×
A cross-sectional follow up study to estimate seroprevalence of coronavirus disease 201...
https://doi.org/10.1097/MD.0000000000028066
Medicine Doi A, Iwata K et. al.

Jan 21st, 2022 - We conducted a study to estimate the seroprevalence of coronavirus disease 2019 (COVID-19) in Kobe, Japan with positive immunoglobulin G (IgG) rate of 3.3% (95% confidence interval [CI] 2.3%-4.6%) in April 2020. Because there were large concerns about the spread of COVID-19 among citizens thereafter, we conduct a follow-up cross-sectional study to estimate the seroprevalence, and we also added ...

Comparison of T-cell immune responses to SARS-CoV-2 spike (S) and nucleocapsid (N) prot...
https://doi.org/10.1136/jclinpath-2021-207556
Journal of Clinical Pathology; van Rooyen C, Brauer M et. al.

Jan 19th, 2022 - To compare specific T-cell responses between laboratory employees in South Africa with and without previously diagnosed SARS-CoV-2 infection. Employees at a private pathology laboratory in South Africa were invited to participate in a nationwide cross-sectional study. T-cell proliferation to SARS-CoV-2 nucleocapsid (N)-proteins and spike (S)-proteins was measured by flow cytometry and compared ...

Seroprevalence and risk factors for SARS-CoV-2 among incarcerated adult men in Quebec, ...
https://doi.org/10.1093/cid/ciac031
Clinical Infectious Diseases : an Official Publication Of... Kronfli N, Dussault C et. al.

Jan 18th, 2022 - People in prison are at increased risk of SARS-CoV-2 infection due to overcrowding and challenges in implementing infection prevention and control measures. We examined the seroprevalence of SARS-CoV-2 and associated carceral risk factors among incarcerated adult men in Quebec, Canada. We conducted a cross-sectional seroprevalence study in 2021 in three provincial prisons, representing 45% of Q...

Does smoking have an impact on the immunological response to COVID-19 vaccines? Evidenc...
https://doi.org/10.1016/j.puhe.2021.12.013
Public Health; Ferrara P, Ponticelli D et. al.

Jan 18th, 2022 - The aim of this study was to investigate the possible impact of smoking on the humoral response to the BNT162b2 mRNA COVID-19 vaccine (also known as the BioNTech-Pfizer COVID-19 vaccine). A longitudinal sero-epidemiological study was conducted in sample of Italian healthcare workers (HCWs). HCWs who were administered two doses of the BNT162b2 mRNA vaccine, 21 days apart, between December 2020 a...

Trend in sensitivity of SARS-CoV-2 serology one year after mild and asymptomatic COVID-...
https://doi.org/10.1093/cid/ciac020
Clinical Infectious Diseases : an Official Publication Of... Bailie CR, Tseng YY et. al.

Jan 14th, 2022 - A key aim of serosurveillance during the COVID-19 pandemic has been to estimate the prevalence of prior infection, by correcting crude seroprevalence against estimated test performance for PCR-confirmed COVID-19. We show that poor generalisability of sensitivity estimates to some target populations may lead to substantial underestimation of case numbers.

Evidence of SARS-CoV-2 Symptomatic Reinfection in Four Health Care Professionals from t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743858
International Journal of Infectious Diseases : IJID : Off... Gargouri S, Souissi A et. al.

Jan 13th, 2022 - Since the onset of the COVID-19 pandemic, cases of reinfection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported, raising additional public health concerns. SARS-CoV-2 reinfection was assessed in healthcare workers in Tunisia, as they are at the greatest exposure to infection by different variants. We conducted whole-genome sequencing of the viral RNA from...

Impaired antibody response to COVID-19 vaccination in advanced HIV infection.
https://doi.org/10.1097/QAD.0000000000003166
AIDS (London, England); Hassold N, Brichler S et. al.

Jan 12th, 2022 - COVID-19 vaccination is reportedly efficient in people living with HIV (PLHIV) but vaccine trials included participants with normal CD4+ T-cell counts. We analyzed seroconversion rates and antibody titers following 2-dose vaccination in PLHIV with impaired CD4+ T-cell counts. We collected retrospective post-vaccination SARS-COV-2 serology results available in a university hospital for PLHIV vac...

Review of Clinical Performance of Serology Based Commercial Diagnostic Assays for Detec...
https://doi.org/10.1089/vim.2020.0313
Viral Immunology; Deshpande PS, Abraham IE et. al.

Jan 11th, 2022 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, which caused the coronavirus disease 2019 (COVID-19) pandemic as declared by the World Health Organization, has created havoc worldwide. The highly transmissible infection can be contained only by accurate diagnosis, quarantining, and exercising social distancing. Therefore, quick and massive deployment of SARS-CoV-2 testin...

COVID-19 Serology Control Panel Using the Dried-Tube Specimen Method.
https://doi.org/10.4269/ajtmh.21-1036
The American Journal of Tropical Medicine and Hygiene; Windsor WJ, Knight V et. al.

Jan 8th, 2022 - The dried-tube specimen (DTS) procedure was used to develop the COVID-19 serology control panel (CSCP). The DTS offers the benefit of shipping materials without a cold chain, allowing for greater access without deterioration of material integrity. Samples in the panel were sourced from COVID-19 convalescent persons from March to May 2020. The immunoglobulin subtypes (total Ig, IgM, and IgG) and...

A 48-Year-Old Previously Healthy Man Presenting with Acute Respiratory Distress Syndrom...
https://doi.org/10.12659/AJCR.934362
The American Journal of Case Reports; Kakizaki R, Tojo R et. al.

Jan 7th, 2022 - BACKGROUND Human parainfluenza viruses (PIVs) belong to the Paramyxoviridae family. PIVs cause lower respiratory tract infections in children and the elderly. In addition, severe pneumonia due to PIVs has been reported in immunocompromised adults. However, no reports have described PIV infections leading to acute respiratory distress syndrome (ARDS) in immunocompetent hosts. CASE REPORT A 48-ye...

Etesevimab - etesevimab injection, solution-Eli Lilly and Company
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=aacdd8a7-18b7-43c6-b866-14aa491a0c15

Jan 4th, 2022 - SPL UNCLASSIFIED SECTION TREATMENT The U.S. Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) to permit the emergency use of the unapproved products bamlanivimab and etesevimab administered together for the treatment of mild to moderate coronavirus disease 2019 (COVID-19) in adults and pediatric patients, including neonates, with positive results of direct SARS-...

Myocardial involvement in children with post-COVID multisystem inflammatory syndrome: a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717054
Journal of Cardiovascular Magnetic Resonance : Official J... Aeschlimann FA, Misra N et. al.

Jan 1st, 2022 - Recent evidence shows an association between coronavirus disease 2019 (COVID-19) infection and a severe inflammatory syndrome in children. Cardiovascular magnetic resonance (CMR) data about myocardial injury in children are limited to small cohorts. The aim of this multicenter, international registry is to describe clinical and cardiac characteristics of multisystem inflammatory syndrome in chi...

SARS-CoV-2 infections in households in a peri-urban community of Lima, Peru: A prospect...
https://doi.org/10.1111/irv.12952
Influenza and Other Respiratory Viruses; Lanata CF, Gil AI et. al.

Dec 29th, 2021 - We assessed the prevalence and incidence of SARS-CoV-2 infections in a prospective study of households in Lima, Peru. Households with a child, a young adult 18-50 years, and an adult age >50 years in peri-urban Lima were followed with twice-a-week household visits during a 2-month period. Nasal swabs and saliva specimens were collected twice weekly, and nasopharyngeal swabs were collected weekl...

Coronavirus disease 2019 (COVID-19) vaccine intentions and uptake in a tertiary-care he...
https://doi.org/10.1017/ice.2021.523
Infection Control and Hospital Epidemiology; Evans CT, DeYoung BJ et. al.

Dec 28th, 2021 - Healthcare workers (HCWs) are a high-priority group for coronavirus disease 2019 (COVID-19) vaccination and serve as sources for public information. In this analysis, we assessed vaccine intentions, factors associated with intentions, and change in uptake over time in HCWs. A prospective cohort study of COVID-19 seroprevalence was conducted with HCWs in a large healthcare system in the Chicago ...

Safety and Tolerability of Hydroxychloroquine in healthcare workers and first responder...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695310
International Journal of Infectious Diseases : IJID : Off... McKinnon JE, Wang DD et. al.

Dec 27th, 2021 - Healthcare workers (HCW) are among the highest risk groups for acquisition of COVID-19 due to occupational exposures. The WHIP COVID-19 study aimed to evaluate the safety and efficacy of hydroxychloroquine (HCQ) as chemoprophylaxis for SARS-CoV-2 infection in this population. HCW, first responders and other occupationally high-risk participants were enrolled in a randomized, placebo-controlled ...

Hospital-wide antigen screening for coronavirus disease in a tertiary reference center ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701976
Medicine Shimamura Y, Komazawa H et. al.

Dec 24th, 2021 - Hospital-wide screenings for coronavirus disease (COVID-19) are important to identify healthcare workers at risk of exposure. However, the currently available diagnostic tests are expensive or only identify past infection. Therefore, this single-center observational study aimed to assess the positivity rate of hospital-wide antigen screening tests for COVID-19 and evaluate clinical factors asso...

Analytical characterization of the SARS-CoV-2 EURM-017 reference material.
https://doi.org/10.1016/j.clinbiochem.2021.12.009
Clinical Biochemistry; Freeman J, Olson K et. al.

Dec 22nd, 2021 - Current serological methods for SARS-CoV-2 lack adequate standardization to a universal standard reference material. Standardization will allow comparison of results across various lab-developed and commercial assays and publications. SARS-CoV-2 EURM-017 is human sera reference material containing antibodies directed against SARS-CoV-2 proteins, S1/S2 (full-length spike [S]), S1 receptor-bindin...

Bamlanivimab - bamlanivimab injection, solution-Eli Lilly and Company
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c7e9d8a6-e8c2-4681-9362-51d5bdbae00d

Dec 22nd, 2021 - SPL UNCLASSIFIED SECTION TREATMENT The U.S. Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) to permit the emergency use of the unapproved products bamlanivimab and etesevimab administered together for the treatment of mild to moderate coronavirus disease 2019 (COVID-19) in adults and pediatric patients, including neonates, with positive results of direct SARS-...

Comparison of Covid-19 antibody status after vaccination between residents in long-term...
https://doi.org/10.1080/23744235.2021.2014559
Infectious Diseases (London, England); Naschitz JE, Kertes J et. al.

Dec 18th, 2021 - To compare 2 CoV-SARS-2 ('anti-s') antibody levels after vaccination between residents in long-term geriatric care (LTGC) and residents in assisted-living facilities who had received two doses of the BNT162b2 vaccine. SARS-CoV-2 serology was tested with Quant II IgG CoV-SARS-2. Blood samples were collected 3-4 months after administration of the second vaccine dose. Anti-s ≥ 50 AU/ml was found i...

Potential SARS-CoV-2 infectiousness among asymptomatic healthcare workers.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682911
PloS One; Pimenoff VN, Elfström M et. al.

Dec 18th, 2021 - A majority of SARS-CoV-2 infections are transmitted from a minority of infected subjects, some of which may be symptomatic or pre-symptomatic. We aimed to quantify potential infectiousness among asymptomatic healthcare workers (HCWs) in relation to prior or later symptomatic disease. We previously (at the onset of the SARS-CoV-2 epidemic) performed a cohort study of SARS-CoV-2 infections among ...