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Clinical features and severe acute respiratory syndrome-coronavirus-2 structural protei...
https://doi.org/10.1371/journal.pone.0273097
PloS One; Cortés-Sarabia K, Cruz-Rangel A et. al.

Aug 16th, 2022 - Severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 infection in children and adolescents primarily causes mild or asymptomatic coronavirus disease 2019 (COVID-19), and severe illness is mainly associated with comorbidities. However, the worldwide prevalence of COVID-19 in this population is only 1%-2%. In Mexico, the prevalence of COVID-19 in children has increased to 10%. As serology...

Predicting past and future SARS-CoV-2-related sick leave using discrete time Markov mod...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374214
PloS One; Lei J, Clements M et. al.

Aug 13th, 2022 - Prediction of SARS-CoV-2-induced sick leave among healthcare workers (HCWs) is essential for being able to plan the healthcare response to the epidemic. During first wave of the SARS-Cov-2 epidemic (April 23rd to June 24th, 2020), the HCWs in the greater Stockholm region in Sweden were invited to a study of past or present SARS-CoV-2 infection. We develop a discrete time Markov model using a co...

Recurrent SARS-CoV-2 Serology Testing and Pandemic Anxiety: A Study of Pediatric Health...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368345
International Journal of Environmental Research and Publi... Li N, Martin SR et. al.

Aug 13th, 2022 - Limited access to SARS-CoV-2 testing has been identified as a potential source of anxiety among healthcare workers (HCWs), but the impact of repeated testing on pandemic-related anxiety in pediatric HCWs has not been examined. We sought to understand the impact of repeated SARS-CoV-2 antibody testing on pediatric HCWs' COVID-19 anxiety. This longitudinal cohort study was conducted between April...

Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results f...
https://doi.org/10.1016/j.ebiom.2022.104208
EBioMedicine Ozonoff A, Schaenman J et. al.

Aug 12th, 2022 - Better understanding of the association between characteristics of patients hospitalized with coronavirus disease 2019 (COVID-19) and outcome is needed to further improve upon patient management. Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) is a prospective, observational study of 1164 patients from 20 hospitals across the United States. Disease severity was assessed using a 7-poi...

Deep venous thrombosis and acute pericarditis associated with severe acute respiratory ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363144
Journal of Medical Case Reports; Lubala TK, Kayembe-Kitenge T et. al.

Aug 10th, 2022 - Since the beginning of the pandemic, no severe pediatric coronavirus disease 2019 cases have been described in Congo. We studied a 3-month-old male child of Congolese origin who was admitted to the pediatric department with 7-day history of fever, unilateral lower leg swelling, and dyspnea. There was no known history of contact with a coronavirus disease 2019 patient, and all the family members...

Strongyloidiasis Hyperinfection Syndrome in COVID-19 Positive Migrants Treated with Cor...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358917
Journal of Immigrant and Minority Health; Jenks NP, Driscoll B et. al.

Aug 9th, 2022 - The aim of this study is to highlight the potentially fatal risk of Strongyloidiasis Hyperinfection Syndrome for hospitalized immigrant patients with moderate to severe COVID-19 disease and undiagnosed Strongyloidiasis. We reviewed electronic medical records of immigrants from 2010 to 2022 and extracted the number of patients with eosinophilia, strongyloidiasis and COVID-19 infection, outpatien...

Bebtelovimab - bebtelovimab injection, solution-Eli Lilly and Company
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fd8dc07c-3aae-4cc2-a547-3a19357411ca

Aug 5th, 2022 - SPL UNCLASSIFIED SECTION HIGHLIGHTS OF EMERGENCY USE AUTHORIZATION (EUA) These highlights of the EUA do not include all the information needed to use BEBTELOVIMAB under the EUA. See the FULL FACT SHEET FOR HEALTHCARE PROVIDERS for BEBTELOVIMAB. BEBTELOVIMAB injection for intravenous use Original EUA Authorized Date: 02/2022 Revised EUA Authorized Date: 08/2022 ----------------------------RECENT...

Estimating transmission dynamics of SARS-CoV-2 at different intraspatial levels in an i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306265
Epidemics Jin S, Dickens BL et. al.

Aug 1st, 2022 - Large, localised outbreaks of COVID-19 have been repeatedly reported in high-density residential institutions. Understanding the transmission dynamics will inform outbreak response and the design of living environments that are more resilient to future outbreaks. We developed an individual-based, multilevel transmission dynamics model using case, serology and symptom data from a 60-day cluster ...

FDA Roundup: July 29, 2022 | FDA
https://www.fda.gov/news-events/press-announcements/fda-roundup-july-29-2022

Jul 29th, 2022 - For Immediate Release: July 29, 2022 Today, the U.S. Food and Drug Administration is providing an at-a-glance summary of news from around the agency: On Tuesday, the FDA updated the FAQs on Testing for SARS-CoV-2 to note that no tests remain on the commercial manufacturer serology test notification list described in the FDA’s Policy for Coronavirus Disease-2019 Tests. All tests previously on th...

Performance of SARS-CoV-2 Antigens in a Multiplex Bead Assay for Integrated Serological...
https://doi.org/10.4269/ajtmh.22-0078
The American Journal of Tropical Medicine and Hygiene; Gwyn S, Abubakar A et. al.

Jul 28th, 2022 - Serosurveillance can provide estimates of population-level exposure to infectious pathogens and has been used extensively during the COVID-19 pandemic. Simultaneous, serological testing for multiple pathogens can be done using bead-based immunoassays to add value to disease-specific serosurveys. We conducted a validation of four SARS-CoV-2 antigens-full-length spike protein, two receptor bindin...

Serological findings following the second and third SARS-CoV-2 vaccines in lung transpl...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311263
Immunity, Inflammation and Disease; Bárczi E, Varga V et. al.

Jul 28th, 2022 - Lung transplant recipients (LuTX) represent a vulnerable population for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Even though many vaccines are already developed, more clinical data need to support effective immunological response in immunocompromised patients. Stable LuTX recipients with no medical history of coronavirus disease (COVID-19) were enrolled. Currently available...

Clinical profile and outcomes of multisystem inflammatory syndrome in children (MIS-C):...
https://doi.org/10.1111/jpc.16129
Journal of Paediatrics and Child Health; Karunakar P, Ramamoorthy JG et. al.

Jul 24th, 2022 - To study the clinical profile and outcomes in children with multisystem inflammatory syndrome in children (MIS-C). Children aged 1 month to 15 years presenting with MIS-C (May 2020 to November 2021) were enrolled. Clinical, laboratory, echocardiography parameters and outcomes were analysed. Eighty-one children (median age 60 months (24-100)) were enrolled. Median duration of fever was 5 days (3...

Emergency department personnel patient care-related COVID-19 risk.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307202
PloS One; Mohr NM, Krishnadasan A et. al.

Jul 23rd, 2022 - Emergency department (ED) health care personnel (HCP) are at risk of exposure to SARS-CoV-2. The objective of this study was to determine the attributable risk of SARS-CoV-2 infection from providing ED care, describe personal protective equipment use, and identify modifiable ED risk factors. We hypothesized that providing ED patient care increases the probability of acquiring SARS-CoV-2 infecti...

Differential avidity determination of IgG directed towards the receptor-binding domain ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349558
Journal of Medical Virology; Bauer G, Struck F et. al.

Jul 20th, 2022 - The avidity (binding strength) of IgG directed towards the receptor-binding domain (RBD) of spike protein has been recognized as a central marker in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology. It seems to be linked to increased infection-neutralization potential and therefore might indicate protective immunity. Using a prototype line assay based on the established rec...

Setting Bias Specifications Based on Qualitative Assays With a Quantitative Cutoff Usin...
https://doi.org/10.1093/ajcp/aqac072
American Journal of Clinical Pathology; Lim CY, Chang WZ et. al.

Jul 19th, 2022 - Automated qualitative serology assays often measure quantitative signals that are compared against a manufacturer-defined cutoff for qualitative (positive/negative) interpretation. The current general practice of assessing serology assay performance by overall concordance in a qualitative manner may not detect the presence of analytical shift/drift that could affect disease classifications. We ...

Acute corticosteroid responsive meningo-encephalitis with cerebral vasculitis after COV...
https://doi.org/10.1055/a-1896-6154
Neuropediatrics Francois G, Cleuziou P et. al.

Jul 12th, 2022 - Various neurologic manifestations have already been described in children during or after severe acute respiratory syndrome coronavirus 2 (SARS-Cov2) infections,. The central nervous system disorders reported in children are mainly encephalopathies during Multisystem inflammatory syndrome (MIS-C). We present here an acute meningo-encephalitis with cerebral vasculitis associated to a COVID-19 in...

Gestational SARS-CoV-2 infection is associated with placental expression of immune and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242701
Placenta Lesseur C, Jessel RH et. al.

Jul 8th, 2022 - Maternal SARS-CoV-2 infection during pregnancy is associated with adverse pregnancy outcomes and can have effects on the placenta, even in the absence of severe disease or vertical transmission to the fetus. This study aimed to evaluate histopathologic and molecular effects in the placenta after SARS-CoV-2 infection during pregnancy. We performed a study of 45 pregnant participants from the Gen...

Safety, Effectiveness, and Immunogenicity 6 Months After BNT162B2 mRNA Vaccine in Frail...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261238
Drugs & Aging; Montejano-Hervás P, Gómez-Pavón J et. al.

Jul 7th, 2022 - Elderly people who reside in long-term care facilities form a frail and vulnerable population, with multiple pathologies and high percentages of cognitive and functional disability. The aims of this study were to assess the safety of vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in frail nursing home residents and to evaluate its effectiveness 6 months after f...

Radiological findings of multisystem inflammatory syndrome in children associated with ...
https://doi.org/10.1259/bjr.20220101
The British Journal of Radiology; Kalın S, Sözeri B

Jun 29th, 2022 - To retrospectively evaluate the imaging and clinical findings of patients diagnosed with multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19. The clinical, laboratory and radiological data of 110 patients (74 male and 36 female) diagnosed with COVID-19-related MIS-C between June 2020 and November 2021 were evaluated retrospectively. Cases with a diagnosis of MIS-C bas...

Validation of laboratory developed serology assays for detection of IgG antibody to sev...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9212509
Journal of Virological Methods; Matefo L, Cloete VV et. al.

Jun 25th, 2022 - Serological assays for detection of IgG, IgM or IgA against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) play an important role in surveillance, antibody persistence, vaccine coverage and infection rate. Serological assays, including both ELISA and rapid lateral flow assays, are available commercially but the cost limits their accessibility for low resource countries. Although s...