ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886664
British Journal of Sports Medicine; Schumacher YO, Tabben M et. al.

Feb 16th, 2021 - The risk of viral transmission associated with contact sports such as football (soccer) during the COVID-19 pandemic is unknown. The aim of this study was to describe the infective and immune status of professional football players, team staff and league officials over a truncated football season resumed at the height of the COVID-19 pandemic in a country with high infection rates and to invest...

COVID-19 antibody screening with SARS-CoV-2 red cell kodecytes using routine serologic ...
https://doi.org/10.1111/trf.16327
Transfusion Nagappan R, Flegel WA et. al.

Feb 16th, 2021 - The Coronavirus disease 2019 (COVID-19) pandemic is having a major global impact, and the resultant response in the development of new diagnostics is unprecedented. The detection of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a role in managing the pandemic. We evaluated the feasibility of using SARS-CoV-2 peptide Kode Technology-modified red cells (C19-k...

Use of dried blood spot samples for SARS-CoV-2 antibody detection using the Roche Elecs...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817498
Journal of Clinical Virology : the Official Publication O... Mulchandani R, Brown B et. al.

Feb 15th, 2021 - Dried blood spot samples (DBS) provide an alternative sample type to venous blood samples for antibody testing. DBS are used by NHS for diagnosing Hepatitis C and by Public Health England for large scale HIV and Hepatitis C serosurveillance; the applicability of DBS based approaches for SARS-CoV-2 antibody detection is uncertain. The study aimed to compare antibody detection in DBS eluates usin...

Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883610
BMJ Open; Ebinger JE, Botwin GJ et. al.

Feb 13th, 2021 - We sought to determine the extent of SARS-CoV-2 seroprevalence and the factors associated with seroprevalence across a diverse cohort of healthcare workers. Observational cohort study of healthcare workers, including SARS-CoV-2 serology testing and participant questionnaires. A multisite healthcare delivery system located in Los Angeles County. A diverse and unselected population of adults (n=6...

An Overview of the Ongoing Clinical Issues of COVID-19.
https://doi.org/10.3928/19382359-20210112-01
Pediatric Annals; Noor A, Krilov LR

Feb 12th, 2021 - Childhood cases of coronavirus disease 2019 (COVID-19) are on the rise as the pandemic continues to rage across the globe. Most children acquire infection from an adult household member. Children may stay asymptomatic, have a pre-symptomatic stage, or present with symptoms (fever, cough, and difficulty breathing being the most common). Nearly one-third of the pediatric cases (32%) in the United...

Impact of Coronavirus Disease 2019 in a French Cohort of Myasthenia Gravis.
https://doi.org/10.1212/WNL.0000000000011669
Neurology Solé G, Mathis S et. al.

Feb 11th, 2021 - To describe the clinical characteristics and outcomes of COVID-19 among patients with MG and identify factors associated with COVID-19 severity in MG patients. The CO-MY-COVID registry was a multicenter, retrospective, observational cohort study conducted in neuromuscular referral centers and general hospitals of the FILNEMUS network (between March 1, 2020, and June 8, 2020), including MG patie...

Quantifying asymptomatic infection and transmission of COVID-19 in New York City using ...
https://doi.org/10.1073/pnas.2019716118 10.1038/s41586-020-2912-6
Proceedings of the National Academy of Sciences of the Un... Subramanian R, He Q et. al.

Feb 11th, 2021 - The contributions of asymptomatic infections to herd immunity and community transmission are key to the resurgence and control of COVID-19, but are difficult to estimate using current models that ignore changes in testing capacity. Using a model that incorporates daily testing information fit to the case and serology data from New York City, we show that the proportion of symptomatic cases is l...

The challenge of avidity determination in SARS-CoV-2 serology.
https://doi.org/10.1002/jmv.26863
Journal of Medical Virology; Bauer G, Struck F et. al.

Feb 10th, 2021 - The serological responses towards severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleoprotein, receptor-binding domain (RBD), and spike protein S1 are characterized by incomplete avidity maturation. Analysis with varying concentrations of urea allows to determine distinct differences in avidity maturation, though the total process remains at an unusually low level. Despite incomp...

Symptoms and laboratory manifestations of mild COVID-19 in a repatriated cruise ship co...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900670
Epidemiology and Infection; Bailie CR, Franklin L et. al.

Feb 10th, 2021 - Much of our current understanding about novel coronavirus disease 2019 (COVID-19) comes from hospitalised patients. However, the spectrum of mild and subclinical disease has implications for population-level screening and control. Forty-nine participants were recruited from a group of 99 adults repatriated from a cruise ship with a high incidence of COVID-19. Respiratory and rectal swabs were t...

Assessment of Seroprevalence of SARS-CoV-2 and Risk Factors Associated With COVID-19 In...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871191
JAMA Network Open; Rogawski McQuade ET, Guertin KA et. al.

Feb 8th, 2021 - Data from seroepidemiologic surveys measuring severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure in diverse communities and ascertaining risk factors associated with infection are important to guide future prevention strategies. To assess the prevalence of previous SARS-CoV-2 infection across Virginia and the risk factors associated with infection after the first wave of coro...