×
Development of in-house, indirect ELISAs for the detection of SARS-CoV-2 spike protein-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439474
PloS One; de la Guardia C, Rangel G et. al.

Sep 15th, 2021 - COVID-19 is the name of the acute respiratory disease caused by the new coronavirus SARS-CoV-2, a close relative of those that caused the severe outbreaks of SARS and MERS several years ago. Since first appearance on December of 2019, the COVID-19 pandemic has cause extremely high levels of mortality, morbidity, global economic breakdown, and the consequent human suffering. The main diagnostic ...

An inventory of diagnostic tools for detection of COVID-19.
https://doi.org/10.2174/1566524021666210910113714
Current Molecular Medicine; Bhatt A, Fatima Z et. al.

Sep 14th, 2021 - The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by SARS-COV-2 has afflicted millions of lives globally and disrupted almost all the activities of mankind. Under such pressing circumstances when there are no effective therapeutics available, fast and accurate diagnosis of the corona virus is the only way out to limit the transmission. Since the inception of COVID-19, the deman...

Neutralizing antibodies response to SARS-CoV-2 are persistent 9 months post symptom ons...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425675
International Journal of Infectious Diseases : IJID : Off... Bylicki O, Delarbre D et. al.

Sep 12th, 2021 - A better understanding of immune response against SARS-CoV-2 infection is critical to predict its dynamics within general population and its impact on vaccination strategy. We assessed both neutralizing antibody (Nab) activity persistence and SARS-CoV-2 serology in serum samples of mild and asymptomatic patients nine months post symptom onset (PSO) in a primary care context among immunocompeten...

Kidney transplant recipients vaccinated before transplantation maintain superior humora...
https://doi.org/10.1111/ctr.14478
Clinical Transplantation; Grupper A, Katchman E et. al.

Sep 11th, 2021 - Majority of transplant recipients did not develop an appreciable humoral response following SARS-CoV-2 vaccine, in contrast to dialysis patients and healthy individuals. We analyzed the serologic response to BNT162b2 (Pfizer-BioNTech) vaccine in a cohort of 19 kidney transplant recipients, vaccinated prior to transplantation, compare to 109 recipients vaccinated after transplantation, and to 39...

Seroprevalence of SARS-CoV-2 antibodies in patients with autoimmune inflammatory rheuma...
https://www.ncbi.nlm.nih.gov/pubmed/34494961
Clinical and Experimental Rheumatology; Eviatar T, Furer V et. al.

Sep 9th, 2021 - To assess the prevalence of anti-SARS-CoV-2 antibodies in autoimmune inflammatory rheumatic disease (AIIRD) patients, and to define clinical factors associated with seropositivity. A cross sectional study was conducted at a tertiary rheumatology department in Israel. Consecutive patients completed a questionnaire and were tested for SARS-CoV-2 anti-nucleoprotein IgG (N-IgG). If this was positiv...

Late reinfection with a different severe acute respiratory syndrome coronavirus-2 clade...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419670
Journal of Medical Case Reports; García-Abellán J, Galiana A et. al.

Sep 8th, 2021 - Differentiating between persistent infection with intermittent viral shedding and reinfection with severe acute respiratory syndrome coronavirus 2 remains challenging. Although a small number of cases with genomic evidence of second infection have been reported, limited information exists on frequency and determinants of reinfection, time between infections, and duration of immunity after the p...

Atypical bacterial co-infections among patients with COVID-19: A study from India.
https://doi.org/10.1002/jmv.27324
Journal of Medical Virology; Chaudhry R, Sreenath K et. al.

Sep 8th, 2021 - Emerging evidence shows co-infection with atypical bacteria in coronavirus disease 2019 (COVID-19) patients. Respiratory illness caused by atypical bacteria such as Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila may show overlapping manifestations and imaging features with COVID-19 causing clinical and laboratory diagnostic issues. We conducted a prospective study to id...

Low seropositivity for SARS-CoV-2 antibodies among healthcare workers after the first C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324404
Public Health; Galanis P, Kaitelidou D et. al.

Sep 6th, 2021 - To estimate the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seropositivity among healthcare workers (HCWs) in Greece and to identify high-risk groups in healthcare facilities. The study design used in this study is a nationwide cross-sectional study. Data were collected from 1 June to 9 July 2020. HCWs in the Greek National Health System were offered a free SARS-C...

False-Positive Rates in Pediatric SARS-CoV-2 Serology Testing.
https://doi.org/10.1093/ajcp/aqab118
American Journal of Clinical Pathology; Henry BM, Benoit SW et. al.

Sep 5th, 2021 - False-Positive Rates in Pediatric SARS-CoV-2 Serology Testing.|2021|Henry BM,Benoit SW,Lippi G,Sabalza M,Venkataraman I,|

Six Month Efficacy and Toxicity Profile of BNT162b2 Vaccine in Cancer Patients with Sol...
https://doi.org/10.1158/2159-8290.CD-21-1072
Cancer Discovery; Waldhorn I, Holland R et. al.

Sep 4th, 2021 - We had previously reported short-term efficacy, immunogenicity and safety of BNT162b2 vaccine among cancer patients with solid tumors. We aimed to evaluate these outcomes at 6-months post-vaccination. Study cohort comprised of patients who were on treatment during vaccination and throughout 6-months post-vaccination. Serological tests were performed after second vaccination and 6-months afterwa...

COVID-19 and Co-infection in Children: The Indian Perspectives.
https://doi.org/10.1093/tropej/fmab073
Journal of Tropical Pediatrics; Raychaudhuri D, Sarkar M et. al.

Sep 4th, 2021 - Assessing the co-infections with COVID-19 is crucial to delineate its true clinical impact. Pediatric information in this aspect is limited. Our study aims to analyze the spectrum of co-infections in pediatric COVID-19 patients and determine the clinical as well as laboratory parameters predicting co-infection. In this prospective observational study conducted from June to December 2020 in a si...

Convalescent plasma associates with reduced mortality and improved clinical trajectory ...
https://doi.org/10.1172/JCI151788
The Journal of Clinical Investigation; Arnold Egloff SA, Junglen A et. al.

Sep 1st, 2021 - Evidence supporting convalescent plasma (CP), one of the first investigational treatments for COVID-19, has been inconclusive, leading to conflicting recommendations. The primary objective was to perform a comparative effectiveness study of CP for all-cause, in-hospital mortality in patients with COVID-19. The multicenter, electronic health records-based, retrospective study included 44,770 pat...

Antibody landscapes of SARS-CoV-2 can reveal novel vaccine and diagnostic targets.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376662
Current Opinion in Virology; Hachim A, Kavian N et. al.

Sep 1st, 2021 - SARS-CoV-2 virions are composed of structural proteins, but during virus infection, an additional 30 proteins could be expressed according to putative open reading frames (ORFs) of the viral genome. Some of these additional proteins modulate cellular processes through direct interactions, their truncations can affect disease pathogenesis and they can also serve as antigenic targets for more spe...

Duration of SARS-CoV-2 sero-positivity in a large longitudinal sero-surveillance cohort...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404407
BMC Infectious Diseases;

Sep 1st, 2021 - Estimating population prevalence and incidence of prior SARS-CoV-2 infection is essential to formulate public health recommendations concerning the COVID-19 pandemic. However, interpreting estimates based on sero-surveillance requires an understanding of the duration of elevated antibodies following SARS-CoV-2 infection, especially in the large number of people with pauci-symptomatic or asympto...

The serological prevalence of SARS-CoV-2 infection in patients with chronic myeloid leu...
https://doi.org/10.1002/cam4.4179
Cancer Medicine; Bonifacio M, Tiribelli M et. al.

Sep 1st, 2021 - Patients with hematological malignancies are at an increased risk of SARS-CoV-2 disease (COVID-19) and adverse outcome. However, a low mortality rate has been reported in patients with chronic myeloid leukemia (CML). Preclinical evidence suggests that tyrosine kinase inhibitors (TKIs) may have a protective role against severe COVID-19. We conducted a cross-sectional study of 564 consecutive pat...

Detection of SARS-CoV-2 antibodies formed in response to the BNT162b2 and mRNA-1237 mRN...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354789
Vaccine Kanji JN, Bailey A et. al.

Aug 30th, 2021 - With rapid approval of SARS-CoV-2 vaccines, the ability of clinical laboratories to detect vaccine-induced antibodies with available high-throughput commercial assays is unknown. We aimed to determine if commercial serology assays can detect vaccine-induced antibodies (VIAs) and understand the vaccination response. This cohort study recruited healthcare workers and residents of long-term care f...

Patterns of negative seroconversion in ongoing surveys of SARS-CoV-2 antibodies among w...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390144
Occupational and Environmental Medicine; Sembajwe G, Rasul R et. al.

Aug 27th, 2021 - Given the importance of continued COVID-19 surveillance, our objective was to present findings from a short follow-up survey of workforce SARS-CoV-2 antibody testing in previously seropositive participants and describe associations between work locations and negative seroconversion. We conducted a follow-up cross-sectional survey on previously seropositive healthcare workers, using questionnair...

Screening Tests in the Era of COVID-19: Implications for the Plastic Surgeon.
https://doi.org/10.1097/PRS.0000000000008278
Plastic and Reconstructive Surgery; Hamilton KL, Rohrich RJ

Aug 26th, 2021 - The novel coronavirus, severe acute respiratory syndrome coronavirus 2, responsible for the coronavirus disease of 2019 (COVID-19) pandemic, has claimed over 2 million lives to date and brought the global economy to a halt, including elective surgery. As the authors emerge from lockdown, new protocols must be implemented to minimize risk by means of appropriate screening of their patients, surg...

SARS-COV-2 seroprevalence among all healthcare workers in a tertiary hospital in Spain.
https://doi.org/10.1080/23744235.2021.1963468
Infectious Diseases (London, England); Cantero M, Millán-Pérez R et. al.

Aug 24th, 2021 - Healthcare workers (HCWs) have been a critical and vulnerable population during SARS-CoV-2 pandemic. The aim of this study was to determine the overall seroprevalence and to evaluate occupational risk factors among HCWs in one of the countries most affected by this pandemic. We conducted a seroprevalence study for SARS-CoV-2 in a tertiary hospital in Madrid (Spain) between 24 April and 8 May 20...

Evaluation of commercial SARS-CoV-2 serological assays in Canadian public health labora...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377389
Diagnostic Microbiology and Infectious Disease; Stein DR, Osiowy C et. al.

Aug 24th, 2021 - The COVID-19 pandemic has led to the influx of immunoassays for the detection of antibodies towards severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the global market. The Canadian Public Health Laboratory Network Serology Task Force undertook a nationwide evaluation of twelve laboratory and 6 point-of-care based commercial serological assays for the detection of SARS-CoV-2 ant...