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Assay dependence of long-term kinetics of SARS-CoV-2 antibodies.
https://doi.org/10.1016/j.diagmicrobio.2021.115403
Diagnostic Microbiology and Infectious Disease; Schallier A, De Baets S et. al.

May 31st, 2021 - Since the worldwide outbreak of the novel coronavirus (SARS-CoV-2), the question raised whether infected patients would elicit long-lasting protective immunity. Several companies developed serological assays for the detection of SARS-CoV-2 antibodies. In this study, we compared 4 different serology assays in convalescents up to 7 months post-infection. Both Abbott assays showed a significative ...

Knowledge, attitude, and practice regarding infection control measures among dental stu...
https://doi.org/10.1080/19338244.2021.1931796
Archives of Environmental & Occupational Health; Elagib MFA, Baldo SMH et. al.

May 28th, 2021 - Among health care professionals, dentists are more prone to infection due to their direct contact with blood and saliva. This study highlights the level of compliance with infection control measures among dental students; and linked this to their knowledge and attitudes regarding infection control measures and proper vaccinations. The study is a multi-centre analytical cross-sectional survey. T...

Outcomes of patients with end stage kidney disease on dialysis with COVID-19 in Abu Dha...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152185
BMC Nephrology; Ahmed W, Al Obaidli AAK et. al.

May 27th, 2021 - Individuals with end-stage kidney disease (ESKD) on dialysis are vulnerable to contracting COVID-19 infection, with mortality as high as 31 % in this group. Population demographics in the UAE are dissimilar to many other countries and data on antibody responses to COVID-19 is also limited. The objective of this study was to describe the characteristics of patients who developed COVID-19, the im...

Seroprevalence of SARS-CoV-2 antibodies in Seattle, Washington: October 2019-April 2020.
https://doi.org/10.1371/journal.pone.0252235
PloS One; McCulloch DJ, Jackson ML et. al.

May 27th, 2021 - The first US case of SARS-CoV-2 infection was detected on January 20, 2020. However, some serology studies suggest SARS-CoV-2 may have been present in the United States prior to that, as early as December 2019. The extent of domestic COVID-19 detection prior to 2020 has not been well-characterized. To estimate the prevalence of SARS-CoV-2 antibody among healthcare users in the greater Seattle, ...

Seroprevalence of SARS-CoV-2 Among Skilled Nursing Facility Residents and Staff Members...
https://doi.org/10.1093/infdis/jiab281
The Journal of Infectious Diseases; Malenfant JH, Eslami M et. al.

May 25th, 2021 - The prevalence of current/past coronavirus disease 2019 (COVID-19) in skilled nursing facility (SNF) residents is unknown because of asymptomatic infection and constrained testing capacity early in the pandemic. We conducted a seroprevalence survey (SPS) to determine a more comprehensive prevalence of past COVID-19 in Los Angeles County SNF residents and staff members. We recruited participants...

Safety of systemic anti-cancer treatment in oncology patients with non-severe COVID-19:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134961
BMC Cancer; van Marcke C, Honoré N et. al.

May 21st, 2021 - The viral pandemic coronavirus disease 2019 (COVID-19) has disrupted cancer patient management around the world. Most reported data relate to incidence, risk factors, and outcome of severe COVID-19. The safety of systemic anti-cancer therapy in oncology patients with non-severe COVID-19 is an important matter in daily practice. ONCOSARS-1 was a single-center, academic observational study. Adult...

Coronavirus (COVID-19) Update: May 21, 2021 | FDA
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-may-21-2021

May 21st, 2021 - For Immediate Release: May 21, 2021 The U.S. Food and Drug Administration (FDA) continued to take action in the ongoing response to the COVID-19 pandemic: The FDA issued a reminder to health care providers to give clear, step-by-step instructions to patients who, in a health care setting, self-collect anterior nasal samples for SARS-CoV-2 testing. Without proper instructions, patients may not c...

Lessons learned from the investigation of a COVID-19 cluster in Creil, France: effectiv...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133048
BMC Infectious Diseases; de Laval F, Grosset-Janin A et. al.

May 20th, 2021 - This study presents the methods and results of the investigation into a SARS-CoV-2 outbreak in a professional community. Due to the limited testing capacity available in France at the time, we elaborated a testing strategy according to pre-test probability. The investigation design combined active case finding and contact tracing around each confirmed case with testing of at-risk contact person...

In Children With Acute-Onset Neuropsychiatric Syndrome, Consider Possibility of COVID-19
https://www.medscape.com/viewarticle/951535

May 20th, 2021 - NEW YORK (Reuters Health) - Doctors should consider that children who present with pediatric acute-onset neuropsychiatric syndrome (PANS) may have COVID-19, a small case series from Italy suggests. "The two young adolescents here reported had a clinical diagnosis of new-onset PANS. Both were previously diagnosed with COVID-19 by a nasal swab," the authors write in The Lancet Child and Adolescen...

SARS-CoV-2 IgG response in symptomatic and asymptomatic COVID-19-infected healthcare wo...
https://doi.org/10.1093/occmed/kqab061
Occupational Medicine (Oxford, England); Cordova E, Bacelar B et. al.

May 19th, 2021 - Healthcare workers (HCWs) accounted for a significant proportion of COVID-19 infections worldwide. Retrospective seroprevalence surveys are often used to screen for unidentified previous infection with SARS-CoV-2. However, the rate of humoral response in HCWs affected by COVID-19 is not well-defined. To assess the specific IgG humoral response in symptomatic and asymptomatic SARS-CoV-2-infected...

FDA In Brief: FDA Advises Against Use of SARS-CoV-2 Antibody Test Results to Evaluate Immunity or Protection From COVID-19, Including After Vaccination | FDA
https://www.fda.gov/news-events/press-announcements/fda-brief-fda-advises-against-use-sars-cov-2-antibody-test-results-evaluate-immunity-or-protection

May 19th, 2021 - For Immediate Release: May 19, 2021 The following quote is attributed to Tim Stenzel, M.D., Ph.D., director of the Office of In Vitro Diagnostics and Radiological Health in the FDA’s Center for Devices and Radiological Health “The FDA is reminding the public of the limitations of COVID-19 antibody, or serology, testing and providing additional recommendations about the use of antibody tests in ...

Longitudinal Serology of SARS-CoV-2-Infected Individuals in India: A Prospective Cohort...
https://doi.org/10.4269/ajtmh.21-0164
The American Journal of Tropical Medicine and Hygiene; Thiruvengadam R, Chattopadhyay S et. al.

May 18th, 2021 - Clinical and epidemiological characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are now widely available, but there are few data regarding longitudinal serology in large cohorts, particularly those from low-income and middle-income countries. We established an ongoing prospective cohort of 3,840 SARS-CoV-2-positive individuals according to RT-PCR in the Delhi-Nation...

Acute Leukoencephalopathy with Restricted Diffusion in an Infant with Severe COVID-19 a...
https://doi.org/10.1093/tropej/fmab026
Journal of Tropical Pediatrics; Kariyappa M, Govindarajan V et. al.

May 17th, 2021 - COVID-19 pandemic is increasingly being recognized in infants and some develop cytokine storm mediated tissue damage. We report 5-month-old infant presenting with fever, refusal of feeds, developing altered sensorium and convulsions during the hospital course, tested positive for SARS-CoV2 RT-PCR in second week of illness. Her serology was also Dengue positive. She had features of cytokine stor...

Persisting Salivary IgG against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complemen...
https://doi.org/10.1093/infdis/jiab256
The Journal of Infectious Diseases; Alkharaan H, Bayati S et. al.

May 12th, 2021 - Declining humoral immunity in COVID-19 patients and the possibility of reinfection have raised concern. Mucosal immunity, particularly salivary antibodies, may be short-lived although long-term studies are lacking. Using a multiplex bead-based array platform, we investigated antibodies specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins in 256 saliva samples from c...

Prospective Case-Control Study of Cardiovascular Abnormalities 6 Months Following Mild ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105493
JACC. Cardiovascular Imaging; Joy G, Artico J et. al.

May 12th, 2021 - The purpose of this study was to detect cardiovascular changes after mild severe acute respiratory syndrome coronavirus 2 infection. Concern exists that mild coronavirus disease 2019 may cause myocardial and vascular disease. Participants were recruited from COVIDsortium, a 3-hospital prospective study of 731 health care workers who underwent first-wave weekly symptom, polymerase chain reaction...

How to interpret and use COVID-19 serology and immunology tests.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106522
Clinical Microbiology and Infection : the Official Public... Ong DSY, Fragkou PC et. al.

May 11th, 2021 - Although molecular tests are considered the reference standard for coronavirus disease 2019 (COVID-19) diagnostics, serological and immunological tests may be useful in specific settings. This review summarizes the underlying principles and performance of COVID-19 serological and immunological testing. Selected peer-reviewed publications on COVID-19 related serology and immunology published bet...

Cardiovascular Abnormalities 6 Months After Mild COVID-19 in Healthcare Workers
https://www.medscape.com/viewarticle/950974

May 11th, 2021 - Mild COVID-19 is very unlikely to cause lasting damage to the structure or function of the heart, according to a study led by University College London researchers and funded by the British Heart Foundation (BHF) and Barts Charity. Participants were recruited from the COVIDsortium, a three-hospital prospective study of 731 health care workers who underwent first-wave weekly symptom, polymerase ...

Correlation between BNT162b2 mRNA Covid-19 vaccine-associated hypermetabolic lymphadeno...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106512
European Journal of Nuclear Medicine and Molecular Imaging; Cohen D, Hazut Krauthammer S et. al.

May 9th, 2021 - Vaccine-associated hypermetabolic lymphadenopathy (VAHL) is frequently observed on [18F]FDG PET-CT following BNT162b2 administration. Recent data suggest a prominent B cell germinal-center (GC) response elicited by mRNA vaccines in draining lymph nodes. Thus, in this study we aimed to explore the correlation between VAHL and humoral immunity as reflected by post-vaccination serologic testing an...

Reassuring Data on Impact of Mild COVID-19 on the Heart
https://www.medscape.com/viewarticle/950840

May 9th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Six months after mild SARS-CoV-2 infection in a representative healthcare workforce, no long-term cardiovascular sequelae were detected compared with a matched SARS-CoV-2 seronegative group. "Mild COVID-19 left no measurable cardiovascular impact on LV structure, function, scar burden, aortic st...

Prevalence of SARS-CoV-2 Antibodies in a Multistate Academic Medical Center.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997730
Mayo Clinic Proceedings; Carter RE, Theel ES et. al.

May 7th, 2021 - To estimate the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in health care personnel. The Mayo Clinic Serology Screening Program was created to provide a voluntary, two-stage testing program for SARS-CoV-2 antibodies to health care personnel. The first stage used a dried blood spot screening test initiated on June 15, 2020. Those participants identi...